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  • The New Health Gap: Science for Emerging Economies vs. the Bottom Billion
    • - Dr. Hans Rosling (2010/11/18)
    • - Category : Special
    Don???t miss this exciting and passionate presentation by Google collaborator and guru of global health data, Dr. Hans Rosling. He???ll unveil the beauty of statistics by turning boring numbers into enjoyable animations that make sense of the world???s global health gaps. Rosling is co-founder of Gapminder, a non-profit organization dedicated to promoting a fact-based world view through increased use and understanding of freely accessible public statistics. Gapminder developed the Trendalyzer software that converts international statistics into moving, interactive and enjoyable graphics. Google acquired the software and has expanded the effort. Rosling uses these animated graphics in talks that are both humorous and deadly serious, with the goal of promoting sustainable global development and encouraging achievement of the UN???s Millennium Development Goals.

    For more info, visit www.gapminder.org

    Also a professor of international health at Sweden???s Karolinska Institute, Rosling co-founded Médecines sans Frontier Sweden. While serving as a doctor in Mozambique from 1979 to 1981, he discovered konzo, a new epidemic paralytic disease. He spent the next two decades investigating the cause, which he traced to the consumption of toxic, ill-processed cassava roots combined with hunger and poverty. In addition, he has written a text book on global health and has initiated university collaborations with Asia and Africa.

    Dr. Rosling is visiting NIH as a Fogarty International Center Scholar-in-Residence, concluding the Center???s 40th anniversary activities. The events have been sponsored by the Foundation for NIH with generous support from Lilly, the Abbott Fund, Bristol-Myers Squibb Foundation, ExxonMobil, Pepsico, Aeras Global TB Vaccine Foundation, the Burroughs Wellcome Fund, Merck, Pfizer, Tibotec and the United Nations Foundation.

    http://www.fic.nih.gov/news/events/rosling.htm

    The New Health Gap: Science for Emerging Economies vs. the Bottom Billion

  • Neuropsychiatric genetics: From mendel to GWAS and back again
    • - David Goldstein, Ph.D., Duke University (2010/11/18)
    • - Category : Neuroscience
    Dr. David Goldstein is Professor of Molecular Genetics & Microbiology, Department of Biology and Director of Duke Institute for Genome Science & Policy, Center for Human Genome Variation since June 2005. Dr. Goldstein received his PhD in Biological Sciences from Stanford University in 1994, and from 1999 to 2005 was Wolfson Professor of Genetics at University College London. In April 2007, he was appointed Honorary Professor, Institute of Neurology, University College London, UK

    Dr. Goldstein is the author of over 100 scholarly publications in the areas of population and medical genetics. His principal interests include human genetic diversity, the genetics of neurological disease, and pharmacogenetics. As part of the Center for HIV-AIDS Vaccine Immunology (CHAVI), his laboratory also has a particular focus on the host genetics of HIV infection. He is the recipient of one of the first seven nationally awarded Royal Society / Wolfson research merit awards in the UK for his work in human population genetics. Dr. Goldstein was awarded the Triangle Business Journal Health Care Heroes Award: Innovator/Researcher Award, March 2008.

    NIH Neuroscience Seminar Series

    Neuropsychiatric genetics: From mendel to GWAS and back again

  • Genetic Predictors of RAF/MEK Dependence (NIH-Only)
    • - Solit, David.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : NCI CCR Grand Rounds (NIH Only)
    Dr. Solit received his M.D. from the University of Pennsylvania School of Medicine. He did his internship and residency in internal medicine at Barnes Hospital in St. Louis, Missouri. He was a fellow in medical oncology and hematology, Memorial Sloan-Kettering Cancer Center (MSKCC) and later did a fellowship in medicine at Weill Medical College of Cornell University in New York. Dr. Solit is a practicing medical oncologist and has held the position of assistant member and assistant attending physician in the Department of Medicine at MSKCC since 2005. He is also an assistant professor of medicine at the Joan and Sanford I. Weill Medical College of Cornell University in New York City. Since 2006, he has served as a Laboratory Head within the MSKCC Human Oncology and Pathogenesis Program where he directs an R01-funded basic science laboratory. In 2007, Dr. Solit was named the Elizabeth and Felix Rohatyn Chair for Junior Faculty and also received both a Kimmel Scholars Award and the Boyer Award for Excellence in Clinical Research. Dr. Solits research focuses on the identification of genetic and epigenetic alterations that cooperate with BRAF and RAS to promote tumorigenesis. A major focus of these efforts is to determine the effect of cooperative oncogenic events on BRAF and RAS addiction in tumors harboring RAS and BRAF mutations with the goal of using these data to accelerate the clinical development of inhibitors of this pathway and the identification of rational combination strategies.

    NCI???s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link: http://bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx.

    Genetic Predictors of RAF/MEK Dependence (NIH-Only)

  • NIH Consensus Development Conference: Lactose Intolerance and Health - Day 2
    • - National Institute of Child Health and Human Development (U.S.) (2010/11/18)
    • - Category : Conferences
    Be part of pivotal discussions on lactose intolerance--the inability to digest significant amounts of lactose, a sugar found in milk and other dairy products. After weighing the evidence from a systematic literature review, expert presentations, and audience input, an impartial, independent panel will present a statement of its collective assessment of the evidence to address five predetermined conference questions; these are listed at http://www.consensus.nih.gov.

    http://consensus.nih.gov/2010/lactose.htm

    NIH Consensus Development Conference: Lactose Intolerance and Health - Day 2

  • Regulatory and Epigenetic Landscapes of Mammalian Genomes
    • - Laura Elnitski, Ph.D. (2010/11/18)
    • - Category : Current Topics in Genome Analysis
    Current Topics in Genome Analysis

    http://genome.gov/COURSE2010

    Regulatory and Epigenetic Landscapes of Mammalian Genomes

  • 7T Seminar Series: Three Years of Experiece at NIH7T
    • - Fukunaga, Masaki.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : 7 T Seminars
    Recent technological advances in high field MRI provide excellent opportunity to investigate anatomical structure and function of the brain in fine scale that we havent reached before. This talk will present three years experience of 7T MRI for brain research at NIH.

    7T Seminar Series: Three Years of Experiece at NIH7T

  • Schizophrenia in the Genomic Age
    • - Daniel Weinberger (NIMH), Joseph Apud (NIMH) (2010/11/18)
    • - Category : Demystifying Medicine
    The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.

    For more information, visit
    http://www1.od.nih.gov/oir/DemystifyingMed

    Schizophrenia in the Genomic Age

  • NIH Consensus Development Conference: Lactose Intolerance and Health - Day 3
    • - National Institute of Child Health and Human Development (U.S.) (2010/11/18)
    • - Category : Conferences
    Be part of pivotal discussions on lactose intolerance--the inability to digest significant amounts of lactose, a sugar found in milk and other dairy products. After weighing the evidence from a systematic literature review, expert presentations, and audience input, an impartial, independent panel will present a statement of its collective assessment of the evidence to address five predetermined conference questions; these are listed at http://www.consensus.nih.gov.

    http://consensus.nih.gov/2010/lactose.htm

    NIH Consensus Development Conference: Lactose Intolerance and Health - Day 3

  • NIH-FDA Joint Announcement
    • - Speakers include HHS Secretary Kathleen Sebelius, NIH Director Francis S. Collins, M.D., Ph.D., and FDA Commissioner Margaret Hamburg, M.D. (2010/11/18)
    • - Category : Special
    The Department of Health and Human Services (HHS) will announce new collaborative efforts between the National Institutes of Health (NIH) and the Food and Drug Administration (FDA) to help speed the translation of research into medical products and therapies.

    NIH-FDA Joint Announcement

  • The Science of Small Clinical Trials Lecture Series: Methods of Particular Interest for Small Clinical Trials (Part 1 of 2)
    • - Office of Rare Diseases Research (NIH) & Office of Orphan Products Development (FDA) (2010/11/18)
    • - Category : Science of Small Clinical Trials
    Over two lectures, Drs. Coffey & Wittes will describe some clinical trial design and analysis methods that are of particular interest in instances of small study populations, including: cross-over, n-of-1, factorial, sequential, adaptive, play-the-winner, risk-based allocation, and case-control, illustrated by case studies of Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrigs Disease) and Mucopolysaccaridosis type VI (Maroteaux-Lamy Syndrome).

    The Science of Small Clinical Trials Lecture Series: Methods of Particular Interest for Small Clinical Trials (Part 1 of 2)

  • CC Grand Rounds - Phenotypes as Clues to Deciphering the Pathogenesis and Treatment of Myositis
    • - Lisa G. Rider, MD, and Frederick W. Miller, MD, PhD (2010/11/18)
    • - Category : Clinical Center Grand Rounds
    Lisa G. Rider, MD,
    Deputy Chief, Environmental Autoimmunity Group,
    Office of Clinical Research, NIEHS

    Frederick W. Miller, MD, PhD,
    Chief, Environmental Autoimmunity Group,
    Office of Clinical Research, NIEHS

    For more information, visit
    http://www.cc.nih.gov/about/news/grcurrent.html

    CC Grand Rounds - Phenotypes as Clues to Deciphering the Pathogenesis and Treatment of Myositis

  • A Case Study Clinical Trial Management in Africa: HPTN 035, A phase 2/2b trial to evaluate topical microbidices
    • - Sharon L. Hillier, Ph.D (2010/11/18)
    • - Category : Special
    Sharon L. Hillier, Ph.D., Principal Investigator of the Microbicide Trials Network and Professor of, Obstetrics, Gynecology and Reproductive Sciences, and Molecular Genetics and Biochemistry at the University of Pittsburgh will discuss issues and challenges surrounding trial implementation.

    The objectives of this seminar series are to share experiences among ICs on practical aspects of conducting clinical trials in low-income or cross-cultural settings , drawing on specific examples of challenges encountered and creative resolutions, and to discuss how these experiences may be applied to current and future trials.

    Background:
    HPTN 035 represents a multi-center clinical trial that evaluated the safety and effectiveness of two candidate microbicides, BufferGel® and PRO 2000 for preventing HIV infection in women. The study was conducted between February 2005 and September 2008 among 3,099 HIV-negative women at seven clinical research sites in Malawi, South Africa, Zambia, Zimbabwe and the United States. The study investigators found the microbicide gel???known as PRO 2000 (Indevus Pharmaceuticals, Inc., Lexington, Mass.)???to be safe and approximately 30 percent effective. This is the first human clinical study to suggest that a microbicide may prevent male-to-female sexual transmission of HIV infection. HPTN 035 was conducted by the Microbicide Trials Network (MTN), an HIV/AIDS clinical trials network established in 2006 by NIAID with co-funding from NICHD and NIMH. Prior to the establishment of the MTN, the study was led by the NIAID-funded HIV Prevention Trials Network (HPTN), from which the study derives its name.

    A Case Study Clinical Trial Management in Africa: HPTN 035, A phase 2/2b trial to evaluate topical microbidices

  • Medicine Dish - Urban Indian Health Programs
    • - Kitty Marx (2010/11/18)
    • - Category : CMS - Centers for Medicare & Medicaid Services
    Experts from the Urban Indian Health Programs, National Council of Urban Indian Health and IHS will cover:
    • Overview of the Urban Indian Health Programs
    • Services provided
    • Challenges encountered
    • Success stories
    • Plans for the future
    Presenters:
    • Kitty Marx, CMS;
    • David Nolley, CMS;
    • Geoffrey Roth, NCUIH;
    • Phyllis Wolfe, IHS;
    • Patrick Rock, MD, Indian Health Board of Minneapolis;
    • Susette Schwartz, JD, Hunter Health Clinic;
    • Donna Polk-Primm, PhD, Nebraska Urban Indian Health Coalition, Inc.;
    • Carmelita Skeeter, Indian Health Care Resource Center of Tulsa

    Medicine Dish - Urban Indian Health Programs

  • Creating Super-regulatory T Lymphocytes
    • - Dr. Michael Dustin (2010/11/18)
    • - Category : Wednesday Afternoon Lectures
    The power of the adaptive immune system is checked by regulatory T lymphocytes to prevent autoimmunity and immunopathology. In the absence of regulatory T cells humans and mice suffer fatal, multiorgan autoimmunity. Regulatory T cells function by a cell-cell contact dependent suppression of other T lymphocyte???s proliferation and effector mechanisms. All T lymphocytes, regulatory and effector, rely on cell-cell junctions for recognition of self and foreign peptides bound to major histocompatibility complex (MHC) proteins that call T cells to action. These immunologically specific cell-cell junctions are described as immunological synapses.

    The immunological synapse is a stable cell-cell junction based on turning the motile machinery to the T cell inward to create a ???bull???s eye??? structure that efficiently gathers MHC-peptide complexes to sustain signaling in an integrin dependent manner. We have compared the immunological synapse of regulatory and adaptive T cells and found a remarkable divergence between the two otherwise similar appearing structures. In effector T cells the mechanoregulatory enzyme PKC-q is polarized toward the immunological synapse, whereas in regulatory T cells the enzyme is excluded from the immunological synapse and is concentrated in the pole of the cell farthest from the synapse- the distal pole. While inhibition of PKC-q in effector T cells blocks proliferation and cytokine production, inhibition of PKC-q in regulatory T cells increases their suppressive activity.

    We further found that inhibition of PKC-q can reverse defective activity of regulatory T cells from patients with rheumatoid arthritis (RA). Along these lines, treatment of regulatory T cells with tumor necrosis factor (TNF), a critical pathogenic cytokine in RA, abrogates regulatory T cell activity, apparently by re-polarizing PKC-q to the immunological synapse. PKC-q inhibition restored activity in TNFa treated regulatory T cells. Pretreatment of regulatory T cells with a PKC-q inhibitor improved their in vivo suppression of colitis in a mouse model. We conclude that T cell receptor activated PKC-q mediates negative feedback on regulatory T cell activity and abrogating this feedback pathways results in ???super??? regulatory T cells with potential for treating autoimmune disease and immunopathology.

    The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    Creating Super-regulatory T Lymphocytes

  • NIMH Neurodevelopment Symposium - February 2010
    • - NIMH-DIRP (2010/11/18)
    • - Category : Special
    The NIMH is hosting a Symposium on Neurodevelopment in connection with the recruitment of tenure-track investigators. The Search Committee invites all interested parties to attend.

    NIMH Neurodevelopment Symposium - February 2010

  • Lunch and Learn Parenting Seminar: Talking with you Tween and Teen about Tough Issues
    • - Eliane Herdani, MS, LCPC (2010/11/18)
    • - Category : Parenting
    During the tween and teen years open and honest communication is essential to forming a strong relationship. Our children live in a complex world that challenges them every day with a wide range of issues that can be difficult to discuss. Attend this seminar to learn tips for talking to your children about tough topics, such as relationships, money, alcohol, sex, and more. Learn ways in which you can share your own values with your children and also set appropriate limits for your maturing teen.

    http://does.ors.od.nih.gov/childcare/

    Acrobat Slides

    Lunch and Learn Parenting Seminar: Talking with you Tween and Teen about Tough Issues

  • SES Performance Management Briefing (HHS-Only)
    • - Andrea Burckman, HHS/OS (2010/11/18)
    • - Category : HHS Only
    Briefing to discuss the revisions made to the SES Performance Paln for FY 2010.

    SES Performance Management Briefing (HHS-Only)

  • 7T Seminar Series: Exploring the Potential of 7T fMRI
    • - Essa Yacoub (2010/11/18)
    • - Category : 7 T Seminars
    Dr. Essa Yacoub is Assistant Professor at University of Minnesota. His research interests include investigation of human brain function at high resolution using high field MRI systems and high field MRI in humans.

    7T Seminar Series: Exploring the Potential of 7T fMRI

  • The NCI Cancer Human Biobank (caHUB) Public Information Meeting
    • - NCI (2010/11/18)
    • - Category : Special
    The NCI invites you to attend one of two public meetings to learn more about the caHUB planning process and mission, and review the implementation, structure, timeline and funding process for this national resource. These meetings will bring together academic and government researchers, non-profit foundations, private industries and interested public.

    http://biospecimens.cancer.gov/cahub/meetings/default.asp

    The NCI Cancer Human Biobank (caHUB) Public Information Meeting

  • Calcium Permeable AMPARs, TARPs, and Plasticity
    • - Stuart Cull-Candy, FMedSci, FRS (2010/11/18)
    • - Category : Neuroscience
    Dr. Cull-Candy has made key contributions to our understanding of the role of glutamate and GABA receptors in synaptic function and plasticity. His recent work has analyzed the roles of TARPS in regulating AMPA receptor permeability and gating. He holds a personal Chair in Neuroscience at UCL and The Gaddum Chair of Pharmacology. He has received many awards and is a fellow of the Royal Society.

    NIH Neuroscience Seminar Series

    Calcium Permeable AMPARs, TARPs, and Plasticity