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  • Heart Health for Women: Using Old Knowledge, Generating New Knowledge
    • - Robertson, Rose Marie.
      National Institutes of Health (U.S.). Office of Research on Womens Health. (2010/11/18)
    • - Category : Womens Health
    Womens Health Special Interest Group (WHSIG) Intramural Program on Research on Womens Health Sponsored by the NIH Office of Intramural Research and the NIH Office of Research on Womens Health.

    Come join your fellow NIH colleagues in a scientific exchange on issues related to the biology and pathology of sex and gender differences and effects on womens health.

    For more information, visit
    http://orwh.od.nih.gov

    Heart Health for Women: Using Old Knowledge, Generating New Knowledge

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  • How hybrid mass spectrometers with multiple analyzers and dissociation methods will transform protein sequence analysis
    • - Joshua Coon (2010/11/18)
    • - Category : Proteomics
    We describe the use of new mass spectrometry technology ？？？ an ETD-enabled Orbitrap ？？？ to characterize and quantify proteomes. The new instrument allows for the implementation of multiple dissociation methods, /i.e./, ion trap CAD, beam-type CAD (HCD), and ETD, and for the automated selection of each in a real-time based on multiple precursor attributes (/i.e./, data-dependent decision tree). Protein quantification is readily accomplished through use of isotopic labels ？？？ either SILAC or iTRAQ. The instrument will likewise propel top-down proteomics as acquisition of ETD-MS/MS spectra in the high resolving power Orbitrap allows for direct analysis of intact proteins on a sub-second timescale with ~ 300 ppb mass accuracies. Such mass accuracies are used to directly annotate ETD tandem mass spectral peaks with ion type and chemical composition. We demonstrate these and many other aspects of the instrument on a variety of applications involving human ES cells, differentiating human ES cells, and induced-pluripotent cells.

    http://proteome.nih.gov

    How hybrid mass spectrometers with multiple analyzers and dissociation methods will transform protein sequence analysis

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  • Multiple Modes of Exocytosis and Endocytosis at a Central Synapse
    • - Wu, Ling-Gang.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : NIH Directors Seminars
    2008-2009 Directors Seminar Series

    For more information, visit
    http://www.nih.gov/about/director/dirsem.htm

    Multiple Modes of Exocytosis and Endocytosis at a Central Synapse

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  • Manipulating hematopoiesis for therapeutic application
    • - Simmons, Paul J.
      National Institutes of Health (U.S.). Stem Cell Interest Group. (2010/11/18)
    • - Category : Stem Cell
    The Stem Cell Interest Group was established to enhance communication and to foster collaboration among scientists from varying disciplines interested in stem cells. Topics of interest include fundamental stem cell biology, ontogeny, gerontology, and the therapeutic potential of stem cells. The SCIG serves as an open forum for discussion and dissemination of knowledge about all aspects of stem cell biology

    For more information, visit
    http://tango01.cit.nih.gov/sig/home.taf?_function=main&SIGInfo_SIGID=115

    Manipulating hematopoiesis for therapeutic application

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  • T cells That See Antigens Independently of MHC (NIH-Only)
    • - Alfred Singer, M.D. (2010/11/18)
    • - Category : NCI CCR Grand Rounds (NIH Only)
    Dr. Singer is Chief of the Experimental Immunology Branch, CCR, NCI. He received his B.S. from MIT and his M.D. from Columbia University and has been working in the field of T cell development for over 30 years. He is a highly original and creative scientist who has made many important contributions to our understanding of T cell immunology and T cell development in the thymus, including such original discoveries as the role of self antigens in thymic selection; thymic crosstalk (the regulation of thymic epithelial cell differentiation by thymocytes); coreceptor tuning (the adjustment of CD8 coreceptor expression levels on T cells to the self-specificity of their TCR), coreceptor reversal (the genetic basis for selection and generation of cytotoxic lineage T cells in the thymus); and the requirement for costimulation for clonal deletion in the thymus. His most recent work has solved two important problems in T cell immunology: how and why the thymus selects an exclusively MHC-restricted T cell receptor repertoire and how CD4/CD8 lineage choice is determined during thymocyte development.

    Dr. Singer has published over 215 papers and reviews and has served on editorial boards of many journals, including serving as Reviews Editor for Immunity and Advisory Editor for The Journal of Experimental Medicine. He has served on numerous Scientific Advisory Boards including advising the Mayo Clinic in Rochester, MN; the National Health Research Institute in Taiwan; the MRC Center for Immune Regulation in Birmingham, England; the Barbara Davis Center for Childhood Diabetes in Denver, CO; and he currently serves as Chairman of the Visiting Professor Advisory Committee for Chiba University in Chiba, Japan.

    Dr. Singer has trained over 40 postdoctoral fellows, many of whom are distinguished scientists and scientific leaders, and was awarded the NCI Outstanding Mentor Award in 2006.

    NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link:
    http://www.bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx

    T cells That See Antigens Independently of MHC (NIH-Only)

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  • NCCAM Distingushed Lecture - Chinese Medicine, Western Science, and Acupuncture
    • - Nuland, Sherwin B.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : NCCAM Lectures
    NCCAM will hold the inaugural lecture of the Stephen E. Straus Distinguished Lecture in the Science of Complementary and Alternative Medicine. Dr. Sherwin B. Nuland, clinical professor of surgery at Yale University and distinguished author, will present the first lecture ？？？Chinese Medicine, Western Science, and Acupuncture.？？？ During visits to China, Nuland observed major surgery done with no anesthesia, aided by acupuncture. In the Straus lecture, he will describe these operations and tell of his experience. In his recent book, The Uncertain Art, Nuland wrote ？？？the basis of acupuncture？？？s practical usefulness, even in the operating room, has still not been explained in terms acceptable to most orthodox Western scientists using orthodox Western investigative methods ... The effectiveness of correctly applied acupuncture is not our only evidence that there are undeniable phenomena that cannot ...be explained by the investigational methods of today？？？s biomedical science.？？？

    Sherwin B. Nuland, M.D. is clinical professor of surgery at the Yale School of Medicine and a member of the executive committee of Yales Interdisciplinary Center for Bioethics. He serves as research affiliate in the Program for the History of Science and Medicine and as a fellow of the Institution for Social and Policy Studies.

    Dr. Nuland is a graduate of the Bronx High School of Science and New York University. In 1955, he received his medical degree from Yale University and went on to complete his surgical training at the Yale-New Haven Medical Center. Dr. Nuland has treated more than 10,000 patients during his 30 years as a practicing surgeon. It was Dr. Nuland？？？s position as the chairman of the Yale-China Association medical committee that enabled him to make observations about the techniques and results of surgical acupuncture.

    A noted author, Dr. Nuland has written 11 books relating to medicine, including The New York Times bestseller and National Book Award winning How We Die, as well as The Uncertain Art: Thoughts on a Life in Medicine. He has also written for The New Yorker, The New York Times, The New Republic, Time, and the New York Review of Books. The Soul of Medicine, Dr. Nuland？？？s most recent contribution to the literary world, is set to be released April 2009.

    This is the first lecture in a series established in honor of Dr. Stephen E. Straus, founding director of the National Center for Complementary and Alternative Medicine (NCCAM) and an internationally recognized clinician-scientist, who died in 2007. The series brings leading figures in science and medicine to the NIH to speak about their perspective on the field of Complementary and Alternative Medicine (CAM). The lectures shed light on the evolution of CAM practice and research, and the current use of CAM by the public.

    NCCAM Distingushed Lecture - Chinese Medicine, Western Science, and Acupuncture

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  • Demystifying Medicine - Fibrous dysplasia of bone and stem cells
    • - Robey, Pamela Gehron.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : Demystifying Medicine
    The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.

    For more information, visit
    http://www1.od.nih.gov/oir/DemystifyingMed

    Demystifying Medicine - Fibrous dysplasia of bone and stem cells

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  • Peroxisome Proliferator-Activated Receptors (PPARs) As Molecular Targets For The Treatment And Prevention Of Diseases
    • - Jeffrey Peters (2010/11/18)
    • - Category : Wednesday Afternoon Lectures
    Dr. Jeffrey Peters completed his graduate training at the University of California at Davis followed by postdoctoral fellowships at the Institute of Toxicology and Environmental Health at UC Davis, and then in the Laboratory of Metabolism at the National Cancer Institute. Dr. Peters has performed seminal research concerning the biological role of the PPAR class of nuclear receptors.

    His more recent research has focused on elucidating functional roles of PPARb/d in disease. His research has had a profound impact on the risk assessment of a broad range of chemicals, helping to focus mechanistic research on the extrapolation of effects in animal models to humans. Additionally, his studies have provided clues to new molecular targets that may be suitable for the treatment and prevention of cancer.

    Dr. Peters is a charter member of the Chemo/Dietary Prevention study section, he has served on a number of national committees, and he is on a variety of editorial boards in addition to serving as an Associate Editor for Toxicological Sciences. He has received a number of awards including the 2007 Society of Toxicology Achievement Award and the Black Award for Excellence in Research at Penn State.

    The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    Peroxisome Proliferator-Activated Receptors (PPARs) As Molecular Targets For The Treatment And Prevention Of Diseases

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  • Effects of Exercise on the Chronic Cardiac Dysfunction Associated with Doxorubicin
    • - Hayward, Reid.
      National Cancer Institute (U.S.). Office of Cancer Complementary and Alternative Medicine. (2010/11/18)
    • - Category : OCCAM Monthly Lecture Series
    The NCIs Office of Cancer Complementary and Alternative Medicine (OCCAM) invites you to view its monthly lecture series.

    With the goal of informing the National Cancer Institute (NCI) community about the variety of ongoing research in cancer and complementary and alternative medicine (CAM), NCIs Office of Cancer Complementary and Alternative Medicine (OCCAM) has created a monthly lecture series on cancer CAM. These hour long lectures, occurring from 10 a.m. - 11 a.m. on the second Wednesday of each month, will feature a fifty minute presentation on a cancer CAM topic and allow ten minutes for questions.

    For more information, visit
    http://www.cancer.gov/cam/news/monthly-lecture-series.html

    Effects of Exercise on the Chronic Cardiac Dysfunction Associated with Doxorubicin

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  • Induction & Regulation of Th17-dependent Airway Hyperresponsiveness
    • - Cook, Donald.
      National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18)
    • - Category : Immunology
    One of NIHs own, Don Cook has made truly pioneering contributions to immunology, including the first chemokine knockout mouse (CCL3), which he used to show for the first time that chemokines regulate viral immunopathogenesis (both Coxsacckie virus myocarditis and influenza virus pneumonia); and the CCR6 knockout mouse, which he used to provide the first evidence that chemokines are critically involved in mucosal immunology. His current work is focused on the molecular and cellular mechanisms underlying allergic sensitization and immunotolerance to inhaled antigens, with the ultimate goal of improving therapies for patients. These studies include the analysis of dendritic cell subsets in the lung, toll-like receptors, cytokines, chemoattractants, and analysis of the impact of route of sensitization and adjuvant on allergic sensitization. Don does important work and is an engaging speaker. His IIG seminar is one you will NOT want to miss.

    http://www.niehs.nih.gov/research/atniehs/labs/lrb/immuno-gen/index.cfm

    For more information, visit
    The Immunology Interest Group

    Induction & Regulation of Th17-dependent Airway Hyperresponsiveness

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  • Medicare Preventive Services - Part 2
    • - Marx, Kitty.
      Centers for Medicare & Medicaid Services (U.S.) (2010/11/18)
    • - Category : CMS - Centers for Medicare & Medicaid Services
    CMS Medicine Dish Series

    CMS presenters will provide an overview of Medicare Preventive Services including the specific services covered, documentation required, and costs to beneficiaries. Benefit changes effective January 1, 2009 will be highlighted.

    Presenters:
    • Kitty Marx, Host, Tribal Affairs Director, OEA CMS
    • Valerie Haugen, Center for Medicare Management, CMS
    • David Nolley, Office of External Affairs, CMS
    Materials related to this broadcast will be posted on the CMS AI/AN website at http://www.cms.hhs.gov/AIAN/MedicineDishBroadcasts.asp.

    E-mail Comments to: medicinedish@cms.hhs.gov

    Medicare Preventive Services - Part 2

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  • Great Teachers - Prevention of Transmission of HIV-1: Clues from the Early 21st Century
    • - Cohen, Myron S.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : Clinical Center Grand Rounds
    Contemporary Clinical Medicine: Great Teachers

    Myron S. Cohen, MD
    Associate Vice Chancellor for Global Health
    J. Herbert Bate Distinguished Professor
    Medicine, Microbiology and Immunology, and Public Health
    Director, UNC Institute for Global Health and Infectious Diseases
    Chief, Division of Clinical Infectious Disease
    University of North Carolina at Chapel Hill School of Medicine

    For more information, visit
    http://www.cc.nih.gov/about/news/grcurrent.html

    Great Teachers - Prevention of Transmission of HIV-1: Clues from the Early 21st Century

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  • NIH 2009 Womens History Month Observance
    • - Dr. Sharon Hrynkow, Associate Director, NIEHS (2010/11/18)
    • - Category : Special
    The 2009 National Women？？？s History Month Program theme is ？？？Women Taking the Lead to Save the Planet？？？, honoring women who have taken the lead in the environmental or ？？？green？？？ movement. This year？？？s theme provides a special opportunity to recognize women？？？s leadership in protecting the environment through research and activities designed to reverse ecological destruction.

    In honor of recognizing Women who protect the environment, the OEODM, NIH along with the Federal Women？？？s Program Network Committee, FWPN presents ？？？What Can Going Green Do for You？？？

    NIH 2009 Womens History Month Observance

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  • NCI and NIH Mitochondria Interest Group Seminar: Johns Hopkins Pedersen Addresses Role of Mitochondria in Cancer
    • - Sponsored by the NCI and NIH (2010/11/18)
    • - Category : Special
    The National Cancer Institute along with the National Institutes of Healths Mitochondria Interest Group invites you to attend an upcoming seminar featuring Dr. Peter Pedersen, Professor of Biological Chemistry at Johns Hopkins University School of Medicine.

    Mitochondrial defects have long been suspected to play an important role in the development and progression of cancer. More than 70 years ago, Warburg pioneered the research on mitochondrial respiration alterations in the context of cancer and proposed a mechanism to explain how they evolve during the carcinogenic process. Dr. Pedersens laboratory investigates the relationship of cell energetics to molecular medicine and cancer. Both mitochondrial and glycolytic processes are being studied at the tissue, cell, and molecular level. The relationships of these processes to cancer also are being studied with the objective of discovering and developing new therapies.

    Dr. Pedersens seminar will explore novel opportunities on further understanding the pathogenesis and improving the treatment of cancer as it specifically relates to the mitochondria.

    NCI and NIH Mitochondria Interest Group Seminar: Johns Hopkins Pedersen Addresses Role of Mitochondria in Cancer

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  • Imaging Circuit Assembly in the Developing Retina
    • - Rachel Wong, Ph.D., Department of Biological Structure, University of Washington (2010/11/18)
    • - Category : Neuroscience
    Dr. Wong studies the development of neural circuits. Her lab applies a multidisciplinary approach to investigate how retinal circuits in zebra fish and mice are assembled appropriately during development. She uses in vivo and in vitro imaging approaches to determine how the unique axonal and dendritic morphologies of all classes of retinal neurons are established during development. She uses transgenic animals lacking specific forms of neurotransmission to examine the role of cell-cell interactions in specifying neuronal structure and connectivity. She also combines imaging methods with electrophysiology approaches to determine how functional circuits are established, and to relate structural changes to neuronal processing.

    Selected Publications:

    Huckfeldt RM, Schubert T, Morgan JL, Godinho L, Di Cristo G, Huang ZJ, Wong RO.
    Transient neurites of retinal horizontal cells exhibit columnar tiling via homotypic interactions.
    Nat Neurosci. 2009 Jan; 12(1):35-43.

    Kerschensteiner D, Wong RO.
    A precisely timed asynchronous pattern of ON and OFF retinal ganglion cell activity during propagation of retinal waves.
    Neuron. 2008 Jun 26; 58(6):851-8.

    Kerschensteiner D, Liu H, Cheng CW, Demas J, Cheng SH, Hui CC, Chow RL, Wong RO.
    Genetic control of circuit function: Vsx1 and Irx5 transcription factors regulate contrast adaptation in the mouse retina.
    J Neurosci. 2008 Mar 5;28(10):2342-52.

    Godinho L, Williams PR, Claassen Y, Provost E, Leach SD, Kamermans M, Wong RO.
    Nonapical symmetric divisions underlie horizontal cell layer formation in the developing retina in vivo.
    Neuron. 2007 Nov 21; 56(4):597-603.

    Mumm JS, Williams PR, Godinho L, Koerber A, Pittman AJ, Roeser T, Chien CB, Baier H, Wong RO.
    In vivo imaging reveals dendritic targeting of laminated afferents by zebrafish retinal ganglion cells.
    Neuron. 2006 Nov 22;52(4):609-21.

    Demas J, Sagdullaev BT, Green E, Jaubert-Miazza L, McCall MA, Gregg RG, Wong RO, Guido W.
    Failure to maintain eye-specific segregation in nob, a mutant with abnormally patterned retinal activity.
    Neuron. 2006 Apr 20;50(2):247-59.

    Morgan JL, Dhingra A, Vardi N, Wong RO.
    Axons and dendrites originate from neuroepithelial-like processes of retinal bipolar cells.
    Nat Neurosci. 2006 Jan;9(1):85-92.

    NIH Neuroscience Seminar Series

    Imaging Circuit Assembly in the Developing Retina

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  • NVAC Vaccine Safety Working Group Stakeholder Meeting
    • - The U.S. Department of Health and Human Services (2010/11/18)
    • - Category : National Vaccine Advisory Committee
    This Stakeholder Meeting will summarize the Working Groups progress to date. Stakeholders will be asked to comment on (1) the content of the draft research agenda, and (2) prioritization criteria for the draft research agenda.
    This meeting builds on earlier consultations with the public that included community dialogues, public comments and a public meeting. For details of each of these consultations, please see the Vaccine Safety Working Group and Public Engagement pages.

    NVAC Vaccine Safety Working Group Stakeholder Meeting

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  • Publishing in Journals
    • - Sponsored by the NIH Office of Intramural Training & Education (2010/11/18)
    • - Category : Special
    Objective: to provide fellows with information on publishing their science.

    Presented by Katrina L. Kelner, PhD. Editor, Translational Medicine, Managing Editor, Research Journals, Science Magazine

    Publishing in Journals

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  • UT-Heart: Whole Organ Simulations Elucidate Healthy Heart Function and Help Understand Disease Conditions
    • - Sugiura, Seiryo.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : Systems Biology
    Systems Biology Speaker Series

    To promote our understanding of the normal and abnormal function of the heart by integrating our knowledge collected at the molecular and the cellular levels, we have developed a multi-scale and multi-physics computer simulation of the heart. This simulator is based on the finite element method and consists of approximately 0.6 million elements for mechanical computation and 20 million elements for electrophysiology and incorporates mathematical models of cardiac excitation-contraction processes in each element. Its morphology is based on multi-detector CT data and has both ventricles and atria with aortic arch. In our model, fiber orientation was mapped and the conduction system was modeled with characteristic electrophysiology. Upon stimulation applied to the pacemaker site, excitation propagates to the adjacent elements resulting in the synchronous contraction and relaxation of the heart. In addition, because the fluid part representing the blood was also modeled and solved simultaneously with the structural part we can reproduce the blood flow in the atria, ventricles and aorta. Such features of the simulator enable us to extract various data and present them as we do in the clinical laboratories. These data includes ECG, UCG, Doppler ECG, Magneto-cardiogram etc. In the presentation, we will show some preliminary data generated with a diseased heart model. http://www.sml.k.u-tokyo.ac.jp/en/report/report01a.html

    http://www.nih.gov/sigs/sysbio

    UT-Heart: Whole Organ Simulations Elucidate Healthy Heart Function and Help Understand Disease Conditions

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  • Google for Researchers
    • - Galen Panger (2010/11/18)
    • - Category : Special
    Google comes to NIH!

    Learn Googles advanced searching techniques for researchers. This event is hosted by Galen Panger from Google. Galen Panger leads the Google for Non-Profits team in the companys Washington, D.C. office, helping non-profits (and librarians!) put Googles free tools and technologies to work for their causes. Prior to joining Google, Galen interned with the World Banks sustainable development unit in West Africa. He graduated from Stanford University with a bachelors in Public Policy in 2007.

    Some of the topics to be covered:
    • Anatomy of a Google search
    • Advanced Google search tips and tools
    • U.S. Government Search
    • Scholar
    • Book Search
    • Blog Search
    • News and News Archives
    • Alerts
    • Reader
    • Trends
    • Docs, Spreadsheets, Charts, Sites and Forms
    • Maps
    • Google Earth
    • Mobile
    • Google for Non-Profits
    • Going social
    Presented by the NIH Library and the DC/Special Libraries Association. This program is part of the NIH Library？？？s Resource Training Program on new and existing research tools.

    Google for Researchers

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  • A Curative Intent: Evaluating Strategies to Eradicate HIV-1 Infection (NIH-Only)
    • - Frank Maldarelli, M.D., Ph.D., Center for Cancer Research, NCI, NIH (2010/11/18)
    • - Category : NCI CCR Grand Rounds (NIH Only)
    Dr. Frank Maldarelli received his Ph.D. from the City University of New York and his M.D. from Mount Sinai School of Medicine. After completing his residency in internal medicine at The Columbia-Presbyterian Hospital, New York, he joined the Laboratory of Molecular Microbiology at the National Institute of Allergy and Infectious Diseases (NIAID) as a Medical Staff Fellow with Malcolm A. Martin and Klaus Strebel. Dr. Maldarelli joined the National Cancer Institute (NCI) in 1998 as Head of the In Vivo Biology Group in the HIV Drug Resistance Program (DRP). Representing the clinical research arm of the DRP, he has extensive collaborations between the DRP in Frederick and both the NCI HIV and AIDS Malignancy Branch and the NIAID AIDS clinical research program in Bethesda.

    Dr. Maldarelli is an Attending Physician in the NIAID/CCMD HIV service, and is currently a faculty member of the International Society of Infectious Diseases HIV Training Program, NIH Infectious Disease Consult Service, and Center for Bio-Medical Communications Infectious Disease Board Review Course, and a lecturer in the Washington D.C. community outreach PACT Program. With colleagues in the In Vivo Biology Group he is engaged in research on four clinical studies projects seeking to elucidate mechanisms underlying the emergence of HIV resistance in vivo, the dynamics of infection under treatment, and the role of resistance mutations in the efficacy and failure of subsequent treatments.

    NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link:
    http://www.bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx

    A Curative Intent: Evaluating Strategies to Eradicate HIV-1 Infection (NIH-Only)

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