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  • Structure and Function of the Anthrax Toxin Pore
    • - Collier, R John.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : Wednesday Afternoon Lectures
    Anthrax toxin represents an interesting example of how a proteinaceous pore transports large globular proteins across a biological membrane. One component of the toxin, termed protective antigen (PA), forms an oligomeric pore in the endosomal membrane and translocates the two enzymatic moieties of the toxin, the lethal factor and the edema factor, across the membrane to the cytosolic compartment. This presentation will summarize current knowledge of the structure of the pore, how it inserts into the endosomal membrane, and how it mediates translocation of its substrate proteins across the bilayer.

    The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    Structure and Function of the Anthrax Toxin Pore

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  • New Insights, New Directions for Treating Major Depression and Bipolar Disorder
    • - Zarate, Carlos A.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : Medicine for the Public
    NIH Clinical Centers 2008 Medicine for the Public Lecture Series

    Mood disorders are serious, debilitating, life-shortening illnesses that affect millions. About one in five Americans could develop a mood disorder during his or her lifetime. The World Health Organization projects that mood disorders will be a leading cause of disability worldwide by 2020. To make treatments work better and find new treatments, we must understand more about what causes mood disorders. Dr. Carlos Zarate will cover the symptoms and treatments for mood disorders and the latest research on what may cause them.

    Dr. Zarate completed a Fellowship in Clinical Psychopharmacology at McLean Hospital from 1992-1993, after which he remained as a staff member until 1998. At McLean Hospital of the Consolidated Department of Psychiatry, Harvard Medical School, Dr. Zarate was the Director of the Bipolar and Psychotic Disorders Outpatient Services, Chair of the Pharmacy and Therapeutic Committee, and Director of the New and Experimental Clinic. From 1998 to 2000 Dr. Zarate was the Chief of the Bipolar and Psychotic Disorders Program, Associate Professor of Psychiatry at the University of Massachusetts Medical School. In January 2001, he joined the Mood and Anxiety Disorders Program at the National Institute of Mental Health (NIMH).

    His achievements and awards include the Ethel-DuPont Warren Award and Livingston Awards, Consolidated Department of Psychiatry, Harvard Medical School; Outstanding Psychiatrist Research Award, Massachusetts Psychiatric Association; Program for Minority Research Training in Psychiatry, American Psychiatric Association; National Institute of Health-National Institute of Mental Health Travel Award, 1994; American College of Neuropsychopharmacology Travel Awards 1994 and 1995; the National Alliance for Research on Schizophrenia and Depression Young Investigator Award, 1996-1998; The Diversity and Advocacy Award, Hispanic Research Initiative Committee, NIMH, 2002; the mentor of the year, intramural program NIMH 2004; and the supervisor of the year NIMH 2005; National Alliance for Research on Schizophrenia and Depression Independent investigator award, 2005-2008; and the National Institutes of Health Director？？？s Award Scientific/Medical 2006.

    He is a member of the Society of Biological Psychiatry, International Society of Bipolar Disorders, and the American College of Neuropsychopharmacology. Dr. Zarate also serves as a member of the Mood Disorders DSM-V Committee.

    Dr. Zarate？？？s research focuses on the pathophysiology and novel therapeutics of mood disorders

    http://www.cc.nih.gov/about/news/mfp.shtml

    New Insights, New Directions for Treating Major Depression and Bipolar Disorder

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  • Interviewing Outside the Ivory Tower
    • - Sponsored by the NIH Office of Intramural Training & Education (2010/11/18)
    • - Category : Career Development/OITE
    Attendees will gain an understanding of typical job interviews in pharma and biotech.

    Interviewing Outside the Ivory Tower

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  • Evolution and Diversity of Pathways for Disulfide Bond Formation and Reduction
    • - Beckwith, Jonathan R.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : Wednesday Afternoon Lectures
    We have evolved E. coli such that it can survive the absence of its essential glutathione and thioredoxin pathways ordinarily required for reduction of cytoplasmic disulfide bonds. These studies reveal remarkable flexibility of certain enzymes in the bacteria and lead to the discovery of similarly evolved enzymes already present in other bacteria. Structural disulfide bonds in proteins are found in many bacteria in extracellular compartments such as the periplasm.

    Using a bioinformatic approach, we have proposed that there is significant diversity in the ability of bacteria to make structural disulfide bonds in proteins and in the machinery they use to make them. In particular, a large number of bacteria utilize a homologue of human vitamin K epoxide reductase (VKOR) to oxidize their DsbA in contrast to many others, such as E. coli, which use the protein DsbB. Bacterial VKOR shows remarkable similarities in properties to its human homologue, which is involved in blood clotting and is the target of Warfarin.

    The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    Evolution and Diversity of Pathways for Disulfide Bond Formation and Reduction

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  • OHR All Hands Meeting - December 2008 (NIH-Only)
    • - Christine M. Major, IPMA-CP, Director, Office of Human Resources and Office of Strategic Management Planning (2010/11/18)
    • - Category : Human Resources (NIH Only)
    For more information, visit http://hr.od.nih.gov/

    OHR All Hands Meeting - December 2008 (NIH-Only)

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  • Recombinant DNA Advisory Committee (RAC) December 2008 - Day 1
    • - National Institutes of Health (U.S.). Recombinant DNA Advisory Committee. (2010/11/18)
    • - Category : Recombinant DNA Advisory Committee
    The RAC is a technical committee whose goal is to consider the current state of knowledge and technology regarding recombinant DNA. This includes review of human gene transfer trials, and an assessment of the ability of DNA recombinants to survive in nature and the potential for transfer of genetic material to other organisms. It also considers hypothetical hazards and methods for monitoring and minimizing risks. Approximately one-third of the 15 members do not have scientific expertise but represent public interests and attitudes. This balance is intended to provide a forum for open public debate of social and scientific issues attendant to recombinant DNA research. The RAC has been overwhelmingly successful in achieving this goal.

    For more information, visit the
    Recombinant DNA Advisory Committee (RAC) Conference Web Site

    Recombinant DNA Advisory Committee (RAC) December 2008 - Day 1

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  • Ethics Rounds - How to Present a Dire Prognosis
    • - Makoul, Gregory.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : Clinical Center Grand Rounds
    Clinical Center Grand Rounds

    Gregory Makoul, PhD
    Chief Academic Officer and Vice President for Academic Affairs
    Saint Francis Hospital and Medical Center, Hartford, Conn.

    For more information, visit
    http://www.cc.nih.gov/about/news/grcurrent.html

    Ethics Rounds - How to Present a Dire Prognosis

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  • Quantitative Proteomics Analysis of Aberrant Molecular Events in Acute Myeloid Leukemia
    • - Marto, Jarrod A.
      National Institutes of Health (U.S.). Proteomics Interest Group. (2010/11/18)
    • - Category : Proteomics
    Acute myeloid leukemia (AML) remains a highly lethal malignancy with limited therapeutic options. Full transformation in AML requires coupling of aberrant molecular events associated with multiple cellular processes. For example, mutation of the FLT-3 receptor tyrosine kinase is frequently observed in AML and drives abnormal proliferation. Signaling from oncogenic FLT-3 phosphorylates the transcription factor C/EBP慣 and leads to disrupted myeloid differentiation. We are using iTRAQ-based quantitative proteomics approaches to explore divergent signaling downstream of two common FLT-3 mutants, and to monitor remodeling of C/EBP慣 protein complexes between transcriptionally competent and repressed states. Representative proteomics data and biochemical results will be described, in addition to and methodological improvements in proteomics-related technologies.

    http://proteome.nih.gov

    Quantitative Proteomics Analysis of Aberrant Molecular Events in Acute Myeloid Leukemia

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  • Healthy Strategies for Surviving the Holidays
    • - Sponsored by Life Work Strategies (2010/11/18)
    • - Category : Work/Life Center
    NIH Work Life Seminar

    Did you know the average holiday meal has a whopping 4500 calories! Part III in our continuing series is the timely topic of Healthy Strategies for Surviving the Holidays. This informative presentation will provide essential tips for navigating this lively party season with enthusiasm. A Fun Fact: The average adult gains 8-10 pounds during the holiday season. Menus are ？？？stuffed？？？ with pastries, pies and desserts. Learn the approach that nutritionists use to enjoy themselves during the festivities without putting on excess weight. Find creative ways to enjoy a cocktail party loaded with appetizers or pickup a few healthy cooking tips for your table!

    For more information, visit
    http://wlc.od.nih.gov

    Healthy Strategies for Surviving the Holidays

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  • Recombinant DNA Advisory Committee (RAC) December 2008 - Day 2
    • - National Institutes of Health (U.S.). Recombinant DNA Advisory Committee. (2010/11/18)
    • - Category : Recombinant DNA Advisory Committee
    The RAC is a technical committee whose goal is to consider the current state of knowledge and technology regarding recombinant DNA. This includes review of human gene transfer trials, and an assessment of the ability of DNA recombinants to survive in nature and the potential for transfer of genetic material to other organisms. It also considers hypothetical hazards and methods for monitoring and minimizing risks. Approximately one-third of the 15 members do not have scientific expertise but represent public interests and attitudes. This balance is intended to provide a forum for open public debate of social and scientific issues attendant to recombinant DNA research. The RAC has been overwhelmingly successful in achieving this goal.

    For more information, visit the
    Recombinant DNA Advisory Committee (RAC) Conference Web Site

    Recombinant DNA Advisory Committee (RAC) December 2008 - Day 2

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  • Advisory Committee to the Director of the NIH - December 2008
    • - Advisory Committee to the Director, National Institutes of Health. Meeting (2010/11/18)
    • - Category : Advisory Committee to the Director of the NIH
    A meeting of the Advisory Committee to the Director (ACD) of the National Institutes of Health (NIH)

    The agenda for the meeting will be posted at a later date on the ACD Web site at
    http://www.nih.gov/about/director/acd/index.htm

    Advisory Committee to the Director of the NIH - December 2008

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  • Ion Channels and Cell Membranes
    • - MacKinnon, Roderick.
      National Institutes of Health (U.S.). Neurobiology Interest Group. (2010/11/18)
    • - Category : Neuroscience
    Electrical signals play many roles in the body. They control the pace of the heart, regulate the secretion of hormones into the bloodstream and transfer information from one cell to the next in the nervous system. Dr. MacKinnons research is aimed at understanding the physical and chemical principles underlying electricity in biology, particularly the passage of inorganic ions, such as potassium and chloride, across cell membranes. They have used mutational analysis to show that potassium channels are tetramers of identical subunits and that specific signature sequence?amino acids are responsible for potassium selectivity. His labs most recent advance was the elucidation of the atomic structure of a K+ channel from mammalian nerve cells. This first example of a eukaryotic membrane protein structure through recombinant expression opens a new era in the study of membrane proteins from complex organisms. (http://www.rockefeller.edu/research/abstract.php?id=132)

    Dr. MacKinnon received his B.A. in biochemistry from Brandeis University and his M.D. from Tufts University School of Medicine. He completed medical residency at Beth Israel Hospital, Harvard Medical School, and postdoctoral work at Brandeis. He joined the faculty at Harvard Medical School before moving to Rockefeller in 1996. Dr. MacKinnon is a member of the National Academy of Sciences. He is the recipient of numerous scientific awards, including the 2003 Nobel Prize in Chemistry.

    NIH Neuroscience Seminar Series

    Ion Channels and Cell Membranes

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  • TRACO: Cervical Cancer Vaccines and Lung Cancer Vaccines
    • - Schiller, John T.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : TRACO
    For more information, visit
    http://ccr.cancer.gov/careers/traco.asp

    TRACO: Cervical Cancer Vaccines and Lung Cancer Vaccines

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  • HIFs, Hypoxia, and Stem Cells
    • - Simon, Celeste.
      National Institutes of Health (U.S.). Stem Cell Interest Group. (2010/11/18)
    • - Category : Stem Cell
    The Stem Cell Interest Group was established to enhance communication and to foster collaboration among scientists from varying disciplines interested in stem cells. Topics of interest include fundamental stem cell biology, ontogeny, gerontology, and the therapeutic potential of stem cells. The SCIG serves as an open forum for discussion and dissemination of knowledge about all aspects of stem cell biology

    For more information, visit
    http://tango01.cit.nih.gov/sig/home.taf?_function=main&SIGInfo_SIGID=115

    HIFs, Hypoxia, and Stem Cells

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  • NIH OEODM American Disabilities Act (ADA) Update Seminar (NIH-Only)
    • - Hadley, Ernest C.
      National Institutes of Health (U.S.). Office of Equal Opportunity and Diversity Management. (2010/11/18)
    • - Category : NIH Only
    This seminar will address in a clear and concise manner the significant changes created by the ADAAA and how they will impact the litigation of disability cases before the Federal Courts and the Equal Employment Opportunity Commission. The seminar will also focus on the practical impact of the changes on the processing of reasonable accommodation requests.

    NIH OEODM American Disabilities Act (ADA) Update Seminar (NIH-Only)

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  • National Cancer Advisory Board Meeting - December 2008
    • - United States. National Cancer Advisory Board. Meeting (2010/11/18)
    • - Category : National Cancer Advisory Board
    This is a regularly scheduled meeting of the National Cancer Advisory Board (NCAB).

    National Cancer Advisory Board Meeting - December 2008

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  • Ready, Set, Goal!
    • - Sponsored by the NIH Office of Intramural Training & Education (2010/11/18)
    • - Category : Career Development/OITE
    Learn how to establish personal, professional and career goals with consideration for your current career status, previous experiences and future aspirations.

    Ready, Set, Goal!

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  • The Next Breath We Take: Trailblazing New Treatments for Asthma
    • - Levine, Stewart J.
      National Institutes of Health (U.S.). Clinical Center. (2010/11/18)
    • - Category : Medicine for the Public
    NIH Clinical Centers 2008 Medicine for the Public Lecture Series

    Asthma is a common ailment, affecting over 22 million Americans. Yet, about 10 percent of all asthma sufferers get no relief from standard treatments that work on others. Dr. Stewart Levine will discuss current research being conducted at NIH and elsewhere to find new and better treatments for this disease that robs people of the very air they breathe.

    Stewart J. Levine earned his undergraduate degree from the State University of New York at Binghamton, Harpur College, where he attained Phi Beta Kappa status and graduated with recognition of his ？？？Outstanding Academic Performance.？？？ He earned his medical degree from the State University of New York at Stony Brook, School of Medicine and completed an internship and residency in internal medicine at St. Vincent？？？s Hospital and Medical Center, New York, N.Y. He obtained fellowship training in pulmonary medicine at the Memorial Sloan-Kettering Cancer Center in New York and served as a clinical assistant attending physician in the Pulmonary Division, Department of Medicine at St. Vincent？？？s Hospital and Medical Center. Dr. Levine came to the National Institutes of Health for fellowship training in critical care medicine and was commissioned as a medical officer in the U.S. Public Health Service in 1990. He was subsequently appointed as a staff clinician in the Critical Care Medicine Department in the NIH Clinical Center. He moved to the National Heart, Lung, and Blood Institute (NHLBI) as at Tenure-Track Investigator in 1998 and he currently serves as a Senior Investigator and Chief of the Asthma and Lung Inflammation Section within the Pulmonary and Vascular Medicine Branch. He is also the Acting Chief of the Pulmonary and Vascular Medicine Branch at NHLBI.

    Dr. Levine is board certified in Internal Medicine, Pulmonary Diseases and Critical Care Medicine by the American Board of Internal Medicine. He is an ad hoc peer reviewer for several medical journals, and has served as a member on a number of NIH and extramural committees.

    Dr. Levine has published widely on topics concerning various pulmonary diseases and conditions. His current research interests center around identifying new therapeutic approaches for the treatment of asthma.

    Dr. Levine was elected to membership in the American Society for Clinical Investigation in 2004. He is also an active member of the American Association for the Advancement of Science, the American Society for Biochemistry and Molecular Biology, the American Thoracic Society, and he is a Fellow of the American College of Chest Physicians.

    http://www.cc.nih.gov/about/news/mfp.shtml

    The Next Breath We Take: Trailblazing New Treatments for Asthma

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  • National Science Advisory Board for Biosecurity (NSABB)
    • - National Science Advisory Board for Biosecurity (U.S.). Meeting (2008 Dec. 10 :
      National Institutes of Health (U.S.). Office of Biotechnology Activities. (2010/11/18)
    • - Category : National Science Advisory Board for Biosecurity
    The NSABB has been established to provide advice, guidance and leadership regarding federal oversight of dual use research, defined as biological research with legitimate scientific purposes that could be misused to pose a biological threat to public health and/or national security. Presentations and discussions at the December 10 meeting which will be held at the Legacy Hotel & Meeting Centre, Rockville, MD, will focus on preliminary findings and recommendations on strategies to optimize programs of personnel reliability for individuals with access to select agents and toxins; a brief overview of Public Consultation meeting in July 2008 on the proposed framework for the oversight of dual use research; a brief update on the activities of the Working Group on Outreach and Education; a brief update on Synthetic Genomics; and, highlights from the November 2008 International Roundtable on Sustaining Progress in the Life Sciences: Strategies for Managing Dual Use Research of Concern.

    For more information, please visit the National Science Advisory Board website: http://www.biosecurityboard.gov

    National Science Advisory Board for Biosecurity (NSABB)

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  • "Horse Song," A Special Presentation for Diabetes Education
    • - Centers for Medicare & Medicaid Services (U.S.) (2010/11/18)
    • - Category : CMS - Centers for Medicare & Medicaid Services
    CMS Medicine Dish Series

    This special broadcast features ？？？Horse Song？？？, a diabetes education video produced by IHS？？？ Four Directions Communications and Northern Navajo Medical Center. This innovative drama portrays the challenges faced by a Navajo family in dealing with diabetes. The program incorporates the Navajo language and culture into this outreach tool. Our Medicine Dish viewers may want to use this video for future diabetes education activities.

    This Broadcast will be Pre-recorded.

    Materials related to this broadcast will be posted on the CMS AI/AN website at http://www.cms.hhs.gov/AIAN/MedicineDishBroadcasts.asp.

    E-mail Comments to: medicinedish@cms.hhs.gov

    "Horse Song," A Special Presentation for Diabetes Education

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