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  • OLAO All Hands Meeting - August 2010 (NIH Only)
    • - Office of Logistics and Acquisition Operations, NIH (2010/11/18)
    • - Category : NIH Only
    Continuous Performance Improvement (CPI)

    OLAO All Hands Meeting - August 2010 (NIH Only)

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  • Moral Development and Professionalism in Medicine: Learning to Use Two Traditions of Open Ocean Navigation
    • - Inui, Thomas.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : Clinical Center Grand Rounds
    Grand Rounds for Clinical Fellows

    Thomas Inui, MD,
    Professor of Medicine; Sam Regenstrief Professor of Health Services Research; Associate Dean for Health Care Research, Indiana University School of Medicine

    Moral Development and Professionalism in Medicine: Learning to Use Two Traditions of Open Ocean Navigation

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  • Medicine Dish: CMS Electronic Health Record (EHR) Incentive Program
    • - Elizabeth Holland, CMS; Jessica Kahn, CMS; Dr. Theresa Cullen, IHS; Jim Lyon, CMS (2010/11/18)
    • - Category : CMS - Centers for Medicare & Medicaid Services
    Experts from CMS and IHS will discuss the Medicare and Medicaid EHR Incentive Program including the new regulations. Topics covered are:
    • Eligibility Requirements for the Medicare EHR Incentive Program
    • Eligibility Requirements for the Medicaid EHR Incentive Program
    • Meaningful Use Requirements for Eligible Professionals,
    • Eligible Hospitals and Critical Access Hospitals
    • Incentive Payment Amounts
    • IHS？？？ Use of Electronic Health Records and Health Information Technology

    Medicine Dish: CMS Electronic Health Record (EHR) Incentive Program

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  • Disparities in the Identification of Children with Autism Spectrum Disorders (ASDs)
    • - National Institute of Child Health and Human Development (U.S.) (2010/11/18)
    • - Category : Conferences
    Heterogeneity in Autism Spectrum Disorder (ASD) has long been recognized. There is increasing evidence that ASD？？？s are often diagnosed several years after the onset of symptoms. This pattern of delayed and sometimes missed ASD diagnosis may be exacerbated among medically underserved racial and ethnic minorities. The Interagency Autism Coordinating Committee？？？s 2009 Strategic Plan for research opportunities has identified improved screening and assessment as part of their research ？？？opportunities？？？. The strategic plan documents that need to identify ？？？sensitive and efficient clinical diagnostic tools for diagnosing ASD in widely diverse populations, including underrepresented racial and ethnic groups, females, younger and older age groups？？？. In response to this gap in research, this symposium will bring together experts in the field of ASD to discuss assessment with particular emphasis on children of diverse backgrounds. The NIH Autism Coordinating Committee was consulted on this workshop and as a result a trans-NIH planning committee was developed for this meeting/workshop.

    Disparities in the Identification of Children with Autism Spectrum Disorders (ASDs)

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  • Lost in Translation: Language Barriers, Interpreters, Communication, and Quality in Healthcare
    • - Glen Flores, MD, University of Texas Southwestern Medical Center, Childrens Medical Center of Dallas (2010/11/18)
    • - Category : Clinical Center Grand Rounds
    Grand Rounds for Clinical Fellows

    Glen Flores, MD
    FAAP, Professor of Pediatrics and Public Health; Director, Div of General Pediatrics, Judith and Charles Ginsberg Chair in Pediatrics, University of Texas Southwestern Medical Center, Childrens Medical Center of Dallas

    Lost in Translation: Language Barriers, Interpreters, Communication, and Quality in Healthcare

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  • Reprogramming Blood Cell Lineages
    • - Thomas Graf, PhD, Center for Genomic Regulation and ICREA Professor, Barcelona, Spain (2010/11/18)
    • - Category : NCRM Interview Lectures
    NCRM (NIH Center for Regenerative Medicine) Lecture

    Thomas Graf became interested in the effects of genes on differentiation early on in his career. Originally a virologist, he co-discovered several avian acute leukemia oncogenes (myc, myb and erb) and developed in vitro cell transformation systems that exhibited the same lineage specificity as in the animal. He showed that a differentiation block is an essential feature of leukemogenesis and that at least two oncogenes need to cooperate to cause acute leukemia. Using a surrogate adult stem cell system, which he developed with leukemic avian cells, he was able to reprogram committed erythroid and myeloid cells first with signal transducing agents and later with lineage specific transcription factors. This led to the discovery of the GATA-1: PU.1 paradigm and to the concept that transcription factor antagonisms and synergisms play a critical role in cell fate decisions. More recently he has shown that a single specific transcription factor can reprogram committed lymphoid cells into macrophages at surprisingly high efficiencies and short time spans. He is currently studying this model system to elucidate how one cell fate is extinguished while a new one is established.

    Thomas Graf is of Austrian-German origin and was raised in Venezuela. After doing his postdoc at Duke University he started his independent career at the Max Planck Institute in Tuebingen, before moving as a professor to the German Cancer Research Center in Heidelberg and as a Program Coordinator to the European Molecular Laboratory in Heidelberg. In 1998 he moved to the Albert Einstein College of Medicine in New York and returned to Europe in Oct. 2006. He is currently the Coordinator of the Differentiation and Cancer Programme at the Center for Genomic Regulation and an ICREA professor in Barcelona, Spain. He has received several biomedical research awards, including the Paul Ehrlich prize, helped organizing numerous conferences, is an elected member of EMBO, Academia Europaea and the Board of Directors of the International Society for Stem Cell Research (ISSCR) and serves on the editorial board of two stem cell journals.

    Reprogramming Blood Cell Lineages

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  • Human iPS Cell Biology and Engineering for Blood Disease Modeling and Treatment
    • - Linzhao Cheng, PhD (2010/11/18)
    • - Category : NCRM Interview Lectures
    NCRM (NIH Center of Regenerative Medicine) lecture

    Dr. Cheng serves as the Associate Director for Basic Research in the Hematology Division. Dr. Linzhao Cheng is a founding member of Stem Cell Program in the Johns Hopkins Institute for Cell Engineering (ICE), established in 2003. He is also a faculty member of the Graduate Training Programs in Cellular and Molecular Medicine, Human Genetics and Molecular Biology and Immunology, and several postdoctoral fellow training programs. After receiving a PhD degree in Molecular Biology and Genetics from Hopkins in 1991, Dr. Cheng has been working on stem cell research in NIH, the biotech industry and academia. He has extensive experience in several types of stem cells including human hematopoietic stem cells (HSC), mesenchymal stem cells/marrow stromal cells (MSC), embryonic stem (ES) cells and induced pluripotent stem (iPS) cells.

    Dr. Cheng？？？s laboratory is working on human stem cell biology and engineering, and their applications in regenerative medicine for curing blood diseases. One of objectives is to understand genetic and epigenetic regulation of cell fate determination in hematopoiesis. His group currently focuses on using human pluripotent stem such as iPS cells from healthy donor and patients, including those with targeted or corrected mutations, to investigate human stem cell biology and diseases.

    Human iPS Cell Biology and Engineering for Blood Disease Modeling and Treatment

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  • CC Grand Rounds: (1) Diabetes Risk in the Workplace: NHLBIs "Keep the Beat" Worksite Wellness Program (2) Heart Disease: Risk Factors and Race
    • - Richard O. Cannon, III, MD, and Anne E. Sumner, MD (2010/11/18)
    • - Category : Clinical Center Grand Rounds
    Richard O. Cannon, III, MD,
    Clinical Director, NHLBI

    Anne E. Sumner, MD,
    Tenure-Track Investigator, Clinical Endocrinology Branch,
    Division of Intramural Research, NIDDK

    For more information, visit
    http://www.cc.nih.gov/about/news/grcurrent.html

    CC Grand Rounds: (1) Diabetes Risk in the Workplace: NHLBIs "Keep the Beat" Worksite Wellness Program (2) Heart Disease: Risk Factors and Race

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  • Skills Desirable for Senior Scientific Research Leaders (NIH-Only)
    • - Dr. Robert Wiltrout, CCR-NCI, Dr. Richard Nakamura, NIMH, Dr. Michele Evans, NIA, Dr. Michael Gottesman, Director, Intramural Research. (2010/11/18)
    • - Category : NIH Only
    The goals of the workshop are to promote a better understanding of the scientific governance structures in place at the NIH and how it varies between ICs and discuss factors considered for selection of a senior research leader (e.g. Scientific Director, or Lab or Branch Chief).

    Skills Desirable for Senior Scientific Research Leaders (NIH-Only)

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  • The Secret Lives of Stem Cells: Genomics and Epigenomics of Pluripotency
    • - Jeanne Loring, PhD, The Scripps Research Institute, La Jolla, California (2010/11/18)
    • - Category : NCRM Interview Lectures
    NCRM (NIH Center for Regenerative Medicine) lecture

    Jeanne Loring, PhD is a Professor and the founding Director of the Center for Regenerative Medicine at The Scripps Research Institute in La Jolla, California. Dr. Loring has held research and management positions at biotechnology companies including Hana Biologics, GenPharm International, Molecular Dynamics, and Incyte Genomics, and was most recently the Co-Director of one of the countrys first NIH-funded Stem Cell Centers, at the Burnham Institute for Medical Research, and the founder of a human embryonic stem cell (hESC)-based company.

    Dr. Loring served as chair of an NIH clinical neuroscience study section, co-chair of NIH Neuroscience Blue Print and NIH Regenerative Medicine Road Map Workshops, and she is a member for the Bill and Melinda Gates Foundation Regulatory and Ethics Board and the board of the University of Massachusetts Stem Cell Bank and Registry.

    Dr. Loring has studied hESCs for more than a decade, and her basic research focuses on discovering the molecular basis of pluripotency and differentiation. She is developing an ethnically diverse panel of iPSCs for drug toxicity screening and works in collaboration with clinical researchers on translational projects, including efforts to prevent rejection of stem cell-derived transplants by inducing immune tolerance, understanding the developmental dysfunction underlying Fragile X/autism, and development of stem cell therapies for arthritis and Alzheimer disease. Her recent publications include the first single nucleotide-level DNA methylation map comparing undifferentiated and differentiated hESCs, the generation of the first Yoruba (Nigerian) iPSC line, and a study showing the lack of ethnic diversity in existing hESC and iPSC lines. She also publishes articles on the ethical and legal issues involved in human stem cell research.

    Dr. Loring was director of two of the NIH Human Embryonic Stem Cell Training Courses and now directs one of the largest stem cell training programs in the country. She authored a popular laboratory manual for human stem cell research (Human Stem Cell Manual: A Laboratory Guide; Elsevier/Academic Press). She is a frequent speaker at town hall meetings, ethics symposia, and educational events for non-scientists, and is featured in a video presentation on the growth of ？？？Stem Cell Tourism,？？？ the dubious practice of offering unproven stem cell ？？？therapies？？？ to desperate victims of incurable disease
    http://www.youtube.com/watch?v=SgHBi1y1KG8

    The Secret Lives of Stem Cells: Genomics and Epigenomics of Pluripotency

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  • Technical Assistance VideoCast for RFA-RR-10-007
    • - Elaine Collier, NCRR, NIH (2010/11/18)
    • - Category : Special
    Technical Assistance VideoCast for RFA-RR-10-007 Clinical and Translational Science Coordinating Center

    Technical Assistance VideoCast for RFA-RR-10-007

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  • ALS-associated structural perturbation of Cu/Zn superoxide dismutase and strategies for protein stabilization
    • - Jeffrey Agar, Ph.D., Department of Chemistry, Brandeis University (2010/11/18)
    • - Category : Proteomics
    NIH Proteomics Interest Group Seminar Series

    Mutations in the gene encoding Cu/Zn-Superoxide dismutase (SOD1) cause a subset of familial ALS (fALS), through an unknown toxic mechanism. We performed H/D exchange on 13 ALS-associated SOD1 variants and have identified structural defects shared by every fALS SOD1 variant tested. A longstanding question is whether post-translational modifications of wild-type SOD1 could cause sporadic ALS. Using SOD1 purified from human nervous tissue we identified post-translational modifications that affect protein structure to a greater extent than some mutations. We designed secondary rescue mutations to prevent some of these modifications, and these mutants completely reverse the toxicity of ALS-associated mutants. Finally, we present first generation compounds that target various disease-associated SOD1 structural modifications, including compounds that result in unprecedented protein stabilization.

    ALS-associated structural perturbation of Cu/Zn superoxide dismutase and strategies for protein stabilization

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  • The National Cancer Advisory Board Meeting - September 2010 (Day 1)
    • - NCI (2010/11/18)
    • - Category : National Cancer Advisory Board
    The 155th meeting of the National Cancer Advisory Board

    The National Cancer Advisory Board Meeting - September 2010 (Day 1)

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  • The National Cancer Advisory Board Meeting - September 2010 (Day 2)
    • - NCI (2010/11/18)
    • - Category : National Cancer Advisory Board
    The 155th meeting of the National Cancer Advisory Board

    The National Cancer Advisory Board Meeting - September 2010 (Day 2)

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  • NIH Health and Wellness Expo 2010 - Natcher Main Auditorium
    • - Dr. Debbie Norris, Lance Breger and Nicole Hollis (2010/11/18)
    • - Category : Focus on You Wellness
    The NIH is pleased to announce the inaugural NIH Health and Wellness Expo presented by the Office of Research Services, Division of Amenities and Transportation Services; the NIH Health and Wellness Council; and, the Recreation and Welfare Association and its Fitness Center Program.

    This event supports: the President？？？s Initiative on a Healthier Federal Workforce; the HHS Healthy People 2010 and 2020; the Presidents Council for Physical Fitness, Sports and Nutrition; and, the HealthierFeds Physical Activity Challenge.

    The event is free and open to the entire NIH community and will feature a wide range of activities including: health screenings, fitness assessments and classes, demonstrations, speakers, and a wide variety of wellness and health information provided by the Institutes and partners at NIH.

    11:00am ？？？ 11:30am ？？？ Opening Remarks

    11:30am ？？？ 11:50am ？？？ Evolving from a Disease Model to a Health Model for Health Care, Dr. Debbie Norris

    12:00pm ？？？ 12:15pm ？？？ Tab Dance Demo

    12:30pm ？？？ 12:50pm ？？？ Kick Start Your Health: Small Steps to Big Results, Lance Berger

    1:00pm ？？？ 1:15pm ？？？ Aikido Demo

    1:25pm ？？？ 1:45pm ？？？ Set Your Path to Fitness: Goal Setting & How to Overcome Setbacks

    1:55pm ？？？ 2:10pm ？？？ Taekwondo Demo

    2:20pm ？？？ 2:40pm ？？？ Going Beyond the Headlines: Sodium & Omega-3s

    For further information go to:
    http://dats.ors.od.nih.gov/wellness

    NIH Health and Wellness Expo 2010 - Natcher Main Auditorium

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  • Great Teachers: Transplantation Neurology: An Evolving Spectrum of Diagnostic Dilemmas
    • - Amy A. Pruitt, MD (2010/11/18)
    • - Category : Clinical Center Grand Rounds
    Contemporary Clinical Medicine: Great Teachers

    Amy A. Pruitt, MD, Associate Professor of Neurology, Department of Neurology, University of Pennsylvania School of Medicine

    For more information, visit
    http://www.cc.nih.gov/about/news/grcurrent.html

    Great Teachers: Transplantation Neurology: An Evolving Spectrum of Diagnostic Dilemmas

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  • NIH Health and Wellness Expo 2010 - Natcher Delegate Room D
    • - Ashley Sky Litecky, Megan Nechanicky, Wylie Belasik and Angela Atwood Moore (2010/11/18)
    • - Category : Focus on You Wellness
    The NIH is pleased to announce the inaugural NIH Health and Wellness Expo presented by the Office of Research Services, Division of Amenities and Transportation Services; the NIH Health and Wellness Council; and, the Recreation and Welfare Association and its Fitness Center Program.

    This event supports: the President？？？s Initiative on a Healthier Federal Workforce; the HHS Healthy People 2010 and 2020; the Presidents Council for Physical Fitness, Sports and Nutrition; and, the HealthierFeds Physical Activity Challenge.

    The event is free and open to the entire NIH community and will feature a wide range of activities including: health screenings, fitness assessments and classes, demonstrations, speakers, and a wide variety of wellness and health information provided by the Institutes and partners at NIH.

    For further information go to:
    http://dats.ors.od.nih.gov/wellness/

    Chapters:

    NIH Health and Wellness Expo 2010 - Natcher Delegate Room D

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  • Effect of GCS-100, a Polysaccharide Derived from Citrus Pectin, on Lymphoma Cells
    • - Dr. Linda Baum, UCLA School of Medicine (2010/11/18)
    • - Category : OCCAM Monthly Lecture Series
    The NCIs Office of Cancer Complementary and Alternative Medicine (OCCAM) invites you to view its monthly lecture series.

    With the goal of informing the National Cancer Institute (NCI) community about the variety of ongoing research in cancer and complementary and alternative medicine (CAM), NCIs Office of Cancer Complementary and Alternative Medicine (OCCAM) has created a monthly lecture series on cancer CAM. These hour long lectures, occurring from 10 a.m. - 11 a.m. on the second Wednesday of each month, will feature a fifty minute presentation on a cancer CAM topic and allow ten minutes for questions.

    For more information, visit
    http://www.cancer.gov/cam/news_lectures.html

    Effect of GCS-100, a Polysaccharide Derived from Citrus Pectin, on Lymphoma Cells

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  • 1st International Workshop on XMRV: Q&A Wrap-up Session
    • - Stuart LeGrice and John Coffin; Virology Education (2010/11/18)
    • - Category : Special
    This scientific conference has assembled an international group of scientists, physicians and epidemiologists to present and discuss, in a public forum, the latest XMRV studies on a range of topics including virus-host interactions, cell type tropism, mode of transmission, animal models, and diagnostic assay development.

    This Web cast Q&A wrap-up session will touch on the latest developments in the field in order to evaluate the state of our knowledge, address controversies, and develop an understanding between experts that will help direct future research.

    This workshop is co-sponsored by the NIH and will be organized by Virology Education.

    For more information, visit
    http://www.virology-education.com/index.cfm/t/Program/vid/1FFCB7B8-FB88-C1D2-92C420E3BCEB0FB0

    1st International Workshop on XMRV: Q&A Wrap-up Session

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  • Clinical Trials: Past, Present and Future - Day 1
    • - NHLBI/NIH (2010/11/18)
    • - Category : Conferences
    This is a two-day workshop of NHLBI/NIH: Sept 13-14, 2010 at Room 9112/9116, Rock2, Bethesda, MD

    Clinical Trials: Past, Present and Future - Day 1

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