전체 8345
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- TARPs and KARPs: Auxiliary Proteins that Modulate AMPA- and Kainate-receptor Kinetics
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- - Howe, James.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Neuroscience
- - Howe, James.
- Dr. James Howe did postdoctoral training with Stuart Cull-Candy and David Colquhoun at University College London before moving to Yale to work with Murdoch Ritchie where he is currently Professor of Pharmacology. Dr. Howes research on the glutamate receptor ion channels which mediate synaptic transmission in the brain uses biophysical approaches to explore their mechanism of action. Most recently he has worked on how TARPS modulate AMPA receptor function and will present new work on a second family of modulatory proteins for kainate receptors.
Selected Publications:
Robert, A., Armstrong, N., Gouaux, J.E., and Howe, J.R. (2005). AMPA receptor binding cleft mutations that alter affinity, efficacy, and recovery from desensitization. J. Neurosci. 25:3752-3762.
Tomita, S., et al. (2005). Stargazin modulates AMPA receptor gating and trafficking by distinct domains. Nature 435:1052-1058.
For more information - NIH Neuroscience Seminar Series
TARPs and KARPs: Auxiliary Proteins that Modulate AMPA- and Kainate-receptor Kinetics
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- Measuring Diet and Physical Activity - with Cell Phones, Digital Imaging, and Wearable Monitors (NIH Only)
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- - Boushey, Carol.
National Institutes of Health (U.S.) (2010/11/18) - - Category : NIH Only
- - Boushey, Carol.
- NIH Obesity Research Task Force Seminar Series
This seminar will feature presentations on: ？？？Improving dietary assessment methods using cell phones and digital imaging,？？？ by Dr. Carol Boushey, Purdue University; and ？？？A new approach in objective measurement of physical activity using wearable monitors,？？？ by Dr. Patty Freedson, University of Massachusetts.
Measuring Diet and Physical Activity - with Cell Phones, Digital Imaging, and Wearable Monitors (NIH Only)
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- Evaluating Positions and Negotiating Job Offers
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- - Sponsored by the NIH Office of Intramural Training & Education (2010/11/18)
- - Category : Career Development/OITE
- You？？？ve got the job offer! Now what do you do? In this workshop, learn what you should consider when beginning negotiations. Also, learn the types of package details you can negotiate from a Dean？？？s perspective.
Topics include:- Should you pursue this offer?
- What to look for when evaluating offers?
- Potential issues for discussion/negotiation, and
- Verbal/written offers.
Evaluating Positions and Negotiating Job Offers
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- Science in the Public Health - Bacteria: Cant live withem, cant live withoutem (HHS Only)
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- - Mike Small, Sally Amero, Cindy Davis, Sue Garges, Chris Ketchum, Vishnu Purohit, Arnold Revzin (2010/11/18)
- - Category : STEP (HHS Only)
- Science in the Public Health
Did you know that your body has 10 times more microbial cells than human cells? While bacteria have historically been associated with illness and disease, they are also integral to your health. The microbial ecosystem in the human body is not fixed but can be influenced by diet, obesity, and other factors, such as antibiotic use or abuse. Current research seeks to characterize our resident bacteria. This forum will present an overview of the fascinating roles of bacteria in human health.
This training is recommended for ESA Credit.
STEP subcommittee for this event:
Chair: Mike Small
Members: Sally Amero, Cindy Davis, Sue Garges, Chris Ketchum, Vishnu Purohit, Arnold Revzin
For more information, visit
http://odoerdb2-1.od.nih.gov/oer/training/step/step_training_20080417.htm
Science in the Public Health - Bacteria: Cant live withem, cant live withoutem (HHS Only)
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- Reconstructing the Circuits of Disease: From Molecular States to Physiological States
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- - Schadt, Eric.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Systems Biology
- - Schadt, Eric.
- Systems Biology Speaker Series
Common human diseases and drug response are complex traits that involve entire networks of changes at the molecular level driven by genetic and environmental perturbations. Efforts to elucidate disease and drug response traits have focused on single dimensions of the system. Studies focused on identifying changes in DNA that correlate with changes in disease or drug response traits, changes in gene expression that correlate with disease or drug response traits, or changes in other molecular traits (e.g., metabolite, methylation status, protein phosphorylation status, and so on) that correlate with disease or drug response are fairly routine and have met with great success in many cases. However, to further our understanding of the complex network of molecular and cellular changes that impact disease risk, disease progression, severity, and drug response, these multiple dimensions must be considered together. Here I present an approach for integrating a diversity of molecular and clinical trait data to uncover models that predict complex system behavior. By integrating diverse types of data on a large scale I demonstrate that some forms of common human diseases are most likely the result of perturbations to specific gene networks that in turn causes changes in the states of other gene networks both within and between tissues that drive biological processes associated with disease. These models elucidate not only primary drivers of disease and drug response, but they provide a context within which to interpret biological function, beyond what could be achieved by looking at one dimension alone. That some forms of common human diseases are the result of complex interactions among networks has significant implications for drug discovery: designing drugs or drug combinations to impact entire network states rather than designing drugs that target specific disease associated genes.
http://www.nih.gov/sigs/sysbio
Reconstructing the Circuits of Disease: From Molecular States to Physiological States
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- Demystifying Medicine - Bacterial Sepsis: A New Epidemic and an Old Receptor
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- - Palmore, Tara N.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Demystifying Medicine
- - Palmore, Tara N.
- The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.
For more information, visit
http://www1.od.nih.gov/oir/DemystifyingMed
Demystifying Medicine - Bacterial Sepsis: A New Epidemic and an Old Receptor
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- Postbac Lecture Series: The Big Picture
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- - Gottesman, Michael M.
National Institutes of Health (U.S.). Office of Intramural Training & Education. (2010/11/18) - - Category : Career Development/OITE
- - Gottesman, Michael M.
- Where is biomedical research heading in the 21st century?
Presented by Michael M. Gottesman, MD, Deputy Director for Intramural Research
Postbac Lecture Series: The Big Picture
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- Medicaid Early & Periodic Screening, Diagnostic, and Treatment (EPSDT) Services
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- - Rodger Goodacre (2010/11/18)
- - Category : CMS - Centers for Medicare & Medicaid Services
- CMS Medicine Dish Series
A panel of CMS experts will discuss:- What services are required under the EPSDT program,
- Who is eligible for services,
- How providers can get reimbursed for services, and
- What are the requirements for States to inform EPSDT-eligible individuals about available services.
Materials related to this broadcast will be posted on the CMS AI/AN website at http://www.cms.hhs.gov/AIAN/MedicineDishBroadcasts.asp.
E-mail Comments to: medicinedish@cms.hhs.gov
Medicaid Early & Periodic Screening, Diagnostic, and Treatment (EPSDT) Services
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- The Use of Curcumin and Flaxseed in Radiation Pneumonopathy
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- - Christofidou-Solomidou, Melpo.
National Center for Complementary and Alternative Medicine (U.S.) (2010/11/18) - - Category : OCCAM Monthly Lecture Series
- - Christofidou-Solomidou, Melpo.
- The NCIs Office of Cancer Complementary and Alternative Medicine (OCCAM) invites you to view its monthly lecture series.
With the goal of informing the National Cancer Institute (NCI) community about the variety of ongoing research in cancer and complementary and alternative medicine (CAM), NCIs Office of Cancer Complementary and Alternative Medicine (OCCAM) has created a monthly lecture series on cancer CAM. These hour long lectures, occurring from 10 a.m. - 11 a.m. on the second Wednesday of each month, will feature a fifty minute presentation on a cancer CAM topic and allow ten minutes for questions.
For more information, visit
http://www.cancer.gov/cam/news/monthly-lecture-series.html
The Use of Curcumin and Flaxseed in Radiation Pneumonopathy
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- Research, Condition, and Disease Categorization (RCDC), NIH RePORTing, and You Open House Meeting
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- - National Institutes of Health (U.S.). Division of Program Coordination, Planning, and Strategic Initiatives. (2010/11/18)
- - Category : Special
- During the 90-minute session, NIH staff will present the new Research Portfolio Online Reporting Tool (RePORT), demonstrate RCDC, and respond to audience questions. These new tools provide access to reports, data, and analyses of NIH research activities, including information on NIH expenditures and the results of NIH-supported research.
Research, Condition, and Disease Categorization (RCDC), NIH RePORTing, and You Open House Meeting
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- Unraveling the Mechanisms & Functions of Arginine Metabolism in Immune Responses
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- - Murray, Peter J.
National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18) - - Category : Immunology
- - Murray, Peter J.
- The innate immune response has two major functions: the early recognition and response to pathogen invaders of all varieties and the subsequent and ongoing optimization of the adaptive (T and B cell-mediated) immune response that is ultimately responsible for the elimination of pathogens and the development of memory. The innate immune response is subject to an extraordinarily complex series of regulatory events to maximize anti-pathogen responses but also to constrain the deleterious effects of innate immune response-driven inflammation. Dr. Murrays laboratory studies the regulatory events that control the innate immune response. Specifically, they focus on macrophage activation and deactivation because these cells are believed to be important drivers of inflammation in many infections and in a variety of chronic and acute inflammatory diseases. Dr. Murray is an engaging speaker has a new exciting story to tell. Dont miss this talk!
http://www.stjude.org/stjude/v/index.jsp?vgnextoid=a44c10e88ce70110VgnVCM1000001e0215acRCRD&vgnextchannel=7cc71436e3218010VgnVCM1000000e2015acRCRD
For more information, visit
The Immunology Interest Group
Unraveling the Mechanisms & Functions of Arginine Metabolism in Immune Responses
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- Great Teachers - Evidence-Based Medicine: A Story of Science, Policy, and Politics
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- - Ransohoff, David F.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Clinical Center Grand Rounds
- - Ransohoff, David F.
- Contemporary Clinical Medicine
Great Teachers
David F. Ransohoff, MD
Professor of Medicine and Clinical Professor of Epidemiology
Director, Clinical Research Curriculum
University of North Carolina School of Medicine
For more information, visit
http://www.cc.nih.gov/about/news/grcurrent.html
Great Teachers - Evidence-Based Medicine: A Story of Science, Policy, and Politics
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- Preparing for grant e-submission: a tutorial for postdocs
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- - Sponsored by the NIH Office of Intramural Training & Education (2010/11/18)
- - Category : Career Development/OITE
- NIH K99/R00 and other grants are now all being submitted electronically. Join us to see what intramural trainees need to know to make a successful submission.
Presented by Megan Cleland, NIH OER.
Preparing for grant e-submission: a tutorial for postdocs
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- Interventions for Healthy Aging and Longevity: Is There a Fountain of Youth?
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- - Cabo, Rafael de.
National Institutes of Health (U.S.) (2010/11/18) - - Category : NIH Directors Seminars
- - Cabo, Rafael de.
- 2008-2009 Directors Seminar Series
For more information, visit
http://www.nih.gov/about/director/dirsem.htm
Interventions for Healthy Aging and Longevity: Is There a Fountain of Youth?
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- Town Hall Meeting and Information Session: BTRIS, the NIH Biomedical Translational Research Information System
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- - Kamerick, Michael.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Special
- - Kamerick, Michael.
- The Biomedical Translational Research Information System (BTRIS) team invites you to a series of lectures focused on informatics in biomedical and translational research. This series brings leading 詮？gures in the study and use of translational information systems from academic centers across the U.S. and will promote discussion about the future of informatics at the Clinical Center.
Learn more about how BTRIS will be developed, opportunities for investigators to participate in its design, and project goals.
For more information, visit http://btris.nih.gov
Town Hall Meeting and Information Session: BTRIS, the NIH Biomedical Translational Research Information System
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- CC Grand Rounds: (1) Designing the Historical Atlas of 1918-1919 Influenza Pandemic in the US (2) Smallpox Vaccination at NIH: Unexpected Findings
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- - Markel, Howard.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Clinical Center Grand Rounds
- - Markel, Howard.
- Contemporary Clinical Medicine
Howard Markel, MD, PhD
The George E. Wantz Distinguished Professor and Director, Center for the History of Medicine, and Professor of Pediatrics and Communicable Diseases
The University of Michigan Medical School, Ann Arbor
Jeffrey Cohen, MD
Chief, Medical Virology Section and Senior Investigator, Laboratory of Clinical Infectious Diseases, NIAID
For more information, visit
http://www.cc.nih.gov/about/news/grcurrent.html
CC Grand Rounds: (1) Designing the Historical Atlas of 1918-1919 Influenza Pandemic in the US (2) Smallpox Vaccination at NIH: Unexpected Findings
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- Towards Imaging Biomarkers for Osteoarthritis: Surprises, Challenges, and Opportunities
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- - Gray, Martha.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Wednesday Afternoon Lectures
- - Gray, Martha.
- Many new therapeutic strategies have been and are being developed to correct, prevent, or slow the progression of osteoarthritis (OA). Our ability to evaluate the efficacy of these techniques, or to determine the situations for which they might provide the most benefit, critically depends on diagnostic measures that can serve as proxies or ？？？biomarkers？？？ for the present or predicted state of the cartilage. Accordingly, much research over the past decade has been devoted to the development of biomarkers for OA, including considerable efforts towards developing imaging biomarkers for OA.
Biomarker development requires two phases of validation. The first is technical validity: is the marker measuring what it aims to measure? The second it pathophysiologic validity: is the information provided by the marker of pathophysiological or clinical use? Many of the magnetic resonance imaging techniques that have been emerging over the past decades appear promising in that they have shown technical validity in measuring the morphologic and molecular state of cartilage, and with emerging clinical studies, efforts are beginning to offer evidence regarding pathophysiological validity. As a case study, this talk will focus on biomarkers for glycosaminoglycan (GAG). In addition to illustrating technical and pathophysiological validity, and some of the surprising insights that have come along the way, we will also explore the way in which such biomarkers might change the scientific and clinical paradigm for advancing our understanding, diagnosis and treatment of osteoarthritis.
Martha Gray recently stepped down after nearly 13 years as Director of Health Sciences and Technology (HST) Division of Harvard and the Massachusetts Institute of Technology (MIT). She holds the J.W. Kieckhefer Professorship and is a Professor in HST and in MIT？？？s Department of Electrical Engineering and Computer Science. With her appointment as the director of HST, Prof. Gray became the first woman to lead a science/engineering department at MIT.
HST is nearly a 40 year old collaboration between MIT and Harvard Medical School for research and education to solve major problems in medicine. HST does this by creating a community of engineers, scientists, physicians, and business leaders. This community is established through multi-disciplinary and multiprofessional environments ？？？ in the classrooms, hospital rooms, and laboratories. The students graduate with MD？？？s, PhD？？？s, S.M.s, MBA？？？s or some combination, and they come out unusually well prepared to lead and innovate.
As director, Prof. Gray shepherded the vigorous growth of HST, so that now it boasts over 400 students, 65 faculties, and nearly 200 affiliated faculties. She has established several major new research and educational programs. For example, she initiated, with colleagues at MIT？？？s Sloan School of Management, a Biomedical Enterprise Program to bring future business leaders into together with HST？？？s scientist？？？s engineers and physicians. In partnership with local teaching hospitals (Massachusetts General Hospital, Children？？？s Hospital, Boston and Brigham and Women？？？s Hospital), she championed the creation of the Martinos Center for Biomedical Imaging, and programs in Biomedical Informatics and Bio-micro-electrical systems (BioMEMs) each involving faculty and training students from Harvard and MIT. Most recently, under sponsorship from the Howard Hughes Medical Institute (HHMI) she has launched a new initiative to bring biomedical training to graduate students other departments at MIT and is working with the Government of India to establish the HST model in India.
Her research centers on ways to diagnose and treat cartilage degeneration (arthritis). Most recently, she and her group created a nondestructive magnetic resonance imaging (MRI) method for assessing cartilage, now being used by many in industry and academia to provide a window into how disease and therapeutic strategies affect cartilage tissue per se. It offers an alternative to radiography that is particularly valuable for early diagnosis and therapy. The significance of her accomplishments was recently recognized by the American Academy of Orthopedic Surgeons and Orthopedic Research Society？？？s, Kappa Delta Award.
Teaching and mentoring are high priorities. Prof. Gray has taught a wide variety of courses including Circuits and Systems, Quantitative Physiology, and Renal Pathophysiology. Prof. Gray and her colleagues also established a popular mentoring program called BioMatrix that invites undergraduates, graduate and medical students, and professionals together; bound by an interest in life sciences, these scientists, engineers, physicians and business people meet monthly over dinner, and in small groups, as desired, at other times.
Prof. Gray？？？s training includes a B.S. in Computer Sciences from Michigan State University, an M.S. in Electrical Engineering from MIT and a Ph.D. in Medical Engineering from HST. Following postdoctoral work at Tufts University and the State University of New York Stony Brook, she joined the MIT faculty in HST and MIT？？？s Department of Electrical Engineering and Computer Science in 1987.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Towards Imaging Biomarkers for Osteoarthritis: Surprises, Challenges, and Opportunities
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- Construction Safety: The Legal Perspective (NIH Only)
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- - Adele L. Abrams, Esq., CMSP (2010/11/18)
- - Category : NIH Only
- Under United States law, responsibility for construction site injuries falls upon several and, frequently many, participants in the construction process, including the injured partys employer, other contractors on the site, the site/project owner, equipment suppliers and distributors, public officials and design professionals. A site owner may have safety responsibilities based upon common law duties as a premises owner to disclose dangerous conditions to users of the premises, even though the contractor assumes a high degree of control, per above.
LEARNING OBJECTIVES:- Understand the current status of federal OSHAs Multi-Employer Policy and pending litigation
- Learn how to minimize risk through Review of Site Specific Safety Plans
- Comprehend the best approaches to contractor prequalification and contract language to reduce legal liability
- Review the basics concerning workers compensation insurance and IRS criteria for determining employee or contractor status
- Learn techniques to manage site safety without opening supervisors to tort exposure for negligent training or supervision
- Develop methods of controlling hazards that can put contractors at risk.
Construction Safety: The Legal Perspective (NIH Only)
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- Budgeting, Relationships & Life Events
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- - Sponsored by Life Work Strategies (2010/11/18)
- - Category : Work/Life Center
- NIH Work Life Seminar
Managing personal finances can be complicated and demanding, especially in todays economy. Different stages of life involve different financial necessities. Whether it is purchasing your first home, starting a family or merging separate households, funding college, changing careers or entering retirement, each stage of life brings different financial needs, opportunities and challenges. This informative seminar will identify ways to budget more effectively for today and provide tips for managing the road ahead financially.
This is a chance to start the New Year with a clean slate and create a fresh perspective for planning your financial goals. Learn how to set priorities for spending and saving money that will help you attain your fiscal milestones. Identify the biggest money zappers in your current spending routine and discover strategies to avoid overspending. Participants will receive a budget worksheet as a tool for categorizing and tracking expenses. It is never too late to change your financial future and this session can help you begin the journey.
For more information, visit
http://wlc.od.nih.gov
Budgeting, Relationships & Life Events
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- The 2nd Pediatric GIST Clinic Invitational Lecture - The IGF-1R antibody trial in patients with Pediatric and wildtype GIST
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- - Janeway, Katherine A.
Pediatric GIST clinic invitational lecture (2010/11/18) - - Category : Special
- - Janeway, Katherine A.
- The Pediatric and wildtype GIST clinic and conference at the National Institutes of Health
For more information, visit http://www.pediatricgist.cancer.gov
The 2nd Pediatric GIST Clinic Invitational Lecture - The IGF-1R antibody trial in patients with Pediatric and wildtype GIST