전체 8345
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- HIV-1 Assembly Explored by Electron Cryocrystallography and Molecular Modeling: Implications for Drug Discovery
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- - Yeager, Mark P.
National Institutes of Health (U.S.). Structural Biology Interest Group. (2010/11/18) - - Category : Structural Biology
- - Yeager, Mark P.
- The SBIG is a clearinghouse for discussions and interactions between scientists interested in all aspects of molecular structure, from experimental determination by x-ray crystallography, electron microscopy, mass spectrometry, and NMR, to theoretical and computational biology and biophysics, and to the biological application of structural data.
For more information, visit
Structural Biology Interest Group
HIV-1 Assembly Explored by Electron Cryocrystallography and Molecular Modeling: Implications for Drug Discovery
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- NIH Community Forum on the Future of Womens Health Research
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- - NIH Community Forum on the Future of Womens Health Research
National Institutes of Health (U.S.). Office of Research on Womens Health. (2010/11/18) - - Category : Womens Health
- - NIH Community Forum on the Future of Womens Health Research
- The NIH Office on Research on Womens Health and the NIH Coordinating Committee on Research on Womens Health are sponsoring an NIH Community Forum on the future of womens health research. Participants will have a chance to engage and discuss pertinent issues with speakers and panelists who work in the field of womens health research. This is an opportunity for the NIH community to help formulate and re-focus the womens health research agenda.
More information about this event can be found at http://orwh.od.nih.gov.
NIH Community Forum on the Future of Womens Health Research
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- US Repatriation State Training (Day 2)
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- - ACF (2010/11/18)
- - Category : Special
- The U.S. Repatriation Program is committed to helping eligible repatriates referred from the U.S. Department of State by providing them with effective and efficient temporary assistance necessary for their transition and reestablishment in the United States
US Repatriation State Training (Day 2)
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- NIH Blue Ribbon Panel at Boston University Medical Center
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- - National Institutes of Health (U.S.). Blue Ribbon Panel to Advise on the Risk Assessment of the National Emerging Infectious Diseases Laboratories at Boston University Medical Center. (2010/11/18)
- - Category : Special
- NIH Blue Ribbon Panel to Advise on the Risk Assessment of the National Emerging Infectious Diseases Laboratories at Boston University Medical Center
Working Group of the Advisory Committee to the Director
May 16, 2008
Massachusetts State House Gardner Auditorium Boston, Massachusetts
AGENDA
9:00 AM Welcome and Opening Remarks - What is the purpose of the Blue Ribbon Panel? Adel Mahmoud, M.D., Ph.D., Professor, Department of Molecular Biology, Princeton University
9:15 AM How is the Panel Approaching its Tasks? Vicki S. Freimuth, Ph.D., Director, Center for Health and Risk Communication, University of Georgia
9:25 AM What are the Panel？？？s Preliminary Findings? Adel Mahmoud, M.D., Ph.D.
9:35 AM What are the Panel？？？s Next Steps? Adel Mahmoud, M.D., Ph.D.
9:45 AM Input from the Citizens of Boston, Surrounding Communities, and the General Public
11:45 AM Wrap Up
12:00 PM Adjourn
NIH Blue Ribbon Panel at Boston University Medical Center
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- Advances in the Understanding of Genetic Susceptibility to Breast Cancer
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- - Garcia-Closas, Montserrat.
National Institutes of Health (U.S.) (2010/11/18) - - Category : NIH Directors Seminars
- - Garcia-Closas, Montserrat.
- 2007-2008 Directors Seminar Series
For more information, visit
http://www.nih.gov/about/director/dirsem.htm
Advances in the Understanding of Genetic Susceptibility to Breast Cancer
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- Neuronal Encoding of Behavioral Relevance in Parietal Cortex
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- - Assad, John A.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Neuroscience
- - Assad, John A.
You are invited to attend the next NIH Neuroscience Series lecture on May 19, 2008 at noon in the Lipsett Amphitheater of the NIH Clinical Center, 10 Center Drive, Bethesda, MD. John A. Assad, Ph.D., Professor, Department of Neurobiology, Harvard Medical School, will present his seminar on Neuronal encoding of behavioral relevance in parietal cortex. Dr. Assad？？？s laboratory uses electrophysiological recording techniques in awake, behaving monkeys to explore mechanisms underlying visual perception. They focus on the question How does what we know influence what we see? Dr. Assad？？？s research has demonstrated how a global understanding of the visual scene exerts a powerful influence over how we perceive its details. Dr. Assad？？？s seminar will describe how the neuronal activity in the parietal cortex encodes visual perception.
NIH Neuroscience Seminar Series
Neuronal Encoding of Behavioral Relevance in Parietal Cortex
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- NIAID DAIDS Strategic Working Group May 2008 - Day 1 (NIH Only)
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- - National Institute of Allergy and Infectious Diseases (U.S.). HIV AIDS Strategic Working Group. (2010/11/18)
- - Category : NIAID Council (NIH Only)
- NIAID/DAIDS will be holding its next Strategic Working Group
NIAID DAIDS Strategic Working Group May 2008 - Day 1 (NIH Only)
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- Human MUC1-C Oncoprotein as a Target for Cancer Treatment (NIH-Only)
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- - Kufe, Donald W.
Center for Cancer Research (National Cancer Institute (U.S.)) (2010/11/18) - - Category : NCI CCR Grand Rounds (NIH Only)
- - Kufe, Donald W.
- Center for Cancer Research - National Cancer Institute Grand Rounds
The primary educational objective of these seminars is to provide new information, ideas, and discussion about timely areas of research with impact on the field of oncology. A secondary educational objective is to elicit participation by individuals from all divisions of the intramural NCI, and thus facilitate more interactions among investigators and groups in the NCI. ABOUT THE SPEAKER: Dr. Kufe received his M.D. from the University of Rochester School of Medicine. He did his internship at Beth Israel Hospital, Boston and his residency at George Washington University Hospital. He did fellowships at Harvard Medical School and the Sidney Farber Cancer Institute. Dr. Kufe has worked at the Dana-Farber Cancer Institute on the molecular biology of human cancer and the development of anti-cancer agents for 30 years. He has served as the deputy director of the Dana-Farber Cancer Center and leader of the Experimental Therapeutics Program. He is leader of Translational Pharmacology and Early Therapeutic Trials at the Dana-Farber/Harvard Cancer Center. Dr. Kufe has more than 500 publications and has served as lead editor of the widely recognized textbook, Cancer Medicine.
Human MUC1-C Oncoprotein as a Target for Cancer Treatment (NIH-Only)
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- NIAID DAIDS Strategic Working Group May 2008 - Day 2 (NIH Only)
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- - National Institute of Allergy and Infectious Diseases (U.S.). HIV AIDS Strategic Working Group. (2010/11/18)
- - Category : NIAID Council (NIH Only)
- NIAID/DAIDS will be holding its next Strategic Working Group
NIAID DAIDS Strategic Working Group May 2008 - Day 2 (NIH Only)
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- GMAC Seminar - May 2008 (HHS Only)
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- - NIH (2010/11/18)
- - Category : GMAC (HHS Only)
- GMAC Subcommittee on Training
http://odoerdb2.od.nih.gov/gmac/gmac/trs_main.html
GMAC Seminar - May 2008 (HHS Only)
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- Condensed History of DNA Repair with Emphasis on Small Lesion Repair
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- - Dr. Sankar Mitra, University of Texas, Galveston (2010/11/18)
- - Category : DNA Repair
- The DNA Repair Interest Group is concerned with all forms of DNA damage and repair. As a major defense against environmental damage to cells DNA repair is present in all organisms examined including bacteria, yeast, drosophila, fish, amphibians, rodents and humans. The members of the DNA Repair Interest Group perform research in areas including DNA repair enzymology and fine structure, mutagenesis, gene and cell cycle regulation, protein structure, and human disease.
For more information, visit the
DNA Repair Interest Group
Acrobat Slides
Condensed History of DNA Repair with Emphasis on Small Lesion Repair
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- Regulation of Inflammation by Ubiquitin Modification of Signaling Components
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- - Dixit, Vishva.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Wednesday Afternoon Lectures
- - Dixit, Vishva.
The NIH Directors Wednesday Afternoon Lecture Series: http://www1.od.nih.gov/wals/schedule.htm
Proper regulation of inflammation is essential for combating pathogen invasion and maintaining homeostasis. Whereas hypo-responsive hosts succumb to infections, unchecked inflammatory reactions promote a variety of debilitating and fatal conditions including septic shock, autoimmune disease, atherosclerosis, graft rejection, and cancer. Pathogens, host immune cell ligands, and pro-inflammatory cytokines such as Tumor Necrosis Factor-a (TNF-a), Interleukin-1-b (IL1-b), and Lipopolysaccharide (LPS) induce an array of inflammatory responses by activating a variety of cell types. Although much is known about how inflammatory responses are initiated and sustained, less is known about how inflammation is attenuated to maintain a homeostatic balance.
The A20 protein is now recognized as a central, negative feedback inhibitor, of NF-kB mediated inflammatory responses. It was originally discovered as an NF-kB inducible gene that was recruited to the assembled proximal signaling complex of pro-inflammatory receptors by virtue of being able to bind to other proximal signaling adaptors including TRAFs and RIP. Analysis revealed seven repeats of a novel type of Cys2/Cys2 zinc finger motif at the carboxy terminus that possessed E3 ligase activity and a amino terminal Ovarian Tumor (OTU) domain that exhibited deubiquitinating activity. Both enzymatic activities were shown to act in concert to attenuate NF-kB signaling from pro-inflammatory receptors.
Dixit is profiled in the April 1, 2004, issue of Nature: http://www.nature.com/nature/journal/v428/n6982/full/nj6982-586c.html
BIOGRAPHICAL SKETCH: Vishva Dixit, a native of Kenya, East Africa, finished medical school at the top of his class at the University of Nairobi in 1980. Following an year of internship, he pursued further medical training at Washington University School of Medicine in St. Louis, Missouri. As a resident in the Department of Pathology, Vishva was fortunate to be awarded a Josiah Macy fellowship that allowed him to interrupt his residency training and do a postdoctoral fellowship in the Department of Biological Chemistry pursuing the biochemistry of extracellular matrix components. Following completion of residency training in 1986 Vishva joined the Department of Pathology at The University of Michigan as Assistant Professor. He rose through the ranks to be appointed full professor in 1995. During his tenure at Michigan his laboratory worked in many areas including matrix biology and on the characterization of a novel family of receptor protein tyrosine kinases. However, he is best known for his work on apoptosis. His laboratory published a series of groundbreaking papers in the mid nineties in which they defined the molecular components of the death receptor pathway. This importance of this work is reflected in the fact that Vishva was the second most highly cited scientist in all scientific disciplines in 1997. In recognition of these contributions in 1996 he was awarded the Warner-Lambert/Parke-Davis Award in Experimental Pathology. He joined Genentech in 1997 as Director on Molecular Oncology. Under his stewardship the Department has excelled in both basic and translational research and is second to none in the Biotechnology sector. Vishva has published well over a hundred scientific articles and has a significant number of patents to his name.
More information available: http://www.gene.com/gene/research/sci-profiles/phychem/dixit/profile.html
Regulation of Inflammation by Ubiquitin Modification of Signaling Components
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- Grocery Shopping Ideas for Wellness
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- - Christina Giallourakis (2010/11/18)
- - Category : Work/Life Center
- NIH Work Life Seminar
Grocery shopping can be stressful and time consuming. Attend this seminar to learn how to plan your shopping trip so you can make successful and sensible food choices. Get tips on navigating the various food aisles, such as produce, meat and poultry, fish, dairy and eggs, soy products, fats, oils, condiments and sweeteners, frozen foods and more!
For more information, visit
http://wlc.od.nih.gov
Grocery Shopping Ideas for Wellness
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- Advances in Pain Research 2008
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- - Symposium on Advances in Pain Research
NIH Pain Consortium. (2010/11/18) - - Category : Conferences
- - Symposium on Advances in Pain Research
- Welcome to the official Web site of the 3rd Annual Symposium on Advances in Pain Research.
The theme of this year？？？s symposium will be Moving Basic Discoveries into the Clinic and Clinical Findings to the Laboratory. Topics will include mechanisms underlying pain therapies, basic discoveries moving toward clinical practice, and parallel pathways of basic and clinical discoveries. A poster session will include a broad selection of current pain research findings presented by young investigators. Members of the extramural scientific community, the NIH scientific community, health care providers, and the public are invited to attend. The event will be hosted by the Co-chairs of the NIH Pain Consortium.
For more information, visit
http://www.edjassociates.com/pain2008/home.asp
Advances in Pain Research 2008
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- The Fourth Annual Scientific Lecture of the Asian American Heritage Month
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- - Shi, Yang.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Special
- - Shi, Yang.
- Throughout his career, Yang Shi has made numerous fundamental contributions to the fields of gene regulation and chromatin biology. Using C.elegans, he identified a critical role for the histone acetylase CBP/p300 in differentiation and demonstrated a dynamic, antagonistic relationship between acetylases and deacetylases in controlling cell fate and tissue development. Yang Shis recent breakthrough is the discovery of the first histone lysine-specific demethylase LSD1.
Histone methylation is a fundamental regulatory mechanism, which impacts transcription, DNA replication and damage response, heterochromatin, and epigenetic state of the cell. Histone methylation patterns correlate with stem cell maintenance and differentiation, and altered histone methylation is linked to numerous human diseases including cancer and neurological disorders. Since the discovery of histone methylation in the 1960s, methylation was viewed as a stable and irreversible modification. This dogma has now been disproved by Yang Shis discoveries. With the identification of LSD1 and the additional demethylases JMJD2A-D, JARID1A-D and UTX/JMJD3, Yang has established that demethylases play a central role in the dynamic regulation of chromatin structure. Yang and his collaborators also solved the first crystal structure of a histone demethylase (JMJD2A), thus providing significant new insights into the chemical and molecular basis of the demethylation reaction. Importantly, Yangs most recent finding of the link between histone demethylation and X-linked mental retardation highlights the important role epigenetic regulators play in neurological disorders. Yang Shis discovery of histone demethylases has created a major new field in molecular biology that is fast moving and has far-reaching implications in biology and medicine.
The epigenetic regulation has emerged as a hot topic in neuroscience recently because of the new insights it provides for the mechanisms underlying various cognitive function such as learning and memory. Studying of epigenetic regulation has shed new lights on several major neurological and psychiatric disorders such as Rett syndrome, post-traumatic stress disorder (PTSD), and depression. Thus, Dr. Shis talk will not only be of interests to the general audience at NIH, but also of special value to the NIH neuroscientists.
More information about the speaker is available at http://www.hms.harvard.edu/dms/bbs/fac/shi_yang.html
The Fourth Annual Scientific Lecture of the Asian American Heritage Month
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- Dynamics of macromolecular complexes in living cells: Multiplex imaging of signaling activities, genetically encoded protein uncaging, and RapR-FAK
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- - Hahn, Klaus M.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Proteomics
- - Hahn, Klaus M.
- This talk will describe approaches to study and manipulate multiple nodes of a signaling pathway in living cells, revealing unexpected relationships between Rho family GTPases in motility. New methods for spatially and temporally controlled manipulation of protein activity will be described, including genetically encoded caged Rac, and Fak activated by drug treatment. These approaches may provide generally applicable tools to study signaling pathways in living cells.
http://proteome.nih.gov
Dynamics of macromolecular complexes in living cells: Multiplex imaging of signaling activities, genetically encoded protein uncaging, and RapR-FAK
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- Recent Advances in Ewings Sarcoma (NIH-Only)
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- - Helman, L.
National Institutes of Health (U.S.) (2010/11/18) - - Category : NCI CCR Grand Rounds (NIH Only)
- - Helman, L.
- Dr. Helman received his M.D. from the University of Maryland School of Medicine in 1980 magna cum laude, and was elected to Alpha Omega Alpha. He completed his internship and residency in Internal Medicine at Barnes Hospital Washington University, serving as the Chief Resident, Washington University VA Medical Service in 1983. He began his Fellowship training at the National Cancer Institute (NCI) in 1983, where he has remained.
He became the head of the Molecular Oncology Section of the Pediatric Oncology Branch, NCI, in 1993, and Chief of the Pediatric Oncology Branch, NCI, in 1997. He was also named a Deputy Director of the Center for Cancer Research, National Cancer Institute, in 2001. He was named Acting Scientific Director for Clinical Research, Center for Cancer Research, National Cancer Institute, in 2005, and named as the permanent Scientific Director in 2007.
Dr. Helmans laboratory currently focuses on three major themes related to the biology and treatment of pediatric sarcomas: (1) the role of insulin-like growth factors on the biology of these tumors; (2) identification of the molecular mechanisms of metastases using animal models of spontaneously metastatic tumors; and (3) translation of these findings into treatments to improve the outcome of patients with pediatric sarcomas.
The primary educational objective of these seminars is to provide new information, ideas, and discussion about timely areas of research with impact on the field of oncology. A secondary educational objective is to elicit participation by individuals from all divisions of the intramural NCI, and thus facilitate more interactions among investigators and groups in the NCI.
Recent Advances in Ewings Sarcoma (NIH-Only)
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- Evolution and the Concept of Species
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- - Noor, Mohamed A F.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Evolution and Medicine
- - Noor, Mohamed A F.
- Evolution and Medicine
Lecture series presented by National Institute of General Medical Sciences, the Office of Science Education, and the National Human Genome Research Institute. For more information, visit
http://www.nigms.nih.gov/News/Meetings/EvolutionSeries2008
Evolution and the Concept of Species
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- National Advisory Allergy and Infectious Diseases Council - May 2008 (NIH Only)
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- - Fauci, Anthony S.
National Advisory Allergy and Infectious Diseases Council (U.S.). Meeting (2010/11/18) - - Category : NIAID Council (NIH Only)
- - Fauci, Anthony S.
- The NAAIDC provides second level peer review of grant applications and discusses concept clearances and other matters pertaining to grant applications for NIAID. Their website http://www.niaid.nih.gov/ncn/budget/default_council.htm
offers information about meeting dates, council members, and has an archive of past meeting minutes. At each meeting, Dr. Antony Fauci, NIAID Director, presents information about the Institute, including new staff, status of the budget, status of research and other areas of interest to the council. A guest speaker also does a presentation. At the May 2008 meeting it will be Dr. Gary Nabel, Director of NIAIDs Vaccine Research Center. Dr. Nabel will present information about the Center and its research.
National Advisory Allergy and Infectious Diseases Council - May 2008 (NIH Only)
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- AIDS Research Advisory Committee - May 2008 (NIH Only)
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- - National Institute of Allergy and Infectious Diseases (U.S.). AIDS Research Advisory Committee. Meeting (2010/11/18)
- - Category : AIDS Research Advisory Committee (NIH Only)
- The AIDS Research Advisory Committee (Committee), National Institute of Allergy and Infectious Diseases (NIAID) is a chartered committee that advises the Director, NIAID, and the Director, Division of AIDS (DAIDS). Specifically, the Committee provides broad scientific, programmatic, and budgetary advice on all aspects of HIV-related research supported by NIAID, including fundamental basic and clinical research, discovery and development of vaccines and other preventative interventions, and training of researchers in these activities. The committee reviews progress and productivity of ongoing efforts, assists in identifying critical gaps/obstacles to progress, and approves of concepts for new initiatives. This meeting includes the review of five concepts for initiatives.
AIDS Research Advisory Committee - May 2008 (NIH Only)