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  • Timing is Everything: Applying Circadian Rhythms Science to Duty Hours Requirements in Medical Training
    • - Sharkey, Katherine M.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : Clinical Center Grand Rounds
    For more information, visit
    http://www.cc.nih.gov/about/news/grcurrent.html

    Timing is Everything: Applying Circadian Rhythms Science to Duty Hours Requirements in Medical Training

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  • IC Budget Officers Training Session (NIH Only)
    • - Mary Cushing, NCI/OD/OM/OBF (2010/11/18)
    • - Category : NBS (NIH Only)
    Budget Officer？？？s Training meeting, on Wednesday, August 27th from 2 to 4 pm, there will be a special IC Budget Officer？？？s Training Session.？？？？ During this meeting Mary Cushing will provide the Budget Officer community with training on the NBS and activities that she will transition as she retires from NIH.

    IC Budget Officers Training Session (NIH Only)

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  • Town-Hall meeting on "The Barriers to Clinical Research" (NIH Only)
    • - National Institute of Allergy and Infectious Diseases (U.S.) (2010/11/18)
    • - Category : NIAID Council (NIH Only)
    Please join us at an all-hands meeting in Lipsett Amphitheater on Tuesday, September 2 from 1:00 to 2:30 p.m. The agenda will include a review of findings from focus groups, recommendations to improve the top four barriers ？？？ IRB review, scientific review, adequacy of resources and tech transfer issues ？？？ and next steps. This will be a great opportunity to provide additional input and we look forward to a robust and thoughtful discussion.

    The NIH Intramural Working Group has charged the Medical Executive Committee to identify constraints to efficient and effective NIH-sponsored clinical research that do not significantly add to research quality, research integrity or human subjects protection. The subcommittee coordinating this effort has representatives from across NIH. The goal is to identify the major barriers and obstacles to research conducted within the NIH intramural program in particular but with a view to also address broader issues that affect clinical research in the United States and abroad and to make recommendations for improvements.

    Town-Hall meeting on "The Barriers to Clinical Research" (NIH Only)

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  • Back to School Strategies for Success: Preschool through Grade School
    • - Sue Cohen (2010/11/18)
    • - Category : Parenting
    Back-to-school struggles are common yet still surprise many parents. In order to help our children cope and succeed, it is valuable to consider the physical and emotional growth from year to year as well as define and communicate expectations. You are invited to attend this age-specific educational sessions designed to review:

    1) your child？？？s point of view & developmental transitions and

    2) best practices for communicating with significant others in your child？？？s world..

    Handout available for download at http://videocast.nih.gov/pdf/parenting090308.pdf.

    Back to School Strategies for Success: Preschool through Grade School

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  • Dying Young as Late as Possible: Planarians, Regeneration and Stem Cells
    • - S찼nchez Alvarado, Alejandro.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : Wednesday Afternoon Lectures
    TALK SUMMARY: It is paradoxical that for many animal (including humans), the apparent anatomical stability of their adult bodies is maintained by constant change. Under normal physiological conditions, the functions of many organs depend on the continuous destruction and renewal of their cells. Equally remarkable is the fact the adult tissues and organs of many organisms can be fully restored after amputation.

    In fact, it appears that metazoans have evolved a series of renewal and repair mechanisms to respond to both trauma and normal wear and tear. Moreover, these mechanisms are under tight regulatory control such that organismal form and function can be maintained throughout life. As important as repair and restoration are to survival of multicellular organisms, we know little about how these processes are effected and regulated at the cellular and molecular levels.

    Here, I will discuss how the study of a simple metazoan, the planarian Schmidtea mediterranea, is beginning to shed light on the way adult animals regulate tissue homeostasis and the replacement of the body parts lost to injury.

    BIOGRAPHICAL SKETCH: Alejandro Sanchez Alvarado was born in Caracas, Venezuela. He received his Bachelors Degree in Molecular Biology and Chemistry from Vanderbilt University in 1986. In 1992, he received his Ph.D. in Pharmacology and Cell Biophysics at the University of Cincinnati School of Medicine, where he studied mouse ES cells and their in vitro differentiation under the tutelage of Dr. Jeffrey Robbins and Thomas Doetschman.

    In 1994, he joined the laboratory of Dr. Donald Brown at the Carnegie Institution of Washington Department of Embryology as a postdoctoral fellow, and in 1995 was appointed Staff Associate. It was during third period that Dr. Sanchez Alvarado began to explore system in which to molecularly dissect the problem of regeneration. In 2002 he became an Associate Professor at the Department of Neurobiology and Anatomy at the University of Utah School of Medicine, and in 2005 he was promoted to Professor and appointed a Howard Hughes Medical Institute Investigator. His current efforts are aimed at elucidating the molecular basis of regeneration using the free-living flatworm Schmidtea mediterranea.

    For more information, visit http://planaria.neuro.utah.edu/

    Dying Young as Late as Possible: Planarians, Regeneration and Stem Cells

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  • Third Annual NCI Alliance for Nanotechnology in Cancer Investigators Meeting, Chicago, IL
    • - National Cancer Institute (2010/11/18)
    • - Category : Special
    Plenary session can be viewed here: http://citvideosla.cit.nih.gov/sla/Nanotech/Mirkin/MirkinSEPT8908.html

    Third Annual NCI Alliance for Nanotechnology in Cancer Investigators Meeting, Chicago, IL

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  • Mechanisms of Dopamine Transmission in the VTA
    • - Williams, John.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : Neuroscience
    Dendritic release of dopamine in the ventral tegmental area acts on D2-dopamine receptors to mediate an inhibitory postsynaptic current (IPSC). This study examines how the rise and fall in extracellular dopamine regulates the kinetics of the IPSC. Extracellular dopamine was measured electrochemically during simultaneous recording of the IPSC. Both the rise and fall of dopamine were rapid relative to the IPSC, suggesting that G-protein dependent potassium channel activation determined the time course of the IPSC. The kinetics of D2 receptor dependent activation of potassium currents was studied using outside-out patch recordings and rapid application of dopamine. Dopamine applied at a minimum concentration of 10 쨉M for a maximum of 100 ms mimicked the IPSC. Shorter applications of higher concentrations did not change the kinetics of the outward current. These measurements were used to construct a model predicting that dopamine travels less then 500 nm from the site of release before binding to D2 receptors.

    Selected Publications:

    Dang, V.C. and Williams, J.T. (2004)
    Chronic morphine treatment reduces recovery from opioid desensitization. J. Neurosci. 24:7699-7706.

    Beckstead, M.J., Grandy, D.K., Wickman, K., and Williams, J.T. (2004)
    Vesicular dopamine release elicits an inhibitory postsynaptic current in midbrain dopamine neurons. Neuron 42:939-946.

    Dumont, E.C. and Williams, J.T. (2004)
    Noradrenaline triggers GABAA-inhibition of bed nucleus of the stria terminalis neurons projecting to the ventral tegmental area. J. Neurosci. 24:8198-8204.

    Paladini, C.A., Mitchell, J.M., Williams, J.T., and Mark, G.P. (2004)
    Cocaine self-administration selectively decreases noradrenergic regulation of metabotropic glutamate receptor-mediated inhibition in dopamine neurons.
    J. Neurosci. 24:5209-5215.

    Paladini, C.A. and Williams, J.T. (2004)
    Noradrenergic inhibition of midbrain dopamine neurons. J. Neurosci. 24:4568-4575.
    Paladini, C.A., Robinson, S., Morikawa, H., Williams, J.T., and Palmiter, R. (2003) Dopamine controls the firing pattern of dopamine neurons via a network feedback mechanism.
    Proc. Natl. Acad. Sci. USA 100:2866-2871.

    For more information see our website - http://neuroseries.info.nih.gov

    Mechanisms of Dopamine Transmission in the VTA

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  • TRACO: Introduction and Lung Cancer
    • - Moody, Terry W.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : TRACO
    For more information, visit
    http://ccr.cancer.gov/careers/traco.asp

    TRACO: Introduction and Lung Cancer

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  • National Cancer Advisory Board Meeting - September 2008
    • - United States. National Cancer Advisory Board. Meeting (2010/11/18)
    • - Category : National Cancer Advisory Board
    This is a regularly scheduled meeting of the National Cancer Advisory Board (NCAB).

    National Cancer Advisory Board Meeting - September 2008

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  • Recombinant DNA Advisory Committee (RAC) September 2008 - Day 1
    • - National Institutes of Health (U.S.). Recombinant DNA Advisory Committee. (2010/11/18)
    • - Category : Recombinant DNA Advisory Committee
    The RAC is a technical committee whose goal is to consider the current state of knowledge and technology regarding recombinant DNA. This includes review of human gene transfer trials, and an assessment of the ability of DNA recombinants to survive in nature and the potential for transfer of genetic material to other organisms. It also considers hypothetical hazards and methods for monitoring and minimizing risks. Approximately one-third of the 15 members do not have scientific expertise but represent public interests and attitudes. This balance is intended to provide a forum for open public debate of social and scientific issues attendant to recombinant DNA research. The RAC has been overwhelmingly successful in achieving this goal.

    For more information, visit the
    Recombinant DNA Advisory Committee (RAC) Conference Web Site

    Recombinant DNA Advisory Committee (RAC) September 2008 - Day 1

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  • NIH Postbac IRTA Fall Orientation/Welcoming
    • - Office of Intramural Training and Education and Postbac IRTA Committee (2010/11/18)
    • - Category : Career Development/OITE
    Join the staff of the Office of Intramural Training and Education (OITE) and the Postbac IRTA Committee for the Fall Welcoming. This is a chance for Postbac trainees to meet the OITE staff, learn about NIH resources and events planned for the year, and discuss issues specific to life at the NIH.

    You will also have the opportunity to meet members of the Postbac IRTA Committee and learn about outside interest groups (social, community service, etc.) that other Postbacs have organized and that are open to all NIH Postbacs.

    NIH Postbac IRTA Fall Orientation/Welcoming

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  • Cell Signaling By Receptor Tyrosine Kinases: From Basic Principles To Cancer Therapy
    • - Schlessinger, Joseph.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : Wednesday Afternoon Lectures
    Receptor tyrosine kinases (RTKs) comprise a large family of cell surface receptors that control many critical cellular processes. Various human diseases are caused by dysfunction in RTKs or in their intracellular signaling pathways. Stem Cell Factor (SCF) initiates its multiple cellular responses by binding to the extracellular region of the RTK KIT, resulting in receptor dimerization and tyrosine kinase activation.

    We have determined the crystal structure of the entire extracellular region of KIT before and after SCF stimulation. The structures show that Kit dimerization is driven by SCF binding whose sole role is to bring two KIT molecules together. Receptor dimerization is followed by conformational changes that enable lateral interactions between membrane proximal Ig-like domains D4 and D5 of two KIT molecules. Experiments with cultured cells show that KIT activation is compromised by point mutations in amino acids critical for D4-D4 interaction. Moreover, a variety of oncogenic mutations are mapped to the D5-D5 interface. Since key hallmarks of KIT structures, ligand-induced receptor dimerization and the critical residues in the D4-D4 interface are conserved in other receptors, the mechanism of KIT stimulation underlies the mechanism of activation of many RTKs.

    Sutent/SU11248 is a new drug that blocks the actions of KIT, PDGF receptor, VEGF receptor and RET. Sutent has been approved by the FDA for the treatment of gastrointestinal stromal tumors (GIST) and for advanced kidney cancers. The approval marks the first time the FDA has approved a new oncology product for two indications simultaneously.

    Joseph Schlessinger has been the William H. Prusoff Professor and Chairman of the Department of Pharmacology at Yale University School of Medicine since 2001. He was the Director of the Skirball Institute for Biomolecular Medicine at New York University (NYU) Medical Center from 1998-2001 and the Milton and Helen Kimmelman Professor and Chairman of the Department of Pharmacology at NYU Medical School from 1990-2001. He was a member of the faculty of the Weizmann Institute from 1978-1991 and the Ruth and Leonard Simon Professor of Cancer Research in the Department of Immunology from 1985-1991. Joseph Schlessinger was a Research Director for Rorer Biotechnology from 1985-1990. He co-founded Sugen, Inc. in 1991 and Plexxikon in 2001. He is currently the Chairman of the Board of Plexxikon and a member of the Scientific Advisory Board of the company.

    Schlessinger received a B.Sc. degree in Chemistry and Physics in 1968 (magna cum laude), and a M.Sc. degree in chemistry (magna cum laude) in 1970 from the Hebrew University in Jerusalem. He obtained a Ph.D. degree in biophysics from the Weizmann Institute of Science in 1974. From 1974-1976, he was a postdoctoral fellow in the Departments of Chemistry and Applied Physics at Cornell University, and from 1977-1978, he was a visiting fellow in the immunology branch of the National Cancer Institute of NIH.

    For more information, visit http://info.med.yale.edu/pharm/chairman

    Cell Signaling By Receptor Tyrosine Kinases: From Basic Principles To Cancer Therapy

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  • Class Control: The Other Side of Tolerance
    • - Matzinger, Polly.
      National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18)
    • - Category : Immunology
    This year？？？s Opening Speaker for the Immunology Interest Group？？？s Wednesday afternoon seminar series is Dr. Polly Matzinger from the Laboratory of Cellular and Molecular Immunology. Polly received her Ph.D. from the University of California at San Diego in the laboratory of Dr. Richard Dutton, where she worked on the problem of MHC restriction of T cell receptor recognition and championed the one receptor model for dual recognition. Her postdoctoral work in Dr. Herman Waldmann？？？s laboratory at Cambridge, UK, focussed her efforts on thymic tolerance, setting the stage for her seminal work at the Basel Institute using professional antigen-presenting cells to demonstrate that developing thymocytes are tolerizable only. In 1989 she moved to the NIH where her focus turned to costimulation and the mechanisms by which the adaptive immune system becomes activated. She proposed the Danger Model in which endogenous alarm signals were viewed as the critical molecular switches for initiating a response following antigen recognition by na챦ve T cells. She also showed that for full differentiation of CD8 cytotoxic T cell responses, the APCs need to be ？？？licensed？？？ by CD4 T cell interactions. More recently, Polly has turned her attention to class regulation in the immune response and the role of the damaged tissue in determining the response？？？s effector nature (Th1, Th2, Th17, etc.). In this regard, she has an interesting view on the nature of T regulatory cells in this process, which you may enjoy hearing about. Polly is a cogent and entertaining speaker and her synthesis of this important area of cellular immunology is an ideal way to return from your summer vacation and re-immerse yourself in intellectual pursuits.

    For more information, visit
    The Immunology Interest Group

    Class Control: The Other Side of Tolerance

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  • Recombinant DNA Advisory Committee (RAC) September 2008 - Day 2
    • - National Institutes of Health (U.S.). Recombinant DNA Advisory Committee. (2010/11/18)
    • - Category : Recombinant DNA Advisory Committee
    The RAC is a technical committee whose goal is to consider the current state of knowledge and technology regarding recombinant DNA. This includes review of human gene transfer trials, and an assessment of the ability of DNA recombinants to survive in nature and the potential for transfer of genetic material to other organisms. It also considers hypothetical hazards and methods for monitoring and minimizing risks. Approximately one-third of the 15 members do not have scientific expertise but represent public interests and attitudes. This balance is intended to provide a forum for open public debate of social and scientific issues attendant to recombinant DNA research. The RAC has been overwhelmingly successful in achieving this goal.

    For more information, visit the
    Recombinant DNA Advisory Committee (RAC) Conference Web Site

    Recombinant DNA Advisory Committee (RAC) September 2008 - Day 2

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  • CMS Quality Initiatives & DMEPOS Update
    • - Dorothy Dupree (2010/11/18)
    • - Category : CMS - Centers for Medicare & Medicaid Services
    CMS Medicine Dish Series

    A Panel will discuss the initiatives, reporting processes, and impact on providers:
    • Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey
    • Reporting Hospital Quality Data for Annual Payment Update (RHQDAPU)
    • Physician Quality Reporting Initiative (PQRI)
    • Changes in Medicare payment and accreditation for suppliers of Durable Medical Equipment, Prosthetics, Orthotics and Supplies (DMEPOS)
    This Broadcast will be Pre-recorded.

    Materials related to this broadcast will be posted on the CMS AI/AN website at http://www.cms.hhs.gov/AIAN/MedicineDishBroadcasts.asp.

    E-mail Comments to: medicinedish@cms.hhs.gov

    CMS Quality Initiatives & DMEPOS Update

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  • Stroke Care: Present and Future Therapy
    • - Kissela, Brett.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : Clinical Center Grand Rounds
    Clinical Center Grand Rounds

    Brett Kissela, MD
    Associate Professor of Neurology, College of Medicine University of Cincinnati

    For more information, visit
    http://www.cc.nih.gov/about/news/grcurrent.html

    Stroke Care: Present and Future Therapy

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  • Cancer Immunology and Immunotherapy: Realizing the Promise (Day 1) (HHS-Only)
    • - National Cancer Institute (U.S.). Center of Excellence in Immunology. (2010/11/18)
    • - Category : HHS Only
    This meeting will host leaders in the field of cancer immunology and immunotherapy, include recent advances in both translational and clinical research, and should provide an exciting forum for discussion and debate on promising immunologic approaches to prevent and treat cancer.

    Sessions will include:
    • Adoptive Cell Transfer
    • Monoclonal Antibodies
    • Costimulatory and Inhibitory Receptors
    • Cancer Vaccines
    • Gene Therapy
    • New Cytokines
    • Regulatory T Cells
    • New Immunotherapy Targets
    Conference Agenda

    For more information, visit http://web.ncifcrf.gov/events/CancerImmunology/default.asp

    Cancer Immunology and Immunotherapy: Realizing the Promise (Day 1) (HHS-Only)

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  • Sex Differences and Obesity in Osteoarthritis of the Knee
    • - Lerner, Amy L.
      National Institutes of Health (U.S.). Womens Health Special Interest Group. (2010/11/18)
    • - Category : Womens Health
    Womens Health Special Interest Group (WHSIG) Intramural Program on Research on Womens Health Sponsored by the NIH Office of Intramural Research and the NIH Office of Research on Womens Health.

    Come join your fellow NIH colleagues in a scientific exchange on issues related to the biology and pathology of sex and gender differences and effects on womens health.


    For more information, visit
    http://orwh.od.nih.gov

    Sex Differences and Obesity in Osteoarthritis of the Knee

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  • Trans-NIH Research Opportunities in Pediatrics
    • - Alexander, Duane F.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : OPASI Rounds
    OPASI ROUNDS Lecture Series

    Dr. Alexander will discuss a number of new and emerging opportunities for pediatric research existing at NIH and offering the potential for collaborative research for many Institutes. They originate from new or revised legislation as well as from Roadmap initiatives. This presentation will focus on a number of these opportunities, including the National Children？？？s Study, Newborn Screening, Best Pharmaceuticals for Children, Pediatric Medical Devices, the Biomarkers Consortium and Clinical and Translational Science Awards.

    The Office of Portfolio Analysis and Strategic Initiatives (OPASI) provides the National Institutes of Health (NIH) and its constituent Institutes and Centers (ICs) with the methods and information necessary to manage their large and complex scientific portfolios, identifies – in concert with multiple other inputs – important areas of emerging scientific opportunities or rising public health challenges, and assists in the acceleration of investments in these areas, focusing on those involving multiple ICs.

    Trans-NIH Research Opportunities in Pediatrics

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  • Cancer Immunology and Immunotherapy: Realizing the Promise (Day 2) (HHS-Only)
    • - National Cancer Institute (U.S.). Center of Excellence in Immunology. (2010/11/18)
    • - Category : HHS Only
    This meeting will host leaders in the field of cancer immunology and immunotherapy, include recent advances in both translational and clinical research, and should provide an exciting forum for discussion and debate on promising immunologic approaches to prevent and treat cancer.

    Sessions will include:
    • Adoptive Cell Transfer
    • Monoclonal Antibodies
    • Costimulatory and Inhibitory Receptors
    • Cancer Vaccines
    • Gene Therapy
    • New Cytokines
    • Regulatory T Cells
    • New Immunotherapy Targets
    Conference Agenda

    For more information, visit http://web.ncifcrf.gov/events/CancerImmunology/default.asp

    Cancer Immunology and Immunotherapy: Realizing the Promise (Day 2) (HHS-Only)

    세미나 비디오 동영상 보기