전체 8345
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- Pathogen Recognition and Signaling in Innate Immunity
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- - Akira, S.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Wednesday Afternoon Lectures
- - Akira, S.
- Mammalian Toll-like receptors (TLRs) play a critical role in detection of invading pathogens as well as triggering of subsequent inflammatory and immune responses. Dr. Shizuo Akiras research has been instrumental in shaping our understanding of innate recognition by these receptors. Amongst the many major discoveries from his laboratory, his research has uncovered the role of TLR4 in the recognition of LPS; identified differential signaling by TLRs though selective use of adaptor proteins, such as MyD88 and TRIF; and described the ability of TLR9 to recognize bacterial DNA containing unmethylated CpG dinucleotides (pathogen-derived DNA) and TLR7 to recognize a derivative of imidazoquinoline, an antiviral chemical compound that is now used for treatment of genital warts caused by papilloma virus as well as single-stranded RNA of viruses, including influenza virus.
Furthermore, he recently demonstrated the role of two DExD/H box RNA helicases --- retinoic acid inducible protein-I (RIG-I) and melanoma differentiation-associated gene 5 (mda-5) --- in anti-viral responses by recognizing RNA in the cytoplasm in a TLR independent manner. Research from Dr. Akiras laboratory continues to be at the forefront of studies on recognition pathways for the induction of innate and adaptive immunity. Dont miss the opportunity to hear from this remarkable scientist.
Dr. Akira has been studying the role of Toll-like receptors (TLRs) and their signaling pathways mainly by gene targeting. He studied the molecular mechanisms of immunoglobulin gene rearrangement as a graduate student at Osaka University and for two years as a postdoctoral fellow at the University of California at Berkeley with Hitoshi Sakano. After returning to Japan, he studied IL-6 gene regulation and IL-6 signaling pathways in the laboratory of Tadamitsu Kishimoto, who discovered interleukin-6. Among his contributions, he cloned two important transcription factors involved in IL-6 signaling, NF-IL6 (also called C/EBP beta) and STAT3. In 1996, Dr. Akira left Dr. Kishimoto？？？s lab to become a professor of biochemistry at Hyogo College of Medicine. At that time he made the seminal observation that mice lacking the adaptor protein MyD88 were unresponsive to lipopolysaccharide (LPS), a major immunostimulatory component in the cell wall of Gram-negative bacteria, indicating that the LPS receptor uses MyD88 for signaling. MyD88 harbors a domain homologous to the cytoplasmic portion of IL-1 receptors and TLR family members. Therefore, he hypothesized that a member of the Toll-like receptor family was a candidate LPS receptor, and began making mice deficient in each of all members of the of TLR family. Together with Dr. Bruce Beutler？？？s findings with LPS unresponsive natural mutant mice, Dr. Akira demonstrated that TLR4 is essential for LPS responsiveness.
Dr. Akira went on to identify ligands of other TLR members using the TLR-deficient mice he had generated. In particular, he made the seminal discovery that bacterial DNA containing unmethylated CpG dinucleotides (pathogen-derived DNA) signaled via TLR9. Furthermore, he demonstrated that TLR7 recognizes a derivative of imidazoquinoline, an antiviral chemical compound that is now used for treatment of genital warts caused by papilloma virus as well as single-stranded RNA of viruses, including influenza virus.
Dr. Akira has subsequently been at the forefront of research that has resulted in major discoveries of TLR signaling and function. These include his demonstration for the first time that the signaling pathways by which individual TLRs signal differ from one another, thereby resulting in different gene expression and biological responses. Furthermore, he showed that the difference in signaling pathways among TLRs is due to selective usage of adaptor molecules, such as MyD88 and TRIF. Finally, he recently demonstrated that pathogen-derived DNA and RNA can be recognized in the cytoplasm in a TLR-independent manner, by signaling through RNA-helicases.
More information available at
http://www.jst.go.jp/erato/project/asm_P/asm_P.html
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Pathogen Recognition and Signaling in Innate Immunity
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- Holocaust Remembrance Program (HHS Only)
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- - Bayer, David.
National Institutes of Health (U.S.) (2010/11/18) - - Category : PSC Programs (HHS Only)
- - Bayer, David.
- Program Support Center
Holocaust Remembrance Program
The keynote speaker is a Holocaust Survivor, Mr. David Bayer
Sponsored by: PSC, AHRQ, FDA, HRSA, IHS, OMH, SAMHSA
Holocaust Remembrance Program (HHS Only)
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- CTSA Workshop: Accelerating the Dissemination and Translation of Clinical Research into Practice
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- - CTSA Community Engagement Workshop
National Center for Research Resources (U.S.) (2010/11/18) - - Category : Conferences
- - CTSA Community Engagement Workshop
- The CTSA Community Engagement Workshop, jointly-sponsored by the National Center for Research Resources (NCRR) and the Association for Prevention Teaching and Research (APTR), is focused on partnering with community health care providers to translate research into practice. The purpose of this workshop is to establish recommendations for academic-community collaborations and partnerships with other community programs in translating science into community based practice.
This is the first in a series of workshops to discuss and share best practices and ways in which researchers can partner with community health care providers to translate clinical research into practice. Participants will develop recommendations for academic-community collaborations and partnerships with other community programs to better facilitate translating science into community-based practice. This workshop will help to identify: 1) key enablers of successful academic-community provider partnerships; 2) effective strategies for dissemination, diffusion, and adoption of research; and 3) public and private-sector partners for collaborative translational research.
This workshop is also jointly sponsored with CDC funds that have been distributed to the Association for Prevention, Teaching, and Research.
CTSA Workshop: Accelerating the Dissemination and Translation of Clinical Research into Practice
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- Sex Matters: A Tale of Two Bones - Sexual Dimorphism in the Skeleton
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- - McGowan, Joan A.
National Institutes of Health (U.S.). Womens Health Special Interest Group. (2010/11/18) - - Category : Womens Health
- - McGowan, Joan A.
- Womens Health Special Interest Group (WHSIG)
Intramural Program on Research on Womens Health
Sponsored by the NIH Office of Intramural Research
and the NIH Office of Research on Womens Health.
Come join your fellow NIH colleagues in a scientific exchange on issues related to the biology and pathology of sex and gender differences and effects on womens health.
For more information, visit
http://orwh.od.nih.gov
Sex Matters: A Tale of Two Bones - Sexual Dimorphism in the Skeleton
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- The Molecular Basis of Memory Loss in Transgenic Models of Alzheimers Disease
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- - Ashe, Karen Hsiao.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Neuroscience
- - Ashe, Karen Hsiao.
- Dr. Ashes research addresses the molecular basis of memory loss and cognitive dysfunction in Alzheimers disease. The studies involve the creation of transgenic mouse models of Alzheimers disease in order to understand how the amyloid-？？ and tau proteins impair memory and cognition. The work has shown that the aggregates of amyloid-？？ and tau proteins which define Alzheimers disease neuropathologically do not cause cognitive deficits in mice. These investigations have led to the discovery of a form of the amyloid-？？ protein called A？？ star (A？？*) that disrupts cognitive function in mice and rats, and revealed a potential mechanism by which interactions with a neuronal receptor may impair memory.
NIH Neuroscience Seminar Series
The Molecular Basis of Memory Loss in Transgenic Models of Alzheimers Disease
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- Trans-NIH Systems Biology Workshop - 2008
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- - Zhao, Keji.
Trans-NIH Systems Biology Workshop (2010/11/18) - - Category : Structural Biology
- - Zhao, Keji.
- This is a new workshop established with the Trans-NIH Initiative in Systems Biology. The workshop is structured to promote scientific discussion and inform colleagues about work that may be related or complementary to their own research. The half-day session has six 30 minute presentations with each followed by a discussion period. Refreshments will be served during the break to encourage informal discussion. All are invited to attend and to consider presenting at future workshops.
For more information, visit
http://sysbiosig.nih.gov/workshop.html
Trans-NIH Systems Biology Workshop - 2008
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- NIH Extramural Administrative Officer Monthly Meeting - May 2008 (NIH Only)
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- - NIH (2010/11/18)
- - Category : Administrative Officer Meetings (NIH Only)
- NIH Extramural Administrative Officer Meeting
NIH Extramural Administrative Officer Monthly Meeting - May 2008 (NIH Only)
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- T Lymphocyte Signaling and Primary Immunodeficiencies: Lessons from X-linked Lymphoproliferative Disease (NIH-Only)
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- - Schwartzberg, Pamela.
National Institutes of Health (U.S.) (2010/11/18) - - Category : NCI CCR Grand Rounds (NIH Only)
- - Schwartzberg, Pamela.
- Center for Cancer Research - National Cancer Institute Grand Rounds
The primary educational objective of these seminars is to provide new information, ideas, and discussion about timely areas of research with impact on the field of oncology. A secondary educational objective is to elicit participation by individuals from all divisions of the intramural NCI, and thus facilitate more interactions among investigators and groups in the NCI.
T Lymphocyte Signaling and Primary Immunodeficiencies: Lessons from X-linked Lymphoproliferative Disease (NIH-Only)
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- Evolution and Human Genetic Diversity: Tales from Africa
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- - Tishkoff, Sarah.
National Institute of General Medical Sciences (U.S.) (2010/11/18) - - Category : Evolution and Medicine
- - Tishkoff, Sarah.
- Evolution and Medicine
The genomes of contemporary humans were shaped by evolutionary forces, such as mutation, selection, migration, and genetic drift. Because Africa plays a central role in the story of human evolution, research there is yielding a wealth of knowledge about human origins and diversity as well as a deeper understanding of evolutionary processes. Dr. Tishkoff has conducted ground-breaking research on African genetic diversity and the genetic basis of adaptation in humans.
Lecture series presented by National Institute of General Medical Sciences, the Office of Science Education, and the National Human Genome Research Institute. For more information, visit
http://www.nigms.nih.gov/News/Meetings/EvolutionSeries2008
Evolution and Human Genetic Diversity: Tales from Africa
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- Demystifying Medicine - Mini Symposium: What Does the Future Hold for Ph.D.s?
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- - Gottesman, Michael M.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Demystifying Medicine
- - Gottesman, Michael M.
- The Demystifying Medicine course finale will have presentations by Drs. Elias Zerhouni (NIH Director), Michael Gottesman (Deputy Director, OIR), Robert Balaban (Scientific Director, NHLBI) and Irwin Arias(NICHD/OD) will present their mini symposium entitled What Does the Future Hold For PhDs (and other postdoctural fellows).
Demystifying Medicine - Mini Symposium: What Does the Future Hold for Ph.D.s?
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- The 21st century Patient - A New Partnership with the Biomedical Enterprise
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- - Lappin, Debra R.
National Library of Medicine (U.S.) (2010/11/18) - - Category : Special
- - Lappin, Debra R.
- The NLM/MLA Joseph Leiter Lecture
Debra R. Lappin is a current member of the Advisory Council to the Director of the CDC, former Co-Chair of a National Partners Task Force on Partner and Public Engagement on the CDCs Health Protection Goals. She was a member of the inaugural Council of Public Representatives, the NIAMS Advisory Council, and the NLM PubMed Central Advisory Council. Ms. Lappin has participated on a number of committees at the National Academy of Sciences, including the Committee on the Organizational Structure of the NIH, which directly informed the 2006 NIH Reform Act.
The 21st century Patient - A New Partnership with the Biomedical Enterprise
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- Epstein-Barr Virus Alteration of Lymphocyte Growth
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- - Kieff, Elliott D.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Wednesday Afternoon Lectures
- - Kieff, Elliott D.
- Human viruses are responsible for about 20% of human malignancies worldwide and offer unique opportunities for early diagnosis, prevention, and therapeutic intervention. Our experiments began with the study of the fundamental mechanisms by which Epstein-Barr Virus (EPV), an important causative agent of lymphomas, Hodgkins Disease and Naso-pharyngeal carcinoma, uniquely and efficiently causes the uncontrolled proliferation and survival of normal human B lymphocytes. We have discovered that the virus uses only five genes to cause B cell proliferation. These genes encode nuclear proteins that usurp control over Notch regulated cell promoters, including the c-myc promoter, and an integral membrane protein that constitutively activates CD40 signaling pathways. We are currently investigating the genetics and biochemistry of the molecular and sub-molecular processes through which the viral proteins effect changes in cell signal transduction, transcription, growth, and survival so as to validate targets that can be used in assays to identify chemical inhibitors.
EBV is unique among human viruses in inducing continuous proliferation of B lymphocytes, the important host cell for EBV latency. In B lymphocytes, EBV encodes nuclear antigen (EBNA) and integral membrane (LMP) proteins, which induce cell cycle transit and lymphoblast proliferation. In humans with normal T cell function, immune T lymphocytes emerge in response to peptides from the EBNAs and LMPs, which are presented in the context of Class I and II MHC molecules on cell surfaces. Immune T cells kill and enforce tight control of EBV infected lymphocytes.
Ongoing projects in our lab involve: (1) Elucidation of the molecular and sub-molecular pathways by which Notch and viral proteins regulate the c-myc promoter. Structural studies of a key viral and cellular interaction site. (2) Elucidation of the molecular and sub-molecular pathways by which CD40 and a viral protein co-stimulate cell growth and survival. (3) Proteinomic and cell genetic screens for novel genes in the CD40 and viral protein NF-kB, Junk, and p38 pathways. (4) Sub-molecular mechanisms by which a viral protein permits episome replication and maintenance.
Elliott Kieff was born in Philadelphia and educated in public schools. He studied Physical Organic Chemistry at the University of Pennsylvania (BA,1963) and Medicine at Johns Hopkins (M.D.,1967). He further trained in Medicine and Microbiology at the University of Chicago. His Ph.D. research with Roizman described the bio-physical properties of the first intact Herpes Virus genomes and the relatedness between the Herpes Simplex 1 and 2 genomes. In 1971, he was appointed Assistant Professor and Director of Infectious Disease at the University of Chicago. He assembled an outstanding Infectious Disease teaching and research Program. His research focused on the Herpes Virus, which Epstein had discovered in African Burkitt Lymphomas and the Henle and Pope labs had discovered could convert human B lymphocytes to perpetually proliferating lymphoblasts (1971).
Dr. Kieff is internationally recognized for his landmark discoveries in elucidating the molecular pathogenesis of EBV infection and lympho-proliferative diseases. His trainees purified EBV, extracted and characterized the DNA and virion proteins, described the extent of virus genome transcription, mRNAs in latently infected cells and in cells replicating virus, derived the first EBV restriction endonuclease maps and first complete molecular clones of Herpes Virus DNAs (EBV), described the EBV proteins expressed in transformed lymphocytes, and evaluated the activity of these proteins expressed by gene transfer in other cells. His laboratory discovered that the EB nuclear protein-2 (EBNA2) and latent infection membrane protein 1 (LMP1) alter cell transcription, growth, and survival. Using antibodies from Pearson and Thorley-Lawson, his group identified the DNA and RNA encoding the principal EBV outer envelop glycoprotein, expressed the recombinant protein, showed that antibody to the recombinant protein neutralized EBV, and with Ellis and Scolnick, expressed the EBV glycoprotein from a VZV vaccine recombinant. In small scale GSK Phase 2 studies, secreted gp350 appears to protect against mononucleosis. In cryo-immune EM and biochemical studies, his lab showed that EBV initially enveloped at the nuclear membrane is rich in gB, whereas enveloped EBV in the cytoplasm and plasma membrane is deficient in gB and rich in gp350, indicative of a 2 stage envelopment process.
Dr. Kieff was promoted to Professor of Medicine, Microbiology, and Virology at Chicago in 1979. In 1987, his lab moved to Harvard and he became Albee Professor of Medicine, Director of Infectious Disease at the Brigham and Womens Hospital and Professor of Microbiology and Molecular Genetics. He directed the Harvard Virology Program from 1992-2005.
At Harvard, his laboratory undertook comprehensive EBV reverse genetic analyses to delineate the EBV genes, open reading frames, and amino acid sequences that are critical for cell transformation. His group elucidated the downstream cellular Notch and TNF receptor signaling pathways through which EBV nuclear proteins 2, LP, 3A and 3C and integral membrane protein LMP1 cause lymphocyte growth and survival. They also showed that EBV nuclear protein 1 mediates episome persistence through an N-terminal chromosome binding domain that can be replaced by Histone H1a or HMGIY and a C-terminal domain that mediates episome replication. His elucidation of and gene expression vectors for viral proteins expressed in transformed lymphocytes and lymphoproliferative diseases facilitated the elucidation of immune-therapeutic strategies. His more recent work has revealed molecular and submolecular targets that would interrupt EBV effects on cell growth and survival.
Dr. Kieff has mentored leading Virologists and Infectious Disease Physicians in basic research, clinical investigation, and scholarly teaching. He has served multiple terms as a Member or Chair of NIH, ACS, and Damon Runyon Study Sections. He has been an active Member of Editorial Boards including Science, Proceedings of the National Academy of Science, Journal of experimental Medicine, Journal of Virology, and Virology. He has also served as a Councilor to NIAID, a member of National Research Council advisory Boards, and a Member of American, European, and Asian Government and Foundation Scientific Review Panels. He is a Member of the American Academy of Arts and Sciences, the Institute of Medicine of the National Academy of Sciences, and of the National Academy of Sciences. He received named Professor-ships, and Scientific Awards and is President of the Association of American Physicians.
More information available at http://www.channing.harvard.edu/kieff.htm
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Epstein-Barr Virus Alteration of Lymphocyte Growth
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- The Deconstruction of Ginseng - What is the Sum of its Parts in Breast Cancer Treatment?
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- - Murphy, Laura.
National Cancer Institute (U.S.). Office of Cancer Complementary and Alternative Medicine. (2010/11/18) - - Category : OCCAM Monthly Lecture Series
- - Murphy, Laura.
- The NCIs Office of Cancer Complementary and Alternative Medicine (OCCAM) invites you to view its monthly lecture series.
With the goal of informing the National Cancer Institute (NCI) community about the variety of ongoing research in cancer and complementary and alternative medicine (CAM), NCIs Office of Cancer Complementary and Alternative Medicine (OCCAM) has created a monthly lecture series on cancer CAM. These hour long lectures, occurring from 10 a.m. - 11 a.m. on the second Wednesday of each month, will feature a fifty minute presentation on a cancer CAM topic and allow ten minutes for questions.
For more information, visit
http://www.cancer.gov/cam/news/monthly-lecture-series.html
The Deconstruction of Ginseng - What is the Sum of its Parts in Breast Cancer Treatment?
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- Medicare-like Rates for Contract Health Services
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- - Dorothy Dupree, Director of Tribal Affairs Group, Centers for Medicare & Medicaid Services (2010/11/18)
- - Category : CMS - Centers for Medicare & Medicaid Services
- CMS Medicine Dish Series
Encore Broadcast of Medicare Like Rates for Contract Health Services
We are pleased to present the next in our monthly satellite broadcast series created for providers in Indian Country. These programs serve as a path to open communication, providing information and promoting discussion about Medicare, Medicaid and State Children？？？s Health Insurance Programs (SCHIP), and other issues important to the health of our people.
This is re-broadcast of a program originally shown in September, 2007. It covers how Medicare-like rates help reduce contract health service expenditures and extend the use of contract health services (CHS) funding. You？？？ll learn about the following:
？？？ When the rule applies
？？？ What services are covered
？？？ How to compute and verify the rates charged by hospitals, and
？？？ What other payments or co-payments may be due
This will be an encore broadcast and we will not be able to take live questions. Please email your questions during the show to MedicineDish@cms.hhs.gov
Materials related to this broadcast will be posted on the CMS AI/AN website at http://www.cms.gov under American Indian Alaska Native Center.
Medicare-like Rates for Contract Health Services
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- PLC Gamma/Calcium Signaling in Immune Cells
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- - Kurosaki, Tomo.
National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18) - - Category : Immunology
- - Kurosaki, Tomo.
- The Immunology Interest Group (IIG) organizes activities designed to promote information exchange and interactions among NIH scientists interested in the field of immunology, broadly defined. Interactions are facilitated via weekly meetings on current topics as well as an annual Immunology Retreat.
For more information, visit
The Immunology Interest Group
PLC Gamma/Calcium Signaling in Immune Cells
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- Great Teachers - Cancer Screening: The Intuition Versus the Science
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- - Kramer, Barnett S.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Clinical Center Grand Rounds
- - Kramer, Barnett S.
- Contemporary Clinical Medicine
Great Teachers
Barnett Kramer, M.D., M.P.H.
Associate Director for Disease Prevention, NIH
For more information, visit
http://www.cc.nih.gov/about/news/grcurrent.html
Great Teachers - Cancer Screening: The Intuition Versus the Science
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- National Advisory Research Resources Council - May 2008
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- - National Advisory Research Resources Council. (2010/11/18)
- - Category : National Advisory Research Resources Council
- During this meeting of the National Advisory Research Resources Council, Dr. Barbara Alving will provide an update on the progress of formulating NCRR？？？s 2009-2013 Strategic Plan. The agenda also features reports on a wide range of NCRR-supported activities that enhance the participation of minority, rural, and other underserved communities in the nation？？？s biomedical research enterprise. During this session, examples from the IDeA and CSTA programs will highlight challenges and best practices to ensure broad community engagement in clinical and translational research.
Additional presentations will describe advances that have been made in the mouse BIRN testbed; provide a progress report from last year？？？s evaluation of the Biomedical Technology Research Resources; and convey an initial report of the Division of Comparative Medicine？？？s 3 types of institutional National Research Service Awards for scientists with a veterinary background. There will also be a special presentation by Dr. Jay Hove, recipient of the Presidential Early Career Award for Scientists and Engineers. The open session will conclude with a Working Group report on the National Synchrotron Light Source II.
The National Advisory Research Resources Council is comprised of 18 appointed members who serve for overlapping four-year terms. The membership includes leaders in scientific disciplines related to the activities of NCRR, as well as members of the general public who are leaders in fields of public and health policies, law, economics, and management. The Council meets three times a year to conduct second-level review of applications as required by law. The Council also advises NCRR on other funding activities, policies, and program considerations.
For more information, visit
http://www.ncrr.nih.gov
National Advisory Research Resources Council - May 2008
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- A Public Health Research Agenda for Integrative Medicine
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- - Bodeker, Gerard.
National Institutes of Health (U.S.) (2010/11/18) - - Category : NCCAM Lectures
- - Bodeker, Gerard.
- The increasing global use of traditional (i.e. indigenous), complementary and alternative medicine raises important public health questions. Integrative medicine (IM) research has focused primarily on clinical and experimental medicine (safety, efficacy and mechanism of action), and regulatory issues, to the general neglect of public health dimensions. A public health research agenda for IM would include a systems approach in considering social, cultural, political and economic contexts of IM use and outcomes, with particular consideration of the needs of high IM users, special groups such as refugees, indigenous peoples, the poor, women users and others, in order to maximize the potential contribution of IM to healthcare globally. A public health & policy framework for IM has been developed and will be presented.
Gerard Bodeker EdD, M.Psych. Chair, Global Initiative for Traditional Systems (GIFTS) of Health, Oxford, UK.; Dept of Clinical Medicine, Division of Medical Sciences, University of Oxford, & Oxford Department of International Development, UK; Adjunct Professor of Epidemiology, Mailman School of Public Health, Columbia University, USA.
Gerry Bodeker Ed.D, M.Psych, an Australian whose doctoral studies were at Harvard, holds faculty appointments in public health at Oxford and Columbia Universities. He chaired the Commonwealth Working Group on Traditional, Complementary and Alternative Medicine and advises UN agencies in this field. He chairs the Global Initiative For Traditional Systems (GIFTS) of Health http://www.giftsofhealth.org, has authored a number of books and has published extensively on integrative medicine. He is editor in chief of the World Health Organisation Global Atlas on Traditional, Complementary and Alternative Medicine (2005) and is a founding board member of The Journal of Alternative & Complementary Medicine. He is an editorial board member of the Oxford University Press journal E-CAM. Gerry Bodeker has contributed a chapter on complementary medicine and a chapter on the health of indigenous peoples to Elsevier？？？s forthcoming Encyclopedia of Public Health. He also has contributed to Manson？？？s Tropical Medicine, and the Oxford Handbook of Tropical Medicine. He chairs the Research Initiative on Traditional Antimalarial Methods (RITAM), and coordinates a refugee health project on traditional medicine at the Thai-Burma border.
A Public Health Research Agenda for Integrative Medicine
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- US Repatriation State Training (Day 1)
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- - ACF (2010/11/18)
- - Category : Special
- The U.S. Repatriation Program is committed to helping eligible repatriates referred from the U.S. Department of State by providing them with effective and efficient temporary assistance necessary for their transition and reestablishment in the United States
US Repatriation State Training (Day 1)
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- Making The Business Case For Value-based Health Care Purchasing
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- - Kessler, Ronald C.
National Institutes of Health (U.S.). Office of Behavioral and Social Sciences Research. (2010/11/18) - - Category : BSSR Lecture Series
- - Kessler, Ronald C.
- BSSR Lecture Series
The presentation reviews recent research carried out by a team of researchers at Harvard Medical School to quantify the workplace costs of illness and the human capital value from the employer perspective of expanded outreach and treatment. A survey tool known as the WHO Health and Work Performance Questionnaire (HPQ), which is now widely-used in workplace Health Risk Appraisal surveys, is described. An example is presented of the HPQ being used to select an intervention target and evaluate the employer return-on-investment of an innovative condition-specific outreach and best-practices treatment program. The presentation closes with a discussion of future directions in workplace social epidemiological research on the costs of illness and the cost-effectiveness of diverse treatment interventions.
Ronald C. Kessler, Ph.D., is a Professor of Health Care Policy at Harvard Medical School. His research deals broadly with the social determinants of mental health and illness as studied from an epidemiological perspective. He is the author of over 500 publications and the recipient of many awards for his research, including Senior Scientist and MERIT awards from the National Institute of Mental Health. He has been rated by ISI as the most widely cited researcher in the world in the field of psychiatry for each of the past nine years. He is a member of the Institute of Medicine of the National Academies of Science. Kessler is the Principal Investigator of the U.S. National Comorbidity Survey, the first nationally representative survey of the prevalence and correlates of mental disorders in the US http://www.hcp.med.harvard.edu/ncs. He is a Co-Director of the World Health Organization？？？s World Mental Health Survey Initiative, a series of comparative community epidemiological surveys of the prevalence of mental disorders, patterns of help seeking for these disorders, and barriers to treatment for these disorders in 28 countries around the world http://www.hcp.med.harvard.edu. In addition to his epidemiological studies, Kessler is involved in evaluating a number of innovative programs for the prevention and treatment of mental illness in high-risk segments of the population. This lecture is an installment of the Behavioral and Social Sciences Research Lecture Series sponsored by the NIH Office of Behavioral and Social Sciences Research and organized by the NIH Behavioral and Social Sciences Research Coordinating Committee.
The Behavioral and Social Sciences Research Coordinating Committee (BSSR CC), with support from the Office of Behavioral and Social Sciences Research (OBSSR), convenes a series of guest lectures and symposia on selected topics in the behavioral and social sciences. These presentations by prominent behavioral and social scientists provide the NIH community with overviews of current research on topics of scientific and social interest. The lectures and symposia are approximately 50 minutes in length, with additional time for questions and discussion. All seminars are open to NIH staff and to the general public.
Making The Business Case For Value-based Health Care Purchasing