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- Mentoring Training Seminar: Summer Interns are Coming--Are you Ready?
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- - Lori M. Conlan, PhD, Director, Off of Postdoctoral Services, OITE (2010/11/18)
- - Category : Career Development/OITE
- Soon the summer interns will descend on the NIH--and your PI may put one or more of them under your charge. Do you know what your inters(s) will do this summer? Have you thought about the best way to design a summer project for a novice? Join us to gather tiups on how to help shape the future of the next generation of scientists, while preserving your own projets (and your sanity!).
http://www.training.nih.gov
Mentoring Training Seminar: Summer Interns are Coming--Are you Ready?
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- Protecting your Borders: Regulated Entry into the Cell
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- - Schmid, Sandra Louise.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Wednesday Afternoon Lectures
- - Schmid, Sandra Louise.
- Cells communicate with their environment and with other cells through their plasma membranes (PM). The major selective pathway for internalization from the plasma membrane is clathrin-mediated endocytosis (CME), which involves the assembly of clathrin coated pits (CCPs) that package cargo molecules, invaginate and pinch off into the cytosol forming clathrin coated vesicles (CCVs). CME governs key cellular processes, including uptake of nutrients, regulation of surface signaling receptors, recycling of synaptic vesicles, and remodeling of PM transporters to control serum homeostasis. Given its importance to cell and organismal physiology, CME is tightly regulated.
We have used quantitative total internal reflection fluorescence microscopy to study CCP dynamics in living cells and identified an endocytosis ？？？checkpoint？？？ that is sensitive to cargo content and regulated by the GTPase dynamin. Dynamin also catalyzes the membrane fission event leading to CCV formation. We have reconstituted dynamin-catalyzed vesicle formation from fluid supported bilayers with excess membrane reservoir (SUPER) templates to gain insight into the mechanisms governing membrane fission. Further insights come from structural studies on the dynamin GTPase domain. Together, these in vivo and in vitro approaches provide evidence that dynamin plays a dual role in CME, functioning at early stages to regulate CCV formation and at later stages to directly mediate membrane fission. Supported by NIH GM42455, GM73165, MH61345
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Protecting your Borders: Regulated Entry into the Cell
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- Molecular Regulation of Lymphocyte Function and Homeostasis
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- - Dr. Michael Lenardo (2010/11/18)
- - Category : Immunology
- Mike Lenardo is one of NIH？？？s star immunologists. As a member of the Laboratory of Immunology for more than 20 years, Mike has made critical discoveries in the areas of apoptosis, human autoimmune disease and immunodeficiency, and gene transcriptional control. He pioneered the concept of activation induce cell death of lymphocytes, worked out many of the underlying mechanisms, and played a seminal role in determining the involvement of Fas and associated molecules in a spectrum of human immune diseases collectively termed autoimmune lymphoproliferative syndrome (APLS). This work also led to the unexpected finding that the state of many TNF family receptors is oligomeric rather than monomeric even in the unliganded state and revealed an unanticipated role for caspases in productive T lymphocyte activation. Beyond his outstanding biological studies in these several areas and in the field of NF-kB transcriptional control, autophagy, and other important facets of immune regulation, he has also been a leader in enriching the immunological community at NIH, creating the extraordinarily successful annual IIG retreat and developing the Graduate Partnership Program. He will speak to us this week about ？？？Molecular Regulation of Lymphocyte Function and Homeostasis.？？？ This is a ？？？Not to Miss？？？ opportunity to hear about the exciting research and insights of one of NIH？？？s best.
The Immunology Interest Group
Molecular Regulation of Lymphocyte Function and Homeostasis
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- NIH Blue Ribbon Panel - April 2010
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- - NIH (2010/11/18)
- - Category : Special
- The purpose of this notice is to inform the public about a meeting of the NIH Blue Ribbon Panel to Advise on the Risk Assessment of the National Emerging Infectious Diseases Laboratories at Boston University Medical Center. The meeting will be held on Wednesday, April 28, 2010, at the Boston Marriott Copley Place, 110 Huntington Avenue, Boston, Massachusetts 02116 from approximately 6:30 p.m. to 9:45 p.m. The Blue Ribbon Panel is holding a public meeting to update the community on the status and proposed approach of the study. The meeting program will include presentations providing an overview of the risk assessment process, as well as breakout sessions in which more detailed presentations and dialogue about the proposed approach will take place.
http://nihblueribbonpanel-bumc-neidl.od.nih.gov/
NIH Blue Ribbon Panel - April 2010
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- Science for All - Blast from the Past: Early Influences on Long-Term Health (HHS Only)
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- - Trevor Archer, Andrew Feinberg, Kjersti Aagaard-Tillery and Nancy Press (2010/11/18)
- - Category : STEP (HHS Only)
- Science for All
Did your grandmother？？？s diet influence your health? What is epigenetics and how does it influence disease risk? How much should public health interventions be aimed at the developmental period? The developmental origins hypothesis proposes that influences in early life can affect long-term health. Now, well-described epigenetic modifications of gene expression may provide a basis for understanding these phenomena. This forum will investigate the science behind this hypothesis and its implications for health policy.
PRESENTERS:
Trevor Archer, Ph.D., NIEHS, NIH
Andrew Feinberg, M.D., M.P.H., Johns Hopkins University
Kjersti Aagaard-Tillery, M.D., Ph.D., Baylor College of Medicine
Nancy Press, Ph.D., Oregon Health Sciences Center
For more information, visit
http://odoerdb2.od.nih.gov/oer/training/step/step_training_20100429.htm
Science for All - Blast from the Past: Early Influences on Long-Term Health (HHS Only)
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- IACC Committee Meeting - April 2010
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- - Thomas Insel, M.D. (2010/11/18)
- - Category : Interagency Autism Coordinating Committee
- The Interagency Autism Coordinating Committee (IACC) is a Federal advisory committee that coordinates all efforts within the Department of Health and Human Services (HHS) concerning autism spectrum disorder (ASD). Through its inclusion of both Federal and public members, the IACC helps to ensure that a wide range of ideas and perspectives are represented and discussed in a public forum.
The IACC mission is to:
Provide advice to the Secretary of Health and Human Services regarding Federal activities related to autism spectrum disorder.
Facilitate the exchange of information on and coordination of ASD activities among the member agencies and organizations.
Increase public understanding of the member agencies activities, programs, policies, and research by providing a public forum for discussions related to ASD research and services.
IACC meetings are open to the public and include presentations and discussions on a variety of topics, including activities and projects of the IACC, recent advances in science and autism policy issues. A portion of each meeting is reserved for public comment.
The Interagency Austism Coordinating Committee
IACC Committee Meeting - April 2010
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- NIMH Schizophrenia Lecture Series: Magnetoencephalography (MEG) and Neuropsychiatry
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- - Richard Coppola, DSc, NIMH, NIH (2010/11/18)
- - Category : Special
- MEG is a neuroimaging method that allows us to study the activity of the brain changes while people are performing cognitive tasks or in other behavioral situations. This helps us understand the parts of the brain used to process information and guide behavior. In patients with different problems, we can study how this activity is modified or even abnormal. An Ask the Doctor session will follow the lecture.
Participants will learn:
？？？ How MEG ？？？sees？？？ the neural activity of the brain
？？？ The methods we use to create images of this activity
？？？ How MEG compares to other imaging modalities such as fMRI
？？？ The networks of the brain involved in memory and attention that are mapped by MEG
？？？ How these networks are modified in patients with schizophrenia, their siblings and possible genetic relations
The NIMH Schizophrenia Lecture Series
NIMH Schizophrenia Lecture Series: Magnetoencephalography (MEG) and Neuropsychiatry
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- Structural Plasticity in the Adult Mammalian Brain
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- - Elizabeth Gould, Ph.D., Princeton University (2010/11/18)
- - Category : Neuroscience
- Dr. Goulds laboratory studies structural plasticity in the adult mammalian brain with the ultimate goal of determining the functional consequences of continued plasticity. They are interested in identifying the environmental, hormonal and neural stimuli that drive changes in structural plasticity. To this end, they are characterizing the regulation of dendritic architecture, dendritic spines and adult neurogenesis by stimuli such as stress, rewarding experience, physical activity, aging, and parenting. Adult neurogenesis in the mammalian hippocampus occurs at a relatively high rate in the dentate gyrus of rodents, though the extent to which new neurons are important for hippocampal function is a matter of ongoing debate and investigation.
NIH Neuroscience Seminar Series
Structural Plasticity in the Adult Mammalian Brain
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- Mechanistic Discovery in Murine Cancer Models: From Basic Discovery to Clinical Translation (NIH-Only)
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- - Van Dyke, Terry A.
Center for Cancer Research (National Cancer Institute (U.S.)) (2010/11/18) - - Category : NCI CCR Grand Rounds (NIH Only)
- - Van Dyke, Terry A.
- Dr. Van Dyke received her Ph.D. in Medical Sciences from the University of Florida in 1981. As a Post-doctoral Fellow in Dr. Arnold Levines lab in the early 1980s, she characterized one of the first transgenic cancer models. In 1993, Dr. Van Dyke joined the University of North Carolina (UNC), where she is currently a Sarah Graham Kenan Distinguished Professor of Genetics with a joint appointment in Biochemistry and Biophysics. UNC affiliations include the Lineberger Comprehensive Cancer Center, Neuroscience Center, Program in Molecular Biology and Biotechnology, Carolina Center for Genome Sciences, and Carolina Center for Cancer Nanotechnology Excellence.In 1998, Dr. Van Dyke became the Facility Director of the UNC Animal Models Core Facility and in 1999, she established the Carolina Mutant Mouse Regional Resource Center (MMRRC), one of four in the country. In the late 1990s, Dr. Van Dyke served as co-chair of an advisory committee to the Director of NCI on the use of mouse models to advance cancer research. This work led to the establishment of the Mouse Models of Human Cancers Consortium (MMHCC). Dr. Van Dyke continued to serve as co-chair of the MMHCC for more than 2 years with its inception and provided significant leadership in initiatives undertaken by the steering committee, including the establishment of a national repository for GEM mice, and internationally accessible database for mouse models of cancer and associated strains, and a web site for information including summaries of human cancers and mouse cancer models. Dr. Van Dyke continues to serve as a MMHCC PI, leading a multi-institutional collaboration on astrocytic cancers.
NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link: http://bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx.
Mechanistic Discovery in Murine Cancer Models: From Basic Discovery to Clinical Translation (NIH-Only)
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- Autism: What Do We Know?
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- - Tom Insel (NIMH) (2010/11/18)
- - Category : Demystifying Medicine
- The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.
For more information, visit
http://www1.od.nih.gov/oir/DemystifyingMed
Autism: What Do We Know?
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- The 5th Annual Pain Consortium Symposium - May 2010
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- - NIH Pain Consortium (2010/11/18)
- - Category : Conferences
- This event highlights recent NIH supported research that has made a significant contribution to the field. The theme for this years symposium is moving toward personalized pain management
The 5th Annual Pain Consortium Symposium - May 2010
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- U.S. Senate Committee on Appropriations - FY 2011 Budget Request for the National Institutes of Health
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- - Francis S. Collins, M.D., Ph.D., Director, National Institutes of Health (2010/11/18)
- - Category : Special
- Labor, HHS, and Education (Chairman Harkin)
Time and Location: 9:30 a.m., Dirksen 124
Agenda: FY 2011 Budget Request for the National Institutes of Health.
Witnesses:
Francis S. Collins, M.D., Ph.D.
Director
National Institutes of Health
Bethesda, Maryland
U.S. Senate Committee on Appropriations - FY 2011 Budget Request for the National Institutes of Health
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- CC Grand Rounds - The Role of Oral Microbiome in the Prevention of Ventilator-Associated Pneumonia
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- - Nancy J. Ames, RN, PhD, CCRN, Patrick R. Murray, PhD and Naomi OGrady, MD (2010/11/18)
- - Category : Clinical Center Grand Rounds
- Clinical Center Grand Rounds
Nancy J. Ames, RN, PhD, CCRN,
Critical Care Clinical Nurse Specialist, Nursing and Patient Care Services, CC
Patrick R. Murray, PhD,
Chief, Microbiology Service, Department of Laboratory Medicine, CC
Naomi OGrady, MD,
Staff Clinician, Critical Care Medicine Department, CC
For more information, visit
http://www.cc.nih.gov/about/news/grcurrent.html
CC Grand Rounds - The Role of Oral Microbiome in the Prevention of Ventilator-Associated Pneumonia
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- What Do We Do When Studies Disagree?
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- - Buring, Julie E.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Wednesday Afternoon Lectures
- - Buring, Julie E.
- Julie Buring, Sc.D.
Professor of Medicine at Harvard Medical School and Brigham and Womens Hospital,
Professor of Epidemiology at the Harvard School of Public Health,
and Director of Research at Harvard Medical Schools Division for Research and Education in Complementary and Integrative Medical Therapies
Our common wisdom says that no one study can definitively evaluate a hypothesis, and that an understanding of where we are in our knowledge of a research question must come from looking at the totality of evidence. Our common wisdom also says that in the hierarchy of clinical study designs available to evaluate a question, the strongest level of evidence will come from well-conducted, large-scale, randomized clinical trials. But what do we do when the studies are completed, and the evidence from the different designs disagrees? Or when the data comes solely from observational studies, for ethical, logistic, or scientific reasons? How can we learn from examples over the last years to better design and more wisely interpret results from the various study designs?
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
What Do We Do When Studies Disagree?
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- SBIRs - Not Just the Basics (HHS-Only)
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- - Erik Edgerton (NIAMS) and Ted Williams (NICHD) (2010/11/18)
- - Category : GMAC (HHS Only)
- This SBIR course is not just for beginners. The presentation focuses on issues prevalent to SBIR grants, including:
(1) the ins and outs of small business F&A rates;
(2) guidelines;
(3) eligibility;
(4) fun with fees;
(5) commercialization;
(6) audits;
(7) business and financial systems;
(8) intellectual property.
This presentation will include the announcement of an exciting news flash, and should not be missed.
For more information, visit
http://odoerdb2-1.od.nih.gov/gmac/gmac/trs_main.html
SBIRs - Not Just the Basics (HHS-Only)
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- Air Quality Building 12 Complex Q&A - May 2010 (NIH Only)
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- - Montley -ARC Environmental (2010/11/18)
- - Category : NIH Only
- Independant Air Quality analysis of the building 12 Complex from 3/31/2010 Q and A
Air Quality Building 12 Complex Q&A - May 2010 (NIH Only)
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- Proteomics When You Slow Down and Enjoy the View
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- - Rachel Loo, UCLA School of Medicine (2010/11/18)
- - Category : Proteomics
Proteomics When You Slow Down and Enjoy the View
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- Chronic Fatigue Syndrome Advisory Committee
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- - HHS Office on Womens Health (OWH) (2010/11/18)
- - Category : Chronic Fatigue Syndrome Advisory Committee
- The Chronic Fatigue Syndrome Advisory Committee (CFSAC) provides advice and recommendations to the Secretary of Health and Human Services via the Assistant Secretary for Health of the U.S. Department of Health and Human Services on issues related to chronic fatigue syndrome (CFS).
Wanda K. Jones, DrPH
Principal Deputy Assistant Secretary for Health
For more information, visit
http://www.hhs.gov/advcomcfs
Chronic Fatigue Syndrome Advisory Committee
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- Workshop on Deconstructing Back Pain (Day 1)
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- - NCCAM (2010/11/18)
- - Category : Conferences
- Goals of the Meeting:
- 1) To identify what types of future studies are needed to better understand chronic back pain.
2) To assess new interventions and management strategies for back pain as a chronic condition.
3) To evaluate the utility of existing datasets and ongoing cohort studies for future studies of chronic back pain.
4) To determine what study designs should be utilized to look at the natural history of back pain.
Workshop on Deconstructing Back Pain (Day 1)
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- The Hair Bundles Protein Constellation
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- - Gillespie, Peter.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Neuroscience
- - Gillespie, Peter.
- Dr. Gillespie？？？s laboratory is broadly focused on the mechanism of mechanotransduction by sensory hair cells of the inner ear. Although the lab uses a multidisciplinary approach, including molecular biology, imaging, genetics, electrophysiology, and other approaches, they specialize in the application of biochemical methods to characterizing hair-cell transduction. Dr. Gillespie has a broad background in biochemistry, with a particular emphasis on the sensitive techniques required for inner-ear biochemistry, given the small amount of protein present in each ear. As a graduate student, he was trained in the laboratory of Joe Beavo, an enzymologist interested in phosphodiesterases. As a postdoc, he worked with Jim Hudspeth and developed the hair-bundle purification that forms the basis for mass spectrometry experiments they use widely in the lab. Dr. Gillespie？？？s lab has exploited this technique for over twenty years to carry out hair-bundle biochemistry experiments.
Seminar Abstract:
The mechanotransduction apparatus of vertebrate hair cells, the sensory cells of the inner ear, remains incompletely characterized. We are taking a biochemical approach to the description of molecules key for hair-cell transduction. Using the twist-off hair-bundle preparation pioneered twenty years ago, we isolate bundles that are >95% pure. Employing sensitive mass-spectrometry approaches with differential quantitation in bundles and whole epithelium, we identified >400 proteins in the bundle preparation with high confidence. Of these, ~75 are highly enriched in hair bundles, and ~175 are at roughly similar concentrations in bundles and epithelium. Of the highly enriched bundle proteins, many are encoded by previously identified deafness genes, genes that lead to deafness when mutated. Because estimates suggest that only a fraction of deafness genes have been identified, many more must be present in the list of enriched hair-bundle proteins. We will use this strategy of complete description of the bundle proteome, as well as targeted immunoprecipitation approaches, to describe molecules essential for mechanotransduction.
NIH Neuroscience Seminar Series
The Hair Bundles Protein Constellation