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  • VRC 10 Year Anniversary Scientific Symposium
    • - NIAID/VRC (2011/04/06)
    • - Category : Conferences
    Description: On March 31, 2011 from 1:00 - 4:45 p.m., the VRC will hold its 10 Year Anniversary Scientific Symposium at the main auditorium of the Natcher Conference Center. The Symposium is designed to review the state of current vaccinology science and future research opportunities.

    For more information, visit
    http://www.niaid.nih.gov/about/organization/vrc/Pages/default.aspx

    VRC 10 Year Anniversary Scientific Symposium

  • CVs and Resumes: Essential Job Search Documents - Career Development Workshop for Staff Scientists/Staff Clinicians
    • - Pat Sokolove, PhD (2011/04/05)
    • - Category : Career Development/OITE
    This workshop will highlight the critical elements and structure of both CVs and resumes. These important job documents serve as the foundation for all job searches, and knowing how to create them based on the employment sector and published position description is essential. Participants will have the opportunity to sign up for a CV/resume consultation in the OITE Career Services Center.

    For more information, visit
    http://www.training.nih.gov

    CVs and Resumes: Essential Job Search Documents - Career Development Workshop for Staff Scientists/Staff Clinicians

  • Mosquito Immunity and Malaria Transmission
    • - Dr. Carolina Barillas Mury, Mosquito Immunity and Vector Competence Section, NIAID (2011/04/05)
    • - Category : NIH Directors Seminars
    Directors Seminar Series

    The Mosquito Immunity and Vector Competence Section investigates the interactions between the mosquito immune system and Plasmodium parasites to understand how they affect disease transmission. Our four major areas of interest are: to investigate the interactions between Plasmodium parasites, the gut microbiota, and mosquito midgut epithelial cells, to understand the regulation of the immune pathways that mediate antiplasmodial responses, to explore hemocyte differentiation and innate immune memory in mosquitoes and to identify the genes that allow some strains of Plasmodium to evade the mosquito immune system.

    Mosquito Immunity and Malaria Transmission

  • Disaster Information Outreach: A Symposium for Information Professionals Meeting Disaster Health Information Needs (Day 1)
    • - Disaster Information Management Research Center, National Library of Medicine (2011/04/03)
    • - Category : Conferences
    This symposium will focus on librarians and libraries providing disaster-related health information for their hospitals, universities, government agencies, and communities. Speakers from the military, federal government, academic institutions, medical settings and voluntary agencies will describe their information needs. Librarians will share their efforts in working with these groups to provide high quality health information during disaster preparedness and response.

    For more information, visit
    http://sis.nlm.nih.gov/dimrc/symposium2011.html

    Disaster Information Outreach: A Symposium for Information Professionals Meeting Disaster Health Information Needs (Day 1)

  • Quantitative Biology and Biomarker Discovery without Immunoassays
    • - Dr. Steven Carr, Director of Proteomics at the Broad Institute of MIT and Harvard (2011/04/03)
    • - Category : Wednesday Afternoon Lectures
    Lack of antibody reagents and robust quantitative methods with sufficient sensitivity, specificity, reproducibility and throughput has significantly hampered our ability to understand dynamic, protein-based biological processes. This deficiency been particularly acute in the area of disease biomarkers where the lack of methods to assay for the presence and level of large (100???s) numbers of minimally credentialed candidate biomarker proteins in patient samples has stymied the introduction of new protein biomarkers into clinical use. My laboratory is addressing this serious barrier by developing targeted mass spectrometry-based technologies to screen and quantify low abundance proteins in a variety of biological contexts including human plasma.

    The methods we have developed enable construction of highly multiplexed (>100plex), sensitive (10???s of copies/cell and <1 ng/mL in blood) assays with near clinical-grade performance for nearly any protein of interest. MS-based assays can also be generically constructed to measure many modifications, mutations and splice variants. We are applying these quantitative approaches in the context of a generalizable proteomics-based discovery-through-verification pipeline to identify early biomarkers of cardiovascular injury, breast cancer and infectious disease. These studies are beginning to demonstrate that modern proteomic technologies when coherently integrated can yield novel, credentialed protein biomarker candidates of sufficient merit to warrant real clinical evaluation.

    The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    For more information, visit:
    http://wals.od.nih.gov/

    Quantitative Biology and Biomarker Discovery without Immunoassays

  • Cytokine Regulation of B-cell Migration Promotes Formation of Autoreactive Germainal Centers
    • - John Mountz (2011/04/03)
    • - Category : Immunology

    Cytokine Regulation of B-cell Migration Promotes Formation of Autoreactive Germainal Centers

  • Pluripotent Stem Cells in Translation: Early Decisions (Day 1)
    • - NIH and FDA (2011/04/02)
    • - Category : Conferences
    The National Institutes of Health and the Food and Drug Administration are collaborating on a series of workshops on moving pluripotent stem cell therapies into the clinic.

    The first two day workshop, ???Pluripotent Cells in Translation: Early Decisions,??? is scheduled for March 21 and 22 at Lister Hill Auditorium on the NIH campus in Bethesda, Maryland. The first day will cover pluripotency and its challenges, sources of pluripotent cells, and stem cell banks; the second day will cover making pluripotent stem cells into a product, product characterization, and emerging technologies.

    The meeting has participation from industry, academic and clinical scientists, the FDA, and the NIH.

    For more information, visit
    http://www.cvent.com/EVENTS/Info/Summary.aspx?e=942182d8-4b08-4a79-8f98-2a3c9df62678

    Pluripotent Stem Cells in Translation: Early Decisions (Day 1)

  • Pluripotent Stem Cells in Translation: Early Decisions (Day 2)
    • - NIH and FDA (2011/04/02)
    • - Category : Conferences
    The National Institutes of Health and the Food and Drug Administration are collaborating on a series of workshops on moving pluripotent stem cell therapies into the clinic.

    For more information, visit
    http://www.cvent.com/EVENTS/Info/Summary.aspx?e=942182d8-4b08-4a79-8f98-2a3c9df62678

    Pluripotent Stem Cells in Translation: Early Decisions (Day 2)

  • Disaster Information Outreach: A Symposium for Information Professionals Meeting Disaster Health Information Needs (Day 2)
    • - Disaster Information Management Research Center, National Library of Medicine (2011/04/02)
    • - Category : Conferences
    This symposium will focus on librarians and libraries providing disaster-related health information for their hospitals, universities, government agencies, and communities. Speakers from the military, federal government, academic institutions, medical settings and voluntary agencies will describe their information needs. Librarians will share their efforts in working with these groups to provide high quality health information during disaster preparedness and response.

    For more information, visit
    http://sis.nlm.nih.gov/dimrc/symposium2011.html

    Disaster Information Outreach: A Symposium for Information Professionals Meeting Disaster Health Information Needs (Day 2)

  • Social Media Tools and the NIH Mission: Innovations for the Future in Womens Health Research, Outreach, and Health Communications
    • - John Burklow, Jonathan Cho, Erik Augustson, Judy Meehan, Carol Krause and Laura Bartlett (2011/04/01)
    • - Category : Womens Health
    2011 ORWH seminar series on social media tools and the NIH mission.

    For more information, visit
    http://orwh.od.nih.gov

    John Burklow, Assoc. Dir., Comm. and Public Liaison, NIH.

    Jonathan Cho, Chief, Com. Tech. Branch, NCI.

    Dr. Erik Augustson, Tobacco Control, NCI.

    Judy Meehan, CEO, Healthy Mothers, Healthy Babies.

    Carol Krause, Comm. Dir., NIDA.

    Laura Bartlett, Spec. Info. Services, NLM.

    Social Media Tools and the NIH Mission: Innovations for the Future in Womens Health Research, Outreach, and Health Communications

  • Epigenetics: Mechanisms and Implications for Studying the Interplay Between Genes and the Environment
    • - Frances Champagne, Ph.D., Columbia University (2011/04/01)
    • - Category : Neuroscience
    Neuroscience Seminar Series

    Dr. Champagne???s laboratory studies how genetic and environmental factors interact to regulate maternal behavior and how natural variations in this behavior can shape the behavioral development of offspring through epigenetic changes in gene expression in a brain region specific manner. In rodents, the quality of postpartum care has long-term effects on response to stress, reward, and to social behavior. These effects are associated with changes in gene expression in the brain. Cross-fostering studies have shown the postnatal environment to be critical to the regulation of these aspects of adult behavior. Interestingly, the quality of maternal care exhibited by mothers also correlates with the quality of care provided in the future by their female offspring. This transmission of maternal behavior from one generation to the next involves changes in the expression of estrogen receptors (ER) in the medial preoptic area (MPOA) of the hypothalamus. These changes are induced during the first week of life and are maintained into adulthood. The Champagne lab has examined the role of epigenetic modifications in the form of DNA methylation in mediating these stable individual differences in gene expression. These epigenetic effects allow for plasticity of phenotype in response to environmental signals that can be observed in subsequent generations. They are currently exploring both genetic and environmental influences on maternal care and the transgenerational impact of these influences for offspring development and behavior.

    For more information, visit:
    http://neuroscience.info.nih.gov

    Epigenetics: Mechanisms and Implications for Studying the Interplay Between Genes and the Environment

  • Fast Food, Sit-downs and Coffee shops: Eating Healthy While Eating Out
    • - Dr. Michael Donovan (2011/04/01)
    • - Category : Focus on You Wellness
    Focus on You Wellness Lecture

    Learn how to maintain a balanced, healthy diet while eating out. Dr. Donovan will reveal some of the best and worst restaurant foods and discuss common restaurant pitfalls and survival strategies.

    Dr. Michael Donovan is a nutritional physiologist and fitness expert specializing in organization and community health promotion. Dr. Donovan was a Presidential Management Fellow with NCI, after earning his Doctorate in Physiology from the University of California, Davis.

    In 2010, he worked with the Office of Research Services to develop the employee wellness and health promotion program at NIH. He has been working in the health and fitness field for over a decade as a nutritionist, fitness trainer and physiologist, and has presented his work on physiology and wellness at national and international conferences.

    Fast Food, Sit-downs and Coffee shops: Eating Healthy While Eating Out

  • Genetic and epigenetic control of pluripotent stem cell differentiation to motor neurons
    • - Hynek Wichterle (2011/04/01)
    • - Category : Stem Cell
    NCRM/SCIG Stem Cell Seminar Series:

    Hynek Wichterle is an assistant professor holding a joint appointment in the Departments of Pathology and Cell Biology, Neurology, and Neuroscience at Columbia University Medical Center in New York. He received his M.S. degree (1993) from Charles University in Prague and his Ph.D. degree (2000) from The Rockefeller University in New York. He trained as a postdoctoral fellow at Columbia University, where he became Assistant Professor in 2004.

    His research focuses on developmental programs underlying specification of neuronal diversity in the developing spinal cord. His lab developed methods for directed differentiation of pluripotent stem cells into spinal motor neurons in a manner that recapitulates normal embryonic development. Using this technology he characterized molecular programs that contribute to rostro-caudal patterning of the developing spinal progenitors, providing ample supply of diverse motor neurons innervating axial, hypaxial and limb muscle targets.

    Together with Dr Christopher Henderson he co-directs Project A.L.S./Jenifer Estess Laboratory for Stem Cell Research that applies the embryonic and induced pluripotent stem cell technologies towards the study and development of new treatments for motor neuron diseases including ALS (Lou Gehrig disease) and Spinal Muscular Atrophy.

    He is a member of the Center for Motor Neuron Biology and Disease and of the Stem Cell Initiative at Columbia University.

    Genetic and epigenetic control of pluripotent stem cell differentiation to motor neurons

  • Lunch and Learn Parenting Seminar: Sleep Matters: Sleep and Sleep Disorders during Adolescence
    • - Daniel S. Lewin, Ph.D., D.ABSM Program Director, Sleep Disorders Medicine National Center on Sleep Disorders Research Division of Lung Diseases, NHLBI, NIH (2011/04/01)
    • - Category : Parenting
    Children and adolescents may be particularly vulnerable to the impact of insufficient sleep and sleep disorders. This presentation will cover a range of topics including, what is normal?, the signs of sleep disorders, and some of the strategies for optimizing sleep for parents and children.

    For more information, visit:
    http://does.ors.od.nih.gov/childcare


    Acrobat Slides

    Lunch and Learn Parenting Seminar: Sleep Matters: Sleep and Sleep Disorders during Adolescence

  • CC Grand Rounds Lecture Series:(1) Main Results of the Action to Control Cardiovascular Disease (ACCORD) Trial in Type 2 Diabetes (2) Results of ACCORD Medical Therapies on Diabetic Retinopathy
    • - (1) Denise Simons-Morton, MD, PhD, Director Division for the Application of Research (2) Emily Y. Chew, MD, Chief, Clinical Trials Branch, and Deputy Director, Division of Epidemiology and Clinical Applications, NEI (2011/04/01)
    • - Category : Clinical Center Grand Rounds
    CC Grand Rounds Lecture Series

    For more information, visit:
    http://www.cc.nih.gov/about/news/grcurrent.html

    CC Grand Rounds Lecture Series:(1) Main Results of the Action to Control Cardiovascular Disease (ACCORD) Trial in Type 2 Diabetes (2) Results of ACCORD Medical Therapies on Diabetic Retinopathy

  • Molecular and Cellular Mechanisms of Store-Operated Calcium Channels
    • - Richard Lewis, Ph.D., Stanford University (2011/03/31)
    • - Category : Neuroscience
    Neuroscience Seminar Series

    Dr. Lewis began his scientific career working with James Hudspeth at the California Institute of Technology characterizing the ionic conductances in hair cells, and then went to work with Mike Cahalan at University of California, Irvine, where he began studying ion channels in T lymphocytes. He started his own laboratory at Stanford University where he continued working on T lymphocytes, and began focusing his attention on the mechanisms of capacitive calcium entry or store-operated channels, a type of calcium channel that serves essential functions from secretion and motility to gene expression and cell growth. His laboratory has made fundamental contributions to our understanding of these store-operated channels, including identification of subunits responsible for channel formation, as well as the transduction of the ER depletion signal to the plasma membrane.

    For more information, visit:
    http://neuroseries.info.nih.gov

    Molecular and Cellular Mechanisms of Store-Operated Calcium Channels

  • Alzheimers Disease: From Genes to Novel Therapeutics
    • - Dr. Rudolph Tanzi, Harvard Medical School (2011/03/31)
    • - Category : Wednesday Afternoon Lectures
    Alzheimer???s disease (AD) is strongly influenced by inheritance and genetic susceptibility as evidenced by numerous family and twin studies. Over the past two and a half decades, our laboratory has co-discovered the three early-onset familial AD genes, APP, PSEN1, and PSEN2, which can carry any of >200 fully penetrant mutations characterized by mendelian inheritance. For late-onset AD, the only well-established risk factor is the epsilon 4 variant of APOE, which increases risk by 3.7-fold in the heterozygous state and >10-fold when two copies are inherited. It has been estimated that 50-70% of the genetic variance of AD remains unexplained by the four established AD genes. We are engaged in two major efforts to identify the additional AD genes as part of our Alzheimer???s Genome Project funded by the Cure Alzheimer???s Fund. First, for published AD candidate genes, we have developed the AlzGene.org website, a comprehensive, online encyclopedia and database, which includes data on >650 AD candidate genes and >~3000 DNA variants that have been tested for association with AD. For all DNA variants tested in at least four independent samples (~300), AlzGene.org provides meta-analyses to determine the most promising AD candidate genes. These studies have led to over 40 candidate AD genes, including APOE, that yield significant results. However, the effects of these variants on risk are tiny compared to APOE (.75???O.R.???1.25).

    We are currently exploring whether these associations are being driven by rare late-onset AD mutations in linkage disequilibrium with the disease-associated common variants. We found this to be the case for the APP alpha-secretase gene, ADAM10,in which we discovered two rare mutations that severely impair ADAM10 cleavage of APP both in vitro and in transgenic mice. Second, in a parallel effort, we have carried out several genome-wide association studies on >800 well-characterized late-onset AD families (NIMH and NCRAD samples) using Affymetrix genotyping arrays containing either one million (6.0) or 500,000 (5.0) genomic single nucleotide polymorphisms (SNPs) as well as arrays containing 20,000 coding SNPs. We have previously reported four novel loci that achieved genome-wide significance (besides APOE) including a novel gene on chromosome 14q, GWA-14q, the ataxin 1 gene, the innate immune system lectin gene, CD33, and the synaptic gene, DLGAP1.

    Functional studies of the ATXN1 gene carried out both in vitro and in vivo in ATXN1 knockout mice show that ATXN1 can regulate Ab levels via modulation of beta-secretase. We will also present new data implicating Ab as an anti-microbial peptide in the innate immune system. These latter data in combination with several novel candidate genes emanating from the Alzheimer???s Genome Project suggest that innate immune system in the brain may play a central role in the etiology and pathogenesis of AD, raising new possibilities for novel drug discovery. Along these lines, I will present data on several promising therapeutics aimed at preventing and treating AD based on knowledge gained from AD genes.

    The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    For more information, visit:
    http://wals.od.nih.gov/

    Alzheimers Disease: From Genes to Novel Therapeutics

  • The Amygdala and Emotion in Human and Nonhuman Primates
    • - Moderator: Richard Nakamura, Ph.D.; Presenters: Betsy Murray, Ph.D. and Ellen Leibenluft, M.D. (2011/03/30)
    • - Category : Oppnet
    OppNet Symposium Series: Human and Model Animal Research in the Basic Behavioral and Social Sciences

    The Amygdala and Emotion in Human and Nonhuman Primates

  • STEP Symposium - I Havent Got Time For The Pain... Is It Ever That Simple? (HHS Only)
    • - Raymond Dionne, Susan Dorsey, Jeffrey Gold, Claudia Campbell (2011/03/27)
    • - Category : STEP (HHS Only)
    Many diseases, syndromes and conditions cause chronic and acute pain that affect quality of life. Pain is the most common reason people seek treatment; however many people still experience pain unnecessarily. Join us for this informative forum to learn about the latest breakthroughs in traditional and non-traditional options for the treatment and management of pain.

    Add to your calendar
    http://odoerdb2-1.od.nih.gov/oer/training/step/icalendar/step_calendar_time_for_pain.ics

    For more information, visit
    http://odoerdb2-1.od.nih.gov/oer/training/step/step_training_20110322.htm

    STEP Symposium - I Havent Got Time For The Pain... Is It Ever That Simple? (HHS Only)

  • A Genomic Analysis of Predisposition to Systemic Autoimmunity
    • - Ward Wakeland (2011/03/27)
    • - Category : Immunology

    A Genomic Analysis of Predisposition to Systemic Autoimmunity