전체 8345
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- Structure and Function of BRCT Phosphoprotein Binding Domains in the DNA Damage Response
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- - Dr Scott Williams, NIEHS (2010/12/24)
- - Category : DNA Repair
- The DNA Repair Interest Group is concerned with all forms of DNA damage and repair. As a major defense against environmental damage to cells DNA repair is present in all organisms examined including bacteria, yeast, drosophila, fish, amphibians, rodents and humans. The members of the DNA Repair Interest Group perform research in areas including DNA repair enzymology and fine structure, mutagenesis, gene and cell cycle regulation, protein structure, and human disease.
Acrobat Slides
For more information, visit the
DNA Repair Interest Group
Structure and Function of BRCT Phosphoprotein Binding Domains in the DNA Damage Response
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- 12th Meeting of the Clinical Trials and Translational Research Advisory Committee
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- - NCI Coordinating Center for Clinical Trials (2010/12/23)
- - Category : Clinical Trials and Translational Research Advisory Committee
- The Committee shall provide advice to the Director, NCI, NCI Deputy Directors, and the Director of each NCI Division on the NCI-supported national clinical trials enterprise to build a strong scientific infrastructure by bringing together a broadly developed and engaged coalition of stakeholders involved in the clinical trials process.
http://deainfo.nci.nih.gov/advisory/ctac/ctacmeetings.htm
12th Meeting of the Clinical Trials and Translational Research Advisory Committee
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- GMAC - ERA Tips to Empower You: Handy Tips on Using QVR (HHS Only)
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- - Thorsten A. Fjellstedt, Ph.D (2010/12/23)
- - Category : GMAC (HHS Only)
- The Query View Report (？？？QVR？？？) System is a web-based decision support system for Extramural Staff, which allows access to all applications and grants in the IMPACII database. This seminar will provide helpful tips for maximizing QVR？？？s usefulness in your daily grants management activities.
For more information, visit
http://odoerdb2-1.od.nih.gov/gmac/gmac/trs_main.html
GMAC - ERA Tips to Empower You: Handy Tips on Using QVR (HHS Only)
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- IL15: A checkpoint in tissue immunity
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- - Bana Jabri (2010/12/22)
- - Category : Immunology
IL15: A checkpoint in tissue immunity
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- Contemporary Clinical Medicine: Great Teachers: ANCA Vasculitis: From Eponym to Possible Cause
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- - Ronald Falk, MD, University of North Carolina, Chapel Hill (2010/12/21)
- - Category : Clinical Center Grand Rounds
- CC Grand Rounds
http://www.cc.nih.gov/about/news/grcurrent.html
Contemporary Clinical Medicine: Great Teachers: ANCA Vasculitis: From Eponym to Possible Cause
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- Interviewing for Graduate School
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- - Sharon L. Milgram, PhD (2010/12/21)
- - Category : Career Development/OITE
- This workshop will discuss the interview process from the perspective of both those doing the interviewing and the applicant. The discussion will cover what to expect, how to prepare, what kinds of questions you might be asked, and appropriate interview behavior. Postbacs who attend will be given priority to meet in small groups for mock interviews.
http://www.training.nih.gov
Interviewing for Graduate School
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- The Challenges of Bringing "omics" to the Clinic - Lessons for Molecular Diagnostics
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- - Dr. Richard Klausner, Former NCI Director (2010/12/21)
- - Category : Wednesday Afternoon Lectures
- The explosion of technologies that allow us to measure many thousands of data points simultaneously has created new research tools and has been very much at the heart of the new systems biology. These technologies have had a huge impact in discovery and offer great promise in the potential of next generation diagnostics, biomarkers and drug discovery and personalized medicine. despite the promise, the translation of these technologies into clinically useful tools has been disappointingly slow. This gap between research tools and clinical tools is the basis for my talk and I will explore one example of how the gap has been breached in oncology molecular diagnostics and explore the lessons therein.
The Challenges of Bringing "omics" to the Clinic - Lessons for Molecular Diagnostics
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- Trauma Spectrum Conference (Day 1)
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- - ORWH (2010/12/19)
- - Category : Conferences
- Mission: To enhance and promote continued collaboration among the Department of Defense, National Institutes of Health, Department of Veterans Affairs and key stake holders such as researchers, academics, other federal partners and military and civilian personnel dedicated to improving the lives of Servicemembers, Veterans and their families.
Purpose: This years conference will focus on emerging polytrauma research and its impact on Servicemembers, Veterans, and their families to:- Discuss emerging research for traumatic brain injury, psychological health conditions, vision and eye injuries, hearing injuries, extremity injuries and amputations.
- Present emerging treatments in support of polytrauma recovery and reintegration.
- Inform practice regarding the needs of caregivers and families dealing with a polytrauma patient.
- Address health, psychosocial, gender, cultural, geographic and other disparities that may impact diagnosis, care, treatment and recovery concerns around polytrauma.
- Raise awareness for future development of treatments, practices, and policies.
- Federal partners will promote research and evidence based practice around polytrauma through enhanced coordination and collaboration across agencies.
- Researchers will update participants with the available research on polytrauma recovery and reintegration.
- Participants and presenters will work together to identify areas for future research on polytrauma and its impact on Servicemembers, Veterans, their families, and caregivers.
- Presenters will identify and present information on existing polytrauma programs.
Trauma Spectrum Conference (Day 1)
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- Putting Together the Human Brain: Lessons from Disease
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- - Joseph Gleeson, , PH.D., University of California (2010/12/19)
- - Category : Neuroscience
- Neuroscience Seminar Series
Dr. Gleesons laboratory studies the genetic and cell biological basis of human brain development, focusing on two major conditions that are important causes of disease in humans. The first is disordered neuronal migration. Neurons that populate the cerebral cortex are not born within the gray matter, but instead they are born along the lining of the lateral ventricle. These young neurons then migrate great distances to achieve proper positioning within the correct lamina of the developing cortex. When this is disrupted, cortical gyri and sulci are malformed and the cortex is improperly laminated. The other condition is congenital ataxia, where humans are born with severe balance disturbances and malformations of the cerebellum. They work on the most common of these disorders known as Joubert syndrome where the cerebellare completely absent. They identified the first genes for this condition, which encode novel proteins. There is evidence to suggest that in this condition the major axonal tracts fail to form properly, suggesting that the genes also play important roles in axonal guidance. The lab is currently studying the molecular basis of Joubert syndrome, identifying additional Jouberin genes, and working to understand the role of these genes in brain development.
http://neuroseries.info.nih.gov
Putting Together the Human Brain: Lessons from Disease
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- DDM Seminar Series: Love Your Job Every Day! (NIH Only)
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- - Simon Sinek, Author of Start with Why: How Great Leaders Inspire Everyone to Take Action (2010/12/19)
- - Category : DDM Seminar Series (NIH Only)
- Click here to respond to a survey about this DDM Seminar. Information will be used to evaluate the program and improve future seminars.
On behalf of Colleen Barros, Deputy Director for Management (DDM), the NIH Training Center is pleased to announce the first seminar of the 2010-2011 DDM Seminar Series featuring Simon Sinek. He will address the NIH community in a presentation on employee engagement titled "Love Your Job Every Day!" Simon Sinek is leading a movement to inspire people to do the things that inspire them. His goal is to help as many people as possible understand why they do what they do so that they are better able to only do the things that inspire them. The most efficient way to do this is by helping organizations understand their ？？？Why？？？ so that everyone who works for those organizations goes home every night feeling inspired and fulfilled.
A trained ethnographer and the author of "Start With Why: How Great Leaders Inspire Everyone to Take Action," Sinek has held a life-long curiosity for why people and organizations do the things they do. Studying the leaders and companies that make the greatest impact in the world and achieve a more lasting success than others, he discovered the formula that explains how they do it. Sinek？？？s simple idea, The Golden Circle, is grounded in the biology of human decision-making and is changing how leaders and companies think and act.
During this interactive presentation, Simon will pose and address thought-provoking questions such as:
- Why is it a short week but it feels like a 90-hour week?
- Why did I work 90 hours and yet feel like the week flew by?
- How do I stay positive every single day?
The DDM Seminar Series is open to all NIH employees and there is no need to pre-register for the event. Participation will be recorded in the HHS Learning Management System (LMS) for those that sign-in and attend.
For more information, visit
http://www.ddmseries.od.nih.gov
Be an interactive participant by submitting questions and comments via the "Live Feedback" feature!
DDM Seminar Series: Love Your Job Every Day! (NIH Only)
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- Forensic Science Careers
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- - Gerald LaPorte, Policy Program Manager of the Office of Investigative & Forensic Sciences, National Institute of Justice; Michael D. Coble, Forensic Biologist of the Applied Genetics Group, National Institute of Standards and Technology; Moses S. Schanfield, Professor of Forensic Science and Anthropology, Department of Forensic Science, George Washington University at MVC; Dave Pauly, Professor of Applied Forensic Science, Methodist University, FBI National Academy - Session 195; Amy Wong, Director of the Northern Laboratory, VA Department of Forensic Science; Lisa M. Calandro, Director of the Forensic Science Applications, Applied Biosystems/Life Technologies. (2010/12/17)
- - Category : Career Development/OITE
- Advances in scientific technologies in examining crime scenes have turned forensic science into a high demand and rapidly growing career field. The forensic science form a vital part of the entire justice and regulatory system and is a rewarding career where the love of science can be applied to the good of society, public health, and public safety. Forensic scientists may work for federal, state, and local government, forensic laboratories, medical examiners offices, hospitals, universities, industrial forensics groups, toxicology laboratories, police departments, medical examiner/coroner offices, or as independent forensic science consultants. This seminar will elucidate wide-ranging career options for those interested in pursuing a career in forensic science. The panel consists of forensic scientists from various fields such as government, academia, and industry, and includes scientists with working experience at the United States Secret Service Laboratory and the Armed Forces DNA Identification Laboratory, as well as a member of the famed Vidocq Society, an unusual, exclusive crime-solving organization, whose members collectively evaluate, investigate, and solve ？？？cold case？？？ homicides and unsolved deaths officially brought to them. Attendees of this seminar will have the opportunity to learn more about the exciting careers and what did it take for the panelists to get into their current positions. This event is sponsored by FELCOM.
Forensic Science Careers
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- CC Grand Rounds: (1) Principles of Pharmacogenomics and Its Applications in Clinical Practices (2) Applications of Pharmacogenomics in Drug Development and Regulatory Review: Recent Relabeling of Drug Products
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- - David A. Flockhart, MD, PhD and Shiew-Mei Huang, PhD (2010/12/17)
- - Category : Clinical Center Grand Rounds
- CC Grand Rounds
David A. Flockhart, MD, PhD,
Chief, Division of Clinical Pharmacology, Department of Medicine,
Professor of Medicine, Medical Genetics and Pharmacology, Indiana University School of Medicine
Shiew-Mei Huang, PhD,
Deputy Director, Office of Pharmacology, US Food and Drug Administration
http://www.cc.nih.gov/about/news/grcurrent.html
CC Grand Rounds: (1) Principles of Pharmacogenomics and Its Applications in Clinical Practices (2) Applications of Pharmacogenomics in Drug Development and Regulatory Review: Recent Relabeling of Drug Products
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- Moving Forward in the Efficient Management and Use of Core Facilities - Day 2
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- - NCRR (2010/12/16)
- - Category : Conferences
- During the past year, NIH and the extramural research community have been focused on bringing improvements to accessing and managing research core facilities. At this year？？？s conference, presenters will provide updates on the actions NIH has taken to address some of the concerns raised at the conference ？？？The Efficient Management and Use of Core Facilities,？？？ held in 2009, and to more deeply explore the key challenges to managing and accessing core facilities. Specifically, this conference will focus on:
- Training for core directors
- Registries of core facilities
- Software for core management
- Guidance on compliance with OMB Circular A-21
A core facility is a centralized shared resource that provides access to instruments, technologies, services, and expert consultation to biomedical or behavioral investigators. NIH funds a significant number of core facilities at institutions throughout the United States. In an era of limited resources and focus on efficiencies, NCRR is committed to bringing the community together to discuss common challenges and to facilitate solutions.
http://www.palladianpartners.com/NCRRCoreFacilities/
Moving Forward in the Efficient Management and Use of Core Facilities - Day 2
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- Genes, Environment, and Development: An Interdisciplinary Approach to Understanding Alcohol Misuse
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- - Danielle M. Dick, Ph.D., Virginia Commonwealth University (2010/12/16)
- - Category : BSSR Lecture Series
- BSSR Lecture Series
NIH Behavioral and Social Sciences Seminar Series
Alcohol dependence is a complex behavioral disorder, known to be influenced by both genetic and environmental factors, with trajectories of risk behavior that manifest long before the eventual development of problems. This talk will present findings across a variety of complementary research areas, including twin studies, gene identification projects, and longitudinal, community-based samples, all of which have the goal of contributing to our understanding of how genetic and environmental influences impact the development of alcohol use disorders. Twin studies allow us to characterize the nature of (latent) genetic and environmental influences on behavior. Data from the Finnish twin studies, population-based epidemiological samples with assessments spanning ages 12 to 26, will be presented that demonstrate the changing influence of genetic effects on alcohol use and related phenotypes as a function of the environment, and across adolescence into young adulthood. A second line of investigation focuses on identifying specific genes involved in alcohol use and related phenotypes. Data will be presented from two of the largest on-going gene identification projects for alcohol dependence: the Collaborative Study of the Genetics of Alcoholism, and the Irish Affected Sib-Pair Study of Alcohol Dependence. Thirdly, in order to understand how genetic influences result in the eventual alteration of risk for psychiatric and substance use outcomes, it will be necessary to characterize the risk associated with identified genes using community-based samples of individuals studied longitudinally. To this end, data will be presented from the Child Development Project, a community-based study of ~500 children followed annually from age 5-25; the Mobile Youth Study, an on-going community-based sample of children ages 10-18 from high-risk, impoverished neighborhoods in Mobile, Alabama; and the Avon Longitudinal Study of Parents and Children, an epidemiological cohort of ~10,000 children enrolled when their mothers were pregnant and assessed yearly -- prenatally through young adulthood. Highlights from these projects will be presented to illustrate how, through interdisciplinary research, we are gaining a greater understanding of how genetic and environmental influences contribute to the risk for alcohol related problems, and how that risk manifests across development.
Genes, Environment, and Development: An Interdisciplinary Approach to Understanding Alcohol Misuse
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- James B. Herrick Symposium - Sickle Cell Disease Care and Research: Past, Present and Future (Day 2)
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- - Sponsors: NHLBI, NHGRI, NIDDK, NICHD, NINDS, NLM, ORDR, NCMHD (2010/12/16)
- - Category : Conferences
- In 1910, Dr. James B. Herrick, an attending physician at Presbyterian Hospital and professor of medicine at Rush Medical College in Chicago, Illinois, published an article on the case of an anemic West Indian patient1. Herrick？？？s clinical and laboratory findings of the patient？？？s "peculiar elongated and sickle-shaped？？？ red blood corpuscles represent the first description of sickle cell anemia in Western medical literature.
To mark the centennial of the publication of Herrick？？？s case report, experts will examine the history and societal impact of the disease and place the disease within the context of existing and future basic, translational and clinical research. Invited speakers will address unresolved challenges and the ongoing burden of the disease. They will also focus on genetic, cellular and clinical perspectives across the lifespan, as well as existing therapeutic options and possible future treatments.
James B. Herrick Symposium - Sickle Cell Disease Care and Research: Past, Present and Future (Day 2)
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- Bioinformatics approaches for sharing biospecimens
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- - NIH Biospecimen Interest Group (2010/12/16)
- - Category : Biospecimens
- A lecture open to the NIH community as well as the public on how bioinformatics can be used to share and collect data about biospecimens.
Bioinformatics approaches for sharing biospecimens
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- Memory CD8 T Cells: Issues of Quantity, Quality and Location
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- - David Masopust (2010/12/16)
- - Category : Immunology
Memory CD8 T Cells: Issues of Quantity, Quality and Location
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- SEER PI Meeting - November 2010 (Day 1)
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- - Surveillance Research Program - SEER (2010/12/16)
- - Category : Conferences
- The SEER PI Meeting provides training and research information on cancer statistics to Cancer Tumor Registrars, Principal Investigators and personnel from the various Cancer Registries throughout the United States.
SEER PI Meeting - November 2010 (Day 1)
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- MeSH at 50 - 50th Anniversary of Medical Subject Headings
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- - Robert Braude, PhD (2010/12/16)
- - Category : Special
- The impact of the Medical Subject Headings (MeSH) vocabulary on access to biomedical information.
MeSH at 50 - 50th Anniversary of Medical Subject Headings
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- Kinyoun Lecture - Treating Auto-inflammatory Diseases with Interleukin-1 Beta Blockade
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- - Charles A. Dinarello, M.D., University of Colorado Denver (2010/12/16)
- - Category : Joseph J. Kinyoun
- 2010 Kinyoun Lecture
Dr. Charles Dinarello, who purified and cloned interleukin-1beta (IL 1beta), once known as the fever molecule, will deliver the 2010 Kinyoun Lecture on Thursday, Nov. 18, at 3 p.m. in Lipsett Amphitheater, Bldg. 10. Dinarello is professor of medicine and immunology at the University of Colorado School of Medicine and a former investigator in NIAID？？？s Laboratory of Clinical Investigation.
Dinarello？？？s talk, titled ？？？Treating Auto-inflammatory Diseases with Interleukin-1 beta Blockade,？？？ will include an overview of autoinflammatory diseases, such as type 2 diabetes mellitus and gout, and describe differences between these and autoimmune diseases. He also will discuss treatment of inflammatory diseases using IL-1beta blocking agents.
Considered one of the founding fathers of cytokine biology, Dinarello？？？s work with IL-1 helped to establish the significance of cytokines in inflammatory diseases. His recognition of the importance of IL-1 in inflammatory diseases led to the development of therapies that inhibit IL-1 and thereby reduce disease severity. These therapies include those based on the IL-1 receptor antagonist, monoclonal antibodies and soluble receptors.
Kinyoun Lecture - Treating Auto-inflammatory Diseases with Interleukin-1 Beta Blockade