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  • CLIC4: How the Multifunctional Protein Impacts Tumor Cell Growth, Angiogenesis and the Formation of a Cancer Stroma (NIH Only)
    • - Stuart H. Yuspa, M.D., NCI, NIH (2010/11/18)
    • - Category : NCI CCR Grand Rounds (NIH Only)
    Dr. Yuspa received his B.S. from Johns Hopkins University and his M.D. from the University of Maryland Medical School. He completed his internship and residency at the Hospital of the University of Pennsylvania and is Board certified in Internal Medicine. He has been a senior investigator at the NCI since 1972. In 1975 he was named as the Chief of the In Vitro Pathogenesis Section of the Laboratory of Experimental Pathology and in 1981 as Chief of the Laboratory of Cellular Carcinogenesis and Tumor Promotion. In 2006, with the merger of three Laboratories, he is now the co-Chief of the Laboratory of Cancer Biology and Genetics. From 1996 until 2006 he was a Deputy Director of the Division of Basic Sciences and then the Center for Cancer Research, NCI. In 2002, he received the outstanding mentor award for NCI. Among his other honors are the Lila Gruber Award of the American Academy of Dermatology, the Charles Heidelberger Memorial Cancer Research Award, and the Clowes Award from the American Association for Cancer Research. In 2007 he received the Lifetime Achievement Award of the American Skin Association for his contributions to research on cutaneous biology and cutaneous cancer. Dr. Yuspa is a fellow of the American Association for the Advancement of Science and the author of more than 395 publications in the fields of carcinogenesis and epithelial differentiation.

    NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. CME credit given via sign-up sheet in lecture hall and at designated video-bridge sites.

    CLIC4: How the Multifunctional Protein Impacts Tumor Cell Growth, Angiogenesis and the Formation of a Cancer Stroma (NIH Only)

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  • Scientific Management Review Board Meeting - September 2010 (Day 1)
    • - Office of the Director, NIH (2010/11/18)
    • - Category : Scientific Management Review Board
    The Scientific Management Review Board was authorized by the NIH Reform Act of 2006 and signed into law by the President in January 2007. The NIH Reform Act provides certain organizational authorities to HHS and NIH officials regarding NIH institutes and centers and the Office of the Director. The purpose of the Scientific Management Review Board is to advise HHS and NIH officials on the use of those organizational authorities.

    For more information, visit
    http://smrb.od.nih.gov

    Scientific Management Review Board Meeting - September 2010 (Day 1)

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  • Clinical Trials: Past, Present and Future - Day 2
    • - NHLBI/NIH (2010/11/18)
    • - Category : Conferences
    This is a two-day workshop of NHLBI, Sept 13-14, 2010 at Rock 2, Bethesda, MD

    Clinical Trials: Past, Present and Future - Day 2

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  • SES Leadership Development Forum - September 2010 (HHS Only)
    • - Bill Corr, Kathleen Sebelius, Ned Holland, Vivek Kundra, Carol Bonosaro, John Berry, Nancy-Ann DeParle, Nancy Sutley, Jeffrey Zients and Denise Wells (2010/11/18)
    • - Category : HHS Only
    For the first time this year, Administration and Department officials speak to Senior Executive Service members at the Department of Health and Human Services to provide updates on the President？？？s and Secretary？？？s priorities. Featuring exciting speakers including Secretary Kathleen Sebelius, Deputy Secretary Bill Corr, and White House officials, this program is the leading training event of the year for HHS executives

    Speakers, in order of their appearance, include: Deputy Secretary Bill Corr; Secretary Kathleen Sebelius; Ned Holland (Assistant Secretary for Administration); Vivek Kundra (U.S. Chief Information Officer), Carol Bonosaro, (President, Senior Executives Association); John Berry (Director, Office of Personnel Management); Nancy-Ann DeParle (Director, White House Office of Health Reform); Nancy Sutley (Chair, Council on Environmental Quality); Jeffrey Zients (Deputy Director for Management, Office of Management and Budget and Federal Chief Performance Officer); and Denise Wells (Deputy Assistant Secretary for the Office of Human Resources).

    SES Leadership Development Forum - September 2010 (HHS Only)

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  • National Advisory Research Resources Council - September 2010
    • - National Center for Research Resources (2010/11/18)
    • - Category : National Advisory Research Resources Council
    The September 14, 2010, meeting of the National Advisory Research Resources Council will feature presentations and discussion on topics including Shared Instrumentation Grants funded by the American Recovery and Reinvestment Act of 2009, translational research advances from the perspective of several NCRR grantees, as well as presentations on moving translation forward through Public Private Partnerships. In addition, NCRR staff members will present Concept Clearances for consideration and approval by Council.

    http://www.ncrr.nih.gov/about_us/advisory_council/

    National Advisory Research Resources Council - September 2010

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  • Analyzing Stem Cells within Intact Drosophila Tissues
    • - Allan Spradling, Ph.D. Director, Department of Embryology at Carnegie Institute, Washington D.C. (2010/11/18)
    • - Category : Stem Cell
    The Stem Cell Interest Group was established to enhance communication and to foster collaboration among scientists from varying disciplines interested in stem cells. Topics of interest include fundamental stem cell biology, ontogeny, gerontology, and the therapeutic potential of stem cells. The SCIG serves as an open forum for discussion and dissemination of knowledge about all aspects of stem cell biology

    For more information, visit
    http://www.hhmi.org/research/investigators/spradling_bio.html

    http://sigs.nih.gov/scig/Pages/default.aspx

    Analyzing Stem Cells within Intact Drosophila Tissues

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  • A Multilevel Strategy for Understanding and Addressing Health Disparities
    • - Richard Warnecke, Ph.D., University of Illinois at Chicago (2010/11/18)
    • - Category : BSSR Lecture Series
    Behavioral and Social Sciences Research Lecture Series

    This presentation will consider the how health disparities are defined, how the determinants of health disparities and those of population health differ and why the distinction is important. Also in considering health disparities and how it is defined, the importance of understanding the different roles of race/ethnicity and poverty or socioeconomics will be discussed. Dr. Warnecke will then examine contextual effects on disparities in breast cancer stage at diagnosis and the role of designation as medically underserved area on stage using data from our project on health disparities in Chicago. Finally, he will discuss how multilevel considerations help us understand how context may inform policy as defined in the Patient Protection and Affordable Care Act.

    A Multilevel Strategy for Understanding and Addressing Health Disparities

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  • Reparative and Regenerative Medicine: A Surgeons Perspective
    • - Dr. Michael Longaker (2010/11/18)
    • - Category : Special
    Dr. Longaker is a pediatric craniofacial surgeon at the Stanford University School of Medicine. His research focuses on the development of new approaches for restoring craniofacial form and function using a combination of stem cell- and bioengineering-based technologies. He will present early clinical data on a new device he and his colleagues developed that helps build healthy tissue while optimizing wound healing and minimizing scarring. Dr. Longaker will also speak about their efforts to use stem cells derived from a patient？？？s own adipose tissue for ？？？bedside tissue engineering.？？？ Such a strategy would involve harvesting cells from a patient, combining them with a biomimetic scaffold, and placing them back in the same patient to restore deficient or dysfunctional tissues. Finally, Dr. Longaker will talk about his recent work in a mouse model to repair cleft palate in utero. (See the abstract for Dr. Longaker？？？s lecture: http://www.nidcr.nih.gov/NewsAndFeatures/Announcements/Longaker.htm).

    http://www.nidcr.nih.gov/NewsAndFeatures/Announcements/NewSeminarSeries.htm

    Reparative and Regenerative Medicine: A Surgeons Perspective

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  • TRACO: Introduction, Lung cancer tyrosin kinase inhibitors
    • - Terry Moody and Giuseppe Giaccone (2010/11/18)
    • - Category : TRACO
    For more information, visit
    http://ccr.cancer.gov/careers/traco.asp

    TRACO: Introduction, Lung cancer tyrosin kinase inhibitors

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  • Scientific Management Review Board Meeting - September 2010 (Day 2)
    • - Office of the Director, NIH (2010/11/18)
    • - Category : Scientific Management Review Board
    The Scientific Management Review Board was authorized by the NIH Reform Act of 2006 and signed into law by the President in January 2007. The NIH Reform Act provides certain organizational authorities to HHS and NIH officials regarding NIH institutes and centers and the Office of the Director. The purpose of the Scientific Management Review Board is to advise HHS and NIH officials on the use of those organizational authorities.

    For more information, visit
    http://smrb.od.nih.gov

    Scientific Management Review Board Meeting - September 2010 (Day 2)

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  • CC Grand Rounds: (1) Developing New Therapeutic Strategies for Severe Asthma (2) Systemic Capillary Leak Syndrome (Clarksons Disease)
    • - Stewart J. Levine, MD and Kirk Druey, MD (2010/11/18)
    • - Category : Clinical Center Grand Rounds
    Stewart J. Levine, MD,
    Chief, Laboratory of Asthma and
    Lung Inflammation Pulmonary and Vascular Medicine Branch, NHLBI

    Kirk Druey, MD,
    Chief, Molecular Signal Transduction Section,
    Laboratory of Allergic Diseases, NIAID

    For more information, visit
    http://www.cc.nih.gov/about/news/grcurrent.html

    CC Grand Rounds: (1) Developing New Therapeutic Strategies for Severe Asthma (2) Systemic Capillary Leak Syndrome (Clarksons Disease)

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  • Recombinant DNA Advisory Committee (RAC) September 2010 - Day 1
    • - NIH (2010/11/18)
    • - Category : Recombinant DNA Advisory Committee
    The RAC is a technical committee whose goal is to consider the current state of knowledge and technology regarding recombinant DNA. This includes review of human gene transfer trials, and an assessment of the ability of DNA recombinants to survive in nature and the potential for transfer of genetic material to other organisms. It also considers hypothetical hazards and methods for monitoring and minimizing risks. Approximately one-third of the 15 members do not have scientific expertise but represent public interests and attitudes. This balance is intended to provide a forum for open public debate of social and scientific issues attendant to recombinant DNA research. The RAC has been overwhelmingly successful in achieving this goal.

    For more information, visit the
    Recombinant DNA Advisory Committee (RAC) Conference Web Site

    Recombinant DNA Advisory Committee (RAC) September 2010 - Day 1

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  • Protein Folding: Seeing is Deceiving
    • - Dr. George Rose (2010/11/18)
    • - Category : Wednesday Afternoon Lectures
    The protein folding problem was first recognized by Hsien Wu (1931) and Mirsky & Pauling (1936), approximately three-quarters of a century ago. The problem ？？？？？？ arguably the most significant unsolved problem in chemical biology ？？？？？？ is inherently grounded in protein thermodynamics, and thermodynamics is surely our most powerful discipline for understanding biological systems. So why does fundamental understanding of protein folding remain an unresolved question?

    In work at the NIH, Anfinsen showed that a proteins three-dimensional structure is a spontaneous consequence of its amino acid sequence in water at physiological temperature and pressure. Remarkably, under dilute solution conditions, a purified protein adopts its native fold without either the addition of energy or assistance from auxiliary cellular components (chaperones notwithstanding). The fold of the protein links the one？？？dimensional, linear world of DNA to the three-dimensional world of biological function; accordingly, protein folding is a cornerstone of life on earth. Yet, in essence, this self-assembly process lies within the province of biophysics, not cell biology.

    The classic folding paradigm, established by Anfinsen and others, has been interpreted to mean that under folding conditions, the native fold is selected from an astronomical number of conceivable alternatives by the constellation of favorable interactions between and among its amino acid sidechains. This plausible idea is entirely consistent with the characteristic close-packing seen in protein crystal structures, where it is apparent that residues distant in sequence are juxtaposed in space, presumably providing both structural stability and topological specificity. Contrary to this view, I will discuss evidence from both experiment and simulations that the overall fold is established prior to eventual sidechain close-packing. Consequently, formation of the folded, hydrogen-bonded framework and its further stabilization via sidechain locking are separable folding events, an enormously simplifying realization.

    The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    Protein Folding: Seeing is Deceiving

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  • Regulatory B10 Cells in Inflammation and Autoimmunity
    • - Thomas Tedder (2010/11/18)
    • - Category : Immunology
    Dr. Thomas Tedder has extensive training in microbiology, biochemistry, cellular immunology and molecular biology. As a graduate student with Dr. Max Cooper at the University of Alabama in Birmingham, a postdoctoral fellow with Dr. Stuart Schlossman at Harvard Medical School, as an independent investigator at Dana-Farber Cancer Institute and Harvard Medical School, and as a Professor of Immunology at Duke University Medical Center, Dr. Tedder has worked to identify human and mouse B lymphocyte-restricted and -associated cell surface molecules, and to determine their roles in lymphocyte function. Dr. Tedder has been among the first to describe and characterize regulatory B cells (B10 cells) in mice and humans and currently lists more than 10 publications on the subject. His lab has been instrumental in determining the cell surface phenotype, mechanism of action, and molecular characterization of B10 cell regulation in autoimmune disease and inflammation.

    The Immunology Interest Group

    Regulatory B10 Cells in Inflammation and Autoimmunity

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  • Recombinant DNA Advisory Committee (RAC) September 2010 - Day 2
    • - NIH (2010/11/18)
    • - Category : Recombinant DNA Advisory Committee
    The RAC is a technical committee whose goal is to consider the current state of knowledge and technology regarding recombinant DNA. This includes review of human gene transfer trials, and an assessment of the ability of DNA recombinants to survive in nature and the potential for transfer of genetic material to other organisms. It also considers hypothetical hazards and methods for monitoring and minimizing risks. Approximately one-third of the 15 members do not have scientific expertise but represent public interests and attitudes. This balance is intended to provide a forum for open public debate of social and scientific issues attendant to recombinant DNA research. The RAC has been overwhelmingly successful in achieving this goal.

    For more information, visit the
    Recombinant DNA Advisory Committee (RAC) Conference Web Site

    Recombinant DNA Advisory Committee (RAC) September 2010 - Day 2

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  • Biospecimens Bioerepositories
    • - Dr. Benjamin Greenberg and James OLeary (2010/11/18)
    • - Category : Biospecimens
    Biospecimens Interest Group

    The Unknown Unknowns of Biorepositories: Overcoming Obstacles" and "Evolving models in patient-driven biorepositories"

    http://sigs.nih.gov/biospecimens

    Biospecimens Bioerepositories

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  • State of Metabolomics Technologies in Translational Research
    • - National Center for Research Resources (2010/11/18)
    • - Category : Conferences
    Metabolomics is an emerging field with tremendous potential to advance our understanding of human health and disease and to inform the development of personalized approaches to disease prevention, diagnosis and treatment. To better understand the potential that this field offers, the trans-NIH Metabolomics Special Interest Group (SIG)is sponsoring a symposium to learn about some of the latest advances in the field. By bringing together NIH-funded metabolomics researchers with other NIH scientists, symposium organizers expect to provide insights into the following:

  • How emerging metabolomics technologies are being and can be applied specifically for translational research, and
  • Potential collaboration among NIH intramural investigators and extramural scientists supported by NIH institutes and centers.

    • State of Metabolomics Technologies in Translational Research

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  • Recombinant DNA Advisory Committee (RAC) September 2010 - Day 3
    • - NIH (2010/11/18)
    • - Category : Recombinant DNA Advisory Committee
    The RAC is a technical committee whose goal is to consider the current state of knowledge and technology regarding recombinant DNA. This includes review of human gene transfer trials, and an assessment of the ability of DNA recombinants to survive in nature and the potential for transfer of genetic material to other organisms. It also considers hypothetical hazards and methods for monitoring and minimizing risks. Approximately one-third of the 15 members do not have scientific expertise but represent public interests and attitudes. This balance is intended to provide a forum for open public debate of social and scientific issues attendant to recombinant DNA research. The RAC has been overwhelmingly successful in achieving this goal.

    For more information, visit the
    Recombinant DNA Advisory Committee (RAC) Conference Web Site

    Recombinant DNA Advisory Committee (RAC) September 2010 - Day 3

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  • Update on Reproductive Health - Controversies and Approaches to Fertility
    • - Alan DeCherney, Teresa K. Woodruff and Lawrence M. Nelson (2010/11/18)
    • - Category : Womens Health
    Womens Health Special Interest Group Lecture Intramural Program on Research on Womens Health In Collaboration with The Intramural Research Program on Reproductive and Adult Endocrinology and the NIH Inter-Institute Endocrinology Fellowship Program

    Alan DeCherney, M.D. Senior Moderator Chief, Reproductive Biology & Medicine Branch (RBMB) National Institute of Child Health and Human Development Bethesda, Maryland

    Teresa K. Woodruff, Ph.D. Thomas J. Watkins Professor of Obstetrics & Gynecology Department of Obstetrics and Gynecology Division of Fertility Preservation Feinberg School of Medicine Northwestern University Chicago, Illinois

    Lawrence M. Nelson, M.D. Investigator Section on Implantation & Oocyte Physiology National Institute of Child Health and Human Development And Board Member, NIH Intramural Program on Research on Women？？？s Health Bethesda, Maryland

    Update on Reproductive Health - Controversies and Approaches to Fertility

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  • Translational Health Disparities Course: Module 1 - Introduction to Health Disparities Research, History of Health Disparities
    • - National Institute on Minority Health and Health Disparities (2010/11/18)
    • - Category : Health Disparities
    After attending this module, participants will be able to: define and understand health disparities; recognize the complexity and multi-disciplinary aspect of health disparities; discuss emerging frameworks and concepts and their impact on health disparity measurements; understand health disparity databases and their application in tracking, detecting, understanding, reducing and eliminating health disparities.

    Translational Health Disparities Course: Module 1 - Introduction to Health Disparities Research, History of Health Disparities

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