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  • Core Curriculum Part 1: Funding Mechanisms (HHS Only)
    • - Chuck Selden (2011/02/02)
    • - Category : Core Curriculum (HHS Only)
    Extramural research activities may be supported by any one of three main mechanisms: grants, contracts and cooperative agreements. A mechanism is a particular type of funding transaction used at the NIH. In general, with grants, investigators are responsible for developing the concepts, methods, and approach for a research project. With contracts, the DHHS awarding unit is responsible for establishing the detailed requirements. With cooperative agreements, both the awarding unit and the recipient have substantial responsibility. The objective for this training is for the trainee to understand the major classes of funding mechanisms and learn a set of skills for answering the question: ？？？Which funding mechanism(s) do I use to facilitate support of this research need?？？？

    For more information, visit
    http://esa.nih.gov/oer/training/esa/esa_cores_2011.htm

    Core Curriculum Part 1: Funding Mechanisms (HHS Only)

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  • Using Omega-3 Fatty Acids to modulate prostate cancer progression
    • - Dr. Linda deGraffenried, Ph.D, University of Texas, Austin (2011/02/01)
    • - Category : OCCAM Monthly Lecture Series
    The NCIs Office of Cancer Complementary and Alternative Medicine (OCCAM) invites you to view its monthly lecture series.

    With the goal of informing the National Cancer Institute (NCI) community about the variety of ongoing research in cancer and complementary and alternative medicine (CAM), NCIs Office of Cancer Complementary and Alternative Medicine (OCCAM) has created a monthly lecture series on cancer CAM. These hour long lectures, occurring from 10 a.m. - 11 a.m. on the second Wednesday of each month, will feature a fifty minute presentation on a cancer CAM topic and allow ten minutes for questions.

    For more information, visit
    http://www.cancer.gov/cam/news_lectures.html

    Using Omega-3 Fatty Acids to modulate prostate cancer progression

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  • Linking Patients to Research Data and Biospecimens Using a Global Unique Patient Identifier
    • - Matthew J. McAuliffe, PhD, Dan Hall, MBA, Dorit S. Berlin, PhD (2011/02/01)
    • - Category : Biospecimens
    The NIH Biospecimens Interest Group (BIG) will sponsor a seminar and discussion focusing on, ？？？Linking Patients to Research Data and Biospecimens Using a Global Unique Patient Identifier.？？？

    Presenters include:
    • Matthew J. McAuliffe, PhD (Chief, Biomedical Imaging Research Services Section (BIRSS), CIT, NIH)
    • Dan Hall, MBA (NDAR Project Science Manager, National Database for Autism Research, NIMH, NIH)
    • Dorit S. Berlin, PhD (Principal Investigator, NIGMS Human Genetic Cell Repository, Coriell Institute for Medical Research)
    For more information, visit
    http://sigs.nih.gov/biospecimens

    Linking Patients to Research Data and Biospecimens Using a Global Unique Patient Identifier

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  • NICHD Advisory Council Meeting - January 2011
    • - NICHD (2011/01/29)
    • - Category : National Advisory Child Health and Human Development Council
    To help achieve the goals of the Institute, the NACHHD Council is charged with advising, consulting with, and making recommendations to the NICHD director on matters relating to the research and research support activities and functions of the Institute.

    NICHD Advisory Council Meeting - January 2011

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  • ICCVAM Workshop Series on Best Practices for Regulatory Safety Testing: Assessing the Potential for Chemically Induced Allergic Contact Dermatitis
    • - Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) (2011/01/29)
    • - Category : Conferences
    The objective of this workshop is to assist participants in gaining a practical understanding of the theory and application of available alternative methods that can be used to meet regulatory testing requirements for assessing the potential for chemically induced allergic contact dermatitis (ACD) and that can also minimize animal use and avoid pain and distress.

    ICCVAM Workshop Series on Best Practices for Regulatory Safety Testing: Assessing the Potential for Chemically Induced Allergic Contact Dermatitis

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  • Using C. elegans to Deconstruct Touch and Pain Sensation
    • - Miriam Goodman, Ph.D., Stanford University (2011/01/28)
    • - Category : Neuroscience
    The ability to detect touch is conserved from echinoderms to humans. It relies on specialized mechanoreceptor neurons that vary in their sensitivity and association with accessory structures. Despite its importance and conservation across taxa, very little is known about how touch works. Dr. Goodmans lab seeks to improve understanding by studying the nematode C. elegans, a simple animal that has only 30 mechanoreceptor neurons. Their work focuses on two classes of mechanoreceptor neurons: the 6 non-ciliated touch receptor neurons (TRNs) that detect touch applied to the body wall and the paired ciliated ASH neurons that detect noxious mechanical stimuli applied to the nose. Genetic analysis has revealed ion channel genes needed for TRN and ASH function. To learn the precise cellular function of such channel proteins and to investigate their gating mechanisms, they combine genetic dissection with in vivo electrophysiology and biomechanical analysis. The picture emerging from their recent work is that touch activates similar ion channels in the nonciliated TRNs and the ciliated ASH neurons, which differ by 100-fold in their sensitivity to external force. Challenges for the future include understanding the basis for differences in sensitivity and the biophysics of mechanotransduction channel gating.

    NIH Neuroscience Seminar Series

    Using C. elegans to Deconstruct Touch and Pain Sensation

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  • Quantitative Proteomics and Metaprotein Expression Modeling: Discovery and Verification of Expression Model for Predicting Differential Treatment Response of HCV Patients
    • - Arthur Moseley, Duke University (2011/01/28)
    • - Category : Proteomics
    NIH Proteomics Interest Group Seminar Series

    Arthur Moseley is the Director of Proteomics for the School of Medicine at Duke University. In this position he is responsible for the development and application of proteomic technologies for open (unbiased) qualitative and quantitative UPLC/MS/MS analyses using high resolution, accurate mass tandem mass spectrometers coupled with ultra-performance nanoscale capillary liquid chromatographs, and for targeted protein quantitation using UPLC/MS/MS with multiple reaction monitoring (MRM). The Proteomics Core Facility has the capability for support a diverse range of research projects, from studies in Basic Sciences Departments through support of clinical trials for Clinical Sciences Departments. The clinical support has included biomarker discovery in studies in the areas of oncology, immunology, and infectious disease. Prior to his position at Duke University, he managed mass spectrometry laboratories at GSK for sixteen years, and for the last six years of these years he lead a transnational laboratory (US/UK) dedicated to proteomic biomarker discovery. Dr. Moseley received his MS in Physical Chemistry from North Carolina State University, and his PhD in Analytical Chemistry from the University of North Carolina at Chapel Hill. His dissertation, under the direction of Professor Jim Jorgenson, addressed the coupling of nanoscale separation with tandem mass spectrometry for the analysis of peptides and proteins.

    Quantitative Proteomics and Metaprotein Expression Modeling: Discovery and Verification of Expression Model for Predicting Differential Treatment Response of HCV Patients

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  • Recombinant DNA Advisory Committee (RAC) December 2010 - Day 1
    • - NIH (2011/01/25)
    • - Category : Recombinant DNA Advisory Committee
    The RAC is a technical committee whose goal is to consider the current state of knowledge and technology regarding recombinant DNA. This includes review of human gene transfer trials, and an assessment of the ability of DNA recombinants to survive in nature and the potential for transfer of genetic material to other organisms. It also considers hypothetical hazards and methods for monitoring and minimizing risks. Approximately one-third of the 15 members do not have scientific expertise but represent public interests and attitudes. This balance is intended to provide a forum for open public debate of social and scientific issues attendant to recombinant DNA research. The RAC has been overwhelmingly successful in achieving this goal.

    For more information, visit the
    http://oba.od.nih.gov/rdna/rdna.html


    NOTE: This event is not streamed by CIT VIDEOCAST. For technical support please contact Granicus Customer Services Department.

    Granicus Customer Care link - http://www.granicus.com/Services/Contact/Contact-Granicus.aspx
    Granicus Customer Services Portal ？？？ http://www.granicus.com/csp
    Business Hours Support
    (5:00am ？？？ 6:00pm PST)
    Phone: 415-357-3618
    Toll Free: 877-889-5495
    After Hours: 415-655-2414
    Email: customercare@granicus.com

    Recombinant DNA Advisory Committee (RAC) December 2010 - Day 1

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  • Recombinant DNA Advisory Committee: Safety Symposium - December 2010 (Day 2)
    • - NIH (2011/01/25)
    • - Category : Recombinant DNA Advisory Committee
    The RAC is a technical committee whose goal is to consider the current state of knowledge and technology regarding recombinant DNA. This includes review of human gene transfer trials, and an assessment of the ability of DNA recombinants to survive in nature and the potential for transfer of genetic material to other organisms. It also considers hypothetical hazards and methods for monitoring and minimizing risks. Approximately one-third of the 15 members do not have scientific expertise but represent public interests and attitudes. This balance is intended to provide a forum for open public debate of social and scientific issues attendant to recombinant DNA research. The RAC has been overwhelmingly successful in achieving this goal.

    For more information, visit the
    http://oba.od.nih.gov/rdna/rdna.html


    NOTE: This event is not streamed by CIT VIDEOCAST. For technical support please contact Granicus Customer Services Department.

    Granicus Customer Care link - http://www.granicus.com/Services/Contact/Contact-Granicus.aspx
    Granicus Customer Services Portal ？？？ http://www.granicus.com/csp
    Business Hours Support
    (5:00am ？？？ 6:00pm PST)
    Phone: 415-357-3618
    Toll Free: 877-889-5495
    After Hours: 415-655-2414
    Email: customercare@granicus.com

    Recombinant DNA Advisory Committee: Safety Symposium - December 2010 (Day 2)

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  • CTSA Pre-submission VideoCast - January 2011
    • - NCRR (2011/01/25)
    • - Category : Special
    NCRR and other NIH staff will explain the goals and objectives of the CTSA program and answer questions. The current CTSA RFA (RFA-RM-10-020) has several changes compared with the previous RFA (RFA-RM-10-001), which was released January 26, 2010. All prospective applicants (including 2007 CTSA Awardees) are invited to submit questions, in advance to Dr. Anthony Hayward, and during the VideoCast by using the live event feedback form.

    CTSA Pre-submission VideoCast - January 2011

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  • Ins and outs of the lysosomal chloride conductance: biophysics to biology for an organellar anion transporter
    • - Joseph Mindell, M.D., Ph.D. (2011/01/25)
    • - Category : NIH Directors Seminars
    Directors Seminar Series

    Dr. Mindell received his B.S. degree in Molecular Biophysics and Biochemistry from Yale University in 1986. In 1994 he received his M.D. and Ph.D. degrees from the Albert Einstein College of Medicine, where he worked with Alan Finkelstein studying the structure and function of ion channels formed by diphtheria toxin. After a residency in internal medicine at Brigham and Womens Hospital, Dr. Mindell did post-doctoral work with Chris Miller at Brandeis University; there he focused on structural and functional characterization of ClC-type chloride channels using cryoelectron microscopy and other approaches. Dr. Mindell joined NINDS as an investigator in 2002. His laboratory is using a combination of structural and functional approaches to answer mechanistic questions regarding ClC channels and other anion transport proteins.

    The Membrane Transport Biophysics Unit focuses on understanding the physical principles governing membrane-protein function. Our major model proteins are members of the ClC family of anion-transport proteins. Use a combination of biochemical and physiological approaches, we seek to understand the protein elements mediating chloride selectivity as well as those involved in regulating the passage of ions across the membrane. Recent developments, including the determination of a high-resolution structure of a bacterial ClC, have allowed us to focus our attention on particular regions of these proteins, which we explore with combinations of biochemistry, genetic mutation, and electrical recordings.

    Ins and outs of the lysosomal chloride conductance: biophysics to biology for an organellar anion transporter

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  • IACC Committee Meeting - January 2011
    • - Thomas Insel, M.D. (2011/01/25)
    • - Category : Interagency Autism Coordinating Committee
    Meeting of the IACC

    IACC Committee Meeting - January 2011

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  • COPE: Improving Outcomes for Premature Infants and Parents
    • - Dr. Bernadette Melnyk, Arizona State University College of Nursing and Health Innovation (2011/01/25)
    • - Category : Special
    The lecture, which will be an annual event, is part of the year-long observation of the Institute？？？s first 25 years at the NIH, commemorating the contributions of nursing science to solving some of America？？？s most important health challenges.

    Dr. Bernadette Melnyk will give the NINR Inaugural Directors Lecture. Dr. Melnyk is an internationally recognized expert in theory-based intervention research and evidence-based practice as well as in child and adolescent mental health. Her Creating Opportunities for Parent Empowerment (COPE) intervention program to improve outcomes among critically ill children, premature infants, and parents has been implemented by hospitals and insurers nationwide. Her extramural research and educational funding totals more than 11 million dollars and her record of scholarship includes over 150 publications, two books, and numerous distinguished awards.

    COPE: Improving Outcomes for Premature Infants and Parents

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  • Applying to Medical School
    • - Dr. William J. Higgins, OITE Pre-Professional Advisor (2011/01/25)
    • - Category : Career Development/OITE
    Make your application to medical (or dental) school the best it can be. This workshop will address deciding where to apply, tips for completing the application, asking for references, and developing your timeline.

    For more information, visit
    https://www.training.nih.gov

    Applying to Medical School

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  • Demystifying Medicine - Helicobacter phylori: the organism, peptic ulcers and cancer
    • - Dr. Steven Czinn, University of Maryland, and Dr. Scott Merrell, USUHS (2011/01/25)
    • - Category : Demystifying Medicine
    This event will include the presentation of patients, pathology, diagnosis and therapy context of major disease problems and current research. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components presented by NIH staff and invitees. These seminar series are primarily directed toward PhD students, clinicians and program managers. All students, fellows and staff are welcome, as well.

    For more information, visit
    http://www1.od.nih.gov/oir/DemystifyingMed

    Demystifying Medicine - Helicobacter phylori: the organism, peptic ulcers and cancer

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  • ICCVAM Workshop Series on Best Practices for Regulatory Safety Testing: Assessing the Potential for Chemically Induced Eye Injuries
    • - Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) (2011/01/25)
    • - Category : Conferences
    The objective of this workshop is to assist participants in gaining a practical understanding of the theory and application of available alternative methods that can be used to meet regulatory testing requirements for assessing the potential for chemically induced eye injuries and that can also minimize animal use and avoid pain and distress.

    ICCVAM Workshop Series on Best Practices for Regulatory Safety Testing: Assessing the Potential for Chemically Induced Eye Injuries

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  • Human Genetics in the Next Generation: Rare Variants and Common Cures
    • - David Goldstein, Ph.D., Director of the Center for Human Genome Variation at Duke University (2011/01/25)
    • - Category : Wednesday Afternoon Lectures
    Genome wide association studies have proven successful in identifying regions of the genome that contain gene variants that influence both common diseases and drug responses. In most instances however it has not been possible to track these associations down to the causal variants that are responsible, and this greatly reduces the utility of these findings in drug development and disease prediction.

    Sequencing based strategies on the other hand offer the promise of identifying the precise mutations and the genes they influence that are responsible both for predisposition to common disease and drug responses. I outline how sequencing the entire genomes of patients is likely to change our understanding of human disease genetics over the next several years. I first contrast human traits that are and are not strongly influenced by common variants. I next review the role of rare copy number variants in schizophrenia and epilepsy and outline a framework for discovery of other kinds of rare high penetrant risk factors focusing on whole genome sequencing and evaluation of candidate variants through a combination of a) testing for cosegregation in multiplex families, b) bioinformatic analyses, and c) frequency comparison in large case control cohorts. Finally, I discuss what I see as the near term opportunities for discovery genetics for both disease predisposition and drug response. The over riding message is of cautious optimism. Although the translational impact of genomic analysis of common diseases and drug responses has been modest to date, there are good reasons to believe that the tools are in place for a more rapid translation of genomic discoveries.

    The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    Human Genetics in the Next Generation: Rare Variants and Common Cures

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  • Cell biology of antigen presentation by dendritic cells
    • - Ira Mellman (2011/01/25)
    • - Category : Immunology
    The Immunology Interest Group (IIG) organizes activities designed to promote information exchange and interactions among NIH scientists interested in the field of immunology, broadly defined. Interactions are facilitated via weekly meetings on current topics as well as an Annual Immunology Retreat.

    The Immunology Interest Group

    Cell biology of antigen presentation by dendritic cells

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  • 6th NIH GIST Clinic Invitational Lecture
    • - Dr Heidi Kong (2011/01/25)
    • - Category : Special
    GIST Clinic Lecture

    For more information, visit
    http://www.pediatricgist.cancer.gov

    6th NIH GIST Clinic Invitational Lecture

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  • Surgeon Generals Call to Action to Support Breastfeeding
    • - U.S. Department of Health and Human Services Office of the Surgeon General (2011/01/25)
    • - Category : Special
    Surgeon General Regina Benjamin will announce the Call to Action to Support Breastfeeding. This new call to action outlines 20 actions to remove some of the obstacles faced by women who want to breastfeed their babies. If you have trouble logging into the Web cast, a listen-only telephone list is available. Please call 1888-989-4985 and enter pass code 8760843.

    For more information, visit
    http://www.surgeongeneral.gov

    NOTE: This event is not streamed by CIT VIDEOCAST. For technical support please contact Granicus Customer Services Department.

    Granicus Customer Care link - http://www.granicus.com/Services/Contact/Contact-Granicus.aspx
    Granicus Customer Services Portal ？？？ http://www.granicus.com/csp
    Business Hours Support
    (5:00am ？？？ 6:00pm PST)
    Phone: 415-357-3618
    Toll Free: 877-889-5495
    After Hours: 415-655-2414
    Email: customercare@granicus.com

    Surgeon Generals Call to Action to Support Breastfeeding

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