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  • Mitochondrial Disease and the NHGRI Undiagnosed Disease Program (UDP)
    • - Bill Gahl, Harvey Mudd, Alex Gorbach, Lynne Wolfe and Camilo Toro (2012/05/09)
    • - Category : Mitochondria
    This Videocast/live presentation will highlight cases of the Undiagnosed Disease Program (UDP) that involve mitochondria, a subset of undiagnosed diseases.

    The speakers include:

    1. Bill Gahl (NHGRI-UDP)？？？ Overview of the UDP

    2. Harvey Mudd (NIMH)？？？ AdoMET abnormalities in mitochondrial DNA depletion disorders

    3. Alex Gorbach (NIBIB)？？？ Infrared Thermogenesis studies in Kearns-Sayre Syndrome (KSS)

    4. Lynne Wolfe (NHGRI-UDP)？？？ Is it or is not a mitochondrial disease ?

    5. Camilo Toro (NHGRI)- Adding Insult to Injury: How a Mutation of Nuclear-encoded Mitochondrial Protein ruins the Function of Another

    Q/A will be an integral part of this session so that the NIH and wider scientific community can learn the mission of the UDP, and understand how to interact with this resource.

    Mitochondrial Disease and the NHGRI Undiagnosed Disease Program (UDP)

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  • Secretory Trafficking and Synapse Remodeling for Neuronal Plasticity
    • - Michael D. Ehlers, MD, PhD, Division of Neuroscience, Pfizer, Inc. (2012/05/09)
    • - Category : Neuroscience
    Neuroscience Seminar Series

    Michael Ehlers is Vice President, Chief Scientific Officer of the Neuroscience Research Unit. Prior to joining Pfizer, Dr. Ehlers was the George Barth Geller Professor of Neurobiology and an Investigator of the Howard Hughes Medical Institute at Duke University Medical Center. Dr. Ehlers grew up rural Nebraska and earned his bachelor？？？s degree in chemistry from Caltech. He holds M.D. and Ph.D. degrees from the Johns Hopkins University School of Medicine, where he studied the regulation and trafficking of glutamate receptors. Dr. Ehlers？？？ research explores the interface between neuronal cell biology and the plasticity of neural circuits. His current efforts are focused on defining mechanisms of neuronal membrane trafficking and glutamatergic synapse plasticity implicated in Alzheimers disease, schizophrenia, and autism. He is the recipient of numerous awards including the 2003 Eppendorf & Science Prize in Neurobiology, the 2007 John J. Abel Award in Pharmacology, the 2007 Society for Neuroscience Young Investigator Award, and the 2009 National Alliance for Schizophrenia and Depression Distinguished Investigator Award.

    For more information go to http://neuroseries.info.nih.gov

    Secretory Trafficking and Synapse Remodeling for Neuronal Plasticity

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  • STEP - Stem Cell Therapy: Hype and Reality (HHS Only)
    • - Maqsood Wani (2012/05/06)
    • - Category : STEP (HHS Only)
    Will your doctor be able to order you a new heart off the shelf? Stem cells offer the promise of replacing damaged tissues and organs. Basic research, combined with advances in bioengineering, provides new insights into clinical interventions, disease modeling, drug screening and cell-based therapeutics. Come and learn about recent developments in different areas of stem cell research including clinical applications, regulatory policies, and ethics.

    For more information go to http://nih-extramural-intranet.od.nih.gov/nih/training/step/step_training_20120503.htm

    STEP - Stem Cell Therapy: Hype and Reality (HHS Only)

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  • Metabolic effects of skeletal muscle hypertrophy caused by myostatin inhibition
    • - Dr. Alexandra McPherron (2012/05/05)
    • - Category : Special
    Metabolomics Interest Group

    Myostatin is a secreted protein produced by skeletal muscle that regulates muscle mass. Myostatin knockout mice, made by deleting the myostatin gene by gene targeting, have a dramatic and widespread increase in skeletal muscle mass. Currently, Dr. McPherrons team is trying to understand how myostatin inhibits skeletal muscle mass at the cellular and molecular level both during development and in adulthood using the mouse as a model system. She will present her teams work on the effects of muscle hypertrophy on metabolism of muscle, fat, liver, and in serum and disucss possible implications of Myostatin inhibitors may be useful therapeutically to treat diabetes or obesity.

    Metabolic effects of skeletal muscle hypertrophy caused by myostatin inhibition

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  • Division of Administration All Hands Meeting - May 2012 (HHS Only)
    • - E.J. (Ned) Holland, Jr., HHS Assistant Secretary for Administration (2012/05/04)
    • - Category : HHS Only
    Quarterly employee briefing by the Assistant Secretary and members of the Division？？？s executive team

    Division of Administration All Hands Meeting - May 2012 (HHS Only)

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  • Tips for Mentoring a Summer Intern and Leading a Journal Club
    • - Lori Conlan, PhD, Director, Office of Postdoctoral Services, OITE; Carla Easter, PhD, Deputy Chief, Education and Community Involvement Branch, NHGRI (2012/05/04)
    • - Category : Career Development/OITE
    Soon the summer interns will descend on the NIH. This provides you the opportunity and responsibility to mentor enthusiastic young scientists. Your PI may put one or more of them under your charge to guide them in your research setting. Do you know what your intern(s) will do this summer? Have you thought about the best way to design a summer project for a novice? This workshop offers tips on how to help shape the future of the next generation of scientists, while preserving your own projects. Additionally, you may choose to lead a summer intern journal club. This workshop will provide guidance in selecting the right articles, guiding a discussion, and mentoring students on discussing scientific topics.

    For more information go to https://www.training.nih.gov

    Tips for Mentoring a Summer Intern and Leading a Journal Club

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  • Demystifying Medicine- Present status and future of careers in biomedical science
    • - J. Craig Venter (2012/05/04)
    • - Category : Demystifying Medicine
    The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.

    For more information go to http://demystifyingmedicine.od.nih.gov/

    Demystifying Medicine- Present status and future of careers in biomedical science

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  • Contemporary Clinical Medicine: Great Teachers: Colon Cancer Screening: Evolution Toward Eradication
    • - David A. Johnson, MD, Professor of Medicine, and Chief of Gastroenterology, Eastern Virigina Medical School (2012/05/04)
    • - Category : Clinical Center Grand Rounds
    Contemporary Clinical Medicine: Great Teachers: Colon Cancer Screening: Evolution Toward Eradication

    For more information go to http://www.cc.nih.gov/about/news/grcurrent.html

    Contemporary Clinical Medicine: Great Teachers: Colon Cancer Screening: Evolution Toward Eradication

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  • ORS Directors Brown Bag Lunch Series - May 2012 (NIH Only)
    • - ORS (2012/05/04)
    • - Category : NIH Only
    This optional lunch series is designed to bring together ORS FTE employees in an informal setting to receive the latest information, ask questions, provide feedback and generally discuss and interact on topics of the day.

    For more information, visit:
    http://orsweb.od.nih.gov/sites/od/default.aspx

    ORS Directors Brown Bag Lunch Series - May 2012 (NIH Only)

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  • Twenty-first Century Neuroscience: From Lab and Clinic to Home, School and Office
    • - Dr. Martha J. Farah, University of Pennsylvania (2012/05/04)
    • - Category : Wednesday Afternoon Lectures
    Until recently, advances in brain science have fallen into one of two categories: basic science and applied medical science. In the past few years a new category of advance has emerged: neuroscience applied to nonmedical problems, from fields as diverse as business, law, education and warfare. I will present possible reasons for this change in the landscape of neuroscience research and development, review some illustrative examples, and discuss some of the ethical, legal and societal implications of nonmedical applied neuroscience.

    The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    For more information, visit:
    The NIH Directors Wednesday Afternoon Lecture Series

    Twenty-first Century Neuroscience: From Lab and Clinic to Home, School and Office

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  • New insights into NER recognition: When being bulky and perturbing is not enough
    • - Dr. Carlos de los Santos - SUNY, Stonybrook, NY (2012/05/03)
    • - Category : DNA Repair
    DNA Repair Interest Group videoconference

    Acrobat Slides

    For more information go to http://sigs.nih.gov/DNA-repair/Pages/default.aspx

    New insights into NER recognition: When being bulky and perturbing is not enough

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  • Using Linked-In Effectively: Seventh in the "How to" Series
    • - Lori Conlan, PhD, Director, Office of Postdoctoral Services (2012/05/03)
    • - Category : Career Development/OITE
    In this How to workshop, we will examine how to use LinkedIn effectively for your career. We will explore creating your profile, getting introduced to others, and finding connections.

    For more information go to https://www.training.nih.gov

    Using Linked-In Effectively: Seventh in the "How to" Series

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  • The Expanding Epilepsy Genome
    • - Jeffrey Noebels, MD, PhD, Baylor College of Medicine (2012/05/02)
    • - Category : Neuroscience
    Neuroscience Seminar Series

    Dr. Noebels laboratory applies mutational analysis to learn how genes regulate neuronal excitability and network synchronization within the mammalian central nervous system. Spontaneous and transgenic mutations that express neurological phenotypes in the mouse provide a valuable opportunity to identify excitability genes and examine their role in synaptic plasticity in the developing brain.

    For more information go to http://neuroseries.info.nih.gov

    The Expanding Epilepsy Genome

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  • Careers in Science Writing: Sixth in the "How To" Series
    • - Lori Conlan, PhD, Director, Office of Postdoctoral Services (2012/05/02)
    • - Category : Career Development/OITE
    Do you want to use your scientific skills, knowledge, and experience and combine them with your love of writing? Have you ever wondered what kinds of skills you would need for a transition into science writing and how you would develop those skills?

    In this How to workshop, we will examine job sectors that employ science writers, the skills needed to get a job in the field, and how to prepare yourself for this career.

    This is the sixth in the new OITE How to series. The series dissects a variety of career path to explore what skills are necessary to succeed and how you can get those skills integrated into your resume as a grad student or postdoc.

    For more information go to https://www.training.nih.gov

    Careers in Science Writing: Sixth in the "How To" Series

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  • Natural Language Processing: State of the Art, Future Directions and Applications for Enhancing Clinical Decision-Making (Day 1)
    • - NLM and NIBIB (2012/05/01)
    • - Category : Conferences
    The first day is focused on reviewing the current state of the art in natural language processing (NLP) issues and is hosted by NLM. The sessions will consider text in English, both in biomedicine and outside that domain, and discuss strategies that are innovative, principled, and hold significant promise (in robustness, generality, and accuracy) in the field.

    On the morning of the second day, activities sponsored by NLM to make specific proposals for NLP research will run in parallel with sessions hosted by NIBIB, which will address the promise and application of natural language processing in clinical decision support (CDS). The presentations will be given by a wide range of perspectives on the potential impact of natural language processing, including from the provider, vendor, patient, payer and government perspectives. The afternoon of the second day will be solely devoted to these topics.

    For more information go to http://www.tech-res.com/NLPCDS/

    Natural Language Processing: State of the Art, Future Directions and Applications for Enhancing Clinical Decision-Making (Day 1)

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  • NLP-CDS: Applications for Enhancing Clinical Decision Making (Day 2)
    • - NLM & NIBIB (2012/04/29)
    • - Category : Conferences
    Specific proposals for NLP research sponsored by NLM

    For more information go to http://www.tech-res.com/NLPCDS/

    NLP-CDS: Applications for Enhancing Clinical Decision Making (Day 2)

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  • CC Grand Rounds: (1) Illuminating Human Disease and Infection (2) Rapamycin-Resistant Allogeneic T Cells: Bench to Bedside
    • - (1) Peter D.Burbelo, PhD, Staff Scientist, Neurobiology and Pain Therapeutics Branch, Laboratory of Sensory Biology, NIDCR (2) Daniel H. Fowler, MD, Senior Investigator, Experimental Transplantation and Immunology Branch, NCI (2012/04/29)
    • - Category : Clinical Center Grand Rounds
    CC Grand Rounds: (1) Illuminating Human Disease and Infection (2) Rapamycin-Resistant Allogeneic T Cells: Bench to Bedside

    For more information go to http://www.cc.nih.gov/about/news/grcurrent.html

    CC Grand Rounds: (1) Illuminating Human Disease and Infection (2) Rapamycin-Resistant Allogeneic T Cells: Bench to Bedside

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  • Regulating the Regulators: Mechanisms Controlling Function and Metabolism of microRNAs
    • - Dr. Witold Filipowicz, University of Basel (2012/04/29)
    • - Category : Wednesday Afternoon Lectures
    Micro-Ribonucleic Acids (miRNAs) are a novel class of 20-nucleotide-long regulatory RNAs expressed in eukaryotes. MiRNAs regulate gene expression post-transcriptionally by imperfectly base-pairing to the three prime untranslated region of mRNAs which results in translational repression or mRNA deadenylation and degradation. The number of different miRNAs in human？？？s reaches 1,000, and 50 percent of all human genes are predicted to be subject to miRNA regulation. Although specific functions and target mRNAs have been assigned to only a fraction of identified miRNAs, much evidence exists that miRNAs participate in the regulation of nearly all cellular and developmental processes. Expression of many miRNAs is tissue or development specific and major changes in miRNA expression are observed in human pathologies, including cancer. Clearly, discovery of miRNAs added a new dimension to the complexity and regulation of eukaryotic genomes.

    I will discuss current knowledge about the mechanism of miRNA-mediated repression of gene expression, particularly a role of Argonaute and GW182 proteins, and a large multiprotein CCR4-NOT complex which functions downstream and mediates both mRNA deadenylation and translational repression. In addition, biogenesis and turnover of miRNAs, and also the miRNA-mediated repression itself, were recently found to be highly regulated processes involving a plethora of factors with many of them implicated in human pathologies. Finally, I will discuss regulation of miRNA function and turnover in neurons. Our recent work revealed that miRNAs in retinal, hippocampal, and cortical neurons turn over much faster than in non-neuronal cells and that miRNA turnover in neurons may be subject to a complex activity-dependent regulation. Blocking action potentials with tetrodotoxin prevents rapid turnover of miRNAs in neurons. Blocking glutamate receptors likewise prevents decay of many miRNAs in hippocampal and embryonic stem cell derived neurons, while the addition of glutamate accelerates it.

    The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    For more information, visit:
    The NIH Directors Wednesday Afternoon Lecture Series

    Regulating the Regulators: Mechanisms Controlling Function and Metabolism of microRNAs

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  • Demystifying Medicine- Gluten Enteropathy: an expanding disease
    • - Bana Jabri, Irwin Rosenberg (2012/04/28)
    • - Category : Demystifying Medicine
    The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.

    For more information go to http://demystifyingmedicine.od.nih.gov/

    Demystifying Medicine- Gluten Enteropathy: an expanding disease

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  • Focus on You Wellness Lecture - Bike Commuting Seminar
    • - Daniel Hoagland (2012/04/27)
    • - Category : Focus on You Wellness
    Focus on You Wellness Lecture

    The Focus on You Wellness Lecture Series continues with an interactive lecture in support of ？？？Bike to Work Day？？？.

    Thinking about commuting by bicycle? It？？？s a great time to start - the weather is great, gas prices are high, theres ongoing BRAC roadway construction, greenhouse gas emissions are rising, and everyone needs regular exercise. Learn the basics of safe bicycle commuting and route choice in this free video and slideshow presentation by the areas leading bike advocacy organization, the Washington Area Bicyclist Association (WABA). WABA literature including the Safe Bicycling in the Washington Area guide, pocket bike law guides, and area bike maps will be available free of charge.

    Focus on You Wellness Lecture - Bike Commuting Seminar

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