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  • NIH VideoCast - How to Maintain Serum Antibody Titers?
    • - David M. Allman, Ph.D.; Associate Professor of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania (2016/03/11)
    • - Category : Immunology
    Immunology Interest Group

    David Allman is an Associate Professor of Pathology and Laboratory Medicine in the Department of Pathology and Laboratory Medicine of the Perelman School of Medicine at the University of Pennsylvania. He described what are now called transitional B cells during his PhD. This work showed that B cell maturation and formation of the B cell repertoire is completed in peripheral lymphoid tissues rather than in the bone marrow. Later, working with Warren Pear, he established roles for Notch in T lineage commitment. Recently he has focused on antibody secreting plasma cells, and has discovered that T-cell independent antigens can induce long-lived antibody responses. His laboratory is currently focused on the signaling and epigenetic mechanisms that support the generation of long-lived plasma cells. Abstract: Longitudinal studies of vaccine efficacy indicate antibody responses to many infectious agents last a lifetime; yet antibody responses to less complex protein antigens commonly exhibit relatively short half-lives. To gain insight into this problem, we are working to characterize the cellular and molecular processes underlying the long-term survival of antibody-secreting plasma cells in the bone marrow. Our work reveals that the bone marrow plasma cell pool is highly dynamic, consisting of both short- and long-lived cells characterized by distinct gene expression profiles and derived from a variety of sources beyond the canonical germinal center pathway.

    NIH VideoCast - How to Maintain Serum Antibody Titers?

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  • NIH VideoCast - Recombinant DNA Advisory Committee - March 2016 (Day 1)
    • - OSP, NIH (2016/03/10)
    • - Category : Recombinant DNA Advisory Committee
    The Recombinant DNA Advisory Committee is a federal advisory committee that provides recommendations to the NIH Director related to basic and clinical research involving recombinant or synthetic nucleic acid molecules. RAC proceedings and reports are posted to the OBA Web site to enhance their accessibility to the scientific and lay public.

    NIH VideoCast - Recombinant DNA Advisory Committee - March 2016 (Day 1)

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  • NIH VideoCast - Using a Health Equity Model to Promote Environmental Approaches to Violence, Alcohol and Other Drug Prevention
    • - Debra Furr-Holden, Ph.D., Johns Hopkins Bloomberg School of Public Health (2016/03/10)
    • - Category : BSSR - Behavioral and Social Sciences
    BSSR Lecture

    To ask QUESTIONS during the Q&A session:

    Twitter: @NIHOBSSR or #BSSRLectureSeries

    Email: isabel.estrada@nih.gov

    It is well established that place matters with respect to health and health outcomes. In studies of behavioral health, including violence, alcohol and other drug use, and mental health there is growing evidence that environmental risk is a strong predictor of behavior in highly disordered environments and may be a more salient predictor of high-risk behavior than individual-level risk factors. The field of health equity research has been defined as the study of the context where people live, work and play and experience health. Essential to the inquiry of health equity are understandings of how the environment shapes and influences opportunities for optimal (or sub-optimal) health as well as structural and policy interventions to address features of the built and social environment to promote behavioral health. Specific examples will be provided of innovative environmental assessment methods that offer the most resolute and policy-relevant approaches to characterizing the environment and environmental risk. In addition, recent examples from current policy-based research and implementation efforts to reduce alcohol outlet-density and expand behavioral health services in Baltimore City will be provided. This action-oriented research builds on recent advancements in the field of geographic information systems and offers promising new lines of research, service and advocacy in the field of health equity researc

    NIH VideoCast - Using a Health Equity Model to Promote Environmental Approaches to Violence, Alcohol and Other Drug Prevention

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  • NIH VideoCast - Introduction to the Principles and Practice of Clinical Research (IPPCR): Information Resources for Clinical Research
    • - Josh Duberman, M.L.I.S., Informationist/Research Librarian, NIH Library (2016/03/09)
    • - Category : IPPCR
    The Introduction to the Principles and Practice of Clinical Research (IPPCR) is a course to train participants on how to effectively conduct clinical research. The course focuses on the spectrum of clinical research and the research process by highlighting epidemiologic methods, study design, protocol preparation, patient monitoring, quality assurance, and Food and Drug Administration (FDA) issues.

    For more information go to http://clinicalcenter.nih.gov/training/training/ippcr1.html

    NIH VideoCast - Introduction to the Principles and Practice of Clinical Research (IPPCR): Information Resources for Clinical Research

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  • NIH VideoCast - The Sensory Neurons of Touch: From Function to Dysfunction
    • - David Ginty, Ph.D., Harvard Medical School (2016/03/08)
    • - Category : National Center for Complementary and Integrative Health
    The National Center for Complementary and Integrative Health (NCCIH) presents the Integrative Medicine Research Lecture Series. The series provides overviews of the current state of research and practice involving complementary health approaches and explores perspectives on the emerging discipline of integrative medicine.

    David Ginty, Ph.D., is the Edward R. and Anne G. Lefler Professor of Neurobiology at Harvard Medical School and an investigator at the Howard Hughes Medical Institute. Dr. Ginty？？？s work is focused on the development, organization, and function of neurons that stimulate the skin and mediate our sense of touch and pain perception. Dr. Ginty？？？s lecture will provide insight from novel tools and techniques developed by him and his team that explore the somatosensory system and the way specific neurons inform our understanding of certain sensations.

    For more information go to https://nccih.nih.gov/news/events/IMlectures

    NIH VideoCast - The Sensory Neurons of Touch: From Function to Dysfunction

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  • NIH VideoCast - Principles of Clinical Pharmacology ~ Quality Assessment of Drug Therapy
    • - Charles E. Daniels, BSPharm., Ph.D., University of California San Diego (2016/03/05)
    • - Category : Principles of Clinical Pharmacology
    The "Principles of Clinical Pharmacology" course is a weekly lecture series covering the fundamentals of clinical pharmacology as a translational scientific discipline focused on rational drug development and utilization in therapeutics. The course is offered annually at the NIH Clinical Center and runs from September through April.

    NIH VideoCast - Principles of Clinical Pharmacology ~ Quality Assessment of Drug Therapy

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  • NIH VideoCast - COPD Town Hall (Day 2)
    • - NHLBI Division of Lung Diseases (2016/03/04)
    • - Category : Conferences
    To create a COPD National Action Plan, COPD stakeholders are convening for the COPD Town Hall at NIH. During the two-day event, the COPD community ？？？ including individuals with COPD and their families, advocates, health care professionals, researchers, community and professional organizations, policymakers, government agencies, industry, and the media ？？？are coming together to help develop a National COPD Action Plan.

    For more information go to http://www.nhlbi.nih.gov/health/educational/copd/get-involved/town-hall.htm

    NIH VideoCast - COPD Town Hall (Day 2)

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  • NIH VideoCast - Demystifying Medicine 2016: Cell Polarity: Mechanisms and Disease in the Nervous System and Liver
    • - Juan Bonifacino, PhD, NICHD, NIH and Irwin Arias, MD, CC/NICHD, NIH (2016/03/04)
    • - Category : Demystifying Medicine
    Demystifying Medicine is an annual course from January to May designed to help bridge the gap between advances in biology and their application to major human diseases. The course includes presentation of patients, pathology, diagnosis, and therapy in the context of major disease problems and current research, primarily directed toward Ph.D. students, fellows, and staff. All are invited.

    For more information go to https://demystifyingmedicine.od.nih.gov/

    NIH VideoCast - Demystifying Medicine 2016: Cell Polarity: Mechanisms and Disease in the Nervous System and Liver

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  • NIH VideoCast - CC Grand Rounds: (1) Recent Clinical Insights into Pediatric Cushing Syndrome and (2) Genetics of Pituitary and Adrenal Tumors Leading to Cushing Syndrome
    • - (1) Maya Lodish, MD, MHSc, Director, Pediatric Endocrinology Fellowship Program, NIH and Staff Clinician, Section on Endocrinology and Genetics, NICHD, NIH and (2) Constantine A. Stratakis, MD, D (Med) Sci Scientific Director, NICHD, NIH (2016/03/04)
    • - Category : Clinical Center Grand Rounds
    CC Grand Rounds: (1) Recent Clinical Insights into Pediatric Cushing Syndrome and (2) Genetics of Pituitary and Adrenal Tumors Leading to Cushing Syndrome

    For more information go to http://www.cc.nih.gov/about/news/grcurrent.html

    NIH VideoCast - CC Grand Rounds: (1) Recent Clinical Insights into Pediatric Cushing Syndrome and (2) Genetics of Pituitary and Adrenal Tumors Leading to Cushing Syndrome

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  • NIH VideoCast - Beyond DNA: Sequence variation in the RNA
    • - Vivian G. Cheung, M.D., Frederick G.L. Huetwell Professor, Department of Pediatrics and Communicable Diseases, Division of Neurology; Professor, Department of Human Genetics; Research Professor, Life Sciences Institute at University of Michigan and Guest Researcher/ Special Volunteer, Neurogenetics Branch, NINDS, NIH (2016/03/04)
    • - Category : WALS - Wednesday Afternoon Lectures
    NIH Director`s Wednesday Afternoon Lecture

    DNA is our genetic blueprint. Generally it is expected that RNA sequences are identical to the underlying DNA. However, there are exceptions to this one-to-one relationship, such as the A-to-G RNA editing mediated by ADAR proteins. The Cheung lab uncovered many more sites where RNA sequences differ from the underlying DNA, beyond those mediated by the known RNA-editing mechanisms. Dr. Cheung will describe their findings of RNA-DNA sequence Differences, RDDs, and how their study of juvenile amyotrophic lateral sclerosis is leading to an understanding of RDD formation.

    For more information go to https://oir.nih.gov/wals

    NIH VideoCast - Beyond DNA: Sequence variation in the RNA

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  • NIH VideoCast - NIH Tribal Consultation Advisory Committee - February 2016 (Day 2)
    • - NIH (2016/03/03)
    • - Category : Advisory Board Meetings and Workshops
    The TCAC is advisory to the NIH, and provides a forum for meetings between elected Tribal officials (or their designated representatives) and NIH officials to exchange views, share information, and seek advice concerning intergovernmental responsibilities related to the implementation and administration of NIH programs. It was established to help ensure that Tribes and AI/AN people have meaningful and timely input in the development of NIH policies, programs, and priorities.

    NIH VideoCast - NIH Tribal Consultation Advisory Committee - February 2016 (Day 2)

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  • NIH VideoCast - Rare Disease Day 2016
    • - ORDR, NIH (2016/03/03)
    • - Category : Conferences
    Rare Disease Day was established to raise awareness with the public about rare diseases, the challenges encountered by those affected, the importance of research to develop diagnostics and treatments, and the impact of these diseases on patients` lives.

    NIH VideoCast - Rare Disease Day 2016

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  • NIH VideoCast - Introduction to the Principles and Practice of Clinical Research (IPPCR): Quality Management in Clinical Research
    • - Elizabeth Ness, R.N., M.S.N. (2016/03/03)
    • - Category : IPPCR
    The Introduction to the Principles and Practice of Clinical Research (IPPCR) is a course to train participants on how to effectively conduct clinical research. The course focuses on the spectrum of clinical research and the research process by highlighting epidemiologic methods, study design, protocol preparation, patient monitoring, quality assurance, and Food and Drug Administration (FDA) issues.

    For more information go to http://clinicalcenter.nih.gov/training/training/ippcr1.html

    NIH VideoCast - Introduction to the Principles and Practice of Clinical Research (IPPCR): Quality Management in Clinical Research

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  • NIH VideoCast - Transatlantic Data Science Workshop 2016
    • - NIH (2016/03/03)
    • - Category : Conferences
    NIH RCUK Big Data Meeting

    This workshop will be an informational and interactive opportunity for early stage investigators to address knowledge gaps in understanding and utilizing health datasets in the US and the UK as well as foster unique collaborations between domain experts and computer scientists, engineers and statisticians. This will be accomplished through didactic sessions with dataset experts, interactive small group working groups and keynote speakers from health and computer science leaders of the US and UK. Collaborations fostered from this meeting will be critical to bringing together the fields of health and computer science as well as in advancing the field of smart and connected health research

    NIH VideoCast - Transatlantic Data Science Workshop 2016

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  • NIH VideoCast - NIH Tribal Consultation Advisory Committee - February 2016 (Day 1)
    • - NIH (2016/03/02)
    • - Category : Advisory Board Meetings and Workshops
    The TCAC is advisory to the NIH, and provides a forum for meetings between elected Tribal officials (or their designated representatives) and NIH officials to exchange views, share information, and seek advice concerning intergovernmental responsibilities related to the implementation and administration of NIH programs. It was established to help ensure that Tribes and AI/AN people have meaningful and timely input in the development of NIH policies, programs, and priorities.

    NIH VideoCast - NIH Tribal Consultation Advisory Committee - February 2016 (Day 1)

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  • NIH VideoCast - COPD Town Hall (Day 1)
    • - NHLBI Division of Lung Diseases (2016/03/02)
    • - Category : Conferences
    To create a COPD National Action Plan, COPD stakeholders are convening for the COPD Town Hall at NIH. During the two-day event, the COPD community ？？？ including individuals with COPD and their families, advocates, health care professionals, researchers, community and professional organizations, policymakers, government agencies, industry, and the media ？？？are coming together to help develop a National COPD Action Plan.

    For more information go to http://www.nhlbi.nih.gov/health/educational/copd/get-involved/town-hall.htm

    NIH VideoCast - COPD Town Hall (Day 1)

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  • NIH VideoCast - Soft, Wireless Optoelectronic Technologies for Neuroscience Research
    • - John Rogers, Ph.D., University of Illinois at Urbana-Champaign (2016/03/02)
    • - Category : Neuroscience
    NIH Neuroscience Series Seminar

    Dr. Rogers lab seeks to understand and exploits interesting characteristics of `soft` materials, such as polymers, liquid crystals, and biological tissues as well as hybrid combinations of them with unusual classes of micro/nanomaterials, in the form of ribbons, wires, membranes, tubes or related. Their aim is to control and induce novel electronic and photonic responses in these materials; they also develop new `soft lithographic` and biomimetic approaches for patterning them and guiding their growth. This work combines fundamental studies with forward-looking engineering efforts in a way that promotes positive feedback between the two. Their current research focuses on soft materials for conformal electronics, nanophotonic structures, microfluidic devices, and microelectromechanical systems, all lately with an emphasis on bio-inspired and bio-integrated technologies. These efforts are highly multidisciplinary, and combine expertise from nearly every traditional field of technical study.

    NIH VideoCast - Soft, Wireless Optoelectronic Technologies for Neuroscience Research

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  • NIH VideoCast - Principles of Clinical Pharmacology ~ Drug Therapy in the Elderly
    • - Dr. Darrell R. Abernethy (2016/03/01)
    • - Category : Principles of Clinical Pharmacology
    The "Principles of Clinical Pharmacology" course is a weekly lecture series covering the fundamentals of clinical pharmacology as a translational scientific discipline focused on rational drug development and utilization in therapeutics. The course is offered annually at the NIH Clinical Center and runs from September through April.

    NIH VideoCast - Principles of Clinical Pharmacology ~ Drug Therapy in the Elderly

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  • NIH VideoCast - RNA-dependent Chromatin Insulator Function
    • - Elissa Lei, Ph.D., Senior Investigator, NIDDK, NIH (2016/03/01)
    • - Category : NIH Director`s Seminars
    NIH Director`s Seminar Series

    A central question in cell biology is how a single genome can give rise to many different cell types with specialized functions and properties. It has become increasingly apparent that proper control of gene expression requires complex organization of DNA at the level of chromatin. Chromatin insulators are DNA-protein complexes that influence gene expression by establishing chromatin domains subject to distinct transcriptional controls, likely through alteration of their spatial arrangement within the nucleus. Our work has focused on elucidating mechanisms of chromatin insulator function and regulation. Using a combination of genetics, biochemistry, cell biology, and high throughput sequencing approaches in the highly tractable model organism Drosophila melanogaster, we have uncovered a noncoding function by which certain mRNAs contribute to chromatin insulator activity. Moreover, our findings have revealed roles for RNA-binding proteins in mediating tissue-specific regulation of chromatin insulators. This seminar will focus on the discovery of these novel paradigms and explore the new questions raised by these insights.

    NIH VideoCast - RNA-dependent Chromatin Insulator Function

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  • NIH VideoCast - CC Grand Rounds: Thyroid Cancer: Diagnostic and Therapeutic Paradigm Shift: When Less is More and (2) Facts and Myths on the Role of Thyroid Stimulating Hormone (TSH) in Thyroid Cancer
    • - (1) Monica Skarulis, MD, Chief, Clinical Endocrine Section, Diabetes, Endocrinology and Obesity Branch, NIDDK, NIH and (2) Joanna Klubo-Gwiezdzinska, MD, PhD Clinical Fellow, Clinical Endocrine Section, Endocrinology and Obesity Branch, NIDDK, NIH (2016/02/26)
    • - Category : Clinical Center Grand Rounds
    CC Grand Rounds: Thyroid Cancer: Diagnostic and Therapeutic Paradigm Shift: When Less is More and (2) Thyroid Cancer: Targeting Metabolic Pathways: When More is Required

    For more information go to http://www.cc.nih.gov/about/news/grcurrent.html

    NIH VideoCast - CC Grand Rounds: Thyroid Cancer: Diagnostic and Therapeutic Paradigm Shift: When Less is More and (2) Facts and Myths on the Role of Thyroid Stimulating Hormone (TSH) in Thyroid Cancer

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