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- 2008 Disability Employment Awareness Month (HHS Only)
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- - Lourake, Andrew.
National Institutes of Health (U.S.) (2010/11/18) - - Category : PSC Programs (HHS Only)
- - Lourake, Andrew.
- America？？？s People, America？？？s Talent, America？？？s Strength!
Biographical Sketch for Lt. Col. Lourake:
A Gulf War veteran, Lt. Colonel Andrew Lourake was a special air missions pilot with duties that included flying the Vice President, until he injured his leg in an off road motorcycle accident. After enduring seventeen surgeries, including two knee replacement surgeries, Colonel Lourakes research led him to conclude his only hope to return to the cockpit was an above-the-knee amputation in combination with being fitted with the world？？？s first completely computer-controlled artificial leg.
Biographical Sketch for Timothy Bladek, Esq.:
As an Appellate Attorney in the Office of Federal Operations, Mr Bladek reviews appeals and writes decisions concerning discrimination claims filed by federal employees, applying the laws and regulations enforced by the Commission. Additionally, Mr. Bladek has extensive experience conducting training courses on substantive EEO law, including disability law, to members of the federal sector community. Prior to his work at the Commission, Mr. Bladek was an attorney at the Merit Systems Protection Board and in private practice, and received his J.D. from Georgetown University Law Center. Mr. Bladek is a member of the Bar in the District of Columbia and the State of Maryland.
2008 Disability Employment Awareness Month (HHS Only)
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- Molecular Control of T Cell Development and Regulatory T Cell Function
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- - Vignali, Dario.
National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18) - - Category : Immunology
- - Vignali, Dario.
- Dario Vignali is interested in the regulation of T cell tolerance. In order to study how signaling by the TCR controls T cell responses in vivo he has developed an efficient and rapid system to generate ？？？retrogenic？？？ mice, which are derived from stem cells transduced with retrovirus vectors. By this approach he has generated a large group of mice expressing various combinations of wild-type and mutant ITAMs in the TCR-CD3 complex. A low number of ITAMs resulted in lethal autoimmune disease due to defective negative selection. A high ITAM number correlated with greater T cell proliferation while maintaining central tolerance. In another recent study he has shown that IL-35 is a novel inhibitory cytokine, specifically produced by Treg cells, which contributes for their suppressive activity. Ectopic expression of IL-35 confers regulatory activity on naive T cells, whereas recombinant IL-35 suppresses T-cell proliferation.
For more information, visit
The Immunology Interest Group
Molecular Control of T Cell Development and Regulatory T Cell Function
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- Risks and Benefits; Special Populations in Research - 2008 (Session 5)
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- - Wendler, David.
National Institutes of Health (U.S.). Clinical Center. Dept. of Bioethics. (2010/11/18) - - Category : Bioethics
- - Wendler, David.
- Ethical and Regulatory Aspects of Clinical Research
Department of Clinical Bioethics
This course is designed to provide a historical context for research regulations and to help researchers and others working in human subject research gain insights and skills into the development of research protocols and their ethical implementation.
Objectives of the Course:
To learn the codes, declarations, and other documents that govern the ethical conduct of human subject research; review the critical elements of informed consent and their implementation in actual informed consent documents for clinical research; explore controversial issues relating to human subject research, including Phase I research, randomization, children in research, international research, etc; review the purpose if IRBs and provide IRB-like experience in reviewing research protocols; understand the experience of human subjects who have participated in research protocols.
For more information, visit
http://www.bioethics.nih.gov
Risks and Benefits; Special Populations in Research - 2008 (Session 5)
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- NIDCD 20th Anniversary Scientific Symposium
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- - NIDCD (2010/11/18)
- - Category : Conferences
- NIDCD celebrated its 20th anniversary with a symposium highlighting two decades of scientific research accomplishments. The symposium consisted of three sessions representing NIDCDs primary areas of research: hearing and balance; smell and taste; and voice, speech, and language.
For more information, visit http://www.nidcd.nih.gov/about/20th_symposium_schedule.htm
NIDCD 20th Anniversary Scientific Symposium
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- NIDCD 20th Anniversary Scientific Symposium
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- - NIDCD (2010/11/18)
- - Category : Conferences
- NIDCD celebrated its 20th anniversary with a symposium highlighting two decades of scientific research accomplishments. The symposium consisted of three sessions representing NIDCDs primary areas of research: hearing and balance; smell and taste; and voice, speech, and language.
For more information, visit http://www.nidcd.nih.gov/about/20th_symposium_schedule.htm
NIDCD 20th Anniversary Scientific Symposium
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- 3-D Tissue Models Round Table
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- - 3-D Tissue Models Round Table
National Institutes of Health (U.S.). Office of Portfolio Analysis and Strategic Initiatives. (2010/11/18) - - Category : Special
- - 3-D Tissue Models Round Table
- The NIH has issued a Roadmap initiative calling for ？？？Transformative R01？？？ applications (http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-08-029.html). NIH will host a meeting to help establish a dialog and begin to address some of the issues in the area of complex, 3-dimensional tissue models. The meeting will be a ？？？Round Table Discussion？？？ hosted by Dr. Alan Krensky (Director, NIH Office of Portfolio Analysis and Strategic Initiatives) and will include about a dozen discussants with experience in the area of in vitro engineered tissues. The broad objective will be to illuminate potential transformative research for the field？？？to distinguish between incremental progress and work that will truly disrupt current paradigms, or create new ones where none exist.
For more information, see http://nihroadmap.nih.gov/T-R01/meeting102408.asp.
3-D Tissue Models Round Table
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- Life-span Development of Expertise
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- - Charness, Neil.
National Institutes of Health (U.S.) (2010/11/18) - - Category : BSSR Lecture Series
- - Charness, Neil.
- What factors enable people to develop and maintain expert performance across the life-span? Dr. Charness will present a framework for understanding expertise development and apply it to the domain of chess skill. He draws on analyses of skill trajectories from archival data sets of high-level performers, practice data from questionnaire studies of players in Europe and North America, experimental studies of early perceptual processes, and simulation studies using neural nets to examine age-knowledge trade-offs relevant to chess and other expert skills.
Dr. Neil Charness is currently Professor of Psychology in the Psychology Department at Florida State University and an Associate of the Pepper Institute on Aging and Public Policy at Florida State University. He received his BA from McGill University, Montreal in 1965 and his MS (1971) and PhD (1974) from Carnegie Mellon University, Pittsburgh.
His research interests involve age and human factors and age and expert performance. His research is funded by grants from the National Institutes of Health (National Institute on Aging) and from a supplement to the NIA grant from NIOSH.
Dr. Charness served as Editor for the Psychology Section of the Canadian Journal on Aging/revue canadienne du vieillissement, and on the Editorial Boards of Psychology and Aging, Psychological Bulletin, and Aging, Neuropsychology and Cognition. He currently serves on the Editorial Board of Journal of Gerontology: Psychological Sciences, and as Chairperson of the Editorial Board for Gerontechnology.
He served on the Boards of the Canadian Association of Gerontology, the Canadian Psychological Association (Chair of the Section on Adult Development on Aging), and as Program Chair for the American Psychological Associations Division 20 (Adult Development and Aging).
Dr. Charness has been elected Fellow of the Canadian Psychological Association, the American Psychological Association (Division 20), the Gerontological Society of America, and the American Psychological Society. He currently serves on the National Academy of Sciences Committee studying Health and Safety Issues for Older Workers.
This lecture is an installment of the Behavioral and Social Sciences Research Lecture Series sponsored by the NIH Office of Behavioral and Social Sciences Research and organized by the NIH Behavioral and Social Sciences Research Coordinating Committee.
The Behavioral and Social Sciences Research Coordinating Committee (BSSR CC), with support from the Office of Behavioral and Social Sciences Research (OBSSR), convenes a series of guest lectures and symposia on selected topics in the behavioral and social sciences. These presentations by prominent behavioral and social scientists provide the NIH community with overviews of current research on topics of scientific and social interest. The lectures and symposia are approximately 50 minutes in length, with additional time for questions and discussion. All seminars are open to NIH staff and to the general public.
Life-span Development of Expertise
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- Using Structural MRI to Map the Functional Anatomy of Language and Reading
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- - Price, Cathy J.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Neuroscience
- - Price, Cathy J.
- Dr. Prices research program aims to establish a functional anatomical model of language that predicts how speech and reading are lost and recovered following neurological damage or developmental delay. The hypothesis is that there are multiple ways that the brain can perform each language task (degeneracy). If this is true, then the effect of damage or developmental delay will depend on whether there is a surviving system available to sustain the task.
To dissociate the neuronal systems for the same task, they use structural and functional MRI of subjects who vary in their cognitive abilities, demographics and neurological status. This allows them to characterize individual variability in the neuronal networks of neurologically normal populations and to examine how brain damage affects cognitive abilities in patient populations. In particular, Dr. Prices lab aims to determine how the impact of damage to one system depends on the integrity of another.
The language tasks they use are designed to tap various aspects of reading, speech perception, speech production and language control (e.g. in bilinguals). Their studies typically compare the neuronal networks for verbal stimuli to those involved in perceptual, conceptual or motor processing of non-verbal stimuli such as music, environmental sounds, numerals and pictures of objects.
NIH Neuroscience Seminar Series
Using Structural MRI to Map the Functional Anatomy of Language and Reading
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- TRACO: Breast Cancer and Genomics
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- - Korde, L.
National Institutes of Health (U.S.) (2010/11/18) - - Category : TRACO
- - Korde, L.
- For more information, visit
http://ccr.cancer.gov/careers/traco.asp
TRACO: Breast Cancer and Genomics
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- The Stem Cell Niche (NIH-Only)
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- - Scadden, David.
National Institutes of Health (U.S.) (2010/11/18) - - Category : NCI CCR Grand Rounds (NIH Only)
- - Scadden, David.
- Dr. Scadden received his M.D. from Case Western Reserve School of Medicine. He performed his internship and residency at Brigham and Women？？？s Hospital in Boston. He did a clinical fellowship in medicine at Harvard Medical School followed by a clinical fellowship in hematology/oncology at Brigham and Women？？？s Hospital, Dana-Farber Cancer Institute. He did subsequent fellowships at Harvard Medical School, Brigham and Women？？？s Hospital, HHMI, and New England Medical Center. He has been on staff at hospitals in the Boston area including Deaconess Hospital, St. Luke？？？s Hospital of New Bedford, Waltham-Weston Hospital , Massachusetts General Hospital, and Brigham and Women？？？s Hospital. He is currently on staff at Dana-Farber Cancer Institute and Massachusetts General Hospital. Dr. Scadden is the Gerald and Darlene Jordan Professor of Medicine at Harvard University. He and Professor Douglas Melton founded and jointly direct the Harvard Stem Cell Institute which is the largest institute dedicated to bringing stem cell biology to medical care in the world. With Professor Melton, Professor Scadden founded and co-chairs the Department of Stem Cell and Regenerative Biology Department at Harvard University, the first department to span faculties in Harvard？？？s 371 year history. Dr. Scadden is a hematologist/oncologist and directs the Center for Regenerative Medicine at the Massachusetts General Hospital while also chairing the Hematologic Malignancies program in the MGH Cancer Center. He is an expert on the medical applications of stem cell biology with a particular emphasis on their use in the settings of cancer and AIDS. He has published more than 250 scientific papers and book chapters and his laboratory has made fundamental contributions in how the stem cell niche regulates stem cell function, in defining the molecules limiting stem cell growth and in discovering a molecular basis for stem cell aging. He is the recipient of numerous honors including membership in the Institute of Medicine of the National Academies of Science and awards from the Doris Duke Charitable Trust, the Burroughs Wellcome Fund and the Leukemia and Lymphoma Society.
NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link:
http://www.bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx
The Stem Cell Niche (NIH-Only)
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- Evolutionary Conserved Pathways Suppress Genomic Instability
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- - Myung, Kyungjae.
National Institutes of Health (U.S.). DNA Repair Interest Group. (2010/11/18) - - Category : DNA Repair
- - Myung, Kyungjae.
- The DNA Repair Interest Group is concerned with all forms of DNA damage and repair. As a major defense against environmental damage to cells DNA repair is present in all organisms examined including bacteria, yeast, drosophila, fish, amphibians, rodents and humans. The members of the DNA Repair Interest Group perform research in areas including DNA repair enzymology and fine structure, mutagenesis, gene and cell cycle regulation, protein structure, and human disease.
Acrobat Slides
For more information, visit the
DNA Repair Interest Group
Evolutionary Conserved Pathways Suppress Genomic Instability
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- GMAC Seminar - NIH Update 2009 (HHS Only)
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- - NIH (2010/11/18)
- - Category : GMAC (HHS Only)
- GMAC Subcommittee on Training
http://odoerdb2.od.nih.gov/gmac/gmac/trs_main.html
GMAC Seminar - NIH Update 2009 (HHS Only)
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- Redox Biology - Epidemiology and Inflammation
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- - Ambs, S.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Redox Biology
- - Ambs, S.
- Redox Biology (RB)
The course is designed for NIH fellows to enhance their knowledge of redox biology. Reactive species such as superoxide, hydrogen peroxide and nitric oxide are associated with cellular toxicity, however, nitric oxide is useful in the treatment cardiovascular disease. The course will examine the role of reactive nitrogen and oxygen species in carcinogenesis, cancer proliferation and angiogenesis.
For more information, visit
http://ccr.cancer.gov/careers/courses/rb
Redox Biology - Epidemiology and Inflammation
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- NINDS Awards Ceremony 2008 (NIH Only)
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- - National Institute of Neurological Disorders and Stroke (2010/11/18)
- - Category : NIH Only
- NINDS AWARDS CEREMONY
For more information, visit http://intranet.ninds.nih.gov/news/nindsnews/2008_NINDS_Annual_Awards_Ceremony.htm
NINDS Awards Ceremony 2008 (NIH Only)
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- PlanFirst, featuring HHS Secretary Mike Leavitt
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- - Leavitt, Michael O.
United States. Dept. of Health and Human Services. (2010/11/18) - - Category : Special
- - Leavitt, Michael O.
- Join us for a special edition of PlanFirst, featuring Secretary Leavitt and a live audience. Secretary Leavitt will provide formal remarks regarding the Nation？？？s pandemic planning effort and will then join a roundtable discussion to address the Nation？？？s level of preparedness and related issues.
PlanFirst, featuring HHS Secretary Mike Leavitt
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- The Molecular Basis of Eukaryotic Transcription
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- - Kornberg, Roger D.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Wednesday Afternoon Lectures
- - Kornberg, Roger D.
- A complete RNA polymerase II transcription system has been derived by the fractionation of yeast and mammalian cell extracts. The required polypeptides comprise the 12-subunit RNA polymerase II, multiple ？？？general transcription factors？？？, and a 20-subunit ？？？Mediator？？？. The general transcription factors are responsible for promoter recognition and for melting the DNA template for the initiation of transcription. Mediator makes the key connection between enhancers and promoters. It transduces regulatory information from activator and repressor proteins to RNA polymerase II.
Structural studies of the RNA polymerase II transcription machinery began with electron microscope analysis of two-dimensional protein crystals formed on lipid layers. This led to the derivation of a 10-subunit form of RNA polymerase II especially conducive to crystallization, and to the use of two-dimensional crystals as seeds for the growth of large single crystals for X-ray analysis. The large size of the polymerase, over half a million Daltons, presented unusual technical difficulties, eventually overcome, and the structure was determined at 2.8 Angstroms resolution.
RNA polymerase II was also crystallized in the form of an actively transcribing complex, containing template DNA and product RNA. The structure of this complex was solved by molecular replacement, revealing the DNA entering and unwinding in the active center cleft. Nine base pairs of DNA-RNA hybrid could be seen extending from the active center at nearly right angles to the entering DNA. Protein-nucleic acid contacts help explain DNA and RNA strand separation, the specificity of RNA synthesis, and RNA and DNA translocation during transcription elongation.
RNA polymerase II crystallography has been extended to general transcription factors. The results have been assembled in a preliminary picture of a complete transcription initiation complex. From this picture, principles of both the initiation of transcription.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
The Molecular Basis of Eukaryotic Transcription
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- Writing Personal Statements for Graduate School
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- - Sponsored by the NIH Office of Intramural Training & Education (2010/11/18)
- - Category : Career Development/OITE
- This workshop will guide you through the process of how to write personal statements for graduate school.
Writing Personal Statements for Graduate School
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- Informed Consent - 2008 (Session 6)
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- - Shah, Seema. (2010/11/18)
- - Category : Bioethics
- Ethical and Regulatory Aspects of Clinical Research
Department of Clinical Bioethics
This course is designed to provide a historical context for research regulations and to help researchers and others working in human subject research gain insights and skills into the development of research protocols and their ethical implementation.
Objectives of the Course:
To learn the codes, declarations, and other documents that govern the ethical conduct of human subject research; review the critical elements of informed consent and their implementation in actual informed consent documents for clinical research; explore controversial issues relating to human subject research, including Phase I research, randomization, children in research, international research, etc; review the purpose if IRBs and provide IRB-like experience in reviewing research protocols; understand the experience of human subjects who have participated in research protocols.
For more information, visit
http://www.bioethics.nih.gov
Informed Consent - 2008 (Session 6)
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- Web Authors Group - Challenges in Search Engine Optimization (NIH Only)
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- - Greg Grothaus, Google (2010/11/18)
- - Category : NIH Only
- You have a complex site with original, compelling, and *important* content. How do you ensure that this content is optimally crawled by, indexed, and listed in search engines?
Greg Grothaus, a lead engineer in Googles Search Quality team, will examine these challenges by highlighting best practices in areas such as site accessibility, rich content, and related issues.
Gregs presentation will help you to...- Make your images more accessible to Googlebot and users.
- Implement Web 2.0 technologies like Flash and AJAX in a way that better enables people to navigate and transact on your site from varied devices.
- Improve how your pages are titled in Googles search results, which can lead to more relevant click-throughs to your site.
- Minimize the number of URLs per page or content block (duplicate content) and learn why this is important.
- Delve into the newer features of Googles Webmaster Tools and explore their strengths and limitations.
Web Authors Group - Challenges in Search Engine Optimization (NIH Only)
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- Autophagy and Antiviral Immunity
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- - Iwasaki, Akiko.
National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18) - - Category : Immunology
- - Iwasaki, Akiko.
- Dr. Iwasaki？？？s research addresses the role of dendritic cells in the induction and maintenance of mucosal immunity, primarily to viral infections, such as HSV-2 and influenza virus. She has been instrumental in determining how T cell responses are induced in the vaginal tract to HSV-2, including the mechanisms of entry and dynamics of viral replication, the ability of DC subpopulations to process and present viral antigens both locally and within lymph nodes, and the role of DC and stromal cell activation by TLR receptors in inducing Th1 responses. She has also made fundamental discoveries on the basic biology of DC recognition and control of virus infections, including the first studies showing TLR9 recognition of viral DNA, and TLR7 activation by single-stranded viral RNA, as well as the importance of local plasmacytoid DCs in providing innate immune protection. Most recently, Dr. Iwasaki has demonstrated that the transport of cytosolic viral replication intermediates into the lysosome by the process of autophagy is important pathway for the TLR7-dependent recognition of single-stranded RNA viruses by pDCs. Dr. Iwasaki is a dynamic scientist, who will most certainly deliver an entertaining and stimulating presentation.
For more information, visit
The Immunology Interest Group
Autophagy and Antiviral Immunity