전체 8345
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- Spatial Genome Organization in the Formation of Translocations and DNA Repair
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- - Misteli, Tom.
National Institutes of Health (U.S.). DNA Repair Interest Group. (2010/11/18) - - Category : DNA Repair
- - Misteli, Tom.
- The DNA Repair Interest Group is concerned with all forms of DNA damage and repair. As a major defense against environmental damage to cells DNA repair is present in all organisms examined including bacteria, yeast, drosophila, fish, amphibians, rodents and humans. The members of the DNA Repair Interest Group perform research in areas including DNA repair enzymology and fine structure, mutagenesis, gene and cell cycle regulation, protein structure, and human disease.
Acrobat Slides
For more information, visit the
DNA Repair Interest Group
Spatial Genome Organization in the Formation of Translocations and DNA Repair
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- Demystifying Medicine - Blindness
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- - Piatigorsky, Joram.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Demystifying Medicine
- - Piatigorsky, Joram.
- The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.
For more information, visit
http://www1.od.nih.gov/oir/DemystifyingMed
Demystifying Medicine - Blindness
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- Finding a Postdoc
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- - Sponsored by the NIH Office of Intramural Training & Education (2010/11/18)
- - Category : Career Development/OITE
- Objective: If you are at the stage in your graduate student career where you are beginning to ask questions such as ？？？Do I need to do a postdoc?？？？ ？？？What kind of postdoc should I do?？？？ or ？？？What can I expect in a postdoc?？？？ then this workshop is for you. This workshop will explore the issues that graduate students need to consider if they plan to pursue a post doctoral position. This workshop would be most beneficial to graduate students who are in their 3rd year or above.
Topics: Determining what type of postdoc to do. What issues should a graduate student be concerned with when looking for a postdoc.
Presented by Sharon L. Milgram, PhD, Director, Office of Intramural Training & Education and Mark VanDoren, Johns Hopkins University
Finding a Postdoc
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- Risk, Resilience, and Gene X Environment Interactions in Primates
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- - Stephen J. Suomi, Ph. D., NICHD (2010/11/18)
- - Category : BSSR Lecture Series
- Recent research with both humans and rhesus monkeys has provided compelling evidence of gene-environment (G x E) interactions throughout development. For example, a specific polymorphism of the serotonin transporter (5-HTT) gene is associated with deficits in infant neurobehavioral functioning, poor control of aggression and low serotonin metabolism during juvenile and adolescent development, and excessive alcohol consumption in early adulthood in monkeys reared with peers but not in monkeys reared by their mother. One interpretation of these findings is that secure attachment relationships somehow confer resiliency to individuals who carry alleles that may otherwise increase their risk for adverse developmental outcomes (？？？maternal buffering？？？). Similar patterns of apparent ？？？buffering？？？ have been demonstrated for G x E interactions involving several other genes with functionally equivalent polymorphisms in both humans and rhesus monkeys. Recent research has suggested that much of this ？？？buffering？？？ may be taking place in the context of early face-to-face interactions between rhesus monkey mothers and their infants. Moreover, the allelic variation seen in these genes in rhesus monkeys and humans but apparently not in other primate species may actually contribute to their remarkable adaptability and resilience at the species level.
About the Speaker
Stephen J. Suomi, Ph.D. is Chief of the Laboratory of Comparative Ethology at the National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH) in Bethesda, Maryland. He also holds appointments as Research Professor at the University of Virginia (Psychology), the University of Maryland, College Park (Psychology), and The Johns Hopkins University (Mental Hygiene), and is an Adjunct Professor at Georgetown University (Psychology), the Pennsylvania State University (Human Development) and the University of Maryland, Baltimore County (Psychology). Dr. Suomi studied Psychology as an undergraduate at Stanford University, then continued his studies as a graduate student at the University of Wisconsin-Madison, receiving his Ph.D. in Psychology in 1971. Dr. Suomi then joined the Psychology faculty at the University of Wisconsin-Madison, where he eventually attained the rank of Professor. In 1983 he left Wisconsin to join the NICHD, when he began his present position.
Dr. Suomi has received international recognition for his extensive research on biobehavioral development in rhesus monkeys and other primate species. His initial postdoctoral research successfully reversed the adverse effects of early social isolation, previous thought to be permanent, in rhesus monkeys.
His subsequent research at Wisconsin led to his election as Fellow in the American Association for the Advancement of Science ？？？for major contributions to the understanding of social factors that influence the psychological development of nonhuman primates.？？？ Since joining the NICHD he has identified heritable and experiential factors that influence individual biobehavioral development, characterized both behavioral and physiological features of distinctive rhesus monkey phenotypes, and demonstrated the adaptive significance of these different phenotypes in naturalistic settings. His present research focuses on 3 general issues: the interaction between genetic and environmental factors in shaping individual developmental trajectories, the issue of continuity vs. change and the relative stability of individual differences throughout development, and the degree to which findings from monkeys studied in captivity generalize not only to monkeys living in the wild but also to humans living in different cultures.
Throughout his professional career Dr. Suomi has been the recipient of numerous awards and honors. To date, he has authored or co-authored over 350 articles published in scientific journals and chapters in edited volumes. He has also delivered over 350 invited colloquia, symposium and workshop presentations, and convention papers in 43 states in the U.S. and in 16 foreign countries.
This lecture is an installment of the Behavioral and Social Sciences Research Lecture Series sponsored by the NIH Office of Behavioral and Social Sciences Research and organized by the NIH Behavioral and Social Sciences Research Coordinating Committee.
The Behavioral and Social Sciences Research Coordinating Committee (BSSR CC), with support from the Office of Behavioral and Social Sciences Research (OBSSR), convenes a series of guest lectures and symposia on selected topics in the behavioral and social sciences. These presentations by prominent behavioral and social scientists provide the NIH community with overviews of current research on topics of scientific and social interest. The lectures and symposia are approximately 50 minutes in length, with additional time for questions and discussion. All seminars are open to NIH staff and to the general public.
Risk, Resilience, and Gene X Environment Interactions in Primates
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- Molecular Detection and Staging of Cancer
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- - Sidransky, David.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Special
- - Sidransky, David.
- NIDCR 2009 Seminar Series: From Basic Research to Therapy -- The Latest Frontier
Dr. David Sidransky of Johns Hopkins University will discuss his recent findings of genetic and epigenetic markers of lung and head and neck cancers, and will describe how genetic alterations can be used to predict the development and progression of these cancers. He will also talk about new xenograft models of human cancers and their use in drug development and personalization of cancer therapies, and the use of technologies to track new markers in these models and in clinical samples.
A pioneer in the molecular detection of cancer, Dr. Sidransky was the first to show that oncogenes and tumor suppressor gene mutations could be detected in urine, stool, and sputum from bladder, colon, and lung cancer patients, respectively. He has also shown that such mutations can be detected in surgical margins and lymph nodes, providing information about the spread of disease that cannot be obtained through standard pathologic examination.
Dr. Sidransky is a Professor of Otolaryngology, Oncology, Pathology, Urology, Genetics, and Cellular and Molecular Medicine at Johns Hopkins University (JHU). He is also the director of head and neck cancer research at the JHU Kimmel Comprehensive Cancer Center as well as a principal investigator at JHU？？？s Head and Neck Cancer SPORE, or Specialized Program of Research Excellence.
For more information, visit http://www.nidcr.nih.gov/NewsAndFeatures/Announcements/NewSeminarSeries.htm
Molecular Detection and Staging of Cancer
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- CC Grand Rounds: (1) Post-Katrina Health Care: Present Status and Future Considerations (2) Recovery and Rebuilding the Safety Net Post-Katrina
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- - Keith C. Ferdinand, MD and Karen B. DeSalvo, MD, MPH, MSc (2010/11/18)
- - Category : Clinical Center Grand Rounds
- Clinical Center Grand Rounds
Keith C. Ferdinand, MD
Chief Science Officer, Association of Black Cardiologists
Clinical Professor, Division of Cardiology, Emory University
Karen B. DeSalvo, MD, MPH, MSc
C. Thorpe Ray Chair, Internal Medicine
Vice Dean, Community Affairs and Health Policy
Chief, General Internal Medicine and Geriatrics
Tulane University School of Medicine
For more information, visit
http://www.cc.nih.gov/about/news/grcurrent.html
CC Grand Rounds: (1) Post-Katrina Health Care: Present Status and Future Considerations (2) Recovery and Rebuilding the Safety Net Post-Katrina
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- Exploring the bacterial internal organization: Cell polarization and cytoskeleton-dependent cell morphogenesis
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- - Jacobs-Wagner, Christine.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Wednesday Afternoon Lectures
- - Jacobs-Wagner, Christine.
- Bacteria, formerly viewed as miniature bags of randomly distributed chemicals, are in fact highly polarized, possess a cytoskeleton, and depend critically on this surprisingly exquisite cellular organization for many cellular functions.
Our laboratory studies the molecular mechanisms involved in this internal organization at multiple levels, from its origin, maintenance and replication in time and space to its function in cell morphogenesis and cell cycle regulation.
We use the morphologically polarized and crescent-shaped bacterium Caulobacter crescentus as a model.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Exploring the bacterial internal organization: Cell polarization and cytoskeleton-dependent cell morphogenesis
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- B Cell Abnormalities in HIV Infection: Impact of Virus-Induced Lymphopenia and Immune Activation
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- - Moir, Susan.
National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18) - - Category : Immunology
- - Moir, Susan.
- Next weeks IIG seminar will be by one of our own investigators, Susan Moir, a staff scientist and expert virologist working at the Laboratory of Immunoregulation, NIAID. In her work in collaboration with Dr. Anthony Fauci, Susan has cleverly characterized immune responses in HIV-infected individuals, both before and after treatment with antiretroviral drugs. Among her discoveries in the field is the finding of various B cell anomalies that occur under high viremic conditions. She has recently reported the existence of a pool of B cells with an exhausted phenotype and reduced memory capability in HIV-infected individuals. Come to see her seminar and open your eyes to the B cell side of retroviral infection!
http://www3.niaid.nih.gov/labs/aboutlabs/lir/immunopathogenesisSection/fauci.htm
For more information, visit
The Immunology Interest Group
B Cell Abnormalities in HIV Infection: Impact of Virus-Induced Lymphopenia and Immune Activation
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- Stars in Nutrition and Cancer: Nanonutrition Frontiers- Lessons Learned from Imaging and Therapy (NIH-Only)
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- - Martin Philbert, Ph.D. (2010/11/18)
- - Category : Stars in Nutrition
- NCI Stars in Nutrition Lecture Series
The recent development of polymer nanoparticles for intracellular imaging has provided for nanometer-scaled measurements of important intracellular physiological ions and small molecules. Further refinements of the technology permit targeting of the nanoparticle to specific organelles and imaging of physical properties such as E-fields propagated by mitochondria and other cytoplasmic elements. The design of these nanoparticles requires the incorporation of high functionality, targeting and biocompatibility. These properties lend themselves to optimized pharmokinetic/pharmocodynamic properties while minimizing toxicity.
Nutritional status is a major modulator of morbidity and mortality for many cancers. Many opportunities exist for the development of nanotechnology approaches for nutrient-based management and treatment of several cancers. However, many of the considerations pertinent to the development of cancer imaging and therapeutic platforms will be critical for the safe development of novel delivery platforms for micro- and other nutrients, the preservation of healthy foodstuffs and the administrationof nutriceuticals.
Meeting Objectives:- To present configuration of polymer nanosensors, imaging nano-agents and photodynamic nanoparticles;
- To show capabilities of sensors, imaging and photodynamic nanoparticles;
- To present data on AD(M)E of polymer nanoparticles; and
- To present a priori considerations of toxicity in the design of useful therapeutic/imaging nanoparticle agents.
For more information, visit
http://prevention.cancer.gov
Stars in Nutrition and Cancer: Nanonutrition Frontiers- Lessons Learned from Imaging and Therapy (NIH-Only)
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- Making the Move to Academics
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- - Sponsored by the NIH Office of Intramural Training & Education (2010/11/18)
- - Category : Career Development/OITE
- Objective: learn what you need to know about navigating the academic environment in your future department. You？？？ll learn important points to consider when deciding what equipment you need to set up your lab and how to find the best people to work in your lab. Also, learn about other expectations of a junior faculty member.
Topics: What to expect; setting up your lab; finding/hiring research assistants.
Presented by Sharon L. Milgram, PhD, Director, Office of Intramural Training & Education
Making the Move to Academics
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- Crystal Structure of Prion Proteins
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- - Yee, Vivien.
National Institutes of Health (U.S.). Structural Biology Interest Group. (2010/11/18) - - Category : Structural Biology
- - Yee, Vivien.
- The SBIG is a clearinghouse for discussions and interactions between scientists interested in all aspects of molecular structure, from experimental determination by x-ray crystallography, electron microscopy, mass spectrometry, and NMR, to theoretical and computational biology and biophysics, and to the biological application of structural data.
For more information, visit
Structural Biology Interest Group
Crystal Structure of Prion Proteins
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- Imaging Experience-dependent Emergence of Functional Circuits in Visual Cortex
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- - Fitzpatrick, David.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Neuroscience
- - Fitzpatrick, David.
- Dr. Fitzpatrick？？？s research focuses on the functional and anatomical organization of neural circuits in the primary visual cortex. His laboratory performs in vivo experiments using a combination of optical imaging, intracellular recording, and neural anatomical tracing techniques to understand how cortical neural circuits represent visual stimuli. His work has contributed to our fundamental understanding of neural connectivity with respect to classical receptive fields, and how stimulus features such as orientation, direction of motion and speed are represented within the visual cortex. Recent work, focusing on the role of visual stimuli during postnatal development has revealed that cortical direction selectivity is driven by early experience with moving visual stimuli. These findings help to underscore other studies from the Fitzpatrick？？？s lab demonstrating the importance of early sensory experience in cortical circuit formation. Dr. Fitzpatrick is a Full Professor in the Department of Neurobiology at Duke University Medical Center, and has recently been named Director of the Duke Institute for Brain Sciences.
Selected Publications:
Li Y, Van Hooser SD, Mazurek M, White LE, Fitzpatrick D.
Experience with moving visual stimuli drives the early development of cortical direction selectivity.
Nature. 2008 Dec 18;456(7224):952-6.
White LE, Fitzpatrick D.
Vision and cortical map development.
Neuron. 2007 Oct 25;56(2):327-38.
Tucker TR, Fitzpatrick D.
Luminance-evoked inhibition in primary visual cortex: a transient veto of simultaneous and ongoing response.
J Neurosci. 2006 Dec 27;26(52):13537-47.
Li Y, Fitzpatrick D, White LE.
The development of direction selectivity in ferret visual cortex requires early visual experience.
Nat Neurosci. 2006 May;9(5):676-81. Epub 2006 Apr 9.
Mooser F, Bosking WH, Fitzpatrick D.
A morphological basis for orientation tuning in primary visual cortex.
Nat Neurosci. 2004 Aug;7(8):872-9.
For more information see our website - NIH Neuroscience Seminar Series
Imaging Experience-dependent Emergence of Functional Circuits in Visual Cortex
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- Applicant Help: ARRA/Recovery Act Construction Programs
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- - Willie D. McCullough, Ph.D. (2010/11/18)
- - Category : Special
- The National Center for Research Resources will hold a videocast on Monday, March 23, 2009, from 1:00 to 2:30 p.m. EDT to answer frequently asked questions about the application process for core facilities improvement projects (RFA-RR-09-007) and construction, renovation and repair improvement projects (RFA-RR-09-008). The seminar is open to the public, and replaces the previously planned seminar that experienced technical difficulties.
Prior to the seminar, participants are asked to review the following information:- Overview slides
- FAQ ？？？ Extramural Research Facilities Improvement Program (C06)
- FAQ ？？？ Core Facility Renovation, Repair and Improvement (G20)
For more information, visit www.ncrr.nih.gov/recovery.
Applicant Help: ARRA/Recovery Act Construction Programs
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- GMAC Seminar - Cost Principles & Administrative Requirements(HHS Only)
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- - NIH (2010/11/18)
- - Category : GMAC (HHS Only)
- GMAC Subcommittee on Training
http://odoerdb2.od.nih.gov/gmac/gmac/trs_main.html
GMAC Seminar - Cost Principles & Administrative Requirements(HHS Only)
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- Demystifying Medicine - Hepatocellular cancer: A global epidemic
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- - Thorgeirsson, Snorri S.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Demystifying Medicine
- - Thorgeirsson, Snorri S.
- The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.
For more information, visit
http://www1.od.nih.gov/oir/DemystifyingMed
Demystifying Medicine - Hepatocellular cancer: A global epidemic
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- Role of MicroRNA in the Pathogenesis of Human Cancer (NIH-Only)
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- - Croce, Carlo.
Center for Cancer Research (National Cancer Institute (U.S.)) (2010/11/18) - - Category : NCI CCR Grand Rounds (NIH Only)
- - Croce, Carlo.
- Dr. Carlo Croce earned his medical degree, summa cum laude, in 1969 from the School of Medicine, University of Rome. He began his career in the United States the following year as an associate scientist at the Wistar Institute of Biology and Anatomy in Philadelphia. In 1980, he was named Wistar Professor of Genetics at the University of Pennsylvania and associate director of the Wistar Institute, titles he held until 1988. From 1988 to 1991, he was director of the Fels Institute for Cancer Research and Molecular Biology at Temple University School of Medicine in Philadelphia. In 1991, Dr. Croce was named director of the Kimmel Cancer Center at Jefferson Medical College at the Thomas Jefferson University in Philadelphia. Under his direction at Ohio State, faculty within the Human Cancer Genetics Program conduct both clinical and basic research. Basic research projects focus on how genes are activated and inactivated, how cell-growth signals are transmitted and regulated within cells, and how cells interact with the immune system. Clinical research focuses on discovering genes linked to cancer and mutations that predispose people to cancer. Dr. Croce, a member of the National Academy of Sciences in the United States and the Accademia Nazionale delle Scienze detta deiXL in Italy, has received numerous significant cancer research awards including the 30th Annual Jeffrey A. Gottlieb Memorial Award and most recently the 2008 Leopold Griffuel Prize awarded by the French Association for Cancer Research. He is principal investigator on seven federal research grants and has authored more than 800 peer-reviewed, published research papers.
NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link:
http://www.bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx
Role of MicroRNA in the Pathogenesis of Human Cancer (NIH-Only)
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- Town Hall Meeting and Information Session: BTRIS, the NIH Biomedical Translational Research Information System
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- - Wilcox, Adam.
Biomedical Translational Research Information System. (2010/11/18) - - Category : Special
- - Wilcox, Adam.
- Form and Function: The Design and Use of Clinical Data Repositories in Supporting the Clinical Research Mission of Columbia University & New York Presbyterian Hospital
Dr. Adam Wilcox is an Assistant Professor at Columbia University and Director of the Systems Technology Interfacing Teaching and Community Hospitals (STITCH) at New York Presbyterian Hospital. His presentation, ？？？Form and Function: The Design and Use of Clinical Data Repositories in Supporting the Clinical Research Mission of Columbia University & New York Presbyterian Hospital？？？, will discuss the issues facing sharing information between three different institutions and the impact of this collaboration on privacy and research quality.
The Biomedical Translational Research Information System (BTRIS) team invites you to a series of lectures focused on informatics in biomedical and translational research. This series brings leading 詮？gures in the study and use of translational information systems from academic centers across the U.S. and will promote discussion about the future of informatics at the Clinical Center.
Learn more about how BTRIS will be developed, opportunities for investigators to participate in its design, and project goals.
For more information, visit http://btris.nih.gov
Town Hall Meeting and Information Session: BTRIS, the NIH Biomedical Translational Research Information System
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- Tumor Stroma & The Immune Response
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- - Hans Schreiber, MD, PhD (2010/11/18)
- - Category : Immunology
- Hans Schreiber has been doing cutting edge work on tumor immunology since the early 80s. Throughout his carrier he has worked to identify the antigenic components of cancer cells and how tumor specific CD8 cells can influence and change tumor immunogenicity. The main focus and novelty of his work, however, is on the role of the tumor stroma in tumor protection as well as tumor rejection by the immune system. Early in the 90s he observed that tumors given as tissues with their established stroma were more difficult to reject than tumor cells given in suspension and that an established subcutaneous tumor was not rejected while a skin graft was, even though both carried the same antigen and were in the same mouse; suggesting a tumor-protected role for the stromal cells. Recently, he found that increasing antigen cross-presentation by tumor stromal cells makes the tumor susceptible to rejection by tumor specific CD8 cells. His talk will focus on the idea that, for optimal tumor rejection, we not only have to attack the tumor cells but also the normal stromal cells, and he will dissect the mechanisms of such rejection. His work will change the way we think about how CD8 cells reject tumors. He is a good and energetic speaker with a challenging and engaging personality.
For more information, visit
The Immunology Interest Group
Tumor Stroma & The Immune Response
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- Your Inner Fish
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- - Shubin, Neil.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Evolution and Medicine
- - Shubin, Neil.
- What does the human hand have in common with the wing of a fly? Are breasts, sweat glands, and scales related? To understand the inner workings of our bodies and the origins of diseases, scientists turn to unexpected sources like worms, flies, and even fish. Dr. Shubin will tell the story of evolution by tracing the organs of the human body back millions of years, long before the first creatures walked the earth.
Dr. Neil Shubin is the author of Your Inner Fish (Pantheon, 2008) and Associate Dean and Professor of Organismal Biology and Anatomy at the University of Chicago.
Lecture series presented by National Institute of General Medical Sciences, the Office of Science Education, and the National Human Genome Research Institute. For more information, visit
http://www.nigms.nih.gov/News/Meetings/EvolutionSeries2009
Your Inner Fish
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- Business Etiquette
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- - Sponsored by the NIH Office of Intramural Training & Education (2010/11/18)
- - Category : Career Development/OITE
- Objective: No matter where your next career path takes you？？？you will need the tools to present yourselves with class and integrity in business situations. This seminar will cover the basics of etiquette including in person and online communications. Additionally, the speaker will cover American business etiquette practices for our non-US fellows. Our speaker is from the Post family of etiquette experts.
Presented by Anna Post, Emily Post Institute
http://www.emilypost.com/
Business Etiquette