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  • Identifying Core Behavioral and Psychosocial Data Elements for the Electronic Health Record
    • - Sponsors: OBSSR; NCI; SBM; NINR; ACSM; PCNA (2011/05/10)
    • - Category : Conferences
    The HITECH Act and the Patient Protection and Affordable Care Act place new emphasis on the widespread and meaningful use of electronic health records (EHRs). This is an important advance, with one significant exception: Currently EHRs fail to capture data reflecting crucial health behaviors and psychosocial issues. Such patient-reported variables are both health outcomes themselves, and major determinants of other health outcomes. Capturing a core set of standard patient-reported variables in the EHR would lead to unprecedented data harmonization and opportunities for improving patient care and health research.

    Several institutes and offices from the National Institutes of Health in collaboration with the Society for Behavioral Medicine are coordinating an effort to evaluate and recommend patient-reported measures of health behaviors and psychosocial factors for use in adult primary care and public health electronic health records (EHRs).

    Identifying Core Behavioral and Psychosocial Data Elements for the Electronic Health Record

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  • Neuroeconomic Approaches to Mental Disorders
    • - P. Read Montague, PhD, Virginia Tech Carilion Research Institute (2011/05/10)
    • - Category : Neuroscience
    Neuroscience Seminar Series

    Dr. Montague is the founding director of the Human Neuroimaging Laboratory and the Computational Psychiatry Unit of the VTCRI. His work centers broadly on human social cognition, decision-making, and willful choice with a goal of understanding the detailed underlying neurobiology of these functions in health and disease. Dr. Montague？？？s work particularly focuses on computational neuroscience ？？？ the connection between physical mechanisms present in real neural tissue and the computational functions that these mechanisms embody. His laboratory uses theoretical, computational, and experimental approaches to these issues. In particular, the group now employs novel approaches to functional neuroimaging, new biomarkers for mental disease, spectroscopy, real-time voltammetery, and computational simulations. He also directs the Roanoke Brain Study (RBS), a project aimed at understanding decision-making through the lifespan and its relationship to brain development, function, and disease.

    Neuroeconomic Approaches to Mental Disorders

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  • Nuclear Receptors and the Epigenomic Regulation of Metabolism
    • - Mitchell Lazar, M.D., Ph.D., University of Pennsylvania School of Medicine (2011/05/10)
    • - Category : Wednesday Afternoon Lectures
    Nuclear receptors transduce environmental and metabolic signals into alterations in gene expression by recruiting coregulators that alter chromatin structure. The nuclear receptor PPARg is the target of antidiabetic thiazolidinedione (TZD) drugs, and a transcriptional regulator of lipid metabolism. The induction of PPARg is required for adipogenesis, and this is regulated by a coordination of hormonal, epigenomic, and transcriptional factors that define a novel early stage of adipognesis. In mature adipocytes, genomic binding of PPARg coordinates metabolic gene pathways that are conserved between rodents and humans. Rev-erb？？ is a nuclear heme receptor that functions as a component of a negative limb of the circadian clock. Heme binding to Rev-erb？？ stabilizes recruitment of a complex containing the corepressor NCoR and histone deacetylase 3 (HDAC3). In liver, circadian expression of Rev-erb？？ leads to its oscillating interaction with the genome, at a cistrome that is enriched near genes involved in lipid metabolism. This directs a circadian recruitment of NCoR and HDAC3 with a rhythm that is anti-phase to histone acetylation and recruitment of RNA polymerase II at these sites and at nearby genes.

    The hepatic rhythm of histone acetylation is abrogated by depletion of HDAC3, which also induces many of the lipid metabolic genes bound by Rev-erb？？ and HDAC3 and causes massive triglyceride accumulation in the liver. Thus HDAC3 orchestrates a circadian epigenomic rhythm that is a major regulator of hepatic lipid metabolism. Comparative analysis of HDAC3 cistromes in other tissues reveals intriguing similarities and differences in transcription factor recruitment, gene targets, and circadian rhythms that may reflect their specific environments and functions. The epigenomic regulation and functions of Rev-erba and PPARg thus highlight the key role of nuclear receptors in the integrated physiology of circadian rhythm and metabolism.

    The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    For more information, visit
    The NIH Directors Wednesday Afternoon Lecture Series

    Nuclear Receptors and the Epigenomic Regulation of Metabolism

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  • Negative Control of NK Cell Activation
    • - Eric Long (2011/05/07)
    • - Category : Immunology


    The Immunology Interest Group

    Negative Control of NK Cell Activation

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  • STEP Symposium: Knowing our DNA Sequence: What it Means for You and Me (HHS Only)
    • - John Belmont, Flavia Facio, Rebecca Fisher, Sara Hull, Laura Rodriguez and Marc Williams (2011/05/06)
    • - Category : STEP (HHS Only)
    Is genome-based medicine the future of healthcare? Since the completion of the human genome sequence we have begun to determine the genetic makeup of individuals. Genome sequence information is already being used to advance our understanding of human biology and origins. Soon our personal genome sequences may be part of our medical records. Join us as we explore the current state of personalized medicine, its potential impact on health and disease, and what the future may hold for us.

    Speakers:

    John W. Belmont, M.D., Ph.D., Professor, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas

    Flavia Facio, M.S., C.G.C., Genetic Counselor, Genetic Disease Research Branch, National Human Genome Research Institute, NIH

    Rebecca Fisher, Patient Advocate

    Sara C. Hull, Ph.D., Director, Bioethics Core, National Human Genome Research Institute, and Faculty, Clinical Center, NIH

    Laura Lyman Rodriguez, Ph.D., Acting Director, Office of Policy, Communications and Education, National Human Genome Research Institute, NIH

    Marc S. Williams, M.D., F.A.A.P., F.A.C.M.G., Director, Intermountain Healthcare Clinical Genetics Institute, Salt Lake City, Utah

    For more information, visit
    http://odoerdb2-1.od.nih.gov/oer/training/step/step_training_20110503.htm

    STEP Symposium: Knowing our DNA Sequence: What it Means for You and Me (HHS Only)

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  • Parallel Development of Blood and Blood Vessels
    • - NIH Center for Regenerative Medicine and Stem Cell Interest Group (2011/05/06)
    • - Category : Stem Cell
    NCRM/SCIG Stem Cell Seminar Series:

    Karen Hirschi, PhD Professor Departments of Pediatrics and Molecular & Cellular Biology Center for Cell and Gene Therapy Baylor College of Medicine

    Parallel Development of Blood and Blood Vessels

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  • Beyond the Nuclear Pore: From mRNA Export to Translation
    • - Susan Wente, Ph.D, Vanderbilt University (2011/05/06)
    • - Category : Wednesday Afternoon Lectures
    The highly selective exchange of proteins and RNA between the nucleus and cytoplasm is essential for cell function, and precisely regulated during cell division, differentiation and death. Many aspects of this process are poorly understood and have direct impacts on human disease. This lecture will have three objectives.
    • One, it will provide background on current models for messenger RNA export from the nucleus to the cytoplasm, and points for key cellular regulation of gene expression.

    • Second, the lecture documents the discovery of essential factors for coupling mRNA export and translation in the budding yeast and cell culture models.

    • Finally, an overall goal is to reveal pathophysiological impacts on development from the study of mRNA export factors in the zebrafish model and human disease linkage analysis.
    This work provides a direct illustration of how discoveries from the analysis of single cell machineries are required for understanding multicellular organism development and pathophysiology.

    The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. For more information, visit:
    The NIH Directors Wednesday Afternoon Lecture Series

    Beyond the Nuclear Pore: From mRNA Export to Translation

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  • Demystifying Medicine - Hearing: Mechanisms and loss
    • - John Niparko (Johns Hopkins), Thomas Friedman (NIDCD) and James Battey (NIDCD) (2011/05/06)
    • - Category : Demystifying Medicine
    This event will include the presentation of patients, pathology, diagnosis and therapy context of major disease problems and current research. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components presented by NIH staff and invitees. These seminar series are primarily directed toward PhD students, clinicians and program managers. All students, fellows and staff are welcome, as well.

    For more information, visit
    http://www1.od.nih.gov/oir/DemystifyingMed

    Demystifying Medicine - Hearing: Mechanisms and loss

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  • CC Grand Rounds:Measuring Stress and Its Impact on Family Caregivers
    • - (1) Margaret Bevans, RN, PhD, Clinical Nurse Scientist, Nursing Research and Translational Science, Nursing and Patient Care Services, CC (2) Esther Sternberg, MD, Chief, Section on Neuroendocrine Immunology and Behavior, NIMH (2011/05/06)
    • - Category : Clinical Center Grand Rounds
    CC Grand Rounds Lecture Series

    For more information, visit
    http://www.cc.nih.gov/about/news/grcurrent.html

    CC Grand Rounds:Measuring Stress and Its Impact on Family Caregivers

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  • Single Cell Analysis Working Group (Day 1)
    • - The NIH Common Fund (2011/05/05)
    • - Category : Conferences
    Single Cell Analysis was identified by the NIH Common Fund through a strategic planning process as an area of cross-cutting research that is especially well-poised for advancement and acceleration. For the purposes of this effort, "single cell analysis" is defined as the examination of the biological properties of a single cell, or an individual cell within a population, not characterization of clonal populations or populations of cells assumed to be same. The objective of this meeting is to further develop and refine this effort.

    For more information, visit:
    http://conferences.thehillgroup.com/DPCPSI/SingleCellMeeting/index.html

    Single Cell Analysis Working Group (Day 1)

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  • Single Cell Analysis Working Group (Day 2)
    • - The NIH Common Fund (2011/05/05)
    • - Category : Conferences
    Single Cell Analysis was identified by the NIH Common Fund through a strategic planning process as an area of cross-cutting research that is especially well-poised for advancement and acceleration. For the purposes of this effort, "single cell analysis" is defined as the examination of the biological properties of a single cell, or an individual cell within a population, not characterization of clonal populations or populations of cells assumed to be same. The objective of this meeting is to further develop and refine this effort.

    For more information, visit:
    http://conferences.thehillgroup.com/DPCPSI/SingleCellMeeting/index.html

    Single Cell Analysis Working Group (Day 2)

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  • The Shape of Things: Complex Genetics in the Domestic Dog
    • - Dr. Elaine Ostrander (2011/05/05)
    • - Category : Conferences
    Dr. Ostranders laboratory is interested in the study of genes important in growth regulation, particularly as it pertains to disease states in humans and canines. Her group aims to find genes that control the morphologic body plan of the domestic dog, which shows an extraordinary level of variation between breeds, and to identify disease susceptibility genes in dogs. Her groups work also focuses on the identification of genes that relate to susceptibility to, progression of, and specific outcomes in individuals with breast and prostate cancer.

    The Shape of Things: Complex Genetics in the Domestic Dog

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  • Double-strand breaks and novel DNA intermediates derived from partial processing of alkylation damage in G2 cells of yeast
    • - Wenjian Ma, Ph.D., Chromosome Stability Group, Laboratory of Molecular Genetics, NIEHS (2011/05/04)
    • - Category : DNA Repair
    DNA Repair Interest Group videoconference

    Young investigator talks:
    1. Dr Wenjian Ma ？？？ NIEHS [origin] - Alkylation base damage is converted into repairable double-strand breaks and complex intermediates in G2 cells lacking AP endonuclease


    Acrobat Slides

    Double-strand breaks and novel DNA intermediates derived from partial processing of alkylation damage in G2 cells of yeast

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  • Demystifying Medicine - Cushings syndrome: adrenocortical hormone regulation and function
    • - Lynnette Nieman (NICHD) and Gordon Hager (NCI) (2011/05/04)
    • - Category : Demystifying Medicine
    This event will include the presentation of patients, pathology, diagnosis and therapy context of major disease problems and current research. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components presented by NIH staff and invitees. These seminar series are primarily directed toward PhD students, clinicians and program managers. All students, fellows and staff are welcome, as well.

    For more information, visit
    http://www1.od.nih.gov/oir/DemystifyingMed

    Demystifying Medicine - Cushings syndrome: adrenocortical hormone regulation and function

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  • What We Have Learned from Structures of the Ribosome
    • - Venki Ramakrishnan, Ph.D., Nobel Laureate and MRC Laboratory of Molecular Biology in Cambridge, UK (2011/05/04)
    • - Category : Wednesday Afternoon Lectures
    The publication of the atomic structures of the 50S and 30S ribosomal subunits in 2000 revolutionized our understanding of protein synthesis. In my talk I will focus on our work, initially on the 30S subunit and subsequently on the entire 70S ribosome, focusing on how the ribosome facilitates the accurate translation of the genetic code.

    The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    For more information, visit:
    The NIH Directors Wednesday Afternoon Lecture Series

    What We Have Learned from Structures of the Ribosome

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  • CC Grand Rounds Lecture: (1) Fetal Alcohol Syndrome: Etiology, Epidemiology, and Advances in Diagnosis (2) Nicotine Pharmacology Versus Nicotine Addiction: Different Sites, Different Mechanisms
    • - (1) Kenneth R. Warren, PhD, Acting Director, NIAAA (2) Elliot A. Stein, PhD, Chief, Neuroimaging Research Branch, Intramural Research Program, NIDA (2011/05/01)
    • - Category : Clinical Center Grand Rounds
    CC Grand Rounds

    For more information, visit:
    http://www.cc.nih.gov/about/news/grcurrent.html

    CC Grand Rounds Lecture: (1) Fetal Alcohol Syndrome: Etiology, Epidemiology, and Advances in Diagnosis (2) Nicotine Pharmacology Versus Nicotine Addiction: Different Sites, Different Mechanisms

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  • Expanding Your Career Networks
    • - Lori Conlan, PhD, OITE (2011/04/30)
    • - Category : Career Development/OITE
    We will discuss both online and in-person networking, an important component of successful career building at all career stages. Not only is it important to develop a network, but it also takes time to manage your network. We will dive deeper into managing networks, covering topics that include identifying career advocates, interacting with colleagues, and building meaningful long-term communication with individuals who may enhance your career.

    For more information, visit: http://www.training.nih.gov

    Expanding Your Career Networks

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  • STEP Symposium: Lifes Matrix: Water on a Very Crowded Planet (HHS Only)
    • - Olivier Blondel (2011/04/30)
    • - Category : STEP (HHS Only)
    Water permeates our bodies and our world. Access to clean drinking water is a basic human need, yet such access is limited in large parts of the world. Moreover, pollution from a variety of sources is an ever-increasing problem. Where are the reserves of drinking water, and are they shrinking? How does access to water affect global health and the success of nations? This forum will address what makes water so special that life cannot exist without it.

    For more information, visit
    http://odoerdb2-1.od.nih.gov/oer/training/step/step_training_20110426.htm

    STEP Symposium: Lifes Matrix: Water on a Very Crowded Planet (HHS Only)

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  • How Does HLA-DM Work?
    • - Kai Wucherpfenning, Dana-Farber Cancer Institute, Harvard Medical School (2011/04/30)
    • - Category : Immunology


    The Immunology Interest Group

    How Does HLA-DM Work?

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  • Measured Motion: The Neurons and Networks of Spinal Motor Control
    • - Thomas Jessell, Ph.D. (2011/04/29)
    • - Category : Neuroscience
    Neuroscience Seminar Series

    For more information, visit: http://neuroseries.info.nih.gov

    Measured Motion: The Neurons and Networks of Spinal Motor Control

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