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  • NICHD Advisory Council - September 2010
    • - NICHD (2010/11/18)
    • - Category : National Advisory Child Health and Human Development Council
    To help achieve the goals of the Institute, the NACHHD Council is charged with advising, consulting with, and making recommendations to the NICHD director on matters relating to the research and research support activities and functions of the Institute.

    NICHD Advisory Council - September 2010

  • Probing the Potential of Human Pluripotent Stem Cells
    • - William Lowry, PhD, UCLA (2010/11/18)
    • - Category : NCRM Interview Lectures
    NCRM (NIH Center for Regenerative Medicine) Lecture

    Bill Lowry grew up in Seattle, WA and received his B.S. from the University of Washington in 1996. He then moved to New York to do his graduate work in signal transduction and cell biology with Xin-Yun Huang at Cornell Medical College in the fall of 1997. Bill then went across the street to work with Elaine Fuchs at the Rockefeller University in 2002 where he studied the mechanisms of quiescence and activation in stem cells of the Epidermis. In the summer of 2006 Bill joined the Department of Molecular, Cell and Developmental Biology at UCLA to explore adult stem cells and embryonic development. Bill holds the Maria Rowena Ross Term Chair in Cell Biology, and is supported by the NIH, March of Dimes, CRCC, and JCCF.

    Probing the Potential of Human Pluripotent Stem Cells

  • National Advisory Allergy and Infectious Diseases Council - September 2010 (NIH-Only)
    • - Dr. Anthony S. Fauci, Director, NIAID and Dr. Kathryn Zoon, Director, Division of Intramural Research, NIAID (2010/11/18)
    • - Category : NIAID Council (NIH Only)
    The National Advisory Allergy and Infectious Diseases Council provide second-level peer review of grant applications in its closed session. In the videocast open session presentations from the Institute Director and the Director, Division of Intramural Research will be given.

    National Advisory Allergy and Infectious Diseases Council - September 2010 (NIH-Only)

  • Strategies or Cognitive Translation from Mouse to Human: Some Examples from Alzheimers Disease, Huntingtons Disease, and Schizophrenia
    • - Timothy J. Bussey, PhD, University of Cambridge, UK (2010/11/18)
    • - Category : Neuroscience
    Dr. Busseys lab is interested in the neurobiology of visual learning, memory and perception. Their research is conducted at two different levels of brain organization, the anatomical systems and neural network levels. The former is concerned with brain structures and their function and relationship to one another. The latter is concerned mainly with neocortical circuitry and the action of neurotransmitters. These two levels are, they think, the appropriate ones at which to begin to address the two ???big questions??? in which they are interested, namely How are visual memory and perception organized in the brain? and What are the mechanisms of visual memory and perception in the brain?

    The research carried out in the CSNLab centres around two fundamental questions: How is visual cognition organized in the brain? And what are the mechanisms of visual cognition in the brain? These pure research questions about the intact brain are complemented by a single ???big question??? pertaining to damaged brains: How can we better understand the effects of brain damage and pathology, with a view toward therapy? They are working toward an answer to these questions through a programme of theoretically-driven experimental research using both healthy subjects and brain-damaged populations. Major areas of research are Alzheimers disease, Schizophrenia and Huntingtons disease.The CSNLab has been funded by grants from the Alzheimer???s Research Trust, BBSRC, Wellcome Trust, MRC and the High Q Foundation, and operates under the auspices of the MRC Wellcome Trust Behavioural and Clinical Neuroscience Institute.

    NIH Neuroscience Seminar Series

    Strategies or Cognitive Translation from Mouse to Human: Some Examples from Alzheimers Disease, Huntingtons Disease, and Schizophrenia

  • AIDS Research Advisory Committee - September 2010 (NIH Only)
    • - Division of AIDS, NIAID (2010/11/18)
    • - Category : AIDS Research Advisory Committee (NIH Only)
    Joint meeting of the NIAID Council AIDS Subcommittee and the AIDS Research Advisory Committee

    AIDS Research Advisory Committee - September 2010 (NIH Only)

  • TRACO: Clinical Trials
    • - J. Janik (2010/11/18)
    • - Category : TRACO
    For more information, visit
    http://ccr.cancer.gov/careers/traco.asp

    TRACO: Clinical Trials

  • TRACO: Small Molecule Inhibitors
    • - D. Auld (2010/11/18)
    • - Category : TRACO
    For more information, visit
    http://ccr.cancer.gov/careers/traco.asp

    TRACO: Small Molecule Inhibitors

  • Translational Health Disparities Course: Module 2 - Application of Data, Measurement Models, and Evaluation Methods in Addressing Population Health and Health Disparities
    • - National Institute on Minority Health and Health Disparities (2010/11/18)
    • - Category : Health Disparities
    After attending this module, participants will be able to: describe the importance of data on race, ethnicity, socioeconomic status, neighborhood effects, and other factors; illustrate the use of quantitative and qualitative methodologies in health disparities research; understand the concepts of grading population health and measuring health status; and understand current issues in measurement, evaluation, and analysis and interpretation of data.

    Translational Health Disparities Course: Module 2 - Application of Data, Measurement Models, and Evaluation Methods in Addressing Population Health and Health Disparities

  • Clinical Trials and Translational Research Advisory Committee (CTAC) Meeting - September 2010
    • - NCI Coordinating Center for Clinical Trials (CCCT) (2010/11/18)
    • - Category : Clinical Trials and Translational Research Advisory Committee
    The CTAC is an external oversight committee, governed by the provisions of the Federal Advisory Committee Act that advises on the NCI-supported national clinical and translational research enterprises, including both intramural and extramural research. The committee is chaired by the NCI Director and members include leading authorities in clinical trials and translational research.

    Clinical Trials and Translational Research Advisory Committee (CTAC) Meeting - September 2010

  • The von Hippel-Lindau Hereditary Cancer Syndrome: Insights into Oxygen Sensing and Cancer (NIH-Only)
    • - William G. Kaelin, Jr., M.D., Dana-Farber Cancer Institute and Harvard Medical School (2010/11/18)
    • - Category : NCI CCR Grand Rounds (NIH Only)
    William G. Kaelin Jr., M.D., is a Professor in the Department of Medicine at the Dana-Farber Cancer Institute and at the Brigham and Womens Hospital, Harvard Medical School, where he currently serves as Associate Director, Basic Science, for the Dana-Farber/Harvard Cancer Center. He obtained his undergraduate and M.D. degrees from Duke University and completed his training in internal medicine at the Johns Hopkins Hospital, where he served as chief medical resident. He was a clinical fellow in medical oncology at the Dana-Farber Cancer Institute and later a postdoctoral fellow in the laboratory of David Livingston, during which time he was a McDonnell Scholar. Dr. Kaelin is a member of the American Society of Clinical Investigation and the American College of Physicians. He recently served on the National Cancer Institute Board of Scientific Advisors, the AACR Board of Trustees, and the Institute of Medicine National Cancer Policy Board. He is a recipient of the Paul Marks Prize for cancer research from the Memorial Sloan-Kettering Cancer Center, the Richard and Hinda Rosenthal Prize from the AACR, and a Doris Duke Distinguished Clinical Scientist award. In 2007 he was elected to the Institute of Medicine. In 2010, Dr. Kaelin was elected to the National Academy of Sciences and was a recipient of the 2010 Canada International Gairdner Award.

    A Howard Hughes Medical Investigator since 1998, Dr. Kaelin???s research seeks to understand how, mechanistically, mutations affecting tumor-suppressor genes cause cancer. His laboratory is currently focused on studies of the VHL, RB-1, and p53 tumor suppressor genes. His long-term goal is to lay the foundation for new anticancer therapies based on the biochemical functions of such proteins. His work on the VHL protein helped to motivate the eventual successful clinical testing of VEGF inhibitors for the treatment of kidney cancer. Moreover, this line of investigation led to new insights into how cells sense and respond to changes in oxygen, and thus has implications for diseases beyond cancer, such as anemia, myocardial infarction and stroke.

    NCI???s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. CME credit available via sign-up sheets in the lecture hall and at designated video-bridge sites only.

    The von Hippel-Lindau Hereditary Cancer Syndrome: Insights into Oxygen Sensing and Cancer (NIH-Only)

  • FGF Signaling in Vertebrate Embroyogenesis: How Sprouty Genes Help Get It Right
    • - Dr. Gail Martin, University of California, San Francisco School of Medicine (2010/11/18)
    • - Category : Special
    UCSFs Dr. Gail Martin will discuss FGF signaling in vertebrate embryogenesis.

    Dr. Martins research is focused on the signaling mechanisms that control organogenesis in the vertebrate embryo, including development of the limbs, kidneys, and teeth. She is particularly interested in the role of fibroblast growth factors (FGFs) in these fundamental processes. Dr. Martin will describe her work in a mouse model on the role of Sprouty genes -- negative inhibitors of FGF signaling -- in vertebrate organ development. She and her colleagues recently found that defects in Sprouty disrupt orientation of the cell division plane. (See the abstract for Dr. Martin???s lecture: http://www.nidcr.nih.gov/NewsAndFeatures/Announcements/Martinabstract.htm).

    Dr. Martin is Professor and Vice Chair, Department of Anatomy, at the University of California, San Francisco School of Medicine. She earned her doctorate in molecular biology from the University of California, Berkeley and did postdoctoral work at University College, London. Dr. Martin has received numerous honors and awards, including the E.G. Conklin Medal from the Society for Developmental Biology, and the Pearl Meister Greengard Prize from the Rockefeller University. She has been elected to the American Academy of Arts and Sciences and the National Academy of Sciences. Dr. Martin has also served as the president of the Society for Developmental Biology.

    FGF Signaling in Vertebrate Embroyogenesis: How Sprouty Genes Help Get It Right

  • Lunch and Learn Parenting Seminar: Home Alone
    • - Kelly Rollins, M.A., Lifework Strategies Inc. (2010/11/18)
    • - Category : Parenting
    All children develop and mature at different rates, so how do you know when your child is ready to stay home alone? Attend this seminar to discuss how to raise responsible children, steps you can take to prepare your child to stay home alone, how to assess your child???s readiness, evaluate sibling relationships, and tips for effective communication.

    Acrobat Slides

    http://does.ors.od.nih.gov/childcare

    Lunch and Learn Parenting Seminar: Home Alone

  • Functional Analysis of XPE and XPD Proteins in Regard to the Phenotype of Xeroderma Pigmentosum Patients
    • - Dr Kiyoji Tanaka, Osaka University (2010/11/18)
    • - Category : DNA Repair
    The DNA Repair Interest Group is concerned with all forms of DNA damage and repair. As a major defense against environmental damage to cells DNA repair is present in all organisms examined including bacteria, yeast, drosophila, fish, amphibians, rodents and humans. The members of the DNA Repair Interest Group perform research in areas including DNA repair enzymology and fine structure, mutagenesis, gene and cell cycle regulation, protein structure, and human disease.

    Acrobat Slides

    For more information, visit the
    DNA Repair Interest Group

    Functional Analysis of XPE and XPD Proteins in Regard to the Phenotype of Xeroderma Pigmentosum Patients

  • NIH Hispanic Heritage Month Program 2010 - The Origins of American Medicine: The Great Encounter of Indigenous, African and European Cultures
    • - Dr. Eloy Rodriguez, Cornell University (2010/11/18)
    • - Category : Hispanic Heritage Observance (NIH Only)
    Please join the NIH in celebration of Hispanic Heritage Month, when we recognize the 2010 National Theme ???Heritage, Diversity, Integrity and Honor: The Renewed Hope of America???. The NIH Office of Equal Opportunity and Diversity Management (OEODM) and the NIH Hispanic Employment Committee (HEC) will welcome Dr. Eloy Rodriguez, Cornell University who will present the: The Origins of American Medicine: The Great Encounter of Indigenous, African and European Cultures.

    In his presentation, Dr. Rodriguez will discuss the use of natural drug extracts by the ancient Aztecs to treat ???breast tumors???, the use of animals to determine drug efficacy, to the creation of original Pan-American ???African-Latina-Indigenous??? medicinal cuisines made from medical foods from Africa, Caribbean, Mexico and South America.

    NIH Director, Dr. Francis S. Collins, has been invited to provide welcome remarks. Introducing the speaker will be Dr. Nora Volkow, Director, NIDA, and providing closing remarks is Mr. Lawrence N. Self, Director, OEODM.

    NIH Hispanic Heritage Month Program 2010 - The Origins of American Medicine: The Great Encounter of Indigenous, African and European Cultures

  • Does Your Research Raise Security Concerns? - Strategies for Promoting Responsible Research in the Life Sciences
    • - Office of Science Policy, Office of the Director, NIH (2010/11/18)
    • - Category : Special
    Advances in the life sciences have the potential to transform our world. From the discovery of novel antimicrobial compounds to the emerging technologies of synthetic biology, life sciences research will lead to new approaches to address human health, environmental and agricultural challenges. However, the same research and technologies that hold such immense promise can, in the wrong hands, be misused to pose a threat to public health and national security. Such research is often called "dual use research." The webcast will include a discussion of dual use research within the context of antimicrobial resistance issues and synthetic biology, as well as various approaches to manage risks associated with dual use research.

    Effective global dialogue on concerns and issues regarding dual use life sciences research is essential to achieving an effective balance between public health priorities and national security concerns. This international Webcast is the second in a series of internet-based meetings aimed at engaging the international community by region.

    http://oba.od.nih.gov/biosecurity/internationalwebcast_europe2010.html

    Does Your Research Raise Security Concerns? - Strategies for Promoting Responsible Research in the Life Sciences

  • NIH Blue Ribbon Panel - September 2010
    • - Office of the Director (2010/11/18)
    • - Category : NIH Blue Ribbon Panel
    The purpose of this notice is to inform the public about a meeting of the NIH Blue Ribbon Panel to Advise on the Risk Assessment of the National Emerging Infectious Diseases Laboratories (NEIDL) at Boston University Medical Campus.

    This meeting is the third in a series of public meetings between the Blue Ribbon Panel and the National Research Council Committee on Technical Input (NRC Committee) to review and discuss the ongoing supplementary risk assessment study being conducted for the Boston University NEIDL.

    http://nihblueribbonpanel-bumc-neidl.od.nih.gov/

    NIH Blue Ribbon Panel - September 2010

  • History, Guidance, and Framework for Ethical Clinical Research - 2010 (Session 1)
    • - Christine Grady, Susan E. Lederer and Heidi Gertner (2010/11/18)
    • - Category : Bioethics
    Ethical and Regulatory Aspects of Clinical Research

    Course Objectives

    By the end of this course, participants will be able to:
    • Utilize a systematic framework for evaluating the ethics of a clinical research protocol.
    • Apply appropriate codes, regulations, and other documents governing the ethical conduct of human subject research to their own research.
    • Discuss controversial issues relating to human subject research, including Phase 1 research, randomization, children in research, international research, etc.
    • Identify the critical elements of informed consent and strategies for implementing informed consent for clinical research.
    • Describe the purpose, function, and challenges of IRBs.
    • Appreciate the experience of human subjects who have participated in research protocols.
    For more information, visit
    http://www.bioethics.nih.gov/hsrc/index.shtml

    History, Guidance, and Framework for Ethical Clinical Research - 2010 (Session 1)

  • CC Grand Rounds (1) Sequencing Human Genomes Circa 2010 (2) Clinical Annotation of Genomes: Challenges and Opportunities
    • - Eric Green, MD, PhD and Leslie Biesecker, MD (2010/11/18)
    • - Category : Clinical Center Grand Rounds
    Eric Green, MD, PhD,
    Director, NHGRI

    Leslie Biesecker, MD,
    Chief, Genetic Disease Research Branch, NHGRI

    For more information, visit
    http://www.cc.nih.gov/about/news/grcurrent.html

    CC Grand Rounds (1) Sequencing Human Genomes Circa 2010 (2) Clinical Annotation of Genomes: Challenges and Opportunities

  • SES FY 10 Performance Management Briefing (HHS-Only)
    • - Ms. Andrea Burckman, Director, Executive and Scientific Resources Division, Department of Health and Human Services (2010/11/18)
    • - Category : HHS Only
    This briefing is provided to assist executives and their rating officials in documenting FY 10 ratings on the Executive/SES Performance Plan (Form HHS-740).

    SES FY 10 Performance Management Briefing (HHS-Only)

  • The Evolution of Primate Color Vision
    • - Dr. Jeremy Nathans (2010/11/18)
    • - Category : Wednesday Afternoon Lectures
    This lecture will cover the molecular genetics of human color vision, and the way in which evolutionary changes at the receptor level have shaped the different color vision capacities of different species as well as differences in color vision among individuals within our own species.

    Lecture Objectives:
    1. Understand the main themes in the history of color vision research;
    2. Understand the way in which gene rearrangements produce variant human red-green color vision;
    3. Understand how genetically engineered mice have contributed to research on primate color vision.
    The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    The Evolution of Primate Color Vision