전체 8345
-
- Control of Tumor Promotion and Metastatic Progression by Inflammatory Signaling
-
- - Dr. Michael Karin, University of California, San Diego (2010/11/18)
- - Category : Wednesday Afternoon Lectures
- Michael Karin, PhD, will present a Wednesday Afternoon Lecture on May 19, 2010. As a distinguished professor of Pharmacology at the University of California, San Diego and an American Cancer Society Research Professor. Dr. Karin will present Control of Tumor Promotion and Metastatic Progression by Inflammatory Signaling.
He is a leading authority on signal transduction pathways that regulate gene expression in response to extracellular stimuli, infection, inflammation and stress. Key achievements include the definition of cis elements that mediate gene induction by hormones, cytokines and stress, identification and characterization of the transcription factors that recognize these elements (members of the AP-1/ATF family) and the protein kinase cascades that regulate their activities, including the Jun kinases (JNK) and IkB kinases (IKK).
Much of Dr. Karin？？？s current activity is focused on understanding the link between inflammation, cancer and metabolic disease as well as on understanding the signaling mechanisms used by receptors involved in inflammation and innate immunity. In addition to establishing molecular links between obesity, inflammation and cancer, this work has revealed new targets for cancer prevention and therapy. Dr. Karin has published over 300 scientific articles and is an inventor on over 30 different patents or pending patent applications. In addition to numerous honors, Dr Karin was ranked first worldwide by the Institute of Scientific Information (ISI) in a listing of most-cited molecular biology and genetic research papers published in prestigious journals.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Control of Tumor Promotion and Metastatic Progression by Inflammatory Signaling
-
- Role of the Protease MALT1 in Lymphocyte Activation and Lymphoma Development
-
- - Thome, Margot.
National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18) - - Category : Immunology
- - Thome, Margot.
- Next week？？？s Immunology Interest Group lecture will be given by Dr. Margot Thome. As a postdoctoral fellow, Dr. Thome did seminal work with Jurg Tschopp on FLIP and resistance to apoptosis. In her own laboratory at the University of Lausanne, Dr. Thome has performed beautiful work on the Carma-Bcl10-Malt1 complex, revealing new functions for these proteins in the activation of NFkB and downstream pathways. Her recent work has revealed surprising features of these proteins, their novel roles in signaling pathways and their contributions to human disease.
The Immunology Interest Group
Role of the Protease MALT1 in Lymphocyte Activation and Lymphoma Development
-
- Reducing Health Disparities Confronting Asian Americans
-
- - Chen, Moon Shao-Chuang.
National Center on Minority Health and Health Disparities (U.S.) (2010/11/18) - - Category : Health Disparities
- - Chen, Moon Shao-Chuang.
- In commemoration of Asian American Heritage Month, the National Center on Minority Health and Health Disparities (NCMHD) presents the next NIH Health Disparities Seminar Series, which focuses on Asian American health disparities and is scheduled for May 20, 2010.
Asian Americans and Native Hawaiians and Other Pacific Islanders are federal census groupings that comprise socio-culturally diverse populations whose lands of origin encompass more than half the worlds surface. Although many Asian Americans have attained high levels of health and prosperity, when they are disaggregated into particular ethnic groups, stark health disparities are revealed. For example, cervical cancer incidence rates are five times higher among Vietnamese American women than white women, and Filipino Americans have much poorer five-year survival rates for colon and rectal cancers compared with the population at large. Although they represent a smaller portion of the American population, Pacific Islanders are also a rapidly growing population and consist of more than 20 major ethnic groups; a disproportionately high rate of diabetes is common to many of these groups. Native Hawaiians in particular, are more than five times more likely than the white population of Hawaii to die from diabetes and have a 50% higher rate of infant mortality.
Moving beyond the model minority myth, Dr. Moon S. Chen, Associate Director for Population Research and Cancer Health Disparities at the UC Davis Cancer Center in Sacramento, will describe the heterogeneity of Asian American and Pacific Islander populations and outline progress in establishing infrastructure, conducting studies, and training a workforce of researchers from these populations to address their health issues.Prospects for reducing the health disparities experienced by Asian American, Native Hawaiian, and Pacific Islander communities will also be discussed.
Dr. Chen, whose grandfather came to California in the late 1800s to seek gold, but instead wound up building the transcontinental railroad along with thousands of other immigrants from China, is a Professor in the Division of Hematology and Oncology in the Department of Internal Medicine at the University of California at Davis School of Medicine. He is the Principal Investigator for the Asian American Network for Cancer Awareness Research and Training (AANCART), which focuses on reducing cancer health disparities among Asian Americans in California, Hawaii, and Seattle, and he leads the NCI and NCMHD-funded program project, Liver Cancer Control Interventions for Asian Americans.
Dr. Moon S. Chen Professor, Division of Hematology and Oncology Principal Investigator, Asian American Network for Cancer Awareness Research and Training (AANCART) Department of Internal Medicine UC Davis Cancer Center
Reducing Health Disparities Confronting Asian Americans, Native Hawaiians, and Other Pacific Islanders (AANHOPIs): Profiles, Progress, and Prospects
http://www.ncmhd.nih.gov
Reducing Health Disparities Confronting Asian Americans
-
- Travel HPOC Meeting for GovTrip (NIH-Only)
-
- - Jennifer Martin (2010/11/18)
- - Category : Travel (NIH Only)
- We will be discussing common GovTrip issues and resolutions, reviewing functionality and answering questions regarding the system.
Travel HPOC Meeting for GovTrip (NIH-Only)
-
- From Rare Gases to Ribosomes
-
- - Dr. Carol Robinson, University of Oxford (2010/11/18)
- - Category : Wednesday Afternoon Lectures
- Carol Robinson, PhD, will present a Wednesday Afternoon Lecture on May 20, 2010. As a Royal Society Research Professor in the Department of Physical and Theoretical Chemistry at the University of Oxford, Dr. Robinson will present From Rare Gases to Ribosomes: Mass Spectrometry for Structural Biology.
She earned her PhD from the University of Cambridge and is a recipient of many prestigious awards, including the Biemann Medal of the American Society for Mass Spectrometry in 2003 and Rosalind Franklin Award of the Royal Society in 2004. In 2004 Professor Robinson became a Fellow of the Royal Society and is the 2010 recipient of the Prelog Medal.
Her research interests are in the areas of mass spectrometry, protein folding and assembly. After an eight year career break, Dr. Robinson？？？s return to research coincided with the introduction of electrospray mass spectrometry, enabling the analysis of individual protein molecules. Her initial research interest was to develop procedures through which it is possible to obtain information about the development of secondary structure during protein folding reactions.
Currently, Dr. Robinson is trying to find associations between complexes that have not been discovered previously. One of the major attractions of this research is that she can study, at very low concentrations, intact complexes that have been taken directly out of cells. She is using mass spectrometry to uncover how the proteins are organised within these structures by using various solution and gas phase approaches to generate smaller subcomplexes.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
From Rare Gases to Ribosomes
-
- TNF Family Cytokines: From Molecule to Malady and Back Again
-
- - Siegel, Richard M.
National Institutes of Health (U.S.) (2010/11/18) - - Category : NIH Directors Seminars
- - Siegel, Richard M.
- The next Directors Seminar Series will be Friday, May 21, 2010. The seminar will take place in Building 1, 3rd floor, Wilson Hall, from 12:00 - 1:00 p.m. The speaker is Dr. Richard Siegel, Acting Chief, Autoimmunity Branch, NIAMS. Dr. Siegels talk is entitled, "TNF family cytokines: From molecule to malady and back again"
TNF Family Cytokines: From Molecule to Malady and Back Again
-
- 7T Seminar Series: Technology for High Resolution fMRI and rs-fMRI at 7T
-
- - Lawrence Wald (2010/11/18)
- - Category : 7 T Seminars
- Dr. Lawrence (Larry) Wald is Director, of the MRI core facility at the Athinoula A. Martinos Center for Biomedical Imaging (Harvard-MIT-Mass General Hospital) and an Associate Professor in the Department of Radiology, Harvard Medical School. Larry is a world leader and pioneer in high field MRI applications and parallel imaging techniques
A major goal of Larry？？？s work is to bring the instrumental resolution of the fMRI experiment to the level where we can explore the biological spatial limits of fMRI. An order of magnitude improvement is needed to readily resolve the next lower level of the cerebral cortex: that of laminar and columnar structures. This includes developing 3D isotropic fMRI encoding methods to increase the spatial resolution of fMRI to approach these technical boundaries.
7T Seminar Series: Technology for High Resolution fMRI and rs-fMRI at 7T
-
- GovTrip 2.0 Awareness Session (NIH-Only)
-
- - Jennifer Martin (2010/11/18)
- - Category : Travel (NIH Only)
- The purpose of this session is to provide an overview of the changes, demonstrate how to process travel in the upgraded system, and address your questions related to the new release.
GovTrip 2.0 Awareness Session (NIH-Only)
-
- National Advisory Allergy and Infectious Diseases Council - May 2010 (NIH-Only)
-
- - Dr. Anthony S. Fauci and Dr. Francis S. Collins (2010/11/18)
- - Category : NIAID Council (NIH Only)
- The NAAIDC provides second level peer review of grant applications and discusses concept clearances and other matters pertaining to grant applications for NIAID. Their website offers information about meeting dates, council members, and has an archive of past meeting minutes. At each meeting, Dr. Anthony Fauci, NIAID Director, presents information about the Institute, including new staff, status of the budget, status of research and other areas of interest to the council. A guest speaker also does a presentation. At the May 24, 2010, meeting, NIH Director Dr. Francis S. Collins will speak.
National Advisory Allergy and Infectious Diseases Council - May 2010 (NIH-Only)
-
- AIDS Research Advisory Committee Meeting - May 2010 (NIH-Only)
-
- - Division of AIDS, NIAID (2010/11/18)
- - Category : AIDS Research Advisory Committee (NIH Only)
- This is the joint meeting of the NIAID Council AIDS Subcommittee and the AIDS Research Advisory Committee.
For more information, visit
http://www3.niaid.nih.gov/about/overview/councilcommittees/arac.htm
AIDS Research Advisory Committee Meeting - May 2010 (NIH-Only)
-
- Patient Advocacy & NIH: Marriage by Choice or Necessity (HHS-Only)
-
- - Chuck Selden (2010/11/18)
- - Category : STEP (HHS Only)
- STEP: Staff Training in Extramural Programs
The role of patient advocacy groups in promoting public health issues has been controversial. Growing from social movement advocacy for faster development of AIDS treatments to current Public Private Partnerships, the relationship between the NIH and patient advocates has come a long way.
Should the practice of involving advocates in NIH activities become more commonplace? How and when should they serve: as consultants for clinical research, in peer review, or as programmatic advisors to the Institutes and Centers? This STEP forum will discuss ways to facilitate working with advocacy groups and explore the benefits to NIH staff, scientists, advocates, and, most importantly, patients.
For more information, visit
http://odoerdb2.od.nih.gov/oer/training/esa/cores_curriculum_2010/core_2/esa_core_2.htm
Patient Advocacy & NIH: Marriage by Choice or Necessity (HHS-Only)
-
- Lunch and Learn Parenting Seminar: Raising Financially Healthy Kids
-
- - Juli Anne Callis, NIHFCUs President and CEO (2010/11/18)
- - Category : Parenting
- This seminar is designed for parents and grandparents with a step-by-step approach to helping kids become habitual savers, smart money managers, and responsible decision makers.
Acrobat Slides
Lunch and Learn Parenting Seminar: Raising Financially Healthy Kids
-
- Exploring Novel Statistical Tools for Recovering the ？？？Missing Heritability？？？ of Complex Traits
-
- - Yao, Yin.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Special
- - Yao, Yin.
- NIMH Statistical Genetics Search Candidate Presentation
Exploring Novel Statistical Tools for Recovering the ？？？Missing Heritability？？？ of Complex Traits
-
- Roadmap to a Healthy Heart: Why Your Genes May Not Be Your Destiny
-
- - Horvath, Keith A.
National Institutes of Health (U.S.). Clinical Center. (2010/11/18) - - Category : Medicine for the Public
- - Horvath, Keith A.
- The Future of Cardiac Surgery
Dr. Keith Horvath, Director, Cardiothoracic Surgery, NIH Heart Center at Suburban Hospital;
Director, Cardiothoracic Surgery Research Program, NHLBI, and
Adjunct Associate Professor, Johns Hopkins University School of Medicine
Epigenetic Influences on Cardiovascular Health and Disease
Dr. Dina Paltoo, Chair, NHLBI Data Access Committee and Program
Director, Advanced Technologies and Surgery Branch, Division of Cardiovascular Diseases, NHLBI
http://www.cc.nih.gov/about/news/mfp.shtml
Roadmap to a Healthy Heart: Why Your Genes May Not Be Your Destiny
-
- Celebrating Plain Language and Clear Communication at the NIH 2010
-
- - Jeff Howe, author of Crowdsourcing and contributing editor to Wired magazine (2010/11/18)
- - Category : Plain Language
- This year？？？s keynote speaker is Jeff Howe, author of Crowdsourcing and contributing editor to Wired magazine. Before coming to Wired, Howe was a senior editor at Inside.com and a writer for the Village Voice. In his fifteen years as a journalist, he has written for Time Magazine, U.S. News & World Report, The Washington Post, Mother Jones and numerous other publications.
At this year？？？s ceremony we will again honor a group of NIH employees whose communication products demonstrate exceptional clarity and focus. The event will conclude with a reception.
Celebrating Plain Language and Clear Communication at the NIH 2010
-
- CC Grand Rounds: (1) Roles for STAT3 in Human Immune Response and Atopy (2) Disrupted Airway Defenses and Environmental Infection Susceptibility
-
- - (1) Joshua D. Milner, MD, Tenure-Track Investigator and Chief, Allergic Inflammation Unit, Laboratory of Allergic Diseases, NIAID (2) Kenneth N. Olivier, MD, MPH, Staff Clinician, Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, NIAID (2010/11/18)
- - Category : Clinical Center Grand Rounds
- Joshua D. Milner, MD,
Tenure-Track Investigator and Chief, Allergic Inflammation Unit, Laboratory of Allergic Diseases, NIAID
Kenneth N. Olivier, MD, MPH,
Staff Clinician, Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, NIAID
For more information, visit
http://www.cc.nih.gov/about/news/grcurrent.html
CC Grand Rounds: (1) Roles for STAT3 in Human Immune Response and Atopy (2) Disrupted Airway Defenses and Environmental Infection Susceptibility
-
- CDCC Preproposal Conference
-
- - Dr. Christine D. Berg (2010/11/18)
- - Category : Special
- This presentation is the formal pre-proposal conference for the request for proposals (RFP) for Centralized folllow-up of the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial (Solicitation Number: N02-CN-05019-61). The project officer, Dr Christine D. Berg, will present responses to questions submitted by potential offerers in advance of the conference. There will also be an opportunity for viewers to submit questions via e-mail during the presentation.
CDCC Preproposal Conference
-
- 2010 Joseph Leiter NLM/MLA Lecture - Knowledge Services and the Role of Medical Libraries in Healthcare IT
-
- - John D. Halamka, MD, MS, Harvard Medical School (2010/11/18)
- - Category : Special
- Dr. Halamka is the chief information officer of Beth Israel Deaconess Medical Center and chief information officer of Harvard Medical School. In his role at the hospital, he is responsible for all clinical, financial, administrative and academic information technology serving 3,000 doctors, 14,000 employees and two million patients. At Harvard Medical School, he oversees all educational, research and administrative computing for 18,000 faculty and 3,000 students. He is also a practicing emergency physician.
In addition, Dr. Halamka participates in several state and national committees. He is chairman of the New England Healthcare Exchange Network (NEHEN), which oversees clinical and administrative data exchange in Massachusetts. Dr. Halamka is also the current chair of the US Healthcare Information Technology Standards Panel (HITSP) and co-chair of the HIT Standards Committee, with the goal of coordinating the process of electronic standards harmonization among stakeholders nationwide.
The Lectureship was established in 1983 to stimulate intellectual liaison between the Medical Library Association and the National Library of Medicine, and to promote biomedical communications.
2010 Joseph Leiter NLM/MLA Lecture - Knowledge Services and the Role of Medical Libraries in Healthcare IT
-
- Interrogating Circulating Tumor Cells to Direct Targeted Cancer Therapies
-
- - Dr. Daniel Haber, Massachusetts General Hospital Cancer Center (2010/11/18)
- - Category : Wednesday Afternoon Lectures
- Dr. Haber will present the development and characterization of a microfluidic device for the efficient capture of circulating tumor cells (CTCs) from blood specimens of patients with cancer. These cells represent potential biomarkers with which to follow disease progression, as well as providing important biological information into the process of metastasis. Examples will be provided, including the monitoring of tumor genotypes in EGFR-mutant lung cancer, as well as the molecular characterization of CTCs from patients with localized and metastastic prostate cancer.
His laboratory interests have focused on the area of cancer genetics, including the etiology of the pediatric kidney cancer Wilms tumor and genetic predisposition to breast cancer. Recently, his laboratory reported that lung cancers with activating mutations in the epidermal growth factor receptor (EGFR) are uniquely sensitive to tyrosine kinase inhibitors that target this receptor. This observation has had important implications for the genotype-directed treatment of non-small cell lung cancer, and more broadly for strategies to identify critical genetic lesions in cancers that may serve as an Achilles heel and be suitable for molecular targeting. In collaboration with Dr. Mehmet Toner？？？s laboratory, Dr. Haber？？？s laboratory has recently established the application of a novel microfluidic technology for quantifying and purifying circulating tumor cells from the blood of patients with various epithelial cancers. This new application has potentially profound implications for early diagnosis of cancer and for noninvasive molecular profiling of cancers during the course of therapy.
Lecture Objectives:
1. Understanding the technological approaches involved in the isolation of extraordinarily rare circulating tumor cells
2. Early insight into the molecular characterization of circulating tumor cells
3. Appreciation for the promise and potential limitations of circulating tumor cell analyses
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Interrogating Circulating Tumor Cells to Direct Targeted Cancer Therapies
-
- Triggering murine arthritis by a single commensal microbe
-
- - Mathis, Diane.
National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18) - - Category : Immunology
- - Mathis, Diane.
- Commensal microbes can have a substantial impact on autoimmune disorders, but the underlying molecular and cellular mechanisms remain largely unexplored. We report that autoimmune arthritis was strongly attenuated in the K/BxN mouse model under germ-free (GF) conditions, accompanied by reductions in serum-autoantibody titers, splenic autoantibody-secreting cells, germinal centers and the splenic T helper (Th)17 cell population. Neutralization of interleukin-17 prevented arthritis development in specific-pathogen-free K/BxN mice due to a direct effect of this cytokine on B cells to inhibit germinal center formation. The systemic immune-system deficiencies of the GF animals reflected a loss of Th17 cells from the small-intestinal lamina-propria in the absence of gut microbiota. Introduction of a single gut-residing species, segmented filamentous bacteria, into GF K/BxN animals reinstated the lamina-propria Th17 compartment, and arthritis rapidly ensued. Thus, a single commensal microbe, via its ability to promote a specific Th-cell subset, can drive an autoimmune disease.
The Immunology Interest Group
Triggering murine arthritis by a single commensal microbe