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  • Health Outcomes Among Children and Families Living in Rural Communities (Day 2)
    • - Eunice Kennedy Shriver National Institute of Child Health and Human Development (2011/12/08)
    • - Category : Conferences
    This trans-agency conference brings together a panel of community members and experts from NIH Institutes and Centers, federal agencies, and organizations to identify gaps in research that address emerging differences between health outcomes for children and families living in rural communities compared to those in urban areas.

    Access to care and services remains a critical issue for improving the health of individuals who live in rural and underserved areas. A growing body of evidence supports the concept that a rural place of residence is associated with poor health outcomes and risky health behaviors. Further, multiple reports (e.g., Rural Healthy People 2010) have documented several unmet health needs of children living in rural communities. These children are reportedly less physically active and have higher rates of tobacco use, overweight/obesity, and dental caries than their urban counterparts. Further, differences in health behavior and outcomes can be exacerbated by poverty and low educational attainment within families living in rural areas.

    There is a need for collaborative research to fully understand the impact of all these health indicators on the long-term health of children living in rural areas. Additional research is also needed to further understand the barriers and challenges associated with the use of technological advances (e.g., telemedicine, telepsychiatry) to improve the quality-of-life of those living in rural areas.

    For more information, visit: http://www.nichd.nih.gov/about/meetings/2011/120211.cfm

    Health Outcomes Among Children and Families Living in Rural Communities (Day 2)

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  • Epigenetics and plasticity in cardiac and intestine progenitor populations
    • - Jonathan Epstein, PhD, University of Pennsylvania (2011/12/08)
    • - Category : NCRM Interview Lectures
    NIH CRM/SCIG Stem Cell Seminar Series:

    Dr. Epsteins laboratory studies molecular mechanisms of neural crest and cardiac development, with a particular interest in applying lessons learned from developmental models to the understanding and therapy of adult diseases. One area of interest relates to the role of the Pax3 transcription factor in neural crest cells. Neural crest can differentiate into a multitude of cell types including nerve, bone, vascular smooth muscle and melanocytes. Defects in neural crest, and mutations in Pax3, can lead to common forms of congenital heart disease. We have used mouse models to elucidate a molecular cascade involved in cardiac neural crest migration and differentiation, implicating members of the BMP, Notch, Semaphorin, myocardin and T-box families in this process. This work has direct relevance to the understanding of the genetic basis of congenital heart disease.

    The Lab also used neural crest as a model of stem cell biology, and we have identified adult neural crest stem cells that reside in the hair follicle and give rise to regenerating melanocytes. Here, Pax3 plays a critical role both in determining cell-fate specification, and also in maintaining the undifferentiated stem cell phenotype until external signals, including induced by Wnt signals, trigger changes in transcriptional complexes and melanocyte differentiation

    Epigenetics and plasticity in cardiac and intestine progenitor populations

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  • Virus Clearance: It Isnt Easy
    • - Dr. Diane E. Griffin, Johns Hopkins School of Public Health (2011/12/07)
    • - Category : Wednesday Afternoon Lectures
    Viruses can cause acute, latent or persistent infections depending on the effectiveness of the immune response in clearance of the virus from sites of infection. Clearance of acute RNA virus infections is generally thought to occur by cytolytic mechanisms within a few days. Our studies of alphavirus encephalitis have shown that clearance of infectious virus from the infected neurons is complete 7-8 days after infection, but that clearance of viral RNA occurs over many weeks and is never complete. Suppression of virus reactivation requires long-term residence of immune cells in the brain and spinal cord. Likewise, our studies of measles virus infection has shown that infectious virus is cleared within 1-2 days after the rash has faded, but clearance of viral RNA from peripheral blood mononuclear cells and lymphoid tissues is ongoing for several months. These findings may help to explain slow resolution of symptoms, prolonged immune suppression and late appearance of disease associated with persistent infection.

    The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    For more information, visit:
    The NIH Directors Wednesday Afternoon Lecture Series

    Virus Clearance: It Isnt Easy

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  • Health Outcomes among Children and Families Living in Rural Communities (Day 1)
    • - Eunice Kennedy Shriver National Institute of Child Health and Human Development (2011/12/07)
    • - Category : Conferences
    This trans-agency conference brings together a panel of community members and experts from NIH Institutes and Centers, federal agencies, and organizations to identify gaps in research that address emerging differences between health outcomes for children and families living in rural communities compared to those in urban areas.

    Access to care and services remains a critical issue for improving the health of individuals who live in rural and underserved areas. A growing body of evidence supports the concept that a rural place of residence is associated with poor health outcomes and risky health behaviors. Further, multiple reports (e.g., Rural Healthy People 2010) have documented several unmet health needs of children living in rural communities. These children are reportedly less physically active and have higher rates of tobacco use, overweight/obesity, and dental caries than their urban counterparts. Further, differences in health behavior and outcomes can be exacerbated by poverty and low educational attainment within families living in rural areas.

    There is a need for collaborative research to fully understand the impact of all these health indicators on the long-term health of children living in rural areas. Additional research is also needed to further understand the barriers and challenges associated with the use of technological advances (e.g., telemedicine, telepsychiatry) to improve the quality-of-life of those living in rural areas.

    For more information, visit: http://www.nichd.nih.gov/about/meetings/2011/120211.cfm

    Health Outcomes among Children and Families Living in Rural Communities (Day 1)

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  • Functional Organization of Attentional Modulation in Primate V4
    • - Anna Wang Roe, PhD, Vanderbilt University (2011/12/07)
    • - Category : Neuroscience
    Neuroscience Seminar Series

    Dr. Roe？？？s lab studies the neuronal circuitry and functional organization underlying visual and tactile behavior in awake, behaving monkeys. To map these functions in the brain, her lab uses an array of optical imaging, fMRI, electrophysiological, anatomical and optogenetics methods. Dr. Roe？？？s work shows that chronic implanted windows on the brain permit: 1) study of sensory and attentional processes and 2) methods to influence brain activity with electrical, laser, and optogenetic stimulation methods. This combined behavioral, functional, anatomical, and neuroengineering approach will lead to development of future mind-machine interfaces that modify and enhance function in normal and diseased states. Dr. Roe has held faculty positions at Baylor College of Medicine and at Yale University. She has been at Vanderbilt University since 2003 where she is presently a Professor in the Department of Psychology, Professor in the Department of Radiology, and an Associate Professor in the Department of Biomedical Engineering.

    For more information, visit: http://neuroseries.info.nih.gov

    Functional Organization of Attentional Modulation in Primate V4

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  • Bioinformatics and Computational Approaches to Integrate Genes and Environment in Autism Research (Day 1)
    • - Dr. Cindy Lawler (2011/12/06)
    • - Category : Conferences
    The meeting will bring together experts in bioinformatics, computational biology and small molecule screening paradigms with key researchers in the genomics, epigenomics, and neurobiology of autism to discuss the possibilities for applying new bioinformatics and screening tools and approaches to advance research on environmental contributors to autism and needed resources to enhance the use of these strategies.

    Bioinformatics and Computational Approaches to Integrate Genes and Environment in Autism Research (Day 1)

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  • Bioinformatics and Computational Approaches to Integrate Genes and Environment in Autism Research (Day 2)
    • - Dr. Cindy Lawler (2011/12/06)
    • - Category : Conferences
    This is a second day meeting that will bring together experts in bioinformatics, computational biology and small molecule screening paradigms with key researchers in the genomics, epigenomics, and neurobiology of autism to discuss the possibilities for applying new bioinformatics and screening tools and approaches to advance research on environmental contributors to autism and needed resources to enhance the use of these strategies.

    Bioinformatics and Computational Approaches to Integrate Genes and Environment in Autism Research (Day 2)

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  • Glycoproteomics Using Mass Spectrometry and Lectin Microarrays
    • - Dr. Hui Zhang, Department of Pathology, Johns Hopkins University (2011/12/04)
    • - Category : Proteomics
    NIH Proteomics Interest Group Lecture:

    Glycosylation is one of the most common forms of protein modifications. Each glycoprotein can be glycosylated at different glycosites and each glycosite may be modified by different glycans. This structural heterogeneity has complicated the study of the structure-function relationships of glycoproteins. To rapid identify and quantify the glycosylation on particular glycosites from complex biological mixtures, glycan-lectin affinity chromatography and chemical immobilization are used to isolate glycopeptides containing certain glycans, followed by mass spectrometry analysis.

    We showed that upon the identification of disease-specific changes in glycosylation using lectin microarray technique, glycosites containing aberrant glycans were readily identifiable and quantifiable using the combination of lectins and mass spectrometry. The application of glycoproteomics may facilitate our understanding of how perturbed glycosylation impacts upon disease progression and could be used to discover glycosylated proteins that could serve as biomarkers or therapeutic targets to improve clinical outcomes of patients.

    Glycoproteomics Using Mass Spectrometry and Lectin Microarrays

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  • 1) Overcoming Barriers and Identifying Opportunities to Collecting High Quality Human Tissues, 2) Rare Disorders Collected and Stored at the NICHD Brain and Tissue Bank, 3) Clinical Biobanking: The Foundation for Personalized Medicine
    • - A. Roger Little, Ph.D.; Ronald Ziekle, Ph.D.; David Carpentieri, M.D. (2011/12/03)
    • - Category : Biospecimens
    Biospecimen Interest Group Presentation

    Overcoming Barriers and Identifying Opportunities to Collecting High Quality Human Tissues: Findings of the Neurobiobank Workgroup

    Rare Disorders Collected and Stored at the NICHD Brain and Tissue Bank for Developmental disorders

    Clinical Biobanking: The Foundation for Personalized Medicine

    For more information, visit
    http://sigs.nih.gov/biospecimens/Pages/default.aspx

    1) Overcoming Barriers and Identifying Opportunities to Collecting High Quality Human Tissues, 2) Rare Disorders Collected and Stored at the NICHD Brain and Tissue Bank, 3) Clinical Biobanking: The Foundation for Personalized Medicine

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  • The Link Between Gaucher Disease and Parkinsonism: From Neuroimaging and Neurobiology
    • - (1) Ozlem Goker-Alpan, MD, Special Consultant, Section on Molecular Neurogenetics, Medical Genetics Branch, NHGRI (2) Joseph C. Masdeu, MD, PhD, Senior Clinician, Section on Integrative Neuroimaging, NIMH (2011/12/03)
    • - Category : Clinical Center Grand Rounds
    CC Grand Rounds

    For more information, visit: http://www.cc.nih.gov/about/news/grcurrent.html

    The Link Between Gaucher Disease and Parkinsonism: From Neuroimaging and Neurobiology

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  • What NIH Grantees Need to Know About the 2011 Revised Financial Conflict of Interest (FCOI) Regulations
    • - NIH Office of Extramural Research (2011/12/03)
    • - Category : Special
    The U.S. Department of Health and Human Services (HHS) and the National Institutes of Health (NIH) issued the final rule that amends the Public Health Service (PHS) regulation on Responsibility of Applicants for Promoting Objectivity in Research for Which PHS Funding is Sought (42 CFR Part 50, Subpart F), commonly referred to as the Financial Conflict of Interest (FCOI) regulation. An institution applying for or receiving NIH funding from a grant or cooperative agreement must be in compliance with all of the revised regulatory requirements no later than August 24, 2012.

    The revised regulation modifies the requirements of the 1995 FCOI regulation in a number of important areas including Investigator disclosure and training requirements, institutional management of financial conflicts, and public accessibility requirements. This webinar will clarify those changes and provide a summary of responsibilities of the grantee institution and its Investigators.

    There will be time allotted for questions from the audience.

    PowerPoint Slides

    Acrobat Slides

    What NIH Grantees Need to Know About the 2011 Revised Financial Conflict of Interest (FCOI) Regulations

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  • ENVIRONMENTS, INFLAMMATION, TRANSGENERATIONAL PERPETUATION OF DISPARITIES IN HEALTH
    • - Thomas McDade, PhD (2011/12/01)
    • - Category : BSSR Lecture Series
    Inflammation is an important part of human immune defenses against infectious disease, but recent research has implicated dysregulated inflammation in the pathophysiology of a wide range of chronic degenerative diseases, as well as adverse birth outcomes. Current understandings of the links between inflammation and disease are based primarily on research in post- epidemiologic transition populations with high levels of overweight/obesity, and low levels of infectious exposures.

    This presentation applies a populations- based, developmental, ecological framework to the study of inflammation in humans, and suggests that environments in infancy are critical to defining how inflammation is regulated in adulthood. The impact of early environments in turn modifies responsiveness to inflammatory stressors later in life, pointing toward a potentially important mechanism in the intergenerational transmission of disparities in health.

    ENVIRONMENTS, INFLAMMATION, TRANSGENERATIONAL PERPETUATION OF DISPARITIES IN HEALTH

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  • Imaging the Connectome
    • - Jeff Lichtman, M.D., Ph.D., Harvard University (2011/12/01)
    • - Category : Neuroscience
    Neuroscience Seminar Series

    Dr. Lichtman？？？s research interests emphasize how mammalian brains accommodate information based on early experiences. He has focused on the dramatic rewiring of neural connections that occurs in early postnatal development. This work has required the development of techniques to visualize the patterns of connections in the nervous system and how they are altered over time. These approaches include automated methods for serial electron microscopy based on a novel microtome and a scanning electron microscope approach.

    For more information, visit: http://neuroseries.info.nih.gov

    Imaging the Connectome

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  • TRACO: Inflammation, Case report
    • - Curtis Harris: Oluwadamilola Olaku (2011/12/01)
    • - Category : TRACO
    The Translational Research in Clinical Oncology (TRACO) course will be held on Monday afternoons from September to December at the Bethesda campus, Bldg. 50 ground floor auditorium. TRACO is designed to provide an overview of general principles of cancer biology and treatment, epidemiology, mechanisms of resistance, metastasis, use of preclinical models, and identification of novel molecular targets. Participants will have an unprecedented opportunity to learn new information, glimpse into future developments of translational research in clinical oncology, meet leaders in cancer research, and interview cancer survivors. These courses are part of a curriculum for training NCI clinical and postdoctoral fellows.

    For more information, visit: http://ccr.cancer.gov/careers/courses/traco

    TRACO: Inflammation, Case report

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  • Asbestos Awareness (NIH Only)
    • - John Veitch (2011/12/01)
    • - Category : Occupational Health & Safety Lectures (NIH Only)
    This presentation on Asbestos safety is considered a mandatory training for most ORF employees. Those who cannot attend will need to view the webcast in the archive.

    Asbestos Awareness (NIH Only)

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  • TRACO: Colon cancer: Tumor Imaging
    • - Matthew Young: Peter Choyke (2011/11/29)
    • - Category : TRACO
    The Translational Research in Clinical Oncology (TRACO) course will be held on Monday afternoons from September to December at the Bethesda campus, Bldg. 50 ground floor auditorium. TRACO is designed to provide an overview of general principles of cancer biology and treatment, epidemiology, mechanisms of resistance, metastasis, use of preclinical models, and identification of novel molecular targets. Participants will have an unprecedented opportunity to learn new information, glimpse into future developments of translational research in clinical oncology, meet leaders in cancer research, and interview cancer survivors. These courses are part of a curriculum for training NCI clinical and postdoctoral fellows.

    For more information, visit: http://ccr.cancer.gov/careers/courses/traco

    TRACO: Colon cancer: Tumor Imaging

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  • The NIH Telework Festival - Workshop - How to Keep the Mission Moving and Driving Towards Excellence (NIH Only)
    • - The NIH Telework and Flexible Work Schedules Workgroup (2011/11/29)
    • - Category : NIH Only
    A panel of IC leadership and representatives from outside organizations will discuss how they maintain productivity and manage performance with their teleworking staff. They will explore the responsibilities of both managers and employees in using telework as an effective and efficient tool.

    For more information, visit: http://meetings.nigms.nih.gov/meetings/TeleworkFestival/

    The NIH Telework Festival - Workshop - How to Keep the Mission Moving and Driving Towards Excellence (NIH Only)

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  • SEER PI Meeting - November 2011 (Day 2)
    • - NCI (2011/11/25)
    • - Category : Conferences
    SEER PI Meeting

    SEER PI Meeting - November 2011 (Day 2)

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  • Innate Natural Killer Receptors and their Ligands: Regulation in Cancer, Infection, Inflammatory Disase, and Steady State
    • - Dr. David Raulet, University of California, Berkeley (2011/11/25)
    • - Category : Immunology
    Immunology Interest Group Seminar

    Innate Natural Killer Receptors and their Ligands: Regulation in Cancer, Infection, Inflammatory Disase, and Steady State

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  • Eighth Annual Interdisciplinary Womens Health Research Symposium
    • - Office of Research on Womens Health, NIH (2011/11/25)
    • - Category : Womens Health
    The event will feature the latest interdisciplinary research findings on women's health and sex and gender factors that affect health and disease.

    For more information, visit: http://orwh.od.nih.gov

    Eighth Annual Interdisciplinary Womens Health Research Symposium

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