전체 8345
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- Multilevel Effects of Functional Loci in Complex Behavior
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- - Goldman, David.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Neuroscience
- - Goldman, David.
- Dr. Goldmans lab generates the clinical dataset collections and collaborations, and encompasses the DNA/Data core, ongoing human research protocols (COMBINE, Ten Tribes Study, Alaska Native Alcohol treatment pharmacogenetics), large scale SNP detection and genotyping, in vitro and in vivo functional analyses of receptor variants, and linkage studies of markers and candidate alleles.
Selected Publications:
Jon-Kar Zubieta, Mary M. Heitzeg, Yolanda R. Smith, Joshua A. Bueller, Ke Xu, Yanjun Xu, Robert A. Koeppe, Christian S. Stohler, David Goldman:
COMT val158met Genotype Affects mu-Opioid Neurotransmitter Responses to a Pain Stressor. Science 2003;299:1240-43.
Michael F. Egan, Terry E. Goldberg, Bhaskar S. Kolachana, Joseph H. Callicott, Chiara M. Mazzanti, Richard E. Straub, David Goldman, and Daniel R. Weinberger:
Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci 2001;98(12):6917？？？22.
Ke Xu, Dirk Lichtermann, Robert H. Lipsky, Petra Franke, Xiehe Liu, Ying Hu, Liping Cao, Sibylle G. Schwab, Dieter B. Wildenauer, Claiton HD Bau, Erica Ferro,
Will Astor, Thembi Finch, Jeanietta Terry, Julie Taubman, Wolfgang Maier, David Goldman:
Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations. Arch Gen Psychiatry 2004;61(6):597-606.
Ahmad R. Hariri, Venkata S. Mattay, Alessandro Tessitore, Bhaskar Kolachana, Francesco Fera, David Goldman, Michael F. Egan, Daniel R. Weinberger:
Serotonin transporter genetic variation and the response of the human amygdala. Science 2002;297(5580):400-3.
For more information see our website - NIH Neuroscience Seminar Series
Multilevel Effects of Functional Loci in Complex Behavior
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- Understanding Nuclear Reprogramming
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- - Hochedlinger, Konrad.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Stem Cell
- - Hochedlinger, Konrad.
- The Stem Cell Interest Group was established to enhance communication and to foster collaboration among scientists from varying disciplines interested in stem cells. Topics of interest include fundamental stem cell biology, ontogeny, gerontology, and the therapeutic potential of stem cells. The SCIG serves as an open forum for discussion and dissemination of knowledge about all aspects of stem cell biology
For more information, visit
http://tango01.cit.nih.gov/sig/home.taf?_function=main&SIGInfo_SIGID=115
Understanding Nuclear Reprogramming
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- National Advisory Allergy and Infectious Diseases Council - September 2008 (NIH Only)
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- - Fauci, Anthony S.
National Advisory Allergy and Infectious Diseases Council (U.S.). Meeting (2010/11/18) - - Category : NIAID Council (NIH Only)
- - Fauci, Anthony S.
- The NAAIDC provides second level peer review of grant applications and discusses concept clearances and other matters pertaining to grant applications for NIAID. Their website http://www.niaid.nih.gov/ncn/budget/default_council.htm
offers information about meeting dates, council members, and has an archive of past meeting minutes. At each meeting, Dr. Antony Fauci, NIAID Director, presents information about the Institute, including new staff, status of the budget, status of research and other areas of interest to the council. A guest speaker also does a presentation. At the September 2008 meeting it will be Dr. Kathryn Zoon, Director of NIAIDs Division of Intramural Research. Dr. Zoon will present information about the division and its research.
National Advisory Allergy and Infectious Diseases Council - September 2008 (NIH Only)
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- TRACO: Clinical Trials and Metastasis
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- - Janik, J.
National Institutes of Health (U.S.) (2010/11/18) - - Category : TRACO
- - Janik, J.
- For more information, visit
http://ccr.cancer.gov/careers/traco.asp
TRACO: Clinical Trials and Metastasis
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- AIDS Research Advisory Committee - September 2008 (NIH Only)
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- - National Institute of Allergy and Infectious Diseases (U.S.). AIDS Research Advisory Committee. Meeting (2010/11/18)
- - Category : AIDS Research Advisory Committee (NIH Only)
- For more information, visit
http://www3.niaid.nih.gov/about/overview/councilcommittees/arac.htm
AIDS Research Advisory Committee - September 2008 (NIH Only)
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- Town Hall Meeting and Information Session: BTRIS, the NIH Biomedical Translational Research Information System
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- - Cimino, James J.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Special
- - Cimino, James J.
- Dr. Jim Cimino, Chief, Laboratory for Informatics Development, NIH CC, will present a demonstration of the Biomedical Translational Research Information System (BTRIS)
BTRIS, the NIH Biomedical Translational Research Information System, will help investigators identify promising new avenues for research and foster data sharing across institutes and with extramural collaborators.
Learn more about how BTRIS will be developed, opportunities for investigators to participate in its design, and project goals.
Town Hall Meeting and Information Session: BTRIS, the NIH Biomedical Translational Research Information System
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- National Advisory Research Resources Council - September 2008
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- - National Advisory Research Resources Council. (2010/11/18)
- - Category : National Advisory Research Resources Council
- During this meeting of the National Advisory Research Resources Council, NCRR Director Barbara Alving, M.D. will unveil the NCRR Strategic Plan 2009-2013. The discussion includes the presentation of a Web site that will track progress made under the plan. The agenda also features reports on a wide range of NCRR-supported activities, including those at the Proteomics Research Resource for Integrative Biology and the Johns Hopkins Institute for Clinical and Translational Research. During this Council meeting, NCRR staff will report on its response to recommendations made in the 2007 evaluation of the Biomedical Technology Research Resources program.
Additional reports will provide information on the progress of Working Groups that help to monitor and direct the activities of: 1) the National Synchrotron Light Source II, and 2) the NCRR-supported Chimpanzee Sanctuary. In addition, Dr. Alving will provide an Institutional Development Award (IDeA) program update. The open session will conclude with the introduction of a planned workshop: Control of Select Pathogens in Animal Facilities, which will address problems and challenges with the detection, control, and elimination of emerging pathogens.
The National Advisory Research Resources Council is comprised of 18 appointed members who serve for overlapping four-year terms. The membership includes leaders in scientific disciplines related to the activities of NCRR, as well as members of the general public who are leaders in fields of public and health policies, law, economics, and management. The Council meets three times a year to conduct second-level review of applications as required by law. The Council also advises NCRR on other funding activities, policies, and program considerations.
For more information, visit
http://www.ncrr.nih.gov
National Advisory Research Resources Council - September 2008
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- So Much to Do, So Little Time: Unraveling the Molecular Mechanisms of Helicases Associated with Human Disease and Aging
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- - Dr. Bob Brosh, NIA, NIH (2010/11/18)
- - Category : DNA Repair
- The DNA Repair Interest Group is concerned with all forms of DNA damage and repair. As a major defense against environmental damage to cells DNA repair is present in all organisms examined including bacteria, yeast, drosophila, fish, amphibians, rodents and humans. The members of the DNA Repair Interest Group perform research in areas including DNA repair enzymology and fine structure, mutagenesis, gene and cell cycle regulation, protein structure, and human disease.
Acrobat Slides
For more information, visit the
DNA Repair Interest Group
So Much to Do, So Little Time: Unraveling the Molecular Mechanisms of Helicases Associated with Human Disease and Aging
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- Back to School Strategies for Success: High School
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- - Fred Evans (2010/11/18)
- - Category : Parenting
- Back-to-school struggles are common yet still surprise many parents. In order to help our children cope and succeed, it is valuable to consider the physical and emotional growth from year to year as well as define and communicate expectations. You are invited to attend this age-specific educational sessions designed to review:
1) your child？？？s point of view & developmental transitions and
2) best practices for communicating with significant others in your child？？？s world.
Handout available for download at http://videocast.nih.gov/pdf/parenting091708.pdf.
Back to School Strategies for Success: High School
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- Computer-based Training in Cognitive Behavioral Therapy (CBT4CBT): New Directions for Behavioral Therapies Research
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- - Carroll, Kathleen.
National Institutes of Health (U.S.) (2010/11/18) - - Category : BSSR Lecture Series
- - Carroll, Kathleen.
- As is the case in many areas of health care but perhaps most evident in the treatment of addiction, there is a tremendous gap between research and practice. In response to this issue, Dr. Carroll and her colleagues developed a computer assisted version of cognitive behavioral therapy (CBT4CBT). CBT has a strong record of efficacy across a range of substance use and psychiatric disorders. The skills-based approaches of CBT are extremely well suited to a computer-based, multimedia format. The multimedia style of CBT4CBT includes presentation of material in a range of formats including multiple videotaped examples that allow users to actually see professionally produced movies of people implementing CBT coping skills in realistic settings. Other examples include interactive graphics and games, verbal instructions and audio voice-overs, interactive assessments, and practice exercises(？？？homework？？？).
A recently published randomized clinical trial of CBT4CBT demonstrated its efficacy in reducing substance use in a heterogeneous group of drug and alcohol users entering a community-based outpatient substance abuse clinic. The initial findings are consistent with previous work demonstrating the efficacy of computerized versions of CBT for the treatment of depression and anxiety. Dr. Carrolls and her colleagues work on CBT4CBT extends these findings in several important ways.- While previous studies have relied predominantly on unblended patient self-reports of improvement, Dr. Carrolls team has demonstrated efficacy with biologically verified outcome indicators (urine and breath samples. They have been able to document significantly longer periods of abstinence among those using the CBT4CBT program.
- They have demonstrated enduring efficacy of the CBT4CBT program, again with biologically-verified outcomes, through a six-month follow-up evaluation.
- They have used independent (blind) ratings of participants？？？ levels of coping skills before and after treatment to demonstrate that the CBT4CBT program actually teaches the targeted coping skills (relative to standard treatment)and that acquisition of these skills contributes to the enduring effects of the program (e.g., evidence of mediation).
- They have demonstrated that the program is highly cost effective, producing significant improvements in outcome at minimal cost. Thus, not only can computer-assisted programs such as CBT4CBT dramatically enhance availability and reduce costs of providing empirically validated therapies, but the level of quality control and standardization is an important strategy for understanding the mechanisms of effective behavioral therapies.
Dr. Kathleen M. Carroll graduated summa cum laude from Duke University, received her Ph.D. in clinical psychology in 1988 from the University of Minnesota, and completed her pre-doctoral training at the Yale University School of Medicine？？？s Division of Substance Abuse, where she was promoted to Professor in 2002. Since 1994 she has served as Scientific Director of the Center for Psychotherapy Development at Yale, NIDA？？？s only Center devoted to behavioral therapies research, and since 1999 she has been Principal Investigator of the New England Node of the National Institute on Drug Abuse？？？s Clinical Trials Network, one of the four founding centers funded in this national infrastructure.
An ISI Thompson ISI Highly Cited Researcher, Dr. Carroll is the author of over 150 peer-reviewed publications as well as numerous chapters and books. Her research has focused on the development and evaluation of behavioral treatments and combinations of behavioral therapies and pharmacotherapies, with an emphasis on improving the quality and rigor of clinical efficacy research in the addictions. Dr. Carroll received a NIH MERIT (Method to Extend Research in Time) in 2003 for her work on developing computer-assisted training in cognitive-behavioral therapy. Dr. Carroll served as President of the American Psychological Association？？？s Division 50 (Addictions) from 2002-2005 and received the Divisions？？？ Distinguished Scientific Contributions to Education and Training Award in 2005.
Computer-based Training in Cognitive Behavioral Therapy (CBT4CBT): New Directions for Behavioral Therapies Research
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- Innovative Employer Caregiving Programs
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- - Centers for Medicare & Medicaid Services (2010/11/18)
- - Category : CMS - Centers for Medicare & Medicaid Services
- The Centers for Medicare & Medicaid Services (CMS) and the New Freedom Initiative (NFI) Subcommittee on Caregiving present a special satellite broadcast, ？？？Innovative Employer Caregiving Programs.？？？ The program is designed to provide employers, caregivers, and human services professionals with information about and examples of successful programs for employed caregivers.
Presenters will discuss the current research and describe programs designed to support employed caregivers. Listeners will hear first hand how employers are addressing this issue, learn how caregivers are finding the support they need to more successfully balance their work and caregiving responsibilities and discover tips and methods for replicating these approaches in their own agencies and companies.
The broadcast will be introduced by Kerry Weems, CMS Acting Administrator.
Why is this important?- A unique opportunity to reach out to organizations that work to support caregivers in their interaction with Medicare and Medicaid.
- Raise awareness and sensitivity to the challenges employed caregivers have in balancing work and their caregiving responsibilities.
- Improve the coordination of resources and services for caregivers, employers and partners.
- Learn about the economic impact caregiving has in the workplace.
- Identify caregiving resources for your work and/or personal needs.
- Identify new partner agencies for current or future HHS collaborations.
Innovative Employer Caregiving Programs
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- Structure and Function of the Immunological Synapse
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- - Andrey Shaw, M.D. (2010/11/18)
- - Category : Immunology
- Andrey is interested in how T cells and NK cells recognize their targets and how this recognition event is translated into an appropriate immunological response. He combines biochemical and genetic analyses with modern imaging methods, which are essential to understand signaling at the single cell level. His work has revealed important features of the immunological synapse, such as T cell receptor signaling prior to synapse formation, and T cell receptor internalization at the center of the synapse. He is using mathematical modeling to develop hypotheses about the role of the synapse in controlling the strength of signals. Andrey is an entertaining speaker, not afraid to challenge established views.
For more information, visit
The Immunology Interest Group
Structure and Function of the Immunological Synapse
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- NIH Diversity Seminar Series - September 2008 (NIH Only)
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- - Dr. Joan Reede, Dean, Office of Diversity and Community Partnerships, Harvard Medical School, Boston, MA. (2010/11/18)
- - Category : Diversity (NIH Only)
- The NIH Diversity Seminar Series provides focused, timely, and relevant educational training that takes into account the professional developmental needs of NIH employees and managers that are necessary to link diversity to organizational performance. Dr. Reede will continue our discourse on diversity as our keynote speaker.
NIH Diversity Seminar Series - September 2008 (NIH Only)
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- Energy Medicine Research in an Oncology Setting
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- - Lutgendorf, Susan.
National Institutes of Health (U.S.) (2010/11/18) - - Category : OCCAM Monthly Lecture Series
- - Lutgendorf, Susan.
- The NCIs Office of Cancer Complementary and Alternative Medicine (OCCAM) invites you to view its monthly lecture series.
With the goal of informing the National Cancer Institute (NCI) community about the variety of ongoing research in cancer and complementary and alternative medicine (CAM), NCIs Office of Cancer Complementary and Alternative Medicine (OCCAM) has created a monthly lecture series on cancer CAM. These hour long lectures, occurring from 10 a.m. - 11 a.m. on the second Wednesday of each month, will feature a fifty minute presentation on a cancer CAM topic and allow ten minutes for questions.
For more information, visit
http://www.cancer.gov/cam/news/monthly-lecture-series.html
Energy Medicine Research in an Oncology Setting
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- The Third Annual Philip S. Chen, Jr., Ph.D. Distinguished Lecture on Innovation and Technology Transfer - Innovation in the Imaging Sciences at the National Institutes of Health
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- - Dr. Robert S. Balaban (2010/11/18)
- - Category : Philip S. Chen
- Dr. Balaban is the Director, Division of Intramural Research and Chief of the Laboratory of Cardiac Energetics in the National Heart Lung and Blood Institute. Please join us for this lecture from a leading NIH inventor in the imaging sciences in this series that honors Dr. Phil Chen？？？s many contributions to the NIH.
The Third Annual Philip S. Chen, Jr., Ph.D. Distinguished Lecture on Innovation and Technology Transfer - Innovation in the Imaging Sciences at the National Institutes of Health
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- Session 1: Overview of the Academic Job Search
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- - Sharon Milgram, PhD (2010/11/18)
- - Category : Career Development/OITE
- As you begin your search for an academic job, it is important to be aware of all the aspects of a well-planned job search. In this workshop, hear an overview of what you need to do to ensure a productive academic job search.
This is a seminar-style presentation. Topics to be covered include:- Finding job announcements
- The application packet:
- CV
- Cover letter
- Letters of recommendation
- Teaching/research statements
- Timeline
- What search committees look for in applicants
Session 1: Overview of the Academic Job Search
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- Learning to Express Human Proteins: Following Evolutions Lead
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- - Hartley, James.
National Institutes of Health (U.S.). Structural Biology Interest Group. (2010/11/18) - - Category : Systems Biology
- - Hartley, James.
- Systems Biology Speaker Series
http://www.nih.gov/sigs/sysbio
Learning to Express Human Proteins: Following Evolutions Lead
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- Fourth Annual NIH Directors Pioneer Award Symposium (Day 1)
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- - NIH Directors Pioneer Awards Symposium (2010/11/18)
- - Category : Conferences
- The event features a keynote address by NIH Director Dr. Elias Zerhouni, talks by scientists who received Pioneer Awards in 2007, poster sessions by Pioneer and New Innovator Award recipients, roundtable discussions, and ample opportunities for informal interaction. At the start of the symposium, Zerhouni will announce the 2008 recipients of NIH Director？？？s Pioneer and New Innovator awards. Both programs support exceptionally creative scientists who take highly innovative, and often unconventional, approaches to major challenges in biomedical or behavioral research.
http://nihroadmap.nih.gov/pioneer/Symposium2008/index.aspx
Fourth Annual NIH Directors Pioneer Award Symposium (Day 1)
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- NCCAM Grantsmanship Workshop 2008 (Day 3)
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- - NCCAM (2010/11/18)
- - Category : Conferences
- The National Center for Complementary and Alternative Medicine (NCCAM), a component of the National Institutes of Health (NIH), will conduct a 3-day grantsmanship workshop. This workshop will provide researchers, fellows, and graduate students with an in-depth understanding of the NIH grants and review processes, clarify Federal regulations and policies, and highlight areas of special interest and concern.
Emphasis will be placed on complementary and alternative medicine (CAM) research. The workshop will include time to interact and discuss research ideas with NCCAM staff. For more information, visit
http://nccam.nih.gov/news/2007/110707.htm
NCCAM Grantsmanship Workshop 2008 (Day 3)
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- Free-choice Activates Decision Circuits
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- - Andersen, Richard A.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Neuroscience
- - Andersen, Richard A.
- The posterior parietal cortex of the brain lies between the sensory and the movement regions of the cerebral cortex and serves as a bridge from sensation to action. Dr. Andersen？？？s lab has found that an anatomical map of plans exists within this area, and that one part is devoted to planning eye movements and another part to planning arm movements. Action plans in the arm movement area exist in a cognitive form, specifying the goal of the intended movement rather than particular signals to various muscle groups. Andersen？？？s lab has used the information gained about parietal cortex to begin development of a cognitive-based neural prosthesis for paralyzed patients.
NIH Neuroscience Seminar Series
Free-choice Activates Decision Circuits