전체 8345
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- 2008 Department-Wide A-123 Kick-Off Training
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- - Office of the Assistant Secretary for Resources and Technology Office of Finance (2010/11/18)
- - Category : Special
- 내용 없음
2008 Department-Wide A-123 Kick-Off Training
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- Demystifying Medicine - Intestinal bacterial infections and the food chain
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- - Savarino, Stephen.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Demystifying Medicine
- - Savarino, Stephen.
- The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.
For more information, visit
http://www1.od.nih.gov/oir/DemystifyingMed
Demystifying Medicine - Intestinal bacterial infections and the food chain
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- eRA Commons: Do You See What the PI Sees? (HHS-Only)
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- - Sponsored by the GMAC Subcommittee on Training (2010/11/18)
- - Category : ERA (HHS Only)
- Have you ever had a call from a frantic or confused PI? Is he or she trying to get into the ERA Commons and is lost? What do the PI and Signing Official see in the Commons? How is it different from IMPACII?
This seminar will inform you on the function of the ERA Commons, how the system is accessed, when it is used, who can use it, how to navigate it. This seminar will be helpful for anyone who deals with grantees that use the Commons, especially new grantees and business offices. Come and see what they see!
Speaker:
Scarlett K. Gibb
Lead, Customer Relationship Manager
eRA External Services Team
Office of Research Information Systems (ORIS), NIH
Seminar Presentation Document:
eRA Commons: What does the PI and SO See?
http://odoerdb2.od.nih.gov/gmac/gmac/trs_main.html
eRA Commons: Do You See What the PI Sees? (HHS-Only)
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- The NIH Biowulf Cluster: 10 Years of Scientific Supercomputing
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- - CIT (National Institutes of Health) (2010/11/18)
- - Category : Conferences
- The NIH Biowulf cluster is a unique parallel processing system that has accelerated NIH intramural research in such fields as statistics, molecular dynamics, structural modeling, bioinformatics, genomics and imaging since its inception in 1999. In the last decade, the NIH Biowulf cluster has grown from 80 processors to 6300+ processors, making it one of the largest general-purpose biomedical computing clusters in the world.
For details and program, go to http://biowulf.nih.gov/symposium
The NIH Biowulf Cluster: 10 Years of Scientific Supercomputing
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- National Cancer Advisory Board - February 2009 (Day 1)
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- - United States. National Cancer Advisory Board. Meeting (2010/11/18)
- - Category : National Cancer Advisory Board
- This is a regularly scheduled meeting of the National Cancer Advisory Board (NCAB).
National Cancer Advisory Board - February 2009 (Day 1)
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- Anti-tumor effects of BZL 101 for patients with advanced breast cancer
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- - Drs. Mary Tagliaferri and Emma Shtivelman, Bionovo Inc., California (2010/11/18)
- - Category : OCCAM Monthly Lecture Series
- The NCIs Office of Cancer Complementary and Alternative Medicine (OCCAM) invites you to view its monthly lecture series.
With the goal of informing the National Cancer Institute (NCI) community about the variety of ongoing research in cancer and complementary and alternative medicine (CAM), NCIs Office of Cancer Complementary and Alternative Medicine (OCCAM) has created a monthly lecture series on cancer CAM. These hour long lectures, occurring from 10 a.m. - 11 a.m. on the second Wednesday of each month, will feature a fifty minute presentation on a cancer CAM topic and allow ten minutes for questions.
For more information, visit
http://www.cancer.gov/cam/news/monthly-lecture-series.html
Anti-tumor effects of BZL 101 for patients with advanced breast cancer
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- Role of Stearoyl-CoA Desaturase-1 in Metabolism: Implication in Human Diseases
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- - Ntambi, James M.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Wednesday Afternoon Lectures
- - Ntambi, James M.
- The rapid adaptation to a modernized lifestyle, characterized by reduced physical activity and increased consumption of processed foods rich in carbohydrate and fat, has resulted in a dramatic rise in the incidence of adult and child obesity in many nations of the World. Obesity increases the risk for numerous conditions that shorten life, including diabetes, coronary artery disease, hypertension, inflammation and fatty liver disease and other symptoms of the metabolic syndrome. The precise etiology of the numerous obesity-related risk factors is still unknown; however an increasing body of evidence indicates that genetics and environmental factors play a major role. Studies of the complex interactions among genes and nutrients are beginning to uncover the role of diets in human health and disease. Diets cause alterations in the expression of genes of lipid and carbohydrate metabolism. A critical regulator gene of energy metabolism is stearoyl-CoA desaturase 1 (SCD1), that encodes an enzyme (SCD) which catalyzes the synthesis of monounsaturated fatty acids mainly oleate. SCD1 expression is elevated in human and rodent obese and insulin resistant states, suggesting that excess oleate synthesis may contribute to the development of these disease states. Animal models with a global deficiency in SCD-1 exhibit a decrease in cellular oleate levels, a decrease in de novo hepatic lipogenesis and are protected from genetic and high-fat-induced obesity, insulin resistance, liver steatosis and other symptoms of the metabolic syndrome. However, in these mice Scd1 is deleted from all tissues presenting a complex phenotype due to metabolic changes occurring in many organs. Therefore, the tissue-specific contribution of SCD1 expression to metabolic outcomes remains to be explored. NIH supports this work.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Role of Stearoyl-CoA Desaturase-1 in Metabolism: Implication in Human Diseases
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- NVAC Vaccine Safety Working Group Meeting
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- - National Vaccine Advisory Committee (National Vaccine Program) (2010/11/18)
- - Category : National Vaccine Advisory Committee
- On February 4, 2008, the NVAC Vaccine Safety Working Group will hold a half-day public meeting in Washington, DC from 8:00am to 12:30pm EST to discuss the outcomes of the three public engagement sessions (Birmingham, Alabama; Ashland, Oregon; and Indianapolis, Indiana) and written comments received by HHS is response to our Request for Information.
For more information, visit http://www.hhs.gov/nvpo/nvac/vaccinesafety.html
NVAC Vaccine Safety Working Group Meeting
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- National Cancer Advisory Board - February 2009 (Day 2)
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- - United States. National Cancer Advisory Board. Meeting (2010/11/18)
- - Category : National Cancer Advisory Board
- This is a regularly scheduled meeting of the National Cancer Advisory Board (NCAB).
National Cancer Advisory Board - February 2009 (Day 2)
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- Mechanism(s) of Action of Regulartory T Cells In Vivo
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- - Davidson, Todd S.
National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18) - - Category : Immunology
- - Davidson, Todd S.
- For more information, visit
The Immunology Interest Group
Mechanism(s) of Action of Regulartory T Cells In Vivo
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- Ethics Rounds - Are Risks to Family Members Grounds for Exclusion?
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- - Magnus, David.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Clinical Center Grand Rounds
- - Magnus, David.
- CC Grand Rounds
David Magnus, PhD
Director, Stanford Center for Biomedical Ethics
Associate Professor of Pediatrics
Stanford University
For more information, visit
http://www.cc.nih.gov/about/news/grcurrent.html
Ethics Rounds - Are Risks to Family Members Grounds for Exclusion?
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- Shotgun Proteomics for Analysis of Cancer？？？Relevant Tissue Proteotypes
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- - Liebler, Daniel C. (2010/11/18)
- - Category : Proteomics
- Shotgun proteomics using liquid chromatography？？？tandem mass spectrometry (LC？？？MS/MS) provides the most powerful analytical platform for global inventory of complex proteomes. Nevertheless, sampling of complex proteomes by current shotgun proteomics platforms is incomplete and this contributes to variability in assessment of peptide and protein inventories by spectral counting approaches. These features of shogun proteomics data pose challenges in comparing proteomes from different biological states. We have implemented a standardized shotgun proteomics analytical platform based on isoelectric focusing of peptide mixtures, followed by reverse phase LC？？？MS/MS on Thermo LTQ and LTQ？？？Orbitrap instruments. Here we describe the development of a statistical approach for comparison of spectral count data from shotgun proteomic datasets and we apply this method to compare proteomes cancer？？？relevant tissue specimens and cell lines. These comparisons yield proteotypes, which comprise distinguishing proteomic characteristics of phenotypes. To this end, we have developed statistical and visualization strategies that reveal the biological differences between tissue specimens. We have compared proteomes of normal colon tissue, colon adenomas and adenocarcinomas, as well as proteomes from a collection of colon cancer cell lines that differ in expression of DNA mismatch repair genes. We demonstrate that these shotgun proteomic datasets are sufficiently rich in quantitative information that they can be analyzed for statistically significant differences and that these global comparisons of proteomes yield meaningful biological information. We also have compared shotgun proteomic analyses of frozen and formalin？？？fixed, paraffin？？？embedded (FFPE) specimens prepared from the same colon adenoma tissues. The major difference between frozen and FFPE proteomes was a decrease in the proportions of lysine C？？？terminal to arginine C？？？terminal peptides observed, but these differences had little effect on the proteins identified. No covalent peptide modifications attributable to formaldehyde chemistry were detected by analyses of the MS/MS datasets, which suggests that undetected, crosslinked peptides comprise the major class of modifications in FFPE tissues. Fixation of tissue for up to two days in neutral buffered formalin did not adversely impact protein identifications. Analysis of archival colon adenoma FFPE specimens indicated equivalent numbers of MS/MS spectral counts and protein group identifications from specimens stored for 1, 3, 5 and 10 years. Analysis of the combined frozen and FFPE data showed a 92% overlap in the protein groups identified. Comparison of gene ontology categories of identified proteins revealed no bias in protein identification based on subcellular localization. These data demonstrate the equivalence of proteome inventories obtained from FFPE and frozen tissue specimens and provide support for retrospective proteomic analysis of FFPE tissues for biomarker discovery.
http://proteome.nih.gov
Shotgun Proteomics for Analysis of Cancer？？？Relevant Tissue Proteotypes
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- How Attention Alters Sensory Signals in The Visual Cerebral Cortex of Monkeys
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- - Maunsell, John.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Neuroscience
- - Maunsell, John.
- Dr. Maunsells lab research is directed at understanding how neuronal signals in visual cerebral cortex generate perceptions and guide behavior. Their approach is to record from individual neurons in trained, behaving monkeys while they perform visual tasks. One line of Dr. Maunsells lab research is examining how paying attention to specific visual targets affects the way that they are represented in the brain, and how changes in the sensory representation caused by attention relate to changes in perception and behavior. Recent experiments have shown that attention increases the strength of neuronal responses without changing their selectivity, effectively representing the attended stimulus as if it were more intense than itreally is. Paired measurements of neuronal responses and behavioral performance have shown that much of the behavioral advantage conferred by attention may be explained by this change it causes in the sensory representation, rather than decision processes. Another line of research has been exploring the more general question of how the activity of given neurons contributes to specific visual behaviors. Measurements of the trial-to-trial correlation between the strength of a neurons responses to a weak stimulus and the animals performance detecting that stimulus have shown that different neurons contribute to a greater or lesser degree to particular behaviors depending on which stimuli they are most sensitive to. With these and other approaches Dr. Maunsell hope to provide a more complete understanding of how individual neurons contribute to specific visual perceptions and behaviors.
Selected Publications:
Yang, T., Maunsell, J.H.R. (2004) The effect of perceptual learning on neuronal responses in monkey visual area V4. Journal of Neuroscience 24:1617-1626.
Cook, E.P., Maunsell, J.H.R. (2004) Attentional modulation of motion integration of individual neurons in the middle temporal area (MT). Journal of Neuroscience 24:7964-7977.
Maunsell, J.H.R. (2004) Neuronal representations of cognitive state: reward or attention? Trends in Cognitive Science 8:261-265.
Williford, T., Maunsell, J.H.R. (2006) Effects of spatial attention on contrast response functions in macaque area V4. Journal of Neurophysiology 96:40-54.
Maunsell, J.H.R., Treue, S. (2006) Feature-based attention in visual cortex. Trends in Neuroscience 29:317-322.
For more information see our website - NIH Neuroscience Seminar Series
How Attention Alters Sensory Signals in The Visual Cerebral Cortex of Monkeys
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- Brain Evolution: Lessons from birds and humans who sing and talk
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- - Jarvis, Erich.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Evolution and Medicine
- - Jarvis, Erich.
- Whether you love listening to songbirds, enjoy singing, wonder how language evolved, or marvel at the organization of the brain, Erich Jarvis has scientific news for you. His cutting edge research on vocal learning in birds has revolutionized our understanding of vertebrate brain organization and evolution.
Dr. Erich Jarvis is an Associate Professor of Neurobiology at Duke University, a Howard Hughes Medical Institute Investigator, and the recipient of the prestigious NIH Pioneer Award.
Lecture series presented by National Institute of General Medical Sciences, the Office of Science Education, and the National Human Genome Research Institute. For more information, visit
http://www.nigms.nih.gov/News/Meetings/EvolutionSeries2009
Brain Evolution: Lessons from birds and humans who sing and talk
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- Stigma: Lessons & New Directions from a Decade of Research on Mental Illness
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- - Pescosolido, Bernice A.
National Institutes of Health (U.S.) (2010/11/18) - - Category : BSSR Lecture Series
- - Pescosolido, Bernice A.
- While the prejudice and discrimination associated with mental illness has long been a concern for researchers, providers and consumers, a two-pronged malaise characterized the research agenda in the 20 years from the 1970？？？s through the 1990？？？s. However, the mid-1990s witnessed a resurgence in both research and policy efforts devoted to mental illness stigma. In this presentation, the findings from a series of collaborative, multi-method studies targeting public stigma, media, and change efforts are described. Results from the first national study of stigma in over 40 years (1996), to the first study of public stigma toward children with mental health problems (2002), to the first theoretically and methodologically coordinated study across 15 countries (2003 ？？？ present) reveal both consistent and surprising findings about the public？？？s view of the underlying causes of mental illness, the social rejection associated with it and its treatment, and the widespread concern with dangerousness and coercion. In addition, the impact of current stigma reductions efforts and logics (i.e., the promise of neuroscientific/biomedical explanations and the most recent PSA campaign) are evaluated in the light of recent data. Together, these studies suggest a set of principles regarding stigma and offer direction on future efforts to improve the lives of persons with mental illness, those who care for them in the community, and the practitioners who develop and deliver services in the treatment sector.
Bernice A. Pescosolido is the Distinguished and Chancellor？？？s Professor of Sociology at Indiana University and Director of the Indiana Consortium for Mental Health Services Research. Professor Pescosolido received a B.A. from the University of Rhode Island in 1974 and a Ph.D. from Yale University in 1982. She has focused her research and teaching on social issues in health, illness, and healing.
Prof. Pescosolido？？？s research agenda addresses how social networks connect individuals to their communities and to institutional structures, providing the wires through which people？？？s attitudes and actions are influenced. This agenda encompasses three basic areas: health care services, stigma, and suicide research. In the early 1990s, Prof. Pescosolido developed the Network-Episode Model which was designed to focus on how individuals come to recognize, respond to the onset of health problems, and use health care services. Specifically, it has provided new insights to understanding the patterns and pathways to care, adherence to treatment and the outcomes of health care. As a result, she has served on advisory agenda-setting efforts at the NIMH, NCI, NHLBI, NIDRR, OBSSR and presented at congressional briefings.
In the area of stigma research, Prof. Pescosolido initiated the first major, national study of stigma of mental illness in the U.S. in over 40 years. Along with Bruce Link, she led a team of researchers that analyzed this data, producing groundwork for the Surgeon General？？？s Report on Mental Health. Currently, she and her colleagues developed a model on the underlying roots of stigma, designed to provide a scientific foundation for new efforts to alter this basic barrier to care. With funding from the Fogarty International Center, she is also leading a team of researchers in the first international study of stigma.
This lecture is an installment of the Behavioral and Social Sciences Research Lecture Series sponsored by the NIH Office of Behavioral and Social Sciences Research and organized by the NIH Behavioral and Social Sciences Research Coordinating Committee.
The Behavioral and Social Sciences Research Coordinating Committee (BSSR CC), with support from the Office of Behavioral and Social Sciences Research (OBSSR), convenes a series of guest lectures and symposia on selected topics in the behavioral and social sciences. These presentations by prominent behavioral and social scientists provide the NIH community with overviews of current research on topics of scientific and social interest. The lectures and symposia are approximately 50 minutes in length, with additional time for questions and discussion. All seminars are open to NIH staff and to the general public.
Stigma: Lessons & New Directions from a Decade of Research on Mental Illness
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- Hematologic Malignancies and their Precursors: New Insight in the Area of Progression (NIH-Only)
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- - Landgren, Ola.
National Institutes of Health (U.S.) (2010/11/18) - - Category : NCI CCR Grand Rounds (NIH Only)
- - Landgren, Ola.
- Dr. Landgren received his M.D. in 1995 from the Karolinska Institute (Stockholm, Sweden). Following clinical training as a hematology/internal medicine specialist physician and receipt of a Ph.D. focusing on diagnostics and prognostics in Hodgkin lymphoma (2002) at Karolinska Institute in Sweden, he worked as an attending physician and conducted clinical research on lymphoproliferative malignancies and related precursors. In 2004, he came to the National Cancer Institute, Genetic Epidemiology Branch, DCEG, where he worked as an Investigator before he joined the Medicial Oncology Branch. Dr. Landgrens major research interests are in the treatment, causation, diagnostics and prognostics, and natural history of multiple myeloma and its precursor condition, monoclonal gammopathy of undetermined significance (MGUS). He also studies related hematologic malignancies and their precursor states (including chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis (MBL); Waldenstroms macroglobulinemia and IgM MGUS), as well as myeloproliferative neoplasms. His research focuses on treatment-, host-, disease-, and immune-related factors in the pathway from precursor to full-blown malignancy, and their relation to outcome.
SELECTED REFERENCES:
1. Landgren O, Kyle RA. Multiple myeloma, chronic lymphocytic leukaemia and associated precursor diseases. British Journal of Haematol. 2007 Dec;139(5):717-23.
2. Landgren O, Kyle RA, Pfeiffer RM, Katzmann JA, Caporaso NE, Hayes, RB, Dispenzieri A, Kumar A, Clark RJ, Baris D, Hoover R, and Rajkumar SV. Monoclonal gammopathy of undetermined significance (MGUS) precedes multiple myeloma: a prospective study. Blood First Edition Paper, prepublished online January 29, 2009; DOI 10.1182/blood-2008-12-194241.
NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link:
http://www.bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx
Hematologic Malignancies and their Precursors: New Insight in the Area of Progression (NIH-Only)
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- Demystifying Medicine - Melanoma and the sun
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- - Hornyak, Thomas.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Demystifying Medicine
- - Hornyak, Thomas.
- The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.
For more information, visit
http://www1.od.nih.gov/oir/DemystifyingMed
Demystifying Medicine - Melanoma and the sun
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- Decision Making in T1 Translational Research (Day 1)
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- - National Center for Research Resources (U.S.) (2010/11/18)
- - Category : Conferences
- This workshop will identify common challenges encountered in T1 translational research, solutions to these problems and best practices for moving projects forward.
The conference will concentrate on:- 1) team science and pathways considerations;
- 2) incorporating advanced technologies and animal models into T1 research; and
- 3) young investigators？？？ needs in the context of problems, solutions and best practices.
For more information, visit http://guest.cvent.com/EVENTS/Info/Summary.aspx?e=6ab5489b-7070-4b24-8602-c0ad62c16a65
Decision Making in T1 Translational Research (Day 1)
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- Core Curriculum Part One - Funding Mechanisms (HHS Only)
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- - NIH (2010/11/18)
- - Category : Core Curriculum (HHS Only)
- 2009 Orientation to NIH Extramural Activities Core Curriculum
ESA Program
For more information, visit
http://odoerdb2-1.od.nih.gov/oer/training/esa/esa_cores_2009.htm
Core Curriculum Part One - Funding Mechanisms (HHS Only)
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- Role of NFkB in Activity of Benzyl Isothiocyanate Against Pancreatic Cancer
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- - Dr. Sanjay Srivastava, Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center (2010/11/18)
- - Category : OCCAM Monthly Lecture Series
- The NCIs Office of Cancer Complementary and Alternative Medicine (OCCAM) invites you to view its monthly lecture series.
With the goal of informing the National Cancer Institute (NCI) community about the variety of ongoing research in cancer and complementary and alternative medicine (CAM), NCIs Office of Cancer Complementary and Alternative Medicine (OCCAM) has created a monthly lecture series on cancer CAM. These hour long lectures, occurring from 10 a.m. - 11 a.m. on the second Wednesday of each month, will feature a fifty minute presentation on a cancer CAM topic and allow ten minutes for questions.
For more information, visit
http://www.cancer.gov/cam/news/monthly-lecture-series.html
Role of NFkB in Activity of Benzyl Isothiocyanate Against Pancreatic Cancer