전체 8345
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- NIH VideoCast - Single molecule studies of the initiation of DNA mismatch repair
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- - Dr. Keith Weninger, North Carolina State University (2016/02/18)
- - Category : DNA Repair
- DNA Repair Interest group
NIH VideoCast - Single molecule studies of the initiation of DNA mismatch repair
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- NIH VideoCast - Introduction to the Principles and Practice of Clinical Research (IPPCR): FDA Product Regulation
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- - Chris Joneckis, Ph.D., FDA (2016/02/18)
- - Category : IPPCR
- The Introduction to the Principles and Practice of Clinical Research (IPPCR) is a course to train participants on how to effectively conduct clinical research. The course focuses on the spectrum of clinical research and the research process by highlighting epidemiologic methods, study design, protocol preparation, patient monitoring, quality assurance, and Food and Drug Administration (FDA) issues.
For more information go to http://clinicalcenter.nih.gov/training/training/ippcr1.html
NIH VideoCast - Introduction to the Principles and Practice of Clinical Research (IPPCR): FDA Product Regulation
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- NIH VideoCast - Open Science as a Social Machine
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- - Barend Mons, Ph.D., Professor in Biosemantics at the Human Genetics department of Leiden University Medical Center (2016/02/17)
- - Category : Special
- NIH Frontiers in Data Science Series
Barend Mons is Chair of the European Commission`s High Level Expert Group for the European Open Science Cloud (EOSC). The EOSC is meant to be a supporting expert infrastructure for Open Science. In this presentation, Dr. Mons will cover the aspects of open and participatory science in which community curation and annotation of data is key. He will emphasise the joint responsibility for data stewardship in Open Science. He will explain the concepts of Nanopublication, the Explicitome, and the concept of FAIR (Findable, Accessible, Interoperable, and Re-usable) data and other research objects with an emphasis on machine actionability of published research objects. Finally, Dr. Mons will outline the future developments of social machines in science and how users and producers of data merge into knowledge creation communities where man-machine interaction is key. Examples will be from his own field: Human Genetics.
For more information go to https://datascience.nih.gov/community/datascience-at-nih/frontiers
NIH VideoCast - Open Science as a Social Machine
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- NIH VideoCast - CC Grand Rounds: Costimulation Blockade for Organ Transplantation
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- - Allan D. Kirk, MD, PhD, David C. Sabiston, Jr. Professor and Chairman Department of Surgery, Duke University School of Medicine and Surgeon-in-Chief, Duke University Health System (2016/02/13)
- - Category : Clinical Center Grand Rounds
- CC Grand Rounds: Great Teachers:The NIH Clinical Center`s 2016 Distinguished Clinical Research Scholar and Educator in Residence Lecture: Costimulation Blockade for Organ Transplantation
For more information go to http://www.cc.nih.gov/about/news/grcurrent.html
NIH VideoCast - CC Grand Rounds: Costimulation Blockade for Organ Transplantation
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- NIH VideoCast - The 4D Nucleome Project: Epigenome Amplification in Lymphocytes
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- - Rafael Casellas, Ph.D.; Senior Investigator, Genomics & Immunity Group, Laboratory of Molecular Immunogenetics, NIAMS, NIH (2016/02/12)
- - Category : Immunology
- Immunology Interest Group
Dr. Rafael Casellas received his Ph.D. in Molecular Immunology from the Rockefeller University in 2002. There, he worked under Dr. Michel Nussenzweig to study the role of immunoglobulin gene expression and recombination in the establishment of B cell tolerance and peripheral activation. From 2002 to 2003 he did postdoctoral training with David Baltimore at the California Institute of Technology, where he continued his studies of B cell activation. In December 2003, Dr. Casellas moved to the Laboratory of Molecular Immunogenetics of NIAMS to create the Genomics & Immunity Group, where he is currently a senior investigator and branch chief. Dr. Casellas is also serving as an adjunct investigator at the Center for Cancer Research, NCI. Rafael？？？s laboratory is interested in understanding how nuclear events (e.g. transcription, epigenetics, recombination) drive early development and peripheral activation of B lymphocytes. His most important findings include the discovery, together with David Levens (NCI), of transcriptome amplification, a process whereby the transcription program of na？？ve lymphocytes is globally and proportionally amplified as they engage in the immune response. Rafael？？？s lab also resolved a long-standing question about the origin of chromosomal translocations in B cell lymphomas. They showed that these genetic aberrations result from promiscuous DNA damage by AID, the immunoglobulin gene mutator, rather than the frequency by which translocating genes interact. Another key finding was that genes expressed in most tissues (e.g. Myc, Pim1) often change their entire enhancer repertoire during development, leading to differential promoter activity. Rafael has organized collaborative projects between intramural and extramural laboratories using the latest technology. In 2011, he established the NIH Mouse Regulome Project, a program that seeks to elucidate how gene expression is regulated in the mouse genome using 3C, genome editing, genomics, and nanoscopy. This dynamic collaboration has so far produced 4 publications in Cell. Currently, the Casellas lab is also contributing to the 4D Nucleome Project, an NIH Director Program that explores the role of nuclear architecture in organismal development.
50 years ago Vincent Allfrey and colleagues discovered that lymphocyte activation promotes histone acetylation and enhances gene expression. Our recent studies confirmed that during stimulation of G0 B cells the transcriptome is globally and proportionally amplified by a mechanism that involves Myc and TFIIH. We have now discovered that B cell chromatin undergoes a comparable amplification in histone acetylation, methylation, and nucleosome remodeling. By means of super-resolution microscopy we have found that this epigenome amplification triggers the spreading of chromatin nanodomains from the periphery to the entire nucleus. Furthermore, nanodomain clusters deconvolute into a mononucleosome fiber by a process that requires ATP synthesis and Myc, and which alters transcription factor dynamics. In stark contrast to quiescent follicular B cells, B-1 and marginal zone-lineage cells display full nanodomain spreading and partial deconvolution. The new data thus reveal key structural and epigenetic changes accompanying cell cycle entry, and help explain the semi-active nature of B lymphocytes constitutively engaged by self-antigens.
NIH VideoCast - The 4D Nucleome Project: Epigenome Amplification in Lymphocytes
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- NIH VideoCast - NIH BRAIN Multi-Council Working Group Meeting - February 2016
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- - National Institute of Neurological Disorders and Stroke, NIH (2016/02/11)
- - Category : Advisory Board Meetings and Workshops
- The purpose of this meeting is to receive feedback and guidance on funding opportunity announcements, incoming applications, and strategic planning for the NIH component of the BRAIN Initiative. The MCWG is comprised of 10 representatives from the Advisory Councils of the 10 participating BRAIN Institutes/Centers (including NINDS), 5 at-large members, and ex officio representatives from the other participating federal agencies. The meeting will also provide an opportunity for private entities/foundations to present their contribution to BRAIN. Information presented and gathered at this meeting will support the development of future funding opportunity announcements for the Initiative, set to continue until 2025.
For more information go to http://braininitiative.nih.gov/about/mcwg.htm
NIH VideoCast - NIH BRAIN Multi-Council Working Group Meeting - February 2016
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- NIH VideoCast - Lateral Violence: How Prevalent is it and What Can You Do to Prevent It?
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- - Barbara A. Jordan, DNP, RN, NEA-BC, Clinical Center, NIH (2016/02/11)
- - Category : Special
- CCND WRNRC
Lateral violence is a phenomenon in which a colleague displays a form of aggression to another colleague. In this session, the participant will learn what lateral violence is, how it is characterized and strategies to cope with and ultimately, prevent it.
NIH VideoCast - Lateral Violence: How Prevalent is it and What Can You Do to Prevent It?
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- NIH VideoCast - Demystifying Medicine 2016: The Intestinal Microbiome and Inflammatory Bowel Disease
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- - Yasmine Belkaid, PhD, NIAID, NIH and Warren Strober, MD, NIAID, NIH (2016/02/11)
- - Category : Demystifying Medicine
- Demystifying Medicine is an annual course from January to May designed to help bridge the gap between advances in biology and their application to major human diseases. The course includes presentation of patients, pathology, diagnosis, and therapy in the context of major disease problems and current research, primarily directed toward Ph.D. students, fellows, and staff. All are invited.
For more information go to https://demystifyingmedicine.od.nih.gov/
NIH VideoCast - Demystifying Medicine 2016: The Intestinal Microbiome and Inflammatory Bowel Disease
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- NIH VideoCast - Introduction to the Principles and Practice of Clinical Research (IPPCR): Scientific Conduct
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- - James L. Gulley, M.D., Ph.D., F.A.C.P., National Cancer Institute, NIH (2016/02/10)
- - Category : IPPCR
- The Introduction to the Principles and Practice of Clinical Research (IPPCR) is a course to train participants on how to effectively conduct clinical research. The course focuses on the spectrum of clinical research and the research process by highlighting epidemiologic methods, study design, protocol preparation, patient monitoring, quality assurance, and Food and Drug Administration (FDA) issues.
For more information go to http://clinicalcenter.nih.gov/training/training/ippcr1.html
NIH VideoCast - Introduction to the Principles and Practice of Clinical Research (IPPCR): Scientific Conduct
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- NIH VideoCast - Internal and external sensory systems
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- - Stephen Liberles, Ph.D., Harvard Medical School (2016/02/09)
- - Category : Neuroscience
- NIH Neuroscience Seminar Series
Neural circuits that generate perception and control behavior are poorly understood at a molecular level. Dr. Liberles lab is interested in understanding how the brain processes external sensory and internal homeostatic signals to initiate behavioral and physiological responses. They study how our senses of smell and taste process different environmental cues (like pheromones, food cues, predator odors) to elicit innate mating, foraging, and avoidance responses. In recent efforts, they are also investigating internal sensory modalities of the vagus nerve.
NIH VideoCast - Internal and external sensory systems
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- NIH VideoCast - National Advisory Neurological Disorders and Stroke (NANDS) Council Meeting - February 2016
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- - National Institute of Neurological Disorders and Stroke, NIH (2016/02/07)
- - Category : National Institute of Neurological Disorders and Stroke
- The 195th meeting of the National Advisory Neurological Disorders and Stroke Council on February 4, 2016.
For more information go to http://www.ninds.nih.gov/find_people/nands/index.htm
NIH VideoCast - National Advisory Neurological Disorders and Stroke (NANDS) Council Meeting - February 2016
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- NIH VideoCast - Principles of Clinical Pharmacology ~ Clinical Analysis of Adverse Drug Reactions
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- - Chris Chamberlain, Pharm.D., BCPS, CDE, FDA (2016/02/06)
- - Category : Principles of Clinical Pharmacology
- The "Principles of Clinical Pharmacology" course is a weekly lecture series covering the fundamentals of clinical pharmacology as a translational scientific discipline focused on rational drug development and utilization in therapeutics. The course is offered annually at the NIH Clinical Center and runs from September through April.
NIH VideoCast - Principles of Clinical Pharmacology ~ Clinical Analysis of Adverse Drug Reactions
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- NIH VideoCast - Time-Varying Effect Modeling to Study Developmental and Dynamic Processes
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- - Stephanie Lanza, Ph.D., Pennsylvania State University (2016/02/05)
- - Category : Medicine: Mind the Gap
- Medicine: Mind the Gap is a seminar series that explores issues at the intersection of research, evidence, and clinical practice？？？areas in which conventional wisdom may be contradicted by recent evidence. From the role of advocacy organizations in medical research and policy, to off-label drug use, to the effectiveness of continuing medical education, the seminar series will aim to engage the National Institutes of Health community in thought-provoking discussions to challenge what we think we know and to think critically about our role in today？？？s research environment.
For more information go to https://prevention.nih.gov/programs-events/medicine-mind-the-gap
Please provide your feedback on the webinar evaluation:
https://www.surveymonkey.com/r/23B76KQ
NIH VideoCast - Time-Varying Effect Modeling to Study Developmental and Dynamic Processes
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- NIH VideoCast - NIAMS Advisory Council - February 2016
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- - NIAMS, NIH (2016/02/05)
- - Category : Advisory Board Meetings and Workshops
- 88th Meeting
National Arthritis and Musculoskeletal and Skin Diseases
Advisory Council
Stephen I. Katz, M.D., Ph.D., Chair
For more information go to http://www.niams.nih.gov/About_Us/Committees/council_roster.asp
NIH VideoCast - NIAMS Advisory Council - February 2016
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- NIH VideoCast - CC Grand Rounds: Ethics Rounds: What is the Appropriate Design for Research on Suicide?
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- - Discussant: Donald Rosenstein, MD, Director, Comprehensive Cancer Support Program and Professor and Vice Chair, Division of Hospital Psychiatry, University of North Carolina at Chapel Hill and Case Presenter: Elizabeth Ballard, MD, Research Fellow, Experimental Therapeutics and Pathophysiology Branch, NIMH, NIH (2016/02/05)
- - Category : Clinical Center Grand Rounds
- CC Grand Rounds: Ethics Rounds: What is the Appropriate Design for Research on Suicide?
For more information go to http://www.cc.nih.gov/about/news/grcurrent.html
NIH VideoCast - CC Grand Rounds: Ethics Rounds: What is the Appropriate Design for Research on Suicide?
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- NIH VideoCast - The 3D genome organization and long-range control of gene expression
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- - Bing Ren, Ph.D., Ludwig Institute for Cancer Research, University of California, San Diego (2016/02/05)
- - Category : WALS - Wednesday Afternoon Lectures
- NIH Director？？？s Wednesday Afternoon Lecture Series
The 3-dimensional (3D) genome organization plays an essential role in orchestrating many essential nuclear processes, including DNA replication, transcription, and repair of DNA damages. Great strides have been made recently in the study of 3D chromatin architecture in mammalian cells, with the development of technologies for genome-wide analysis of chromatin interactions at increasing precision and concepts such as "chromosome territories," "topologically associating domains," and "chromatin loops". For his lecture, Dr. Ren will discuss how these advances are transforming the study of gene regulatory mechanisms in mammalian cells. He will give specific examples that illustrate the role of 3D chromatin organization in developing revolutionary tools in sequencing diploid genomes; elucidate the molecular basis of genetic disorders caused by genome structural variations; and offer a functional characterization of enhancers, a class of gene regulatory sequences that can activate target genes at a large genomic distance. The dysfunction of enhancers has been implicated in the etiology of cancer, diabetes, and a broad spectrum of other human diseases.
For more information go to https://oir.nih.gov/wals
NIH VideoCast - The 3D genome organization and long-range control of gene expression
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- NIH VideoCast - An Unexpected Role for DNA Damage Response Kinases in Antigen Receptor Signaling.
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- - Carrie L. Lucas, Ph.D.; Laboratory of Immunology, NIAID, NIH (2016/02/05)
- - Category : Immunology
- Carrie Lucas is a Postdoctoral Fellow in Mike Lenardo？？？s lab in NIAID who will transition soon to an Assistant Professor position in Immunobiology at Yale University School of Medicine. Carrie received her PhD from Harvard Medical School, where she studied CD8 T cell tolerance in mouse models of allogeneic bone marrow transplantation. As a postdoc, she has studied signal transduction in human lymphocytes with a particular focus on phosphoinositide 3-kinase (PI3K) signaling in patients with inherited mutations in PI3K subunits. Some of her recent awards include the AAI-Life Technologies Trainee Achievement Award, the Keystone Symposia Future of Science Award, and the K99/R00 Pathway to Independence Grant. Outside of science, her daughter and husband fill her personal time with all sorts of adventures, including hiking, skiing, and running. In this seminar, Carrie will present her journey from studies in PI3K patients to her more recent discovery of a critical role for a PI3K-like kinase and its downstream DNA damage response effector kinase in antigen receptor signaling.
NIH VideoCast - An Unexpected Role for DNA Damage Response Kinases in Antigen Receptor Signaling.
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- NIH VideoCast - The Telomere Syndromes: A Paradigm for Molecular Medicine
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- - Mary Armanios, M.D., Associate Professor, Department of Oncology, Johns Hopkins University School of Medicine (2016/02/05)
- - Category : Geroscience
- The Trans-NIH GeroScience Interest Group (GSIG) cordially invites you to its winter seminar, featuring Dr. Mary Armanios. Dr. Mary Armanios is an Associate Professor in the Department of Oncology, Johns Hopkins University School of Medicine.
Dr. Armanios？？？ clinical and research interests focus on disorders caused by telomere dysfunction. Their goal is to define approaches to surveillance, diagnosis and treatment for patients with telomere-mediated disease. Human syndromes associated with telomere shortening were first identified in the context of dyskeratosis congenita, a premature aging syndrome that predisposes to cancer. Dyskeratosis congenita patients and patients with telomere-mediated syndromes have an increased risk for developing certain malignancies which include myelodysplastic syndromes, myeloid leukemia and squamous cell carcinomas of the upper aerodigestive tract. The GeroScience Interest Group (GSIG) was formed to enhance opportunities for discussion of the intersection between the biology of aging and the biology of disease and conditions that are of interest across ICs. It is focused on basic biology, but with a longer view towards translation. Please send your questions related to the seminar to kohanskir@mail.nih.gov.
For more information go to http://sigs.nih.gov/geroscience/Pages/default.aspx
NIH VideoCast - The Telomere Syndromes: A Paradigm for Molecular Medicine
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- NIH VideoCast - Demystifying Medicine 2016: Where Do Viruses Come From and How Do They Do What They Do & From A to E: 2000 Years of Hepatitis Virus History
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- - Harvey Alter, MD, CC, NIH and John Coffin, PhD, NCI, NIH/Tufts (2016/02/04)
- - Category : Demystifying Medicine
- Demystifying Medicine is an annual course from January to May designed to help bridge the gap between advances in biology and their application to major human diseases. The course includes presentation of patients, pathology, diagnosis, and therapy in the context of major disease problems and current research, primarily directed toward Ph.D. students, fellows, and staff. All are invited.
For more information go to https://demystifyingmedicine.od.nih.gov/
NIH VideoCast - Demystifying Medicine 2016: Where Do Viruses Come From and How Do They Do What They Do & From A to E: 2000 Years of Hepatitis Virus History
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- NIH VideoCast - Introduction to the Principles and Practice of Clinical Research (IPPCR) 2016: Data Management & Case Report Form Development in Clinical Trials
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- - Marge Good, RN, MPH, OCN, NCI, NIH (2016/02/04)
- - Category : IPPCR
- The Introduction to the Principles and Practice of Clinical Research (IPPCR) is a course to train participants on how to effectively conduct clinical research. The course focuses on the spectrum of clinical research and the research process by highlighting epidemiologic methods, study design, protocol preparation, patient monitoring, quality assurance, and Food and Drug Administration (FDA) issues.
For more information go to http://clinicalcenter.nih.gov/training/training/ippcr1.html
NIH VideoCast - Introduction to the Principles and Practice of Clinical Research (IPPCR) 2016: Data Management & Case Report Form Development in Clinical Trials
