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  • Contemporary Clinical Medicine: Great Teachers - The Sea Within Us: Clinical Disorders of Water Homeostasis
    • - Schrier, Robert W.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : Clinical Center Grand Rounds
    Contemporary Clinical Medicine: Great Teachers

    Robert W. Schrier, MD
    Professor of Medicine, Division of Renal Diseases and Hypertension
    University of Colorado Denver, School of Medicine

    For more information, visit
    http://www.cc.nih.gov/about/news/grcurrent.html

    Contemporary Clinical Medicine: Great Teachers - The Sea Within Us: Clinical Disorders of Water Homeostasis

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  • Acupuncture and Cancer Pain
    • - Dr. Ruixin Zhang, Center for Integrative Medicine, University of Maryland School of Medicine (2010/11/18)
    • - Category : OCCAM Monthly Lecture Series
    The NCIs Office of Cancer Complementary and Alternative Medicine (OCCAM) invites you to view its monthly lecture series.

    With the goal of informing the National Cancer Institute (NCI) community about the variety of ongoing research in cancer and complementary and alternative medicine (CAM), NCIs Office of Cancer Complementary and Alternative Medicine (OCCAM) has created a monthly lecture series on cancer CAM. These hour long lectures, occurring from 10 a.m. - 11 a.m. on the second Wednesday of each month, will feature a fifty minute presentation on a cancer CAM topic and allow ten minutes for questions.

    For more information, visit
    http://www.cancer.gov/cam/news/monthly-lecture-series.html

    Acupuncture and Cancer Pain

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  • Signaling Pathways That Regulate T Cell Development and Differentiation
    • - Berg, Leslie.
      National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18)
    • - Category : Immunology
    The research in Dr. Bergs laboratory is aimed at understanding the signal transduction pathways important for T lymphocyte development and activation. Using a combination of mouse genetics (transgenics and knockouts), biochemistry, and cellular immunology her current work focuses on three projects: First, characterization of the tyrosine kinase, Jak3, involved in cytokine receptor signaling, using Jak3-deficient mice. These mice have severe defects in lymphocyte development and function. Second, characterization of a novel tyrosine kinase, Itk, involved in T cell receptor signaling. Using Itk-deficient mice generated in the lab she is currently examining the role of this protein in lymphocyte development and activation. Finally, defining the role of Eph receptor tyrosine kinases and their ligands, ephrins, in T lymphocyte maturation. This latter family of proteins is known to play a role in cell migration and tissue patterning during the development of many organ systems in the body; and she is investigating a potential role for these receptor-ligand interactions during thymic development and T cell maturation.

    The Immunology Interest Group

    Signaling Pathways That Regulate T Cell Development and Differentiation

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  • Find and Apply for Grants with Grants.gov
    • - Kitty Marx (2010/11/18)
    • - Category : CMS - Centers for Medicare & Medicaid Services
    CMS Medicine Dish Series

    An expert from Grants.gov will cover:
    • How to register in Grants.gov
    • to find, apply and track applications using Grants.gov
    • Helpful tips to ensure your application is successfully completed
    Presenters:
    • Kitty Marx, Host, Tribal Affairs Director, OEA CMS
    • Michael Pellegrino, Outreach Director, Grants.gov Program Management Office
    For more information, visit www.cms.hhs.gov/AIAN/10_MedicineDishBroadcasts.asp

    Find and Apply for Grants with Grants.gov

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  • Gridlock on the Genomic Beltway: How Epigenetic Gene Silencing Shapes our Cellular Phenotypes
    • - Rauscher, F J.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : Wednesday Afternoon Lectures
    Dr. Rauschers research at Wistar focuses on the molecular genetics of cancer. In particular, he is interested in the structure-function aspects of tumor suppressor and oncogene proteins, mechanisms of transcriptional regulation, transcriptional control of cellular differentiation programs and organogenesis.

    Several years ago, he and his research team described the function of the WT1 gene that, when mutated, causes Wilms Tumor. More recently, Dr. Rauscher and his team discovered BAP1, a gene encoding an enzyme that helps regulate levels of BRCA1 and is involved in the development of breast and lung cancers.

    The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    Gridlock on the Genomic Beltway: How Epigenetic Gene Silencing Shapes our Cellular Phenotypes

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  • Recovery to Discovery: NIH ARRA Staff Award & Appreciation Event (NIH-Only)
    • - NIH Office of the Director (2010/11/18)
    • - Category : NIH Only
    This event will recognize NIH staff for their involvement in NIH Recovery-Act related activities. Dr. Raynard Kington and Dr. Larry Tabak will provide opening remarks and ？？？The Directors？？？ will share their musical talents in this fall-festival appreciation event. Emcee will be Mr. John Burklow.

    Recovery to Discovery: NIH ARRA Staff Award & Appreciation Event (NIH-Only)

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  • NCI/Penn Medicine Science Writers Seminar: Radiation Therapy for Cancer
    • - Vikram, Bhadrasain.
      National Cancer Institute (U.S.) (2010/11/18)
    • - Category : Special
    A NCI science writers seminar to discuss new treatments, technologies and research advances in radiation therapy for cancer.

    Welcome: Mike Miller, NCI Office of Media Relations; Holly Auer, Penn Medicine

    Stephen Hahn, M.D., Chair, Department of Radiation Oncology, Penn Medicine
    Proton therapy and conventional radiation: What clinical trials can teach us

    James Metz, M.D., Vice Chair, Clinical Operations Division, Department of Radiation Oncology, Penn Medicine
    Multi-modal therapy: How proton therapy can combine with novel chemotherapy agents and surgery to improve outcomes (Case study: Lung cancer)

    Bhadrasain Vikram, M.D., Chief, Clinical Radiation Oncology Branch, NCI
    Drugs developed as preventive in case of nuclear attack could be used to lessen side-effects from radiation therapy for cancer; comparative effectiveness studies

    Richard Maughan, Ph.D., Director of Medical Physics, Penn Medicine
    High-Tech, Personalized Care: Behind the scenes with proton therapy technology

    For more information, visit
    http://www.cancer.gov/newscenter

    NCI/Penn Medicine Science Writers Seminar: Radiation Therapy for Cancer

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  • Host Defense Gone Awry: From Inflammation to Cancer
    • - Wahl, Sharon M.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : Anita B. Roberts
    The Anita B. Roberts Lecture Series

    This series highlights outstanding research achievements of women scientists at the NIH. The seminar is dedicated to Dr. Anita Roberts and honors her role as an exceptional mentor and scientist.

    Anita joined the NIH in 1976 and spent 30 years at NCI, rising to Chief of the Laboratory of Cell Regulation and Carcinogenesis. She died of gastric cancer in May 2006, leaving a legacy that touched both the professional and personal lives of all who knew her. Her work focused primarily on TGF-beta and its role in the growth of epithelial and lymphoid cells. In 2003, Thomas Scientifics Science Watch listed her among the 50 most-cited scientists during 1982 to 2002, a feature called Twenty Years of Citation Superstars.

    Anita was a superstar to many for her mentoring talent and her ability to balance family and work life. Her successful lab was well known for meeting family needs and for providing an environment both intellectually and emotionally enriching. The lecture series in her name serves to highlight the fact that the NIH recognizes the value and necessity of a supportive workplace.

    For more information, visit
    http://www1.od.nih.gov/oir/sourcebook/comm-adv/wsa.htm

    Host Defense Gone Awry: From Inflammation to Cancer

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  • TRACO: Imaging and Prostate Cancer
    • - Choyke, Peter L.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : TRACO
    For more information, visit
    http://ccr.cancer.gov/careers/traco.asp

    TRACO: Imaging and Prostate Cancer

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  • Role of Artemis in the Regulation of the Mammalian Cell Cycle
    • - Legerski, Randy.
      National Institutes of Health (U.S.). DNA Repair Interest Group. (2010/11/18)
    • - Category : DNA Repair
    The DNA Repair Interest Group is concerned with all forms of DNA damage and repair. As a major defense against environmental damage to cells DNA repair is present in all organisms examined including bacteria, yeast, drosophila, fish, amphibians, rodents and humans. The members of the DNA Repair Interest Group perform research in areas including DNA repair enzymology and fine structure, mutagenesis, gene and cell cycle regulation, protein structure, and human disease.

    Acrobat Slides

    For more information, visit the
    DNA Repair Interest Group

    Role of Artemis in the Regulation of the Mammalian Cell Cycle

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  • Reversing Genetic Disease Phenotypes with Hematopoietic Stem Cell Therapy (NIH-Only)
    • - Dennis D. Hickstein, M.D. (2010/11/18)
    • - Category : NCI CCR Grand Rounds (NIH Only)
    NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link:
    http://www.bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx

    Reversing Genetic Disease Phenotypes with Hematopoietic Stem Cell Therapy (NIH-Only)

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  • 2009 NCI Directors Award Ceremony
    • - National Cancer Institute (U.S.) (2010/11/18)
    • - Category : Special
    Since the National Cancer Act was passed by Congress in 1971, making cancer research a national priority, NCI employee efforts have led to significant progress in cancer detection, diagnosis, prevention, treatment, and survivorship. Each year at the NCI Director？？？s Award Ceremony, we recognize the outstanding contributions of our colleagues that aid in the continued advancement of this progress.

    2009 NCI Directors Award Ceremony

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  • NCI Directors Consumer Liaison Group 52nd Meeting (Day 1)
    • - National Cancer Institute (2010/11/18)
    • - Category : Directors Consumer Liaison Group
    is the 52nd meeting of the National Cancer Institute Director？？？s Consumer Liaison Group (DCLG). The DCLG is NCI？？？s all-consumer advisory committee that indentifies and responds to issues and challenges facing the Institute at the request of the Director. The DCLG provides relevant, non-scientific skills and perspectives in order to improve research outcomes by identifying new approaches, promoting innovation, recognizing unforeseen risks or barriers, and identifying unintended consequences that could result from NCI decisions. This meeting will focus on NCI？？？s therapeutics development program as well as provide updates on the NCI National Outreach Network and the DCLG Advocate？？？s in Research Working Group.

    http://dclg.cancer.gov

    NCI Directors Consumer Liaison Group 52nd Meeting (Day 1)

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  • Risks and Benefits - 2009 (Session 5)
    • - Dave Wendler, Sara Chandros Hull, Crystal Mackall, Jorge Tavel and Tito Fojo (2010/11/18)
    • - Category : Bioethics
    Ethical and Regulatory Aspects of Clinical Research

    Department of Clinical Bioethics

    This course is designed to provide a historical context for research regulations and to help researchers and others working in human subject research gain insights and skills into the development of research protocols and their ethical implementation.

    Objectives of the Course:

    To learn the codes, declarations, and other documents that govern the ethical conduct of human subject research; review the critical elements of informed consent and their implementation in actual informed consent documents for clinical research; explore controversial issues relating to human subject research, including Phase I research, randomization, children in research, international research, etc; review the purpose if IRBs and provide IRB-like experience in reviewing research protocols; understand the experience of human subjects who have participated in research protocols.

    8:30-9:15？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？ ？？？？ Assessment of Risks and Benefits

    ？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？ Dave Wendler PhD

    ？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？ NIH Clinical Center Dept of Bioethics

    ？？？？？？？？？？？？？？？？？？？？？？ ？？

    9:15-9:25？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？ Discussion

     

    9:25-10:10 ？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？ Ethical Issues in the Use of Stored Tissue and Data

    Sara Chandros Hull, Ph.D.

    NHGRI and Dept of Bioethics

     

    10:10-10:20？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？ Discussion

     

    10:20-10:35？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？ Break

     

    10:35- 11:30？？？？ ？？？？？？？？？？？？？？？？？？？？ Investigator Panel

    ？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？ Crystal Mackall MD (pediatrics)

    ？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？ Jorge Tavel MD？？ (HIV/ international/ flu vaccine)

    ？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？ Tito Fojo MD？？ (medical oncology)

    For more information, visit
    http://www.bioethics.nih.gov

    Risks and Benefits - 2009 (Session 5)

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  • Innate immune defense against intestinal bacteria
    • - Pamer, Eric.
      National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18)
    • - Category : Immunology
    Infection with antibiotic-resistant bacteria, such as vancomycin-resistant Enterococcus (VRE), can occur following broad-spectrum antibiotic therapy. Antibiotic treatment of mice dramatically down-regulates intestinal expression of RegIIIg, a secreted C-type lectin that kills Gram-positive bacteria, including VRE. Down-regulation of RegIIIg markedly decreases in vivo killing of VRE in the intestine of antibiotic treated mice. Stimulation of intestinal TLR4 by oral administration of lipopolysaccharide (LPS) re-induces RegIIIg, thereby boosting innate immune resistance of antibiotic treated mice against VRE. LPS induces RegIIIg expression by stimulating TLRs in non-hematopoietic cells. Systemic administration of bacterial flagellin also induces expression of RegIIIg and provides protection against VRE colonization. In this case, however, TLR signaling occurs in hematopoietic cells. Interleukin-22 induction is central to TLR-mediated induction of RegIIIg. These studies indicate that TLR-signaling in cells of different lineage induces production of IL-22 and stimulates intestinal innate immune defenses. An excellent talk awaits!

    The Immunology Interest Group

    Innate immune defense against intestinal bacteria

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  • Careers in Public Health
    • - National Institutes of Health (U.S.). Office of Intramural Training & Education. (2010/11/18)
    • - Category : Career Development/OITE
    Public health careers offer something for everyone. Epidemiology and biostatistics involve mathematics and modeling. Environmental health includes a wide range of science skills. Health administration incorporates business and management skills. Health education involves skills required to develop community-wide prevention programs. Health policy includes an understanding of law-making processes.

    Speakers:
    Lorien Abroms, ScD, School of Public Health and Health Services, George Washington University

    Michael Ward, Associate Dean for Student Affairs, Johns Hopkins Bloomberg School of Public Health.

    Careers in Public Health

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  • Ethics Rounds - The Ethics of Using Lotteries as Incentives for Clinical Research
    • - Cowan, Tyler.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : Clinical Center Grand Rounds
    Ethics Rounds

    Tyler Cowan, PhD
    Professor of Economics, George Mason University

    For more information, visit
    http://www.cc.nih.gov/about/news/grcurrent.html

    Ethics Rounds - The Ethics of Using Lotteries as Incentives for Clinical Research

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  • Grants.gov Quarterly Stakeholder Webcast - October 2009
    • - Michael Pellegrino, Vince Sprouls and Bob Beattie (2010/11/18)
    • - Category : Grants.gov
    The Grants.gov Quarterly Stakeholder Webcast is a quarterly meeting where applicants and grantors are provided information regarding the Grants.gov program. The session is interactive so the grant community can e-mail questions during the broadcast.

    Michael Pellegrino, Grants.gov
    Vince Sprouls, Grants.gov
    Bob Beattie, University of Michigan

    Agenda:
    • Introduction
    • FY 09 Year in Review
    • Technical Augmentation Design (Boost)
    • Security Assessment
    • Applicant Perspective ？？？ Guest Speaker

    Grants.gov Quarterly Stakeholder Webcast - October 2009

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  • NCI Directors Consumer Liaison Group 52nd Meeting (Day 2)
    • - National Cancer Institute (2010/11/18)
    • - Category : Directors Consumer Liaison Group
    is the 52nd meeting of the National Cancer Institute Director？？？s Consumer Liaison Group (DCLG). The DCLG is NCI？？？s all-consumer advisory committee that indentifies and responds to issues and challenges facing the Institute at the request of the Director. The DCLG provides relevant, non-scientific skills and perspectives in order to improve research outcomes by identifying new approaches, promoting innovation, recognizing unforeseen risks or barriers, and identifying unintended consequences that could result from NCI decisions. This meeting will focus on NCI？？？s therapeutics development program as well as provide updates on the NCI National Outreach Network and the DCLG Advocate？？？s in Research Working Group.

    http://dclg.cancer.gov

    NCI Directors Consumer Liaison Group 52nd Meeting (Day 2)

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  • Intra- and Inter-Species Cell-to-Cell Communication in Bacteria
    • - Bassler, Bonnie L.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : Wednesday Afternoon Lectures
    Bacteria communicate with chemical languages that allow them to synchronize their behavior and thereby act as enormous multi-cellular organisms. This process, called quorum sensing, enables bacteria to successfully infect and cause disease host organisms. Investigations of the molecular mechanisms underlying quorum sensing are leading to the development of novel strategies to interfere with quorum sensing. These strategies form the basis of new therapies to be used as antibiotics.

    The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    Intra- and Inter-Species Cell-to-Cell Communication in Bacteria

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