전체 8345
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- Histone Deacetylases and Molecular Chaperones: A Stressful Alliance in Cancer Cells (NIH-Only)
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- - Kapil Bhalla, M.D., Medical College of Georgia (2010/11/18)
- - Category : NCI CCR Grand Rounds (NIH Only)
- Kapil Bhalla, M.D., is the founding Director of the Medical College of Georgia Cancer Center. He is a Georgia Research Alliance Eminent Scholar in Cancer and occupies the Cecil F. Whitaker, Jr., M.D. Chair in Cancer at MCG. He is also the Georgia Cancer Coalition？？？s Distinguished Cancer Scholar. A 1976 graduate of the University of Delhi？？？s Maulana Azad Medical College in India, Dr. Bhalla completed internships in Pathology and Internal Medicine and a residency, also in Internal Medicine, at St. Michael？？？s Medical Center in Newark, N.J. He completed a fellowship in Hematology and Oncology in 1983 at Columbia University College of Physicians and Surgeons in New York. He is Board-certified in Internal Medicine, Hematology and Medical Oncology. Dr. Bhalla is a member of the American Society of Clinical Oncology, the American Society of Hematology and the American Association for Cancer Research. Dr. Bhalla has served as the Chair of the Neoplasia and subsequently of Lymphoid Neoplasia Committee of the American Society of Hematology. He is a past recipient of the American Cancer Society？？？s Career Development Award and the Leukemia & Lymphoma Society of America？？？s Fellow and Scholar Awards. Dr. Bhalla is a former member of the National Institutes of Health？？？s Experimental Therapeutics II Study Section from 1993 to 1997, and the former Chairperson of the Developmental Therapeutics Study Section from 2005 to 2007. He continues to serve as an ad-hoc member of NIH and NCI study sections. He is the author of more than 150 scholarly articles on cancer research and clinical trials. Dr. Bhalla also serves as the associate editor of Cancer Research and is a member of the editorial boards of Blood, Molecular Cancer Therapeutics, Clinical Cancer Research, Cancer Biology and Therapy and Cell Cycle. Dr. Bhalla？？？s research focus is cancer epigenetics and chaperone biology as well as novel targeted therapeutics of leukemia and cancer. He started and oversees the functions of the first dedicated Phase I and II cancer clinical trials unit of the Medical College of Georgia.
NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link: http://bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx
Histone Deacetylases and Molecular Chaperones: A Stressful Alliance in Cancer Cells (NIH-Only)
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- NCI Communication Roundtable Seminar: Public Cancer Communication: Evidence About Information Seeking and Scanning, Anti-Tobacco Public Service Announcements, and Genetic Risk
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- - Robert Hornick, Caryn Lerman, and Joseph Cappella (2010/11/18)
- - Category : Special
- Researchers from the NCI-funded Effects of Public Information in Cancer (EPIC) Center at the Annenberg School for Communication of the University of Pennsylvania will present research findings on communication channels people use to make decisions around cancer prevention, screening, treatments, and living after a cancer diagnosis and effects on their behavior; identifying effective content and format features of anti-tobacco PSAs designed to motivate smokers to quit; and how media covers genetic risk, distortions of basic science in press coverage and press releases, and effects on healthy choices.
Each seminar in the series, designed for those interested in using current communication research information to enhance the impact and effectiveness of health-related communications, will include a networking session from 11:30 a.m. to 12:00 p.m. The series is sponsored by the NCI Communications Strategy Roundtable, Office of Communications and Education, NCI. This seminar is produced in collaboration with the Health Communications & Informatics Research Branch in the Division of Cancer Control and Population Sciences, NCI
NCI Communication Roundtable Seminar: Public Cancer Communication: Evidence About Information Seeking and Scanning, Anti-Tobacco Public Service Announcements, and Genetic Risk
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- CC Grand Rounds: (1) Imaging of Localized Prostate Cancer: Prelude to Focal Therapy (2) Revisiting Old Targets and Exploring New Ones in Patients with Advanced Prostate Cancer
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- - Peter Choyke, MD and William L. Dahut, MD (2010/11/18)
- - Category : Clinical Center Grand Rounds
- Peter Choyke, MD,
Chief, Molecular Imaging Program, NCI
William L. Dahut, MD,
Clinical Director, NCI and Chief, Genitourinary Section, Medical Oncology Branch, NCI
For more information, visit
http://www.cc.nih.gov/about/news/grcurrent.html
CC Grand Rounds: (1) Imaging of Localized Prostate Cancer: Prelude to Focal Therapy (2) Revisiting Old Targets and Exploring New Ones in Patients with Advanced Prostate Cancer
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- Transcriptional Control of Adipogenesis and Systemic Energy Homeostasis
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- - Dr. Bruce Spiegelman, Dana-Farber Cancer Institute/Harvard Medical School (2010/11/18)
- - Category : Wednesday Afternoon Lectures
- Dr. Spiegelman received a B.S. with highest honors from the College of William and Mary, and a Ph.D. from Princeton University. His graduate work was immediately followed by postdoctoral research at the Massachusetts Institute of Technology. Dr. Spiegelman was elected to the National Academy of Science in 2002.
His lab is focused on the regulation of energy homeostasis in mammals, primarily at the level of gene transcription. This includes the problems of fat cell development, control of metabolic rates and the pathways of glucose and lipid metabolism. These studies have applications to the development of new therapies for diabetes, obesity, muscular and neurodegenerative diseases.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Transcriptional Control of Adipogenesis and Systemic Energy Homeostasis
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- Inflammatory Diseases Regulated by T-bet
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- - Dr. Laurie Glimcher, Harvard (2010/11/18)
- - Category : Immunology
- *ATTENTION* - This Immunology Interest Group lecture has material in the slides that has not been published. For this reason the speaker has asked us not to broadcast this material and there are no slides shown in the IIG presentation.
Laurie Glimcher is a leader in the biochemical and genetic elucidation of the molecular pathways that regulate CD4 T helper cell development and activation. She has made major contributions to our understanding of the transcriptional pathways that control this important immune checkpoint. She helped to define the genetic bases of both IL-4 and IFNg expression in T cells. Her group identified the proto-oncogene c-maf as the transcription factor responsible for TH2-specific IL-4 expression. Subsequently, she discovered the first TH1-specific transcription factor, T-bet and demonstrated that this single factor is a master-regulator of IFNg gene expression and the TH1 phenotype and controls Type 1 immunity in cells of both the adaptive and innate immune system. She showed that the transcription factor, XBP-1 controls plasma cell differentiation and the Unfolded Protein response. Most recently her laboratory has identified new proteins that control osteoblast commitment and activation and bone formation. This body of work may provide a conceptual framework to therapeutically manipulate these responses in the settings of inflammatory and autoimmune diseases and cancer. She will speak next week on inflammatory diseases that are regulated by T-bet.
The Immunology Interest Group
Inflammatory Diseases Regulated by T-bet
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- National Advisory Child Health and Human Development Council - June 2010
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- - NICHD (2010/11/18)
- - Category : National Advisory Child Health and Human Development Council
- To help achieve the goals of the Institute, the NACHHD Council is charged with advising, consulting with, and making recommendations to the NICHD director on matters relating to the research and research support activities and functions of the Institute.
National Advisory Child Health and Human Development Council - June 2010
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- A Prokaryotic Perspective on Pentameric Ligand Gated Ion Channel Structure and Function
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- - Raimund Dutzler, Ph.D. (2010/11/18)
- - Category : Neuroscience
- Dr. Dutzlers research group is interested in the mechanisms of transmembrane ion transport. The group takes a multidisciplinary approach combining biochemistry X-ray crystallography and electrophysiology to study the structure and function of ion channels and ion transporters. Dr. Dutzler has solved original x-ray structures of bacterial homologs of several important transporter classes, including the ClC family of chloride channels and transporters and the cys-loop family of neurotransmitter receptors. These structures have yielded important mechanistic insights into both classes of proteins. In addition, Dr. Dutzlers group has used novel combinations of structural and biochemical approaches to obtain functional information regarding these transport proteins.
NIH Neuroscience Seminar Series
A Prokaryotic Perspective on Pentameric Ligand Gated Ion Channel Structure and Function
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- NIMH Schizophrenia Lecture Series: Antipsychotic Treatment and Tolerability
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- - Gerald Overman, Pharm.D, BCPP (2010/11/18)
- - Category : Special
NIMH Schizophrenia Lecture Series: Antipsychotic Treatment and Tolerability
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- Keeping Your Credit Score Healthy
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- - Rosemary Hill, Money Management International (2010/11/18)
- - Category : Focus on You Wellness
- Focus on You Wellness Lecture Series.
Financial wellness is an important part of decreasing stress and anxiety and increasing ones holistic health. Come learn about managing your finances and keeping your credit score in the right zone with financial expert, Rosemary Hill from Money Management International, a parter of the NIH Federal Credit Union. In todays economy, you cannot afford to miss this advice!
Keeping Your Credit Score Healthy
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- Statistical Methods for Genetic Analysis of Complex Diseases
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- - Ruzong Fan (2010/11/18)
- - Category : Special
- NIMH Statistical Genetics Search Candidate Presentation
Statistical Methods for Genetic Analysis of Complex Diseases
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- Prostate Cancer Prevention by Soy: Pitfalls and Opportunities
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- - Dr. Maarten Bosland, University of Illinois at Chicago (2010/11/18)
- - Category : OCCAM Monthly Lecture Series
- The NCIs Office of Cancer Complementary and Alternative Medicine (OCCAM) invites you to view its monthly lecture series.
With the goal of informing the National Cancer Institute (NCI) community about the variety of ongoing research in cancer and complementary and alternative medicine (CAM), NCIs Office of Cancer Complementary and Alternative Medicine (OCCAM) has created a monthly lecture series on cancer CAM. These hour long lectures, occurring from 10 a.m. - 11 a.m. on the second Wednesday of each month, will feature a fifty minute presentation on a cancer CAM topic and allow ten minutes for questions.
For more information, visit
http://www.cancer.gov/cam/news_lectures.html
Prostate Cancer Prevention by Soy: Pitfalls and Opportunities
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- Great Teachers - Hospital Infections: Rumors and Reality
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- - Tara Palmore, MD, Deputy Hospital Epidemiologist, CC and Staff Clinician, NIAID (2010/11/18)
- - Category : Clinical Center Grand Rounds
- John Laws Decker Memorial Lecture: Hospital Infections: Rumors and Reality
Great Teachers - Hospital Infections: Rumors and Reality
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- Developmental Biology and Prevention and Treatment of Craniofacial Malformations
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- - Dr. Yang Chai (2010/11/18)
- - Category : Special
- Dr. Yang Chai has developed cutting edge molecular tools that have helped to uncover the nature of growth factors and signaling pathways that control cell fate in the neural crest. For example, he and his colleagues created genetically engineered mice that allowed them to pinpoint the role of several growth factors that signal neural crest cells to properly form teeth, jaw, and palate. Dr. Chai will discuss how manipulating these growth factors and their signaling pathways could lead to prevention and treatment of congenital abnormalities of the head and face.
Dr. Chai is the George and MaryLou Boone Professor of Craniofacial Biology, director of the Center for Craniofacial Molecular Biology, and associate dean of research at the Herman Ostrow School of Dentistry of the University of Southern California (USC). Dr. Chai holds a D.M.D. from Peking University, Beijing, China, where he also trained in oral and maxillofacial surgery. He earned a Ph.D. in craniofacial biology at USC and conducted post-doctoral training from 1991-1994. In 1996 he received his D.D.S. from USC and joined the faculty that year. Dr. Chai has received many honors and awards, including several teaching awards. He has also chaired the Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration.
http://www.nidcr.nih.gov/NewsAndFeatures/Announcements/NewSeminarSeries.htm
Developmental Biology and Prevention and Treatment of Craniofacial Malformations
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- Regulation of T Cell Effector Functions Through the Cytoskeleton
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- - Chan, Andy.
National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18) - - Category : Immunology
- - Chan, Andy.
- Andy Chan began his career identifying a novel form of the fourth component human complement and characterized its structure function relationship. But perhaps he is most well known for his outstanding contribution towards understanding the biochemistry of signaling pathways downstream of the T cell receptor. He was responsible for discovering the Syk family kinase Zap-70 when he was in Art Weiss？？？ lab. He also discovered that Zap-70 deficiency in humans is associated with severe combined immunodeficiency and also described its importance in T cell development. He continued to work on Syk family kinases in both B and T cells for several years and really mapped out the mechanisms by which these kinases control antigen receptor signaling and in these two cell populations. He also discovered the molecule BLNK a linker protein in B cell activation that facilitates signaling downstream of Syk and controls B cell development. Among many other discoveries, he also described the role of Grb2 in T cell development and more recently has worked on the molecule Crtam that controls late phase polarity and differentiation in T cells. Andy？？？s career can be best described as an immunologist committed to understanding signaling in immune cells giving equal emphasis to B and T cells. There is no doubt that his talk will be excellent as he will describe his recent work on regulators of effector T cell differentiation.
The Immunology Interest Group
Regulation of T Cell Effector Functions Through the Cytoskeleton
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- Bringing Gender Home: Implementing Gender Responsive HIV/AIDS Programming for US Women and Girls
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- - Howard Koh, Assistant Secretary for Health (2010/11/18)
- - Category : Conferences
- The purpose of the OWH Gender Forum is to promote increased leadership in gender responsive programming for women and girls. Forum participants will also identify and address the various roles and behavior of women and girls that increases their risk for contracting and/or transmitting STDs including HIV/AIDS.
Bringing Gender Home: Implementing Gender Responsive HIV/AIDS Programming for US Women and Girls
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- Advisory Committee to the Director of the NIH - June 2010
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- - Office of the Director, NIH (2010/11/18)
- - Category : Advisory Committee to the Director of the NIH
- A meeting of the Advisory Committee to the Director (ACD) of the National Institutes of Health (NIH)
The agenda for the meeting will be posted at a later date on the ACD Web site at
http://www.nih.gov/about/director/acd/index.htm
Advisory Committee to the Director of the NIH - June 2010
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- 2010 Institute on Systems Science and Health - ISSH (Day 1)
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- - NIH Office of Behavioral and Social Sciences Research & Centers for Disease Control and Prevention (2010/11/18)
- - Category : Institute on Systems Science and Health (ISSH)
- The 2010 Institute on Systems Science and Health (ISSH) will provide investigators with a thorough introduction to selected systems science methodologies that may be used to study behavioral and social dimensions of public health. Participants in the week-long Institute will focus on one of three methodologies: agent-based modeling, system dynamics modeling, or network analysis.
For more information, visit
http://issh.aed.org/index.html
2010 Institute on Systems Science and Health - ISSH (Day 1)
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- 2010 Institute on Systems Science and Health - ISSH (Day 2 - AM)
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- - Institute on Systems Science and Health
National Institutes of Health (U.S.). Office of Behavioral and Social Sciences Research. (2010/11/18) - - Category : Institute on Systems Science and Health (ISSH)
- - Institute on Systems Science and Health
- The 2010 Institute on Systems Science and Health (ISSH) will provide investigators with a thorough introduction to selected systems science methodologies that may be used to study behavioral and social dimensions of public health. Participants in the week-long Institute will focus on one of three methodologies: agent-based modeling, system dynamics modeling, or network analysis.
For more information, visit
http://issh.aed.org/index.html
2010 Institute on Systems Science and Health - ISSH (Day 2 - AM)
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- Heart Rate as a Measure of Sympathetic Parasympathetic Balance
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- - Richard Sloan, Columbia University and David S. Goldstein, NINDS, NIH (2010/11/18)
- - Category : NCCAM Lectures
- NCCAM Complementary and Integrative Medicine Research Lecture
Richard Sloan, Ph.D., Nathaniel Wharton Professor of Behavioral Medicine, Columbia University; David S. Goldstein, M.D., Ph.D., Chief, Clinical Neurocardiology Section, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health
Dr. Sloans principal work focuses on identifying the autonomic nervous system mechanisms linking psychological risk factors such as depression, hostility, and anxiety to heart disease. Research studies addressing this include determining whether reducing hostility and anger, by cognitive-behavioral treatment, enhances cardiac autonomic control and examining the impact of aerobic training on neurogenesis.
Dr. Goldsteins research interests are in catecholamine systems, clinical autonomic disorders, and scientific integrative medicine. The Clinical Neurocardiology Section, which he founded and directs, carries out mainly patient-oriented research about disorders of brain regulation of the cardiovascular system. The research emphasizes diseases of the autonomic nervous system in which the sympathetic nervous system or catecholamines play prominent roles, such as autonomic failure syndromes and neurogenetic conditions featuring abnormal catecholamine synthesis or metabolism.
The Complementary and Integrative Medicine Consult Service lecture series sponsored by NCCAM provides NIH clinical center staff with opportunity to learn more about how the integration of various complementary and alternative medicine treatments can affect approaches in the research and practice for medicine
For more information, visit
at http://nccam.nih.gov/consultservice
Heart Rate as a Measure of Sympathetic Parasympathetic Balance
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- Localizing Mechanotransducer Channels to the Tips of Auditory Hair Cell Stereocilia
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- - Anthony Ricci, Ph.D., Stanford University (2010/11/18)
- - Category : Neuroscience
- The auditory system is a remarkable feat of engineering capable of detecting motion at the atomic level and transmitting this information to the brain with precise timing and fidelity. Dr. Riccis lab uses advanced electrophysiologic, imaging, molecular and pharmacologic techniques to probe mechanisms of mechanotransduction and synaptic transmission at the auditory periphery. There are several independent lines of research in their laboratory.
Mechanotransduction, the conversion of mechanical stimulation into an electrical signal, is complex and involves a variety of proteins, many of which have not yet been identified. A major goal of their laboratory is to delineate the functional relevance of mechanotransduction and to identify proteins and their function in this process. To date, they have identified and characterized the tuning properties of the sensory hair bundle and mechanotransducer channels, identifying at least two new physiologically relevant contributions of these channels. They have performed the only single channel study of mechanotransducer channels, demonstrating tonotopic variations in the intrinsic channel properties. They have also performed the only kinetic analysis of activation, again demonstrating tonotopic variations in the kinetics of the mechanotransduction channel. In addition, they have pharmacologically characterized and biophysically mapped the transducer channel pore.
Recently Dr. Riccis lab has developed a high speed confocal imaging system that will allow them to optically monitor calcium changes associated with mechanotransduction, allowing them to localize the site of mechanotransduction and directly investigate mechanisms of calcium, regulation.
NIH Neuroscience Seminar Series
Localizing Mechanotransducer Channels to the Tips of Auditory Hair Cell Stereocilia