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  • NIH VideoCast - National Cancer Advisory Board Virtual Meeting - February 2016
    • - NCI, NIH (2016/02/26)
    • - Category : National Cancer Advisory Board
    The 5th Virtual meeting of the National Cancer Advisory Board

    NIH VideoCast - National Cancer Advisory Board Virtual Meeting - February 2016

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  • NIH VideoCast - Interleukin 35 (IL-35) and IL-35-producing Regulatory B Cells (i35-Bregs): Critical Regulators of Autoimmune Diseases.
    • - Charles E. Egwuagu, Ph.D., M.P.H.; Chief, Molecular Immunology Section; Laboratory of Immunology, National Eye Institute, NIH (2016/02/26)
    • - Category : Immunology
    Immunology Interest Group

    Charles E. Egwuagu is Chief of the Molecular Immunology Section, National Eye Institute (NEI), NIH. He received his Ph.D in Epidemiology and Microbiology from Yale University Graduate School and a Master of Public Health (M.P.H) degree in Infectious Disease Epidemiology from Yale School of Medicine, New Haven, Connecticut. Dr. Egwuagu did a 2-year Post-doctoral Fellowship in Molecular Immunology at NEI/NIH and then served as a Commissioned Officer of the United States Public Health Service (PHS) for 10 years, attaining the rank of Captain (06). Research in the Egwuagu laboratory is on autoreactive lymphocytes that mediate CNS autoimmune diseases, such as Uveitis and Multiple Sclerosis. Focus is on cytokine signaling with particular interest in the roles of JAK/STAT pathway and suppressors of cytokine signaling (SOCS) proteins in the regulation of lymphocyte development and cell-fate decisions. Beginning with his seminal finding that susceptibility or resistance to organ-specific autoimmune disease is inversely correlated with expression level of the relevant autoantigen in the thymus, his work evolved towards characterization of lymphocyte subsets that mediate uveitis. These studies culminated in an important paper in Nature Medicine showing that Th17 cells mediate uveitis and are inhibited in the neuroretina by Interleukin 27 (IL-27). More recently his lab discovered a novel regulatory B cell population that produces IL-35 (i35-Breg) and now pioneering the use of adoptive Breg/i35-Breg therapy for organ-specific autoimmune diseases. Dr. Egwuagu is a recipient of The United States Public Health Service Commendation Medal, Howard Hughes Medical Institute/NIH Scholar Program Mentoring Award and is a Standing Member of the CMIA (Cellular & Molecular Immunology-A) NIH Study Section. Abstract: Seminar will focus on the immunobiology of Interleukin 35 (IL-35), our discovery of a novel regulatory B cell population that produces IL-35 (i35-Breg) and pioneering work on the use of IL-35 and adoptive Breg/i35-Breg therapy for organ-specific autoimmune diseases. Seminar will conclude with recent data addressing the question of whether Breg constitutes a unique B cell lineage or merely peripheral B cells that are induced to produce regulatory cytokines during inflammation, akin to inducible Tregs.

    NIH VideoCast - Interleukin 35 (IL-35) and IL-35-producing Regulatory B Cells (i35-Bregs): Critical Regulators of Autoimmune Diseases.

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  • NIH VideoCast - Demystifying Medicine 2016: Shingles (Herpes Zoster) Revisited
    • - Jeffery Cohen, MD, NIAID, NIH and Lesia Dropulic, MD, NIAID, NIH (2016/02/25)
    • - Category : Demystifying Medicine
    Demystifying Medicine is an annual course from January to May designed to help bridge the gap between advances in biology and their application to major human diseases. The course includes presentation of patients, pathology, diagnosis, and therapy in the context of major disease problems and current research, primarily directed toward Ph.D. students, fellows, and staff. All are invited.

    For more information go to https://demystifyingmedicine.od.nih.gov/

    NIH VideoCast - Demystifying Medicine 2016: Shingles (Herpes Zoster) Revisited

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  • NIH VideoCast - Introduction to the Principles and Practice of Clinical Research (IPPCR): Electronic Health Records and Clinical Data Interchange Standards
    • - Stephen E. Wilson, Dr. PH., FDA (2016/02/25)
    • - Category : IPPCR
    The Introduction to the Principles and Practice of Clinical Research (IPPCR) is a course to train participants on how to effectively conduct clinical research. The course focuses on the spectrum of clinical research and the research process by highlighting epidemiologic methods, study design, protocol preparation, patient monitoring, quality assurance, and Food and Drug Administration (FDA) issues.

    For more information go to http://clinicalcenter.nih.gov/training/training/ippcr1.html

    NIH VideoCast - Introduction to the Principles and Practice of Clinical Research (IPPCR): Electronic Health Records and Clinical Data Interchange Standards

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  • NIH VideoCast - Introduction to the Principles and Practice of Clinical Research (IPPCR): Considering Inclusion in Research: Scientific and Policy Perspectives
    • - Janine Clayton, M.D., Director, Office of Research on Women？？？s Health, NIH and Meredith D. Temple-O`Connor, Ph.D., Inclusion Policy Officer, Office of Extramural Research, NIH (2016/02/24)
    • - Category : IPPCR
    The Introduction to the Principles and Practice of Clinical Research (IPPCR) is a course to train participants on how to effectively conduct clinical research. The course focuses on the spectrum of clinical research and the research process by highlighting epidemiologic methods, study design, protocol preparation, patient monitoring, quality assurance, and Food and Drug Administration (FDA) issues.

    For more information go to http://clinicalcenter.nih.gov/training/training/ippcr1.html

    NIH VideoCast - Introduction to the Principles and Practice of Clinical Research (IPPCR): Considering Inclusion in Research: Scientific and Policy Perspectives

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  • NIH VideoCast - Focus on You Wellness Lecture Series: Sit Less Move More Reducing Sedentary Behaviors
    • - Josephine Boyington PhD., NHLBI, NIH (2016/02/24)
    • - Category : Focus on You Wellness
    Focus on you wellness lecture American Heart Month Observance will feature presentation plus exercise demonstrations

    NIH VideoCast - Focus on You Wellness Lecture Series: Sit Less Move More Reducing Sedentary Behaviors

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  • NIH VideoCast - Loss of Skills and Onset Patterns in Neurodevelopment Disorders: Understanding the Neurobological Mechanisms
    • - NIH (2016/02/23)
    • - Category : Interagency Autism Coordinating Committee
    The NIH Autism Coordinating Committee in a cross-NIH committee that coordinates scientific activities related to autism research, including developing initiatives and convening scientific workshops to identify gap areas and opportunities for advancing the field. The NIH ACC has identified a need for identifying scientific methods to better understand the phenomenon of loss of skills characterizing the onset of symptoms in a subset of children with ASD and related disorders.

    NIH VideoCast - Loss of Skills and Onset Patterns in Neurodevelopment Disorders: Understanding the Neurobological Mechanisms

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  • NIH VideoCast - A molecular rationale for the unpredictable nature of behavior
    • - Lisa Stowers, Ph.D., The Scripps Research Institute (2016/02/23)
    • - Category : Neuroscience
    NIH Neuroscience Series Seminar

    Dr. Stowers lab is studying how cues in the environment are detected and transformed into electrical activity in the brain to generate behavior. They are identifying the coding logic of all aspects of the system: (1) specific pheromone chemosignals that generate stereotypic behavior; (2) sensory neurons that detect pheromones and other specialized chemosignals; (3) the neural and molecular mechanisms in the brain that result in stereotypic behavior.

    They are studying several independent stereotypic behaviors in the mouse: male-male aggression, pup-suckling, inter-species fear, female reproductive behavior, and scent marking. Analysis of these behaviors in parallel will enable them to determine the neural mechanisms that specify each behavior as well as the common mechanisms that underlie general principles of stereotypic behavior.

    NIH VideoCast - A molecular rationale for the unpredictable nature of behavior

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  • NIH VideoCast - NLM Board of Regents Meeting - February 2016 (Day 2)
    • - NLM, NIH (2016/02/20)
    • - Category : Advisory Board Meetings and Workshops
    NLM Advisory Council Meeting

    Agenda

    For more information go to https://www.nlm.nih.gov/od/bor/bor.html

    NIH VideoCast - NLM Board of Regents Meeting - February 2016 (Day 2)

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  • NIH VideoCast - Principles of Clinical Pharmacology ~ Drug Therapy in Pregnant and Nursing Women
    • - Catherine Stika, MD, Northwestern University (2016/02/20)
    • - Category : Principles of Clinical Pharmacology
    The "Principles of Clinical Pharmacology" course is a weekly lecture series covering the fundamentals of clinical pharmacology as a translational scientific discipline focused on rational drug development and utilization in therapeutics. The course is offered annually at the NIH Clinical Center and runs from September through April.

    NIH VideoCast - Principles of Clinical Pharmacology ~ Drug Therapy in Pregnant and Nursing Women

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  • NIH VideoCast - NIMHD Advisory Council - February 2016
    • - NIMHD, NIH (2016/02/19)
    • - Category : Advisory Board Meetings and Workshops
    This is the 41st Meeting of the NIMHD Advisory Council open session.

    NIH VideoCast - NIMHD Advisory Council - February 2016

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  • NIH VideoCast - ACHDNC Meeting (Day 2)
    • - HRSA (2016/02/19)
    • - Category : Advisory Board Meetings and Workshops
    ACHDNC provides expert advice and recommendations to the Secretary about the development of newborn screening activities, technologies, policies, guidelines, and programs for effectively reducing morbidity and mortality in newborns and children having, or at risk for, heritable disorders. In addition, the Committee？？？s recommendations regarding additional conditions/heritable disorders for screening that have been adopted by the Secretary are included in the Recommended Uniform Screening Panel (RUSP) and constitute part of the comprehensive guidelines supported by the Health Resources and Services Administration. The committee is composed of 15 voting members.

    NIH VideoCast - ACHDNC Meeting (Day 2)

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  • NIH VideoCast - Demystifying Medicine 2016: Atopy: The Common and The Rare Allergies in the Genomic Era
    • - Pamela Guerrerio, MD, PhD, NIAID, NIH and Joshua Milner, MD, NIAID, NIH (2016/02/19)
    • - Category : Demystifying Medicine
    Demystifying Medicine is an annual course from January to May designed to help bridge the gap between advances in biology and their application to major human diseases. The course includes presentation of patients, pathology, diagnosis, and therapy in the context of major disease problems and current research, primarily directed toward Ph.D. students, fellows, and staff. All are invited.

    For more information go to https://demystifyingmedicine.od.nih.gov/

    NIH VideoCast - Demystifying Medicine 2016: Atopy: The Common and The Rare Allergies in the Genomic Era

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  • NIH VideoCast - Clinical Cases from the NIH Clinical Center: From Pathogenesis to Treatment of Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated Temperature Syndrome (CANDLE), a Rare Type I IFN-mediated Autoinflammatory Disease
    • - Lead Presenters: Gina Montealegre, MD, MPH Staff Clinician, Translational Autoinflammatory Disease Section, NIAMS, NIH; Chyi-Chia Richard Lee, MD, PhD Staff Clinician and Dermatopathologist, Laboratory of Pathology, Center for Cancer Research, NCI, NIH and Raphaela Goldbach-Mansky, MD, MHS Acting Chief, Translational Autoinflammatory Disease Section, NIAMS, NIH (2016/02/19)
    • - Category : Clinical Center Grand Rounds
    Clinical Cases from the NIH Clinical Center: From Pathogenesis to Treatment of Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated Temperature Syndrome (CANDLE), a Rare Type I IFN-mediated Autoinflammatory Disease

    For more information go to http://www.cc.nih.gov/about/news/grcurrent.html

    NIH VideoCast - Clinical Cases from the NIH Clinical Center: From Pathogenesis to Treatment of Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated Temperature Syndrome (CANDLE), a Rare Type I IFN-mediated Autoinflammatory Disease

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  • NIH VideoCast - Dissecting Regulatory Mechanisms in TLR-Activated Macrophages through Genetic Screening.
    • - Iain Fraser, Ph.D.; Chief, Signaling Systems Unit, Laboratory of Systems Biology, NIAID, NIH (2016/02/19)
    • - Category : Immunology
    Immunology Interest Group

    This week？？？s IIG speaker will be none other than NIH？？？s own Iain Fraser. Iain received his Ph.D. in biochemistry from Imperial College, University of London. He was a Wellcome Trust International postdoctoral fellow at the Vollum Institute in Portland, Oregon, following which he joined the Alliance for Cellular Signaling (AfCS) research consortium as lead scientist of the molecular biology group at the California Institute of Technology, rising to co-director of the AfCS Molecular Biology Laboratory. He was recruited to NIAID in 2008 as leader of the PSIIM Molecular and Cell Biology Team, and became Chief of the Signaling Systems Unit (SSU) in the NIAID Laboratory of Systems Biology (LSB) in 2011. Here at NIH Iain has been conducting cutting edge studies using siRNA methods to probe macrophage sensing of pathogens. Combining large-scale screens with modern methods for single cell analysis and computational modeling, he and his colleagues have uncovered a number of novel aspects to PAMP sensing by macrophages, such as a previously unsuspected role for Ikaros in ligand concentration discrimination and major species differences in IRAK function. He has developed many novel reporters for probing macrophage signaling, fostered development of new software tools for analyzing screening data, and made inroads into understanding multi-ligand sensing of intact bacteria by macrophages. He is a member of the international RNAi consortium, served as a member of the IIG steering committee, and is part of the leadership of the Systems Biology Interest Group. Iain is an outstanding speaker and the combination of exciting data on innate immune cell function with his ability to make large-scale data understandable for a broad audience promises to make this a lecture not to be missed. Abstract: Toll-like receptors (TLRs) are a major class of pattern recognition receptors mediating the host response to microbial and inflammatory stimuli. I will describe the use of high-throughput genome-scale technologies (such as siRNA screening and profiling of RNA expression and protein-DNA binding) to broadly characterize the response of innate immune cells to TLR pathway activation. In a comparative screen of canonical TLR pathway genes in human and mouse macrophages, we observe a pattern of conserved signaling module dependencies across species, but with numerous species-specific requirements at the individual gene level. I will further demonstrate how systematic screening and computational analysis can identify important characteristics of innate immune responses across species, dissect distinct innate effector response pathways, and potentially identify specific therapeutic targets for regulating TLR-driven outputs in disease states.

    NIH VideoCast - Dissecting Regulatory Mechanisms in TLR-Activated Macrophages through Genetic Screening.

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  • NIH VideoCast - ACHDNC Meeting (Day 1)
    • - HRSA (2016/02/18)
    • - Category : Advisory Board Meetings and Workshops
    ACHDNC provides expert advice and recommendations to the Secretary about the development of newborn screening activities, technologies, policies, guidelines, and programs for effectively reducing morbidity and mortality in newborns and children having, or at risk for, heritable disorders. In addition, the Committee？？？s recommendations regarding additional conditions/heritable disorders for screening that have been adopted by the Secretary are included in the Recommended Uniform Screening Panel (RUSP) and constitute part of the comprehensive guidelines supported by the Health Resources and Services Administration. The committee is composed of 15 voting members.

    For more information go to http://www.hrsa.gov/advisorycommittees/mchbadvisory/heritabledisorders/

    NIH VideoCast - ACHDNC Meeting (Day 1)

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  • NIH VideoCast - CRAN Joint Council Meeting - February 2016
    • - NIAAA, NIDA and NCI (2016/02/18)
    • - Category : Advisory Board Meetings and Workshops
    CRAN is the joint National Advisory Council of NIAAA, NIDA and NCI Collaborative Research on Addiction at NIH initiative to integrate resources and expertise to advance substance use, abuse, and addiction research and public health outcomes.

    NIH VideoCast - CRAN Joint Council Meeting - February 2016

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  • NIH VideoCast - To tweet or not to tweet: Community-based participatory research approaches to advance wellness and violence prevention via social media
    • - Ann Marie White, Ph.D., University of Rochester Medical Center and Ms. Melanie Funchess, Director, Mental Health Association (2016/02/18)
    • - Category : BSSR - Behavioral and Social Sciences
    NIH Behavioral and Social Sciences Seminar Series

    To ask QUESTIONS during the Q&A session:
    Twitter: @NIHOBSSR or #BSSRLectureSeries
    Email: Isabel.estrada@nih.gov

    Many health-related concerns due the interplay of community members？？？ social media and geographical uses exist. However, rapid deployment of massive amounts of social media data and big data analytic tools for sensing can also become a health intervention aid for local communities. We examine this dynamic interplay through a focus on natural helpers, individuals who others routinely turn to for help and support, and whose efforts can reduce violence risks and promote mental health and wellness in local communities.

    During this presentation, we will describe how a community can begin to develop and deploy its own sensing methods for health-related content signals in its social media use through academic-community partnered research.

    Learn more and REGISTER: http://events.r20.constantcontact.com/register/event?oeidk=a07ebuktp0l650017e7&llr=vykrlptab

    NIH VideoCast - To tweet or not to tweet: Community-based participatory research approaches to advance wellness and violence prevention via social media

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  • NIH VideoCast - Vision for the Future: Cell Therapy for Ocular Disease
    • - Dennis O. Clegg, Ph.D., University of California Santa Barbara (2016/02/18)
    • - Category : Special
    The National Eye Institute AGI Seminar Series in Neuroregeneration explores topics relevant to regenerative neuroscience, with special emphasis on the visual system.

    NIH VideoCast - Vision for the Future: Cell Therapy for Ocular Disease

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  • NIH VideoCast - Principles of Clinical Pharmacology ~ Developmental and Pediatric Pharmacology
    • - Dr. John N. van den Anker (2016/02/18)
    • - Category : Principles of Clinical Pharmacology
    The "Principles of Clinical Pharmacology" course is a weekly lecture series covering the fundamentals of clinical pharmacology as a translational scientific discipline focused on rational drug development and utilization in therapeutics. The course is offered annually at the NIH Clinical Center and runs from September through April.

    NIH VideoCast - Principles of Clinical Pharmacology ~ Developmental and Pediatric Pharmacology

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