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  • National Cancer Advisory Board (NCAB) June 2004 - Day 1
    • - United States. National Cancer Advisory Board. Meeting (2010/03/04)
    • - Category : Advisory Boards

    National Cancer Advisory Board (NCAB) June 2004 - Day 1

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  • Pre-Application Conference for Community Networks RFA - NCI CRCHD - CA-05-012
    • - NCI Center to Reduce Cancer Health Disparities (2010/03/04)
    • - Category : Center to Reduce Cancer Health Disparities (CRCHD)

    Community Networks RFA

    PowerPoint Dr. Freeman

    PowerPoint Dr. Chu

    PowerPoint Freda Yoder

    PowerPoint Instructions

    Acrobat Checklist

    Acrobat Enrollment

    Acrobat Application

    Acrobat Budget

    Acrobat Project Budget

    Acrobat Modular Budget

    Pre-Application Conference for Community Networks RFA - NCI CRCHD - CA-05-012

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  • Mechanisms and Therapeutic Applications of Immune Stimulatory Bacterial CpG DNA
    • - Arthur M. Krieg, M.D., Coley Pharmaceutical Group (2010/03/04)
    • - Category : Wednesday Afternoon Lectures
    Unmethylated CpG dinucleotides in bacterial or viral DNA can engage the Toll-like receptor (TLR)9, thereby stimulating innate and adaptive immunity. These immune effects can be mimicked by synthetic oligodeoxynucleotides containing CpG motifs (CpG ODN). In humans only B cells and plasmacytoid dendritic cells (pDC) express TLR9 and are activated directly by CpG ODN. Depending on the structure and sequence of the CpG ODN, at least three distinct classes of immune effects can be induced. Depending on their class, CpG ODN activate B cells to proliferate and secrete immunoglobulin; and pDC to secrete a variety of Th1-like cytokines, chemokines, and type I interferons, and to express increased costimulatory molecules. When activated by CpG, pDC gain the ability to stimulate Th1-like T cell responses.

    NIH Director's Wednesday Afternoon Lecture Series

    Mechanisms and Therapeutic Applications of Immune Stimulatory Bacterial CpG DNA

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  • Development of Alternative Strategies for Smallpox Vaccination
    • - Graham, Barney S.
      National Institutes of Health (U.S.) (2010/03/04)
    • - Category : Clinical Center Grand Rounds

    Development of Alternative Strategies for Smallpox Vaccination

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  • Neural and Psychological Basis of Compulsive Drug Seeking: Implications for Treatment
    • - Barry Everitt, Ph.D., Cambridge University (2010/03/04)
    • - Category : Wednesday Afternoon Lectures
    Associative learning impacts the establishment of addictive behavior. Both pavlovian and instrumental conditioning contribute to the development of compulsive drug-seeking and this will be illustrated by experiments using rats self-administering cocaine or heroin. The initial, goal-directed actions by which animals and humans self-administer cocaine can become compulsive and habitual, driven and maintained by the presence of drug-associated cues in the environment ??? cues that can also precipitate relapse after abstinence.

    For more information, visit
    Barry Everitt

    The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    Neural and Psychological Basis of Compulsive Drug Seeking: Implications for Treatment

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  • Endocrine Secretion From Salivary Glands: What Would Pavlov Think? - Advances in Treatment of Lupus Nephritis
    • - Baum, Bruce J.
      National Institutes of Health (U.S.) (2010/03/04)
    • - Category : Clinical Center Grand Rounds

    Endocrine Secretion From Salivary Glands: What Would Pavlov Think? - Advances in Treatment of Lupus Nephritis

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  • Playing Dice with NK Cells: Probabilistic Switches Control Ly49 Expressions
    • - Anderson, Stephen.
      National Institutes of Health (U.S.) (2010/03/04)
    • - Category : Immunology

    Playing Dice with NK Cells: Probabilistic Switches Control Ly49 Expressions

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  • Inhibition of Mismatch Repair by Cadmium
    • - Gordenin, Dmitry.
      National Institutes of Health (U.S.). DNA Repair Interest Group. (2010/03/04)
    • - Category : DNA Repair

    Inhibition of Mismatch Repair by Cadmium

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  • Demystifying Medicine - Immune Deficiency Disease: Disease and Genetics
    • - Steve Holland and Jennifer Puck (2010/03/04)
    • - Category : Demystifying Medicine
    "Demystifying Medicine" is a weekly course, primarily for Ph.D. students, post-doctoral fellows, and staff at the National Institutes of Health. Physicians and other students are also welcome to participate. The course is led by Dr. Win Arias, Professor of Physiology and Medicine at Tufts School of Medicine in Boston and NIH Adjunct Investigator and Special Assistant in the Office of Intramural Research.

    For more information, visit
    http://www1.od.nih.gov/oir/DemystifyingMed/index.html

    Demystifying Medicine - Immune Deficiency Disease: Disease and Genetics

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  • George Beadle and the Emergence of Genetics as a Molecular Science
    • - Singer, Maxine. (2010/03/04)
    • - Category : Special

    George Beadle and the Emergence of Genetics as a Molecular Science

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  • Great Teachers - Optimizing Antimicrobial Treatment: When More Is Better???When Less Is Best
    • - Gerberding, Julie.
      National Institutes of Health (U.S.) (2010/03/04)
    • - Category : Clinical Center Grand Rounds

    Great Teachers - Optimizing Antimicrobial Treatment: When More Is Better???When Less Is Best

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  • Greater Potency of Adult Stem Cells
    • - Catherine M. Verfaillie, M.D., University of Minnesota (2010/03/04)
    • - Category : Wednesday Afternoon Lectures
    The quintessential stem cell is the embryonal stem (ES) cell which has unlimited selfrenewal and multipotent differentiation potential. Stem cells have also been identified in most tissues. Compared with ES cells, tissue specific stem cells have less self-renewal ability and, although they differentiate into multiple lineages, they are not multipotent. A large number of recent published studies have suggested that tissue specific stem cells may have the ability to generate cells of tissues from unrelated organs.

    For more information, visit
    Catherine Verfaillie

    NIH Director's Wednesday Afternoon Lecture Series

    Greater Potency of Adult Stem Cells

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  • T Lymphocyte Activation: From Self-Recognition to Dynamic In Vivo Visualization and on to In Silico Modeling
    • - Germain, Ron.
      National Institutes of Health (U.S.) (2010/03/04)
    • - Category : Immunology

    T Lymphocyte Activation: From Self-Recognition to Dynamic In Vivo Visualization and on to In Silico Modeling

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  • Effective Family Caregiving
    • - NIH Work/Life Center (2010/03/04)
    • - Category : Work/Life Center
    Caring for elderly relatives is a real challenge for families. Learn a team approach to caregiving, how to meet problems as a family, and how to mediate the (inevitable) disagreements.

    The NIH Work/Life Center, in conjunction with the Employee Assistance Program, is pleased to announce the "Faces and Phases of Life" seminar series. This successful series brings expert speakers to campus to address a broad range of quality of work and quality of life issues.

    For more information, visit the
    NIH Work/Life Center

    Effective Family Caregiving

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  • Protein Microarrays for Signaling Pathway Mapping
    • - Oroszlan, Peter L.
      National Institutes of Health (U.S.) (2010/03/04)
    • - Category : HIV Drug Resistance

    Protein Microarrays for Signaling Pathway Mapping

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  • RNA-Triggered Genetic Silencing Mechanisms
    • - Andrew Fire, Ph.D., Carnegie Institution of Washington (2010/03/04)
    • - Category : Wednesday Afternoon Lectures

    The genetic landscape faced by a living cell is constantly changing. Developmental transitions, environmental shifts, and pathogenic invasions lend a dynamic character to both the genome and its activity pattern. A variety of natural mechanisms are utilized by cells adapting to genetic change. These include normal developmental mechanisms and a subset of defense systems for responding to pathogens. At the root of these studies are questions of how a cell can distinguish "self" versus "nonself" and "wanted" versus "unwanted" gene expression.

    For more information, visit
    Andrew Fire

    The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    RNA-Triggered Genetic Silencing Mechanisms

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  • Herbal Medicine: Ancient Practice Meets Modern Science
    • - Norman R. Farnsworth, Ph.D., University of Illinois at Chicago (2010/03/04)
    • - Category : Special
    National Center for Complementary and Alternative Medicine (NCCAM) lecture

    During this lecture, Dr. Farnsworth, a world renowned scholar and leader in the scientific standardization and study of botanical products for medical and dietary use, will speak on his research in herbal medicine and current studies under way. Dr. Farnsworth will also describe the challenges in this research, including plant collection, identification, isolation of active ingredients, understanding how the botanicals work, and whether they are safe and effective.

    Norman R. Farnsworth, Ph.D.
    Director, Program for Collaborative Research in the Pharmaceutical Sciences College of Pharmacy
    University of Illinois at Chicago

    For more information, visit
    http://nccam.nih.gov

    Herbal Medicine: Ancient Practice Meets Modern Science

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  • From Long-Term Gradients to Local Cell Shape Changes: How the Drosophila Embryo Controls Its Morphogenesis
    • - Eric F. Wieshaus, Ph.D., Princeton, Nobel Laureate, l995 (2010/03/04)
    • - Category : Wednesday Afternoon Lectures
    The NIH Director's Wednesday Afternoon Lecture Series

    After the Drosophila embryo has completed thirteen rounds of nuclear division, it consists of a single cell with about 6000 nuclei. In the ninety minutes that follow, it undergoes a series of profound morphological changes that convert the syncytial embryo into cellular blastoderm in which the 6000 cells have assigned fates and undergo region-specific cell shape changes. In the past 15 years, we have learned a great deal about the gradients and transcription factors that control cell fate, but we know much less about the cell biological mechanisms that convert those cell fate decisions into actual cell behaviors. Because the cell changes and movement in Drosophila share common feature with the behaviors of cells in all embryos, it is likely that understanding those mechanisms will shed light on fundamental processes controlling cell adhesion, cytoskeletal dynamics, protein targeting and cell polarity.

    From Long-Term Gradients to Local Cell Shape Changes: How the Drosophila Embryo Controls Its Morphogenesis

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  • Honest Jim Revealed - The Writings of James D. Watson
    • - Friedberg, Errol C.
      National Institutes of Health (U.S.). DNA Repair Interest Group. (2010/03/04)
    • - Category : DNA Repair

    Honest Jim Revealed - The Writings of James D. Watson

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  • Controlling T Cells' Obsession with Self: Sugar and Spice and All Things Nice?
    • - Steve Jameson (2010/03/04)
    • - Category : Immunology
    The Immunology Interest Group (IIG) organizes activities designed to promote information exchange and interactions among NIH scientists interested in the field of immunology, broadly defined. Interactions are facilitated via weekly meetings on current topics as well as an annual Immunology Retreat.

    For more information, visit
    The Immunology Interest Group

    Controlling T Cells' Obsession with Self: Sugar and Spice and All Things Nice?

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