전체 8345
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- A Look at the Unconscious Brain Under General Anesthesia
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- - Dr. Emery Brown, Massachusetts Institute of Technology (2011/03/09)
- - Category : Wednesday Afternoon Lectures
- General anesthesia is a drug-induced, reversible condition comprised of five behavioral and physiological states: unconsciousness, amnesia (loss of memory), analgesia (loss of pain sensation), akinesia (immobility), and cardiovascular, respiratory and thermoregulatory stability with control of the stress response. The mechanisms by which anesthetic drugs induce the state of general anesthesia is considered one of the biggest mysteries of modern medicine. We have been using three experimental paradigms to study general anesthesia-induced loss of consciousness in humans: combined fMRI/EEG recordings, high-density EEG recordings and intracranial recordings. These studies are allowing us to establish precise neurophysiological, neuroanatomical and behavioral correlates of general anesthesia. We will discuss the relation between our findings and two other important altered states of arousal: sleep and coma. Our findings suggest that the state of general anesthesia is not as mysterious as currently believed.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
A Look at the Unconscious Brain Under General Anesthesia
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- Mechanisms of Immunological Memory After Vaccination or Infection
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- - Mark Slifka (2011/03/09)
- - Category : Immunology
Mechanisms of Immunological Memory After Vaccination or Infection
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- Translating metabolic exchange with imaging mass spectrometry
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- - Pieter Dorrestein, UCSD (2011/03/09)
- - Category : Proteomics
- NIH Proteomics Interest Group Seminar Series
Pieter C. Dorrestein is an Assistant Professor in the Skaggs School of Pharmacy and Pharmaceutical Sciences and the Departments of Pharmacology, Chemistry and Biochemistry at the University of California, San Diego.
Dr. Pieter Dorrestein was born in Utrecht, Netherlands, in 1974. He completed his undergraduate at Northern Arizona University under the guidance of Prof. John MacDonald. Pieter continued on to Cornell University for graduate school in the department of Chemistry and Chemical Biology where he worked on metabolite biosynthetic pathways with Prof. Tadhg Begley. During his post-doctoral years, at the University of Illinois, as an NIH-NRSA fellow (co)-sponsored by Prof. Neil Kelleher and Prof. Christopher Walsh, he exploited high-resolution mass spectrometry to elucidate the biosynthesis of natural products of therapeutic value. In September of 2006, Pieter moved to his current position as an assistant professor at the Skaggs School of Pharmacy and Pharmaceutical Sciences and Departments of Pharmacology, Chemistry and Biochemistry at UC-San Diego. In 2007 Pieter also became a member of the Center for Marine Biotechnology and Biomedicine at the Scripps Institution of Oceanography. The Dorrestein lab is a chemical biology laboratory that emphasizes mass spectrometric, including proteomic and MALDI-imaging based, approaches to understand the functions of orphan genes from microorganisms responsible for the production of natural products or toxins. In addition, the Dorrestein lab aims to detect and understand the function of post-translational modifications.
Translating metabolic exchange with imaging mass spectrometry
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- NCI Board of Scientific Advisors - March 2011
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- - NCI (2011/03/08)
- - Category : NCI Board of Scientific Advisors
- The 48th Meeting of the National Cancer Institute Board of Scientific Advisors.
NCI Board of Scientific Advisors - March 2011
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- Demystifying Medicine - Chronic Fatigue Syndrome: Is there a virus?
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- - Shyh-Ching Lo (FDA), Fred Gill (NIDDK) and Harvey Alter (NIDDK) (2011/03/06)
- - Category : Demystifying Medicine
- This event will include the presentation of patients, pathology, diagnosis and therapy context of major disease problems and current research.
The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components presented by NIH staff and invitees. These seminar series are primarily directed toward PhD students, clinicians and program managers. All students, fellows and staff are welcome, as well.
For more information, visit
http://www1.od.nih.gov/oir/DemystifyingMed
Demystifying Medicine - Chronic Fatigue Syndrome: Is there a virus?
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- Sleep-dependent mechanisms for nervous system plasticity following novel sensory experiences
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- - Dr. Sara J Aton (2011/03/06)
- - Category : Special
- Basic Research Tenure Track Candidate
Sleep-dependent mechanisms for nervous system plasticity following novel sensory experiences
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- Regulation of neural development in dentate neurons by Disrupted-In-Schizophrenia 1 (DISC1)
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- - Dr. Ju Young Kim (2011/03/06)
- - Category : Special
- NIMH DIRP Human Genetics Candidate
Regulation of neural development in dentate neurons by Disrupted-In-Schizophrenia 1 (DISC1)
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- Demystifying Medicine - Multiple scleroisis: an autoimmune dilemma
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- - Bibi Bielekova (NINDS) and Joan Ohayon (NINDS) (2011/03/06)
- - Category : Demystifying Medicine
- This event will include the presentation of patients, pathology, diagnosis and therapy context of major disease problems and current research.
The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components presented by NIH staff and invitees. These seminar series are primarily directed toward PhD students, clinicians and program managers. All students, fellows and staff are welcome, as well.
For more information, visit
http://www1.od.nih.gov/oir/DemystifyingMed
Demystifying Medicine - Multiple scleroisis: an autoimmune dilemma
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- Creating Intimacy: Chromosomal Connections for Gene Expression and Crossovers
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- - Barbara Meyer, Ph.D., University of California at Berkeley (2011/03/05)
- - Category : Wednesday Afternoon Lectures
- In all plants and animals, chromosomes must be properly replicated, repaired, expressed, recombined, and segregated for genome stability. Emerging work has shown these four processes to be controlled, in part, by an overlapping set of proteins that influence chromosome structure. This talk will focus on the shared mechanisms and protein complexes that control gene expression, chromosome segregation, and recombination.
Gene expression in higher organisms is controlled by diverse regulatory mechanisms that function over a wide range of distances. Some mechanisms affect expression of genes across large chromosomal territories or along entire chromosomes, while others only act locally on individual genes. In the former case, specific chromosome architecture and chromosome compartmentalization within the nucleus can be critical for controlling gene expression. X-chromosome dosage compensation is exemplary for dissecting the coordinate regulation of gene expression over vast distances and the role of chromosome structure in controlling gene expression. Dosage compensation is an essential process, which ensures that males (XO or XY) and females (XX) express equal levels of gene products from their X chromosomes, despite their difference in X-chromosome dose.
The need for dosage compensation emerged evolutionarily as organisms adopted mechanisms for determining sex that relied on the complement of sex chromosomes. Strategies for dosage compensation differ in mammals, flies, and worms, but invariably a regulatory complex is targeted to the sex chromosome of one sex to modulate transcript levels across the entire chromosome. In the round worm C. elegans, a specialized dosage compensation complex (DCC) is targeted to both X chromosomes of hermaphrodites to repress transcript levels by about half. We showed the worm DCC resembles condensin, a protein complex required for the compaction, resolution, and segregation of chromosomes during both mitosis and meiosis.
The DCC not only resembles condensin, it shares many components with two other condensin complexes in the worm, and DCC components also participate in other aspects of chromosome dynamics, including chromosome segregation and the regulation of crossovers between maternal and paternal chromosomes during meiosis. The condensin complex that regulates dosage compensation differs by only one subunit from the condensin complex that regulates crossovers. One important conclusion from our work is that reshuffling of the interchangeable molecular parts--individual condensin subunits--can create independent molecular machines with similar architectures, but with very different functions.
This talk will feature the roles of condensin components in the regulation of meiotic crossovers in germ cells and the mechanisms by which the DCC recognizes and binds X chromosomes in somatic cells to achieve X-chromosome-wide gene regulation. A common theme is the importance of controlling chromosome structure in regulating gene expression, crossover formation, and chromosome segregation.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Creating Intimacy: Chromosomal Connections for Gene Expression and Crossovers
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- Its a Small World: Tiny Technologies and Regenerative Medicine
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- - Sangeeta N. Bhatia, M.D., Ph.D., Massachusetts Institute of Technology (2011/03/05)
- - Category : Wednesday Afternoon Lectures
- Our laboratory studies how micro- and nanoscale systems can be deployed to understand, diagnose, and treat human disease. In this talk, I will describe our progress in two application areas: liver disease and cancer. In the area of hepatic tissue engineering, we are developing microtechnology tools to understand how ensembles of cells coordinate to produce tissues with emergent properties in the body. We have used this understanding to fabricate human microliver tissues in both 2D and 3D formats that enable us to study the pathogenesis of human drug-drug interaction, drug-induced liver disease, and viral infection.
In the area of cancer, we are developing nanotechnology tools to meet the challenge of delivering cargo into the tumor microenvironment where transport is dominated by diffusion. Our strategy is to design nanotechnologies which emulate natures mechanisms of homing, activation, and amplification to deliver cytotoxic drugs, imaging agents, and siRNA to tumors. Thus, using nature as a guide, we are establishing a framework for building systems from micro- and nanoscale components that function collectively to treat human disease.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Its a Small World: Tiny Technologies and Regenerative Medicine
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- Core Curriculum Part 3: Review Policies and Procedures (HHS Only)
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- - Chuck Selden (2011/03/05)
- - Category : Core Curriculum (HHS Only)
- The first level of review is carried out by a Scientific Review Group (SRG) composed primarily of non-federal scientists who have expertise in relevant scientific disciplines and current research areas. The second level of review is performed by Institute and Center (IC) National Advisory Councils or Boards. Councils are composed of both scientific and lay members chosen for their expertise, interest, or activity in matters related to health and disease. Only applications that are favorably recommended by both the SRG and the Advisory Council may be recommended for funding.
For more information, visit
http://esa.nih.gov/oer/training/esa/esa_cores_2011.htm
Core Curriculum Part 3: Review Policies and Procedures (HHS Only)
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- Rare Disease Day at NIH - Afternoon Session
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- - ORDR & Clinical Center (2011/03/05)
- - Category : Conferences
- Staff and public are invited to attend Rare Disease Day at NIH, a day-long celebration recognizing rare diseases research activities supported by several government agencies and advocacy organizations. Rare Disease Day was established to raise public awareness about rare diseases, the challenges encountered by those affected, the importance of research to develop diagnostics and treatments, and the impact of these diseases on patients？？？ lives. There are about 7,000 rare diseases identified in the United States. About 80 percent of rare diseases are genetic in origin and it is estimated that about half of all rare diseases affect children.
Organizers have put together an agenda of scheduled talks？？？including two from NIH Bench-to-Bedside Award investigators？？？and posters and exhibits from many groups relevant to the rare diseases research community. NIH Director Dr. Francis S. Collins will speak to attendees.
In association with the Global Genes Project (a grassroots effort to use jeans to raise awareness for rare genetic disorders), organizers urge all attendees to wear their favorite pair of jeans.
Co-sponsored by the NIH Office of Rare Diseases Research and the Clinical Center. This is a free event that is scheduled from 8:30 am to 5:30 pm, with a lunch break and poster session from 11:30 am to 1:30 pm. Pre-registration is encouraged.
Sign language interpreters will be provided.
Rare Disease Day at NIH - Afternoon Session
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- STEP Symposium - Look Whos Talking: Communicating Your Message Fearlessly and Flawlessly (HHS Only)
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- - Alan Alda, Stephen Kosslyn, Nan Tolbert, Barrett Whitener, and Nicole Fleisher (2011/03/05)
- - Category : STEP (HHS Only)
- Ever look out into the audience during your presentation and notice that everyone is busy tapping away on their BlackBerrys? How do you capture and hold your audience？？？s attention? What should be on your slides, how much text, which font, and what about illustrations? NIH has important information to share with the world？？？come to this forum to learn how to dazzle your audience with any topic, from scientific data to administrative policy. You are an expert in your field？？？now be an expert communicator! And don？？？t miss an improvisational theater demonstration designed to improve your communication skills, led by actor Alan Alda.
SPEAKERS:- Alan Alda, Emmy and Golden Globe-winning actor, author, and science communications advocate, The Center for Communicating Science, Stony Brook University, Stony Book, NY
- Stephen M. Kosslyn, Ph.D., Stanford University, Stanford, CA
- Nan Tolbert, The Communication Center, Washington DC
- Barrett Whitener, M.A., IQ Solutions, Rockville, MD
Nicole Fleisher (Chair), Victoria Bishton, Jody Engel,Valerie Maholmes, Dick Okita, Jerry Phelps, and Yasaman Shirazi
Add to your calendar
http://odoerdb2-1.od.nih.gov/oer/training/step/icalendar/step_calendar_communicating.ics
For more information, visit
http://odoerdb2-1.od.nih.gov/oer/training/step/step_training_20110301.htm
STEP Symposium - Look Whos Talking: Communicating Your Message Fearlessly and Flawlessly (HHS Only)
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- From Malignant Glioma to Mental illness: Role of Olig2 in brain disorders
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- - Dr. Shwetal Mehta (2011/03/04)
- - Category : Special
- NIMH DIRP Human Genetics Candidate
From Malignant Glioma to Mental illness: Role of Olig2 in brain disorders
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- Cytoskeletal dynamics in lymphocyte activation and inhibition
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- - Carl June (2011/03/02)
- - Category : Immunology
Cytoskeletal dynamics in lymphocyte activation and inhibition
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- OHR Brown Bag Session: Collaborative Communication: How to Influence Without Authority! (NIH Only)
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- - Chuck Ward (2011/03/02)
- - Category : Human Resources (NIH Only)
- Professional Development
OHR Brown Bag Session: Collaborative Communication: How to Influence Without Authority! (NIH Only)
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- AIDS Research Advisory Committee - February 2011 (NIH Only)
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- - Division of AIDS (2011/03/01)
- - Category : AIDS Research Advisory Committee (NIH Only)
- One of three annual advisory committee meetings, to provide guidance to the Director of DAIDS and NIAID
AIDS Research Advisory Committee - February 2011 (NIH Only)
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- ASA All Hands Meeting - February 2011 (HHS Only)
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- - Ned Holland (2011/03/01)
- - Category : HHS Only
- ASA All Hands Meeting
ASA All Hands Meeting - February 2011 (HHS Only)
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- DDM Seminar Series: Staying In the Zone... by Maintaining a Winning Team Attitude! (NIH Only)
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- - Mark Crear, Two-Time Olympic Medalist (2011/02/25)
- - Category : DDM Seminar Series (NIH Only)
- Acrobat Slides
Click here http://omsps.od.nih.gov/Lists/DDM%20Seminar%20Series/overview.aspx to respond to a survey about this DDM Seminar. Information will be used to evaluate the program and improve future seminars.
On behalf of Colleen Barros, Deputy Director for Management (DDM), the NIH Training Center is pleased to announce the 2nd seminar of the 2010-2011 DDM Seminar Series featuring Mark Crear. He will address the NIH community in a presentation on the importance of perseverance, teamwork and mutual respect that is essential to maintaining a winning team titled ？？？Staying In the Zone？？？ by Maintaining a Winning Team Attitude!"
Dr. Mark Crear is not only a two-time Olympic Medalist, but also an entrepreneur, motivational speaker, consultant, published author, ordained minister, and doctor of philosophy (PhD). This USC alumnus has over 15 years of world-class Olympic-level success and first captured attention by winning the 1996 Olympic silver medal with a broken arm and the 2000 Olympic bronze medal with a double hernia.
Mark Crear has been around the world presenting keynote and inspirational messages to various organizations... his unique way of using his Olympic experience as a hurdler to illustrate how to overcome hurdles and ？？？Stay in the Zone？？？ is encouraging, motivating, educational, yet entertaining.
Mark？？？s proven successful program is based on his methodology he refers to as the 4P？？？s - Purpose, Power, Priorities, and Permission.
During this interactive presentation, Mark will address building and maintaining motivation in yourself; improving team cohesion and teamwork, and developing a championship attitude; overcoming hurdles of life and weather the storm; and uncovering the attitudes, behaviors and beliefs that are stunting your organization？？？s performance.
The DDM Seminar Series is open to all NIH employees and there is no need to pre-register for the event. Participation will be recorded in the HHS Learning Management System (LMS) for those that sign-in and attend. Be an interactive participant by submitting questions and comments via the "Live Feedback" feature!
DDM Seminar Series: Staying In the Zone... by Maintaining a Winning Team Attitude! (NIH Only)
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- Heart Healthy Tips - Exercises & Myths, Facts about Your Hips & Other Good Ways & Reasons to Keep Your Heart Happy
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- - Ms. Terry Bowers, NIH R&W Fitness Center (2011/02/25)
- - Category : Focus on You Wellness
- Focus on You Wellness Lecture Series
Terry Bowers has been in the fitness industry since the late 70？？？s and is internationally certified in personal training and group exercise by the American Council on Exercise, nutrition counseling by American Fitness Professionals and Associates and Zumba. Her presentations become interactive group performances engaging the audience in a multimedia presentation using music, movement and humor.
The NIH is committed to promoting and protecting the health of our employees as we work to further the NIH mission of extending healthy life and reducing the burden of disease and disability for people around the world. Wellness lectures will move to various locations each month including on- and off-campus sites.
Heart Healthy Tips - Exercises & Myths, Facts about Your Hips & Other Good Ways & Reasons to Keep Your Heart Happy