전체 8345
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- Demystifying Medicine - HIV/AIDS: Ongoing epidemic and new treatments (NIH Only)
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- - Chris Lane (NIAID) and John Coffin (NCI) (2011/03/26)
- - Category : Demystifying Medicine
- This event will include the presentation of patients, pathology, diagnosis and therapy context of major disease problems and current research.
The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components presented by NIH staff and invitees. These seminar series are primarily directed toward PhD students, clinicians and program managers. All students, fellows and staff are welcome, as well.
For more information, visit
http://www1.od.nih.gov/oir/DemystifyingMed
Demystifying Medicine - HIV/AIDS: Ongoing epidemic and new treatments (NIH Only)
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- Workplace Ergonomics (NIH Only)
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- - LT. Jeremy Mason, Ms. Susan McDonald (2011/03/26)
- - Category : Occupational Health & Safety Lectures (NIH Only)
- DOHS Seminar Series
The Office of Research Services, Division of Occupational Health and Safety in partnership with the Division of Amenities and Transportation Services Wellness Program is proud to present a new Seminar Series focused on Employee Workplace Health and Safety.
Join us for this new monthly seminar series. The first topic will feature office ergonomics by LT Jeremy Mason and Susan McDonald from the Division of Occupational Health and Safety. LT Mason and Ms. McDonald will provide tips on how to set up your work station to avoid neck, arm, or back discomfort while working at the computer.
LT Jeremy Mason is an industrial hygienist who has worked in the field of ergonomics for five years. Susan McDonald is a certified industrial hygienist who has worked in the field of ergonomics for nine years. Before coming to NIH, Ms. McDonald worked at the State Department, providing ergonomic evaluations and assistance to office workers. In addition to computer work station ergonomics, LT Mason and Ms. McDonald also provide assistance to laboratory employees with ergonomic concerns.
Workplace Ergonomics (NIH Only)
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- Core Curriculum Part 4: Staff Interactions (HHS Only)
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- - Chuck Selden (2011/03/25)
- - Category : Core Curriculum (HHS Only)
- Panel discussants will make remarks and describe the helpful staff interactions in which they have participated, spending about 15 minutes per segment, as guided by the ？？？Life Cycle of a Research Concept？？？ timeline based on that provided by Dr. Tingley (NIAID). Then the Case study breakout groups will discuss cases for 15 to 20 minutes at a time. Especially creative solutions from the breakouts can be shared with the whole class, and the faculty can make brief comments on the different actions or solutions to the cases.
Core Curriculum Part 4: Staff Interactions (HHS Only)
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- Neural Plasticity and Diversity in the Adult Mammalian Brain
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- - Dr. Fred Gage, The Salk Institute for Biological Studies (2011/03/25)
- - Category : Wednesday Afternoon Lectures
- The first part of the talk will focus on evidence supporting the birth and maturation of new neurons in the adult dentate gyrus of the hippocampus in the mammalian brain. The mechanism by which the cells integrate and become functional will be discussed. In addition, the potential functional significance for adult neurogenesis in the context of the normal function of the hippocampus will be discussed. In the second part of the talk I will focus on the recent finding that LINE-1 (Long Interspersed Nucleotide Elements-1 or L1) retroelements are active in somatic neuronal progenitor cells (NPCs) providing an additional mechanism for neuronal diversification. Together with their mutated relatives, retroelement sequences constitute 45% of the mammalian genome with L1 elements alone representing 20%.
The fact that L1 can retrotranspose in a defined window of neuronal differentiation, changing the genetic information in single neurons in an arbitrary fashion, allows the brain to develop in distinctly different ways. This characteristic of variety and flexibility may contribute to the uniqueness of an individual brain. However, the molecular mechanism that regulates L1 expression in NPCs is not completely understood. L1s are likely silenced in neural stem cells due to Sox2-mediated transcription repression. Down-regulation of Sox2 accompanies chromatin modifications, such as DNA de-methylation and histone acetylation, which in turn may trigger neuronal differentiation. The characterization of somatic neuronal diversification will not only be relevant for the understanding of brain complexity and neuronal organization in mammals, but may also shed light on the differences in cognitive abilities.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Neural Plasticity and Diversity in the Adult Mammalian Brain
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- CC Grand Rounds Lecture Series:(1) PARP Inhibitors: How Successful Have We Been in Modulating DNA Damage? (2) The Evolving Role of PARP Inhibitors in Breast and Ovarian Cancers
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- - (1) Shivaani Kummar, MD, Head, Early Clinical Trials Development, Office of the Director, Division of Cancer Treatment and Diagnosis, NCI (2) Elise C. Kohn, MD, Head, Medical Ovarian Cancer Clinic, and Head, Molecular Signaling Section, Medical Oncology Branch, Center for Cancer Research, NCI (2011/03/25)
- - Category : Clinical Center Grand Rounds
- CC Grand Rounds
For more information, visit:
http://www.cc.nih.gov/about/news/grcurrent.html
CC Grand Rounds Lecture Series:(1) PARP Inhibitors: How Successful Have We Been in Modulating DNA Damage? (2) The Evolving Role of PARP Inhibitors in Breast and Ovarian Cancers
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- (1) Advances in Gene Therapy for Inherited Immunodeficiences (2) The Two Faces of Congenital Adrenal Hyperplasia: A Rare Disease, But a Common Condition
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- - (1) Fabio Candotti, MD, Head, Disorders of Immunity Section, Genetics and Molecular Biology Branch, NHGRI (2) Deborah P. Merke, MD, MS, Chief, Pediatric Consult Service, CC and Clinical Investigator, Program in Developmental Endocrinology and Genetics, NICHD (2011/03/23)
- - Category : Clinical Center Grand Rounds
- CC Grand Rounds Lectures
For more information, visit:
http://www.cc.nih.gov/about/news/grcurrent.html
(1) Advances in Gene Therapy for Inherited Immunodeficiences (2) The Two Faces of Congenital Adrenal Hyperplasia: A Rare Disease, But a Common Condition
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- PSC All Hands Meeting - March 2011 (HHS Only)
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- - PSC Director, Paul Bartley (2011/03/23)
- - Category : PSC Programs (HHS Only)
- First quarter meeting
PSC All Hands Meeting - March 2011 (HHS Only)
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- TCR Signaling Mutants Uncover Rare Innate-like T Cell Populations
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- - Gary Korezky, University of Pennsylvania (2011/03/23)
- - Category : Immunology
TCR Signaling Mutants Uncover Rare Innate-like T Cell Populations
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- Healthy Cooking Tips Cooking Healthy with Color
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- - Chef Lucy White RD (2011/03/22)
- - Category : Focus on You Wellness
- Focus on You Wellness Lecture Cooking Demonstration
Healthy Cooking Tips Cooking Healthy with Color
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- NIH 2011 Womens History Month Observance (NIH Only)
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- - Dr. Sally Rockey, NIH Deputy Director for Extramural Research (2011/03/22)
- - Category : NIH Only
- NIH Annual Womens History Month Observance program.
Theme: Our History is Our Strength
NIH 2011 Womens History Month Observance (NIH Only)
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- The epidemiology of testicular germ cell tumors: hormonal aspects
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- - Katherine McGlynn (2011/03/22)
- - Category : NIH Directors Seminars
- Directors Seminar Series
The epidemiology of testicular germ cell tumors: hormonal aspects
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- The University Perspective: Managing the Grant Lifecycle (HHS-Only)
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- - Speakers from University of MD; sponsored by GMAC Subcommittee on Training (2011/03/20)
- - Category : GMAC (HHS Only)
- Understanding how federal funds flow through a university？？？s administrative offices is essential to helping awarding agencies communicate with researchers and navigate the application and award process. This workshop will inform attendees how applications are created, reviewed, routed and approved at the various campus levels. We will also explore how universities manage federal awards and what is done at the University of Maryland to help ensure compliance with Federal, State and University laws and policies. We will also explain how universities develop F&A rates, and how reimbursement of these costs is essential to the survival of research institutions. Our colleagues from the University of Maryland College Park promises to be a lively discussion!
For more information, visit
http://odoerdb2-1.od.nih.gov/gmac/gmac/trs_main.html
The University Perspective: Managing the Grant Lifecycle (HHS-Only)
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- In Search of the Holy Grail of Fly Motion Vision
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- - Dr. Alexander Borst, Max Planck Institute of Neurobiology (2011/03/20)
- - Category : Wednesday Afternoon Lectures
- Neurons responding to moving stimuli in a directionally selective way are found in the visual systems of almost all species, yet the underlying neural mechanisms and circuits giving rise to this particular response property are still elusive. In the fly, large motion-sensitive neurons located in the so-called lobula plate respond to optic flow stimuli. These cells receive input from a retinotopically organized array of local motion-sensitive elements which are described in quantitative detail by a formal model called the Reichardt detector. However, despite decades of research, it is still not known what neurons constitute the Reichardt detector and what biophysical mechanisms underlie the mathematical operations postulated in this model. Thus, the neural implementation of the Reichardt detector somehow became the holy grail of fly motion vision. The talk will summarize some recent progress made along this direction, using the fruit fly Drosophila melanogaster and combining electrophysiology with the powerful genetics available in this organism.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
In Search of the Holy Grail of Fly Motion Vision
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- Comprehensive Metabolic Profiling for Defining Obesity and Diabetes Mechanisms
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- - Dr. Christopher Newgard, Duke University Medical Center (2011/03/19)
- - Category : Wednesday Afternoon Lectures
- We seek to apply comprehensive metabolic analysis tools (sometimes called ？？？metabolomics？？？) for understanding of mechanisms underlying chronic human diseases such as diabetes, obesity, and cardiovascular disease. Current approaches include analysis of metabolic flux by 13C NMR-based mass isotopomer analysis (in collaboration with Drs. Shawn Burgess and A. Dean Sherry and associates, Dallas, TX) and metabolic profiling of important groups of metabolic intermediates by both ？？？targeted？？？ and ？？？unbiased？？？ mass spectrometry (in collaboration with Drs. James Bain, Robert Stevens, Olga Ilkayeva, Brett Wenner, Michael Muehlbauer, Mark Butler, and David Millington at Duke).
These tools have been used to investigate the mechanism of glucose-stimulated insulin secretion and mechanisms of its impairment in type 2 diabetes. The tools have also been used to define mechanisms underlying development of peripheral insulin resistance in animals and humans. For example, we have recently identified perturbations of branched chain amino acid (BCAA) catabolism in multiple cohorts of insulin resistant humans compared to normally insulin sensitive controls and have translated these findings to rodent models to demonstrate a contribution of BCAA to development of insulin resistance that is independent of body weight. Finally, in collaboration with Dr. Alan Attie at the University of Wisconsin, we have integrated transcriptomic and metabolomic analysis to identify new pathways that control hepatic gluconeogenesis and PEPCK expression. These examples will serve to illustrate the potential of comprehensive metabolic profiling methods for providing insights into diabetes and obesity mechanisms.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Comprehensive Metabolic Profiling for Defining Obesity and Diabetes Mechanisms
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- Training on Human Subjects Protections: Part 2 (HHS Only)
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- - Ann Hardy and Maria Stagnitto (2011/03/19)
- - Category : ESA (HHS Only)
- Featured Speakers:
Pearl O？？？Rourke, MD, Director of Human Research Affairs at Partners HealthCare Systems in Boston and Associate Professor of Pediatrics at Harvard Medical School. Pearl has worked as a pediatric critical care physician and clinical researcher and has served as an IRB member. From 1995-96, she did a Robert Wood Johnson Health Policy fellowship working for Senator Edward Kennedy; following this, she served as Deputy Director of NIH？？？s Office of Science Policy for several years. Pearl is currently a member of the NHGRI Advisory Council. She is an engaging and highly sought-after speaker on ethical issues such as privacy, genetics, and stem cells.
Laura Rodriguez, PhD, Acting Director, Office of Policy, Communications and Education and Senior Advisor to the Director for Research Policy at the National Human Genome Research Institute. Laura has helped develop and implement policies related to genetics research, in particular NIH？？？s policy for data sharing in Genome-wide association studies(GWAS) and the establishment of NIH？？？s database of Genotypes and Phenotypes (dbGaP).
Nicole Lockhart, PhD, is a Biospecimen Technology Program Manager at the National Cancer Institute？？？s Office of Biorepositories and Biospecimen Research. She currently serving as the Director of Ethical and Regulatory Affairs for the cancer Human Biobank (caHUB), a national biobanking initiative under development by NCI. In this role, she leads a team responsible for the development of caHUB policies for ethical and regulatory issues related to human subject protection, including informed consent, data and specimen access, and material transfer agreements.
For more information, visit
http://odoerdb2.od.nih.gov/oer/training/esa//esa_training_20110310.htm
Training on Human Subjects Protections: Part 2 (HHS Only)
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- Planning for Career Satisfaction & Success - Defining the Process
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- - Sharon L. Milgram, PhD (2011/03/19)
- - Category : Career Development/OITE
- Career Development
This workshop will help you understand how your personal interests, skills, and values contribute to your future career success. Topics to be covered include the importance of career decision making, self-assessment, transferrable skills, networking, defining success, personal needs, work/life balance, and defining short-term and long-term goals. The workshop will provide insight into planning a job search, finding jobs, and using internet and community resources.
For more information, visit
http://www.training.nih.gov
Planning for Career Satisfaction & Success - Defining the Process
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- Role of histone ubiquitination in the DNA damage response
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- - Dr. Xiaochun Yu - University of Michigan (2011/03/19)
- - Category : DNA Repair
- DNA Repair Interest Group videoconference
Role of histone ubiquitination in the DNA damage response
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- Demystifying Medicine - Diabetes: mechanisms and fatty liver
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- - Rana Malek (NIDDK) and Yaron Rotman (NIDDK) (2011/03/19)
- - Category : Demystifying Medicine
- This event will include the presentation of patients, pathology, diagnosis and therapy context of major disease problems and current research.
The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components presented by NIH staff and invitees. These seminar series are primarily directed toward PhD students, clinicians and program managers. All students, fellows and staff are welcome, as well.
For more information, visit
http://www1.od.nih.gov/oir/DemystifyingMed
Demystifying Medicine - Diabetes: mechanisms and fatty liver
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- Regulating B Cell Immunity
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- - Michael McHeyzer-Williams, Scripps Research Institute (2011/03/18)
- - Category : Immunology
Regulating B Cell Immunity
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- CIT Services Seminar - Telework 101 (NIH Only)
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- - CIT (2011/03/18)
- - Category : NIH Only
- CIT Services Seminar Series
The CIT Services Seminar Series will be a quarterly meetings focused on showcasing CIT？？？s diverse technology service offerings currently available to the NIH community. And it will also provide an opportunity to introduce future services. These seminars are intended for current and potential CIT customers and are geared towards managers or technical leads. This is a great chance to get questions answered about any of CIT？？？s service offerings.
Telework 101
Telework has become a challenge at NIH due to the Telework Enhancement Act of 2010 which encourages telework throughout government. Telework is a useful model？？？it can help you attract and retain the best qualified employees, provide your staff with uninterrupted blocks of time to work on key projects, and give your organization a way of functioning more effectively during crisis situations and other business interruptions. Having the right tools can make a telework program extremely successful and easy to manage.
CIT Services Seminar - Telework 101 (NIH Only)