전체 8345
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- Signal Transduction and T Cell Differentiation
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- - OShea, John J.
National Institutes of Health (U.S.). Immunology Interest Group (2010/11/18) - - Category : Immunology
- - OShea, John J.
- For more information, visit
The Immunology Interest Group
Signal Transduction and T Cell Differentiation
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- Great Teachers - The Art and Science of Hypertension Treatment
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- - Sica, Domenic A.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Clinical Center Grand Rounds
- - Sica, Domenic A.
- Contemporary Clinical Medicine
Great Teachers
Domenic A. Sica, MD
Professor of Internal Medicine, Division of Nephrology, and Professor of Pharmacology and Toxicology
Virginia Commonwealth University Medical Center
For more information, visit
http://www.cc.nih.gov/about/news/grcurrent.html
Great Teachers - The Art and Science of Hypertension Treatment
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- Social Determinants of Health: From Research to Action
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- - Marmot, M G.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Special
- - Marmot, M G.
- Health inequalities within and between countries are a significant feature of the global health scene. The Commission on Social Determinants of Health takes the view that health inequalities must be tackled by action on the underlying social determinants of health. Health inequalities that are avoidable or remediable are inequitable and addressing them is a matter of social justice. The potential economic and social returns on improving healthy equity are substantial.
The Commission on Social Determinants of Health was set up by the World Health Organisation to collate global evidence, raise societal debate and recommend policies with the goal of improving health and reducing health inequities between groups. A major thrust of the Commission is turning public health knowledge into political action.
The role of the research community is crucial: the need for more research is apparent, but there is enough evidence to take action, and action needs to be evaluated.
The Commission on Social Determinants of Health presented its final report and recommendations to the Director General of the World Health Organisation and it was published on 28th August 2008. This keynote lecture will lay out some of the Commission쨈s key findings in support of a whole systems approach to tackling health inequities.
Social Determinants of Health: From Research to Action
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- Emerging Balance between Reward Systems and Risk Taking in Adolescence: Implications for Developing Substance Abuse
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- - Mayes, Linda C.
National Institutes of Health (U.S.). Behavioral and Social Sciences Research Coordinating Committee. (2010/11/18) - - Category : BSSR Lecture Series
- - Mayes, Linda C.
- Adolescents, particularly those from high risk environments, are especially likely to engage in risky behaviors including drug use and abuse. Emotional regulation, stress responsiveness, reward sensitivity, impulse regulation, and decision-making are hypothesized to be involved in adolescent engagement in risky behaviors. Each of these capacities reflects the emerging maturation of subcortical to cortical neural circuitry involved in stress-reward systems and in the development of capacities for behavioral inhibition. During adolescence, the prefrontal cortex is relatively immature and undergoes refinement of neuronal connections. At the same time, dopaminergically regulated subcortical brain systems responsive to stress are more active in adolescence than at any other point in adulthood. Hence, in adolescence, increased dopamine input at times of increased stress may overly impair decision making and judgment in immature prefrontal circuits. This emerging balance between ？？？emotional regulation？？？ and ？？？inhibition-rational decision？？？ systems is delayed by factors such as early childhood stress or prenatal drug exposure. Thus, prenatally drug-exposed adolescents growing up in chronic adversity may be especially vulnerable to early addiction because of poor emotional regulatory mechanisms, which make them more sensitive to stress and have an attendant negative impact on inhibition, impulse control, and decision making. Understanding mechanisms for initiating drug use during a critical developmental period will allow more effective and targeted interventions for adolescents at risk for addiction.
This lecture is an installment of the Behavioral and Social Sciences Research Lecture Series sponsored by the NIH Office of Behavioral and Social Sciences Research and organized by the NIH Behavioral and Social Sciences Research Coordinating Committee.
The Behavioral and Social Sciences Research Coordinating Committee (BSSR CC), with support from the Office of Behavioral and Social Sciences Research (OBSSR), convenes a series of guest lectures and symposia on selected topics in the behavioral and social sciences. These presentations by prominent behavioral and social scientists provide the NIH community with overviews of current research on topics of scientific and social interest. The lectures and symposia are approximately 50 minutes in length, with additional time for questions and discussion. All seminars are open to NIH staff and to the general public.
Emerging Balance between Reward Systems and Risk Taking in Adolescence: Implications for Developing Substance Abuse
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- Translational Genomics in Neuroblastoma
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- - Khan, Javed.
National Institutes of Health (U.S.) (2010/11/18) - - Category : NIH Directors Seminars
- - Khan, Javed.
- 2008-2009 Directors Seminar Series
For more information, visit
http://www.nih.gov/about/director/dirsem.htm
Translational Genomics in Neuroblastoma
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- A Role for Nitric Oxide in Olfactory Information Processing in the Mouse
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- - Gelperin, Alan.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Neuroscience
- - Gelperin, Alan.
- Nitric oxide is an important interneuronal signaling molecule that appears prominently in the olfactory systems of many species. Its synthetic enzyme neuronal nitric oxide synthase is concentrated within particular interneurons of the olfactory bulb, as are enzymes activated by nitric oxide that alter neuronal excitability. Using innovative new techniques, Dr. Gelperin？？？s laboratory explores many aspects of information processing by the olfactory system, including roles of nitric oxide.
Dr. Gelperin received his B.A. from Carleton College, his Ph.D. from the University of Pennsylvania, and trained as a postdoc with Kenneth Roeder at Tufts University. He joined the faculty of the Biology Department at Princeton University as an assistant professor, and a few years later became Chairman of its Program in Neuroscience. Dr. Gelperin spent several very productive years as a member of the Biological Computation Research Department at Bell Labs. The recipient of numerous awards, Dr. Gelperin is presently a member of the Monell Chemical Senses Center, and an Adjunct Professor in the Neuroscience Department at the University of Pennsylvania.
NIH Neuroscience Seminar Series
A Role for Nitric Oxide in Olfactory Information Processing in the Mouse
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- TRACO: Cancer Stem Cells and Case Reports
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- - Vonderhaar, Barbara K.
National Institutes of Health (U.S.) (2010/11/18) - - Category : TRACO
- - Vonderhaar, Barbara K.
- For more information, visit
http://ccr.cancer.gov/careers/traco.asp
TRACO: Cancer Stem Cells and Case Reports
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- Science in the Public Health - Post Traumatic Stress Disorder: What are the Facts? (HHS Only)
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- - Keane, Terence Martin.
National Institutes of Health (U.S.). Staff Training-Extramural Programs Committee. (2010/11/18) - - Category : STEP (HHS Only)
- - Keane, Terence Martin.
- Science in the Public Health
Post Traumatic Stress Disorder (PTSD) affects millions of Americans every year？？？and not just from combat. Anyone who has gone through a natural disaster or other overwhelming stress can develop PTSD. This condition is devastating and costs millions of dollars in lost productivity and medical treatment. What are the causes and clinical manifestations of PTSD? Are there biomarkers for diagnosis of PTSD? What are the treatments for PTSD? Join us to discuss these timely questions with a panel of military, disaster relief, and medical experts.
This training is recommended for ESA Credit.
STEP subcommittee for this event:
Chair: Bob Mays
Members: Carol Alderson, Valery Gordon, Valerie Maholmes, Eduardo Montalvo, Linda Porter, Vishnu Purohit, Mike Small, Natasha Spaid
For more information, visit
http://odoerdb2-1.od.nih.gov/oer/training/step/step_training_20081216.htm
Science in the Public Health - Post Traumatic Stress Disorder: What are the Facts? (HHS Only)
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- New Frontiers in Traumatic Brain Injury: Evaluation and Treatment
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- - Chan, Leighton.
National Institutes of Health (U.S.). Clinical Center. (2010/11/18) - - Category : Medicine for the Public
- - Chan, Leighton.
- NIH Clinical Centers 2008 Medicine for the Public Lecture Series
Because of traumatic brain injury, the Centers for Disease Control and Prevention estimate, more than 5 million Americans will need life-long help to perform daily activities. The U.S. Department of Defense？？？s Deployment Health Clinical Center reports that the rate of combat-related brain injuries in service members returning from Iraq and Afghanistan appears to be higher than in military previous conflicts. Dr. Leighton Chan will talk about current research aimed at broader understanding of the effects of traumatic brain injury and more personalized treatments for it.
Dr. Leighton Chan is the Chief of Rehabilitation Medicine at the NIH Clinical Center. He received his B.A. degree from Dartmouth College, Hanover, New Hampshire with a major in political science. He graduated from the UCLA School of Medicine in 1990. Dr. Chan then completed postgraduate training in Physical Medicine and Rehabilitation at the University of Washington. During his training he also obtained a Master of Science degree in rehabilitation science. Subsequently, he completed a Robert Wood Johnson Clinical Scholar Fellowship, earned a master of public health degree at the University of Washington School of Public Health and was a Congressional Fellow for the Honorable Jim McDermott (Washington).
From 1994 to 2006, Dr. Chan was on the faculty of the University of Washington？？？s Department of Rehabilitation Medicine. From 2002 to 2006, he was associate professor. He is board certified in physical medicine and rehabilitation and in electrodiagnostic medicine.
His research interests include health services research, quality of care given to Medicare beneficiaries, and Medicare payment policy issues. He has published more than 60 peer reviewed articles and numerous book chapters. Dr. Chan？？？s awards include the Young Academician Award from the Association of Academic Physiatrists and a Presidential Citation Award for excellence in research from the American Academy of Physical Medicine and Rehabilitation. He was elected to the Institute of Medicine in 2007.
http://www.cc.nih.gov/about/news/mfp.shtml
New Frontiers in Traumatic Brain Injury: Evaluation and Treatment
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- DNA End Processing by Mre11/Rad50 Complexes
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- - Dr. Tanya Pauli, University of Texas (2010/11/18)
- - Category : DNA Repair
- The DNA Repair Interest Group is concerned with all forms of DNA damage and repair. As a major defense against environmental damage to cells DNA repair is present in all organisms examined including bacteria, yeast, drosophila, fish, amphibians, rodents and humans. The members of the DNA Repair Interest Group perform research in areas including DNA repair enzymology and fine structure, mutagenesis, gene and cell cycle regulation, protein structure, and human disease.
Acrobat Slides
For more information, visit the
DNA Repair Interest Group
DNA End Processing by Mre11/Rad50 Complexes
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- The U.S. Commitment to Global Health
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- - Varmus, Harold.
National Institutes of Health (U.S.) (2010/11/18) - - Category : David E. Barmes
- - Varmus, Harold.
- The 2008 David E. Barmes Global Health Lecture
Harold Varmus, former Director of the National Institutes of Health and co-recipient of a Nobel Prize for studies of the genetic basis of cancer, is President of Memorial Sloan-Kettering Cancer Center in New York City. Dr. Varmus chairs the Scientific Board of the Bill & Melinda Gates Foundations Grand Challenges in Global Health program and leads the Advisory Committee for the Global Health Division. He was a member of the World Health Organization (WHO) Commission on Macroeconomics and Health, and is a co-founder of the Public Library of Science, a leading publisher of open access journals. In addition, he serves as co-chair of the Institute of Medicines committee on The U.S. Commitment to Global Health. The committee will issue its interim report on the day preceding the lecture.
NIDCR and Fogarty jointly host the annual Barmes Lecture, which honors the late David E. Barmes. Dr. Barmes was a special expert for international health at the NIDCR. Prior to joining NIDCR, he served in senior management positions related to oral health, health promotion, and non-communicable diseases at the World Health Organization in Geneva.
The reception is sponsored by the Foundation for the National Institutes of Health, with generous support from Lilly, Abbott Fund, Bristol-Myers Squibb Foundation, ExxonMobil, PepsiCo, Aeras Global TB Vaccine Foundation, Burroughs Wellcome Fund, Merck, Pfizer, tibotec, and the United Nations Foundation.
The annual lecture series honors the late David E. Barmes, a long-standing World Health Organization employee, special expert for international health in the NIDCR Office of International Health, and ardent spokesman for global health. The lecture is jointly sponsored by NIDCR and the Fogarty International Center.
The U.S. Commitment to Global Health
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- A Pediatricians Perspective on the Human Genome Project and Genomic Pediatrics
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- - Morton, D Holmes.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Wednesday Afternoon Lectures
- - Morton, D Holmes.
- The Clinic for Special Children was founded in 1989 in Lancaster County Pennsylvania as a place where the knowledge of genetics would be Translated into principles of medical care to help children with inherited disorders. Much of the knowledge of the human genome project was produced in laboratories far from the bedside, ultimately, the Translation of this information into medical practice requires a commitment to care for the patient. The every day practice of medicine is the frontier of Translational Genetics. An understanding, an acceptance, that many common illnesses arise in all people from genetic predispositions, but are nonetheless treatable, may finally be the most important contribution that the Plain Communities, and our Clinic for Special Children, will make to the practice of medicine.
D. Holmes Morton calls himself a country doctor. Yet while his clinics parking lot is more likely to be filled with horses and buggies than cars, what goes on within his lab is the highest of high-tech.
Morton is the founder and director of the Clinic for Special Children, serving a largely Old Order Amish and Mennonite clientele in Lancaster County, Pennsylvania. The clinic is a non-profit medical and diagnostic service for children with inherited metabolic disorders, which are more common here due to the general practice of marrying only within ones tight-knit community.
From their base surrounded by alfalfa fields in Strasburg, Penn., Morton and his small team treat biochemical disorders such as glutaric aciduria (GA1), maple syrup urine disease (MSUD), Crigler-Najjar syndrome and medium-chain acyl-CoA dehydrogenase deficiency (MCADD) - all told, over 100 different genetic disorders, some never seen before. The mission of the clinic is to advance methods of newborn screening, to improve follow-up services, to develop better diagnostic methods, and to further clinical research in an ongoing effort to improve treatment and outcomes for children who suffer from rare inherited disorders.
The clinic studies how genetic errors alter the growth, structure, and function of the developing brain, relying on clinical examinations, imaging studies, and molecular testing. Through candidate gene analysis and genome-wide mapping studies, Mortons lab can detect about 80 gene mutations found in the Plain People populations of Pennsylvania. The ability to accurately and inexpensively diagnose patients in a timely manner through DNA-based testing is invaluable for preventing the devastating effects of many genetic disorders, he said.
A high school drop out from rural West Virginia and a graduate of Harvard Medical School, Morton received the Albert Schweitzer Prize for Humanitarianism in 1993 and was awarded a MacArthur Foundation genius grant in 2006.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
A Pediatricians Perspective on the Human Genome Project and Genomic Pediatrics
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- Th2 Cell Hyporesponsiveness During Chronic Helminth Infection
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- - Pearce, Edward J.
National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18) - - Category : Immunology
- - Pearce, Edward J.
- For more information, visit
The Immunology Interest Group
Th2 Cell Hyporesponsiveness During Chronic Helminth Infection
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- Structural Analysis of an Ancient Pathway Linking Gq-Coupled Receptors to RhoA
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- - Tesmer, John.
National Institutes of Health (U.S.). Structural Biology Interest Group. (2010/11/18) - - Category : Structural Biology
- - Tesmer, John.
- The SBIG is a clearinghouse for discussions and interactions between scientists interested in all aspects of molecular structure, from experimental determination by x-ray crystallography, electron microscopy, mass spectrometry, and NMR, to theoretical and computational biology and biophysics, and to the biological application of structural data.
For more information, visit
Structural Biology Interest Group
Structural Analysis of an Ancient Pathway Linking Gq-Coupled Receptors to RhoA
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- Goal Setting for the New Year
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- - Sponsored by Life Work Strategies (2010/11/18)
- - Category : Work/Life Center
- NIH Work Life Seminar
As the New Year approaches, a majority of us begin to think about setting goals for the future in both our personal and professional lives. The New Year is a new beginning or a time to start fresh, when new goals, changing plans, and new directions fuel our thoughts for improvement and growth. Yet, even with all this initial enthusiasm, staying motivated, committed, and moving toward the accomplishment of our goals is often very challenging. Approximately 40% of individuals make resolutions each year that involve change yet 80% lose their momentum to achieve their goals within 5-6 weeks.
Whether the goal is work-related or something of a more personal nature, it must generate excitement and be something you believe you can accomplish. The goal setting process can create increased motivation for working toward an objective, as well as frame your perception of success. This seminar will identify the critical elements of goal setting and provide individuals with tools to strengthen their resolutions and clarify their objectives. Participants will develop a clear vision for establishing a course of action to define objectives based on key decisions and priorities, which in turn supports the achievement of their goals. Today is the prefect time to think about the future, and this workshop can be the first step in the planning process.
For more information, visit
http://wlc.od.nih.gov
Goal Setting for the New Year
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- Dissecting a Circuit for Olfactory Behavior
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- - Bargmann, Cornelia I.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Neuroscience
- - Bargmann, Cornelia I.
- Dr. Bargmann？？？s laboratory investigates how the neural circuits in C. elegans develop, identifies the genes and neural pathways for its navigation behaviors and asks how sensory inputs regulate those circuits.
C. elegans, a worm with just 302 neurons, shows an unexpected sophistication in its ability to detect and respond to olfactory stimuli, making it an ideal subject in which to study these interactions. C. elegans senses hundreds of different odors, discriminates among them and then generates different behaviors in response. Since the worm？？？s nervous system has so few neurons, it？？？s possible to determine which neurons generate these behaviors. In C. elegans, as in other animals, odors are detected by G protein coupled odorant receptors. Each sensory neuron is primarily dedicated to a single behavioral task, such as attraction or repulsion, and activation of the correct sensory neuron is all it takes to generate a characteristic behavior. Dr. Bargmann？？？s lab investigates how sensory signaling pathways and the neurons downstream translate those sensory cues into behavioral responses. Because so much of how the nervous system functions is dictated by the precise synaptic connections between neurons, Dr. Bargmann is also investigating the development of neural circuits in order to better understand how an animal processes information and routes it along the complex neural web. By combining genetics with C. elegans behavior, she has found a gene that determines whether a worm prefers to eat alone or socially, and another gene that allows them to discriminate among different odors. More recently, work by Dr. Bargmann led to the discovery that the worms she studies are capable of learning and later remembering to reject a novel food that makes them ill.
Dr. Bargmann studied for her Ph.D. under Robert Weinberg at MIT, graduating in 1987. She pursued a postdoctoral fellowship with H. Robert Horvitz, also at MIT, until 1991, when she accepted a faculty position at UCSF. She remained there until 2004, when she joined Rockefeller University as the Torsten N. Wiesel Professor. Dr. Bargmann is an investigator at the Howard Hughes Medical Institute and a member of the National Academy of Sciences and the American Academy of Arts and Sciences.
NIH Neuroscience Seminar Series
Dissecting a Circuit for Olfactory Behavior
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- Implementing Cell and Gene Therapies for Cancer in an Academic Setting (NIH-Only)
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- - Brenner, Malcolm K.
National Institutes of Health (U.S.) (2010/11/18) - - Category : NCI CCR Grand Rounds (NIH Only)
- - Brenner, Malcolm K.
- NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link:
http://www.bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx
Implementing Cell and Gene Therapies for Cancer in an Academic Setting (NIH-Only)
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- MicroRNA Pathways in Animal Development
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- - Ambros, Victor.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Wednesday Afternoon Lectures
- - Ambros, Victor.
- MicroRNAs are small regulatory RNA molecules, encoded in the genome, that base-pair with specific messenger RNAs and control their translation. MicroRNAs function in diverse physiological and developmental processes in animals, and in the nematode C. elegans, certain microRNAs figure prominently in the control of developmental timing by the heterochronic gene pathway. The genetic control of C. elegans developmental timing has provided a powerful model system for the genetic analysis of the function of certain microRNAs that are highly conserved between worms and mammals. C. elegans developmental timing mutants have moreover identified proteins that are part of the regulatory machinery associated with microRNAs and that could serve to mediate the regulation of microRNA activity by signaling pathways.
Victor Ambros grew up in Vermont and graduated from MIT in 1975. He did his graduate research (1976-1979) with David Baltimore at MIT, studying poliovirus genome structure and replication. He began to study the genetic pathways controlling developmental timing in the nematode C. elegans as a postdoc in H. Robert Horvitzs lab at MIT, and continued those studies while on the faculty of Harvard (1984-1992), Dartmouth (1992-2007) and the University of Massachusetts, Medical School (2008-present). In 1993, Ambros and co-workers Rosalind Lee and Rhonda Feinbaum identified the first microRNA, the product of the heterochronic gene lin-4 in C. elegans. Currently, the chief research interest of the Ambros lab is understanding the roles of microRNA-mediated regulatory pathways in animal development and human disease.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
MicroRNA Pathways in Animal Development
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- New Insights into T Cell Tolerance and Differentiation
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- - Dong, Chen.
National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18) - - Category : Immunology
- - Dong, Chen.
- For more information, visit
The Immunology Interest Group
New Insights into T Cell Tolerance and Differentiation
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- Proteogenomics, and Other Non-Traditional Applications of Mass Spectrometry
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- - Bafna, Vineet.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Proteomics
- - Bafna, Vineet.
- In this talk, we will discuss some novel uses of mass spectrometric data. First, we apply MS2 data for eukaryotic gene discovery. To do this, we must overcome a number of challenges, including computational bottlenecks, confidence assignment to peptide identification, and identification of spliced-peptides, (peptides that cross splice junctions). Our proteogenomic survey of Arabidopsis resulted in the identification of over 800 novel genes, which will be included in TAIR 9 release.
Second, we apply mass spectrometry data for antibody sequencing using a novel technique, genome-anchoring. Our method allows the unambiguous reconstruction of mouse antibody sequence using tandem MS2 data.
Finally, we describe a novel computational method for computing the relative abundance of a protein relative to another, contradicting the apparent truism that protein quantification is limited to measuring relative expression of a single protein.
http://proteome.nih.gov
Proteogenomics, and Other Non-Traditional Applications of Mass Spectrometry