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  • Training on Human Subjects Protections: Part 1 (HHS Only)
    • - Ann Hardy and Maria Stagnitto (2010/12/16)
    • - Category : ESA (HHS Only)
    This introductory session will cover basic ethical principles, human subjects protection regulations, OHRPs role, NIH policies and procedures, and staff responsibilities with a focus on practical applications to NIH grant review and administration.

    Training on Human Subjects Protections: Part 1 (HHS Only)

  • Exploring Post-translational Modifiation of the Mitochondrial Subproteome: an Expanding Role in Heart Disease
    • - Jennifer Van Eyk, Ph.D., The Johns Hopkins NHLBI Proteomics Center (2010/12/16)
    • - Category : Proteomics
    NIH Proteomics Interest Group Seminar Series

    ProtIG is an NIH Special Interest Group (SIG) that organizes seminars and workshops in relevant areas of proteomics, including talks on separation and protein identification methods, determination of post-translational modifications, protein-protein interactions, and bioinformatics and data management.

    Exploring Post-translational Modifiation of the Mitochondrial Subproteome: an Expanding Role in Heart Disease

  • NIH/AHRQ Conference on Methodological Challenges in Comparative Effectiveness Research - Day 2
    • - NIH & AHRQ (2010/12/16)
    • - Category : Conferences
    The conference will make use of case studies that pose difficult questions about what kinds of research, methods and analyses should be used to address limitations in current evidence for interventions and tests being examined by decision-making bodies. The cases will address a variety of important comparative effectiveness research questions facing U.S. researchers, care providers, health systems, and patients. This conference is being convened at a historic moment for the biomedical, clinical, biostatistical, research design and health services research communities. With the passage of the Patient Protection and Affordable Care Act (PPACA), the nation stands at a critical juncture, as it ramps up efforts to streamline the delivery of high quality healthcare, bend the cost curve and ensure improved health outcomes.

    NIH/AHRQ Conference on Methodological Challenges in Comparative Effectiveness Research - Day 2

  • Leptin Signaling Pathway Genes and Pediatric Obesity
    • - Dr. Jack Yanovski (2010/12/16)
    • - Category : NIH Directors Seminars
    NIH Director???s Seminar Series

    Leptin Signaling Pathway Genes and Pediatric Obesity

  • Probabilistic Inference in Neural Circuits: From Humans to Insects
    • - Alexandre Pouget, Ph.D., University of Rochester (2010/12/16)
    • - Category : Neuroscience
    Neuroscience Seminar Series

    A wide range of behaviors can be formalized as instances of probabilistic inferences. This includes odor recognition in insects, navigation in rodents, motor control, decision making in primates, simple arithmetic in children and monkeys, and causal reasoning in humans, to name just a few. In all cases, the probabilistic inferences involve products of distributions and marginalization. Dr. Pougets lab will show that, given the type of variability reported in neural responses, products of distributions can be implemented through linear operations over firing rates, while marginalization over Gaussian random variables requires a particular nonlinearity known as quadratic divisive normalization. Both operations are conspicuous in many neural circuits raising the possibility that seemingly unrelated behaviors could in fact rely on very similar neural mechanisms across different species.

    http://neuroseries.info.nih.gov

    Probabilistic Inference in Neural Circuits: From Humans to Insects

  • TRACO: Vaccines and Inflammation
    • - J. Morris and C. Harris (2010/12/16)
    • - Category : TRACO
    For more information, visit
    http://ccr.cancer.gov/careers/traco.asp

    TRACO: Vaccines and Inflammation

  • An APN-led Intervention for Hematopoietic Cell Transplant (HCT) (NIH Only)
    • - Marcia Grant, City of Hope Medical Center, Duarte, CA (2010/12/16)
    • - Category : NCI CCR Grand Rounds (NIH Only)
    NCI???s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. CME credit given via sign-up sheet in lecture hall and at designated video-bridge sites.

    An APN-led Intervention for Hematopoietic Cell Transplant (HCT) (NIH Only)

  • The National Cancer Advisory Board Meeting - December 2010
    • - NCI (2010/12/16)
    • - Category : National Cancer Advisory Board
    The 156th meeting of the National Cancer Advisory Board

    The National Cancer Advisory Board Meeting - December 2010

  • Preparing for the MCAT
    • - Dr. William Higgins, OITE Pre-Professional Advisor (2010/12/16)
    • - Category : Career Development/OITE
    This workshop will provide you with strategies for attacking the different sections of the MCAT. It will cover topics including how to study, deciding what to study, test taking strategies, and tips for test day.

    https://www.training.nih.gov

    Preparing for the MCAT

  • Trauma Spectrums Conference (Day 2)
    • - ORWH (2010/12/16)
    • - Category : Conferences
    Mission: To enhance and promote continued collaboration among the Department of Defense, National Institutes of Health, Department of Veterans Affairs and key stake holders such as researchers, academics, other federal partners and military and civilian personnel dedicated to improving the lives of Servicemembers, Veterans and their families.

    Purpose: This years conference will focus on emerging polytrauma research and its impact on Servicemembers, Veterans, and their families to:
    • Discuss emerging research for traumatic brain injury, psychological health conditions, vision and eye injuries, hearing injuries, extremity injuries and amputations.
    • Present emerging treatments in support of polytrauma recovery and reintegration.
    • Inform practice regarding the needs of caregivers and families dealing with a polytrauma patient.
    • Address health, psychosocial, gender, cultural, geographic and other disparities that may impact diagnosis, care, treatment and recovery concerns around polytrauma.
    • Raise awareness for future development of treatments, practices, and policies.
    Objectives:
    • Federal partners will promote research and evidence based practice around polytrauma through enhanced coordination and collaboration across agencies.
    • Researchers will update participants with the available research on polytrauma recovery and reintegration.
    • Participants and presenters will work together to identify areas for future research on polytrauma and its impact on Servicemembers, Veterans, their families, and caregivers.
    • Presenters will identify and present information on existing polytrauma programs.
    http://www.dcoe.health.mil/training/upcomingconferences.aspx

    Trauma Spectrums Conference (Day 2)

  • Personal Genomes, Environments & Traits (GET)
    • - Dr. George Church, Harvard Medical School (2010/12/16)
    • - Category : Wednesday Afternoon Lectures
    Personal Genomes, Environments & Traits (GET) : Technology for Aging, Alcohol, Allergy, Arthritis, Cancer, Cardiovascular, Developmental, Dental, Metabolic, Mental, Neurological and Sensory Health and Diversity

    Lecture Objectives:
    1. Changes in technologies for diagnostic genetics
    2. Discuss genome sequencing progress
    3. Consenting for broad Trait Data

    The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    Personal Genomes, Environments & Traits (GET)

  • Its a hard Notch life: Imposing T Cell Identity within the thymus
    • - Avinash Bhandoola (2010/12/16)
    • - Category : Immunology
    The Immunology Interest Group (IIG) organizes activities designed to promote information exchange and interactions among NIH scientists interested in the field of immunology, broadly defined. Interactions are facilitated via weekly meetings on current topics as well as an Annual Immunology Retreat.

    The Immunology Interest Group

    Its a hard Notch life: Imposing T Cell Identity within the thymus

  • TRACO: Stem Cells and Nanotechnology
    • - Bussard and McNeil (2010/12/16)
    • - Category : TRACO
    For more information, visit
    http://ccr.cancer.gov/careers/traco.asp

    TRACO: Stem Cells and Nanotechnology

  • STEP Symposium: Got Stress? Manage your energy, Prioritize your Time (HHS Only)
    • - Sheldon Cohen, Joseph J. Hurrell Jr., Susan Bowen and Barbara E. Moquin (2010/12/16)
    • - Category : STEP (HHS Only)
    We all know people in our office who seem unflappable, get all their work done, and dont work overtime. Then there are the rest of us who come in early and stay late, but were still not caught up. How can we learn to manage our energy, prioritize our activities and reduce the stress of modern life? Are there ways to change the organizational culture to reduce workplace stress? Take a break from the end-of-the-year frenzy and join us as we explore the science of stress and strategies for staying cool under pressure.

    For more information, visit
    http://odoerdb2-1.od.nih.gov/oer/training/step/step_training_20101214.htm

    STEP Symposium: Got Stress? Manage your energy, Prioritize your Time (HHS Only)

  • Cellular Reprogramming with mRNA: The Medium is the Message
    • - Luigi Warren, PhD (2010/12/16)
    • - Category : NCRM Interview Lectures
    NCRM Interview Lectures

    A key feature of the transcription factor network which controls human development is that only a tiny fraction of the network???s vast number of potential gene expression states is stable. This subset includes a few hundred states that encode and specify all the cell phenotypes arising in the mature organism and during development. An implication is that if expression of the cellular transcriptional network can be forced into a state which approaches one of these stable ???attractor??? states, the network might collapse towards the attractor, redefining cellular identity. That this is possible is demonstrated in somatic nuclear transfer, in natural and artificially-induced cell fusion, and most remarkably, in cellular reprogramming based on ectopic expression of a handful of master regulators, as in the case of induced pluripotency. What if we could modulate the levels of transcription factors simply by adding appropriate cocktails of messenger RNA to cell culture media? Then we might be able to play the transcriptional network like a keyboard, guiding cells towards any fate we chose ??? and, we could do it without leaving a mark on the genome. The demonstration that long-term administration of mRNA encoding Yamanaka factors can rapidly and efficiently turn somatic fibroblasts into pluripotent stem cells suggests that this approach will emerge as important new paradigm for future work in regenerative medicine.

    Cellular Reprogramming with mRNA: The Medium is the Message

  • James B. Herrick Symposium - Sickle Cell Disease Care and Research: Past, Present and Future (Day 1)
    • - Sponsors: NHLBI, NHGRI, NIDDK, NICHD, NINDS, NLM, ORDR, NCMHD (2010/11/19)
    • - Category : Conferences
    In 1910, Dr. James B. Herrick, an attending physician at Presbyterian Hospital and professor of medicine at Rush Medical College in Chicago, Illinois, published an article on the case of an anemic West Indian patient1. Herrick???s clinical and laboratory findings of the patient???s "peculiar elongated and sickle-shaped??? red blood corpuscles represent the first description of sickle cell anemia in Western medical literature.

    To mark the centennial of the publication of Herrick???s case report, experts will examine the history and societal impact of the disease and place the disease within the context of existing and future basic, translational and clinical research. Invited speakers will address unresolved challenges and the ongoing burden of the disease. They will also focus on genetic, cellular and clinical perspectives across the lifespan, as well as existing therapeutic options and possible future treatments.

    James B. Herrick Symposium - Sickle Cell Disease Care and Research: Past, Present and Future (Day 1)

  • Pharmacological Quiescence, DNA Repair and Radioresistance
    • - Dr Norman Sharpless, University of North Carolina (2010/11/19)
    • - Category : DNA Repair
    The DNA Repair Interest Group is concerned with all forms of DNA damage and repair. As a major defense against environmental damage to cells DNA repair is present in all organisms examined including bacteria, yeast, drosophila, fish, amphibians, rodents and humans. The members of the DNA Repair Interest Group perform research in areas including DNA repair enzymology and fine structure, mutagenesis, gene and cell cycle regulation, protein structure, and human disease.

    Acrobat Slides

    For more information, visit the
    DNA Repair Interest Group

    Pharmacological Quiescence, DNA Repair and Radioresistance

  • Grants.gov Quarterly Stakeholder Webcast - November 2010
    • - Grants.gov PMO, Philip Clark, PM (2010/11/19)
    • - Category : Grants.gov
    Grants.gov uses the quarterly webcasts to communicate the status of important program initiatives and operational status to stakeholders that include Applicants, Grantor Agencies, OMB, Congress and Third Party Vendors. The webcasts also offer stakeholders the opportunity to interact with the PMO and guests through live question and answer segments.

    Grants.gov Quarterly Stakeholder Webcast - November 2010

  • Medicine Dish: Medicare Part D and Program Updates
    • - Pam Schweitzer, IHS; Kay Pokrzywa, CMS; Roslyn Thomas, CMS; Rosie Norris, CMS; Stacey Platte, CMS; Kitty Marx, CMS; David Nolley, CMS (2010/11/19)
    • - Category : CMS - Centers for Medicare & Medicaid Services
    Experts from CMS and IHS will discuss Medicare Part D and recent Medicare program changes. Topics covered are:
    • Creditable coverage letters
    • Plan changes for 2011
    • LIS, redeeming, and reassignment
    • Medicare Open Enrollment
    • Medicare program updates
    • Demonstration of the new Medicare Plan Finder on www.medicare.gov

    Medicine Dish: Medicare Part D and Program Updates

  • Genes versus Fast Foods: Eat, Drink and Be Wary
    • - Helen Hobbs, M.D, UT Southwestern (2010/11/19)
    • - Category : Wednesday Afternoon Lectures
    Lecture Summary:
    Insufficient time has elapsed for our genomes to adapt to the caloric abundance and reduced physical activity accompanying industrialization. Diseases of dietary excess, rather than nutritional deficiency are the major causes of death and disability in the Western world. Using human genetics, we have identified new genes and sequence variations conferring susceptibility (and resistance) to metabolic disorders associated with diabetes and heart disease.

    Lecture Objectives:
    1. Review strategies used to identify genetic variants contributing to common diseases associated with dietary excess.

    2. Demonstrate role of genes involved in lipid metabolism in susceptibility (and resistance) to metabolic and cardiovascular disease.

    3. Appreciate how human genetics can provide mechanistic insights into the relationship between phenotypes and diseases.

    The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    Genes versus Fast Foods: Eat, Drink and Be Wary