전체 8345
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- The Science of Small Clinical Trials Lecture Series: Introduction; Fundamentals (Part 2 of 2)
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- - National Institutes of Health (U.S.). Office of Rare Diseases Research. (2010/11/18)
- - Category : Science of Small Clinical Trials
- Over two lectures, Dr. Day will define/describe basic terms and concepts involved in clinical trials, including randomization, different forms of bias, blinding, the role of placebos, varieties of controls, exploratory data analysis and forms of statistical testing, multiplicity, precision and accuracy, endpoint selection, P-values and confidence limits, repeated measures, stratification, and analysis of covariance; case studies will be presented for Fabrys Disease & Pediatric Inflammatory Bowel Disease.
http://small-trials.keenminds.org/
The Science of Small Clinical Trials Lecture Series: Introduction; Fundamentals (Part 2 of 2)
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- African American History Month (HHS-Only)
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- - John Hope Bryant, American Financial Literacy Activist, Author, CEO Operation HOPE, Motivational Speaker (2010/11/18)
- - Category : PSC Programs (HHS Only)
- Parklawn/Rockville agencies co-sponsored commemorative event, "The History of Black Economic Empowerment"
African American History Month (HHS-Only)
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- CC Grand Rounds: (1) A Clinical Update on Autism and the Autism Spectrum Disorders (2) Cognition and Brain Function Connectivity in Autism
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- - Susan E. Swedo, MD, and Alex Martin, PhD (2010/11/18)
- - Category : Clinical Center Grand Rounds
- Susan E. Swedo, MD,
Chief, Pediatrics and Developmental Neuroscience Branch, NIMH
Alex Martin, PhD,
Chief, Section on Cognition Neuropsychology,
Laboratory of Brain Cognition, NIMH
For more information, visit
http://www.cc.nih.gov/about/news/grcurrent.html
CC Grand Rounds: (1) A Clinical Update on Autism and the Autism Spectrum Disorders (2) Cognition and Brain Function Connectivity in Autism
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- Constructing Emotion
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- - Lisa Feldman Barrett, Ph.D. (2010/11/18)
- - Category : BSSR Lecture Series
- The scientific study of emotion has been gripped in an ？？？emotion paradox？？？ for the last century: human perceivers are able to easily and effortlessly experience anger, sadness, and fear and to see these emotions in others as easily as they read words on a page. Perceiver-independent (objective) measurements, however, are unable to consistently and specifically distinguish between discrete emotion categories. In this talk, Dr. Barrett presents evidence for one resolution to this paradox: Emotions are complex psychological states that can be causally reduced to a set of more basic ingredients, that they are psychologically primitive and are more clearly respected by the brain, and that there are emotion categories like anger, sadness, fear, disgust, and happiness. Emotions may be the targets of explanation in science, but they are not, themselves, natural kinds.
Lisa Feldman Barrett, PhD, is currently Professor of Psychology and Director of the Interdisciplinary Affective Science Laboratory at Boston College, with appointments at Harvard Medical School and Massachusetts General Hospital. Dr. Barrett？？？s research focuses on the nature of emotion from social-psychological, psychophysiological, cognitive science, and neuroscience perspectives, and takes inspiration from anthropology, philosophy, and linguistics.
This lecture is an installment of the Behavioral and Social Sciences Research Lecture Series sponsored by the NIH Office of Behavioral and Social Sciences Research and organized by the NIH Behavioral and Social Sciences Research Coordinating Committee.
The Behavioral and Social Sciences Research Coordinating Committee (BSSR CC), with support from the Office of Behavioral and Social Sciences Research (OBSSR), convenes a series of guest lectures and symposia on selected topics in the behavioral and social sciences. These presentations by prominent behavioral and social scientists provide the NIH community with overviews of current research on topics of scientific and social interest. The lectures and symposia are approximately 50 minutes in length, with additional time for questions and discussion. All seminars are open to NIH staff and to the general public.
Constructing Emotion
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- Tuning Depression Circuits Using Deep Brain Stimulation
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- - Dr. Helen Mayberg (2010/11/18)
- - Category : Wednesday Afternoon Lectures
- Critical to development of deep brain stimulation (DBS) as a novel therapy for treatment resistant depression has been the evolving characterization of brain systems mediating normal and abnormal mood states as well as those mediating successful and unsuccessful response to various antidepressant interventions. Building on converging functional neuroimaging evidence implicating the subcallosal cingulate as a critical node within this depression network, we targeted this region adapting neuromodulation techniques routinely used to treat Parkinson？？？s disease and other movement disorders. The theoretical and data-driven foundation for piloting this new procedure as well as long-term clinical and imaging findings from ongoing experimental studies will be presented.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Tuning Depression Circuits Using Deep Brain Stimulation
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- Regulation of Inflammation and Immunopathology During Helminth Infections, Colitis, and Airway Allergy
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- - Wilson, Mark S.
National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18) - - Category : Immunology
- - Wilson, Mark S.
- Next weeks seminar will be given by MARK WILSON, a creative and highly interactive postdoctoral fellow from NIAID working in the area of inflammation immunology. Mark, a native of the UK, has a dual background in parasitology and allergy (rhinitis). He was able to merge his talents in both fields during his doctoral work at the University of Edinburgh with Rick Maizels. There he addressed the question of how intestinal nematode infection influences the outcome of allergic responses. These studies led to a seminal publication in JEM elucidating a major role for helminth-induced regulatory T cells in suppressing allergic airway inflammation. In later work, he extended these studies by identifying a helminth-induced regulatory B cell population triggered by worms that is able to suppress both experimental allergic and autoimmune diseases. In 2005 Mark joined Tom Wynns lab in the Immunopathogenesis section of LPD, NIAID as a Visiting Fellow and has used his enormous talent in crossing disciplines, experimental systems and collaborations to take full advantage of his NIH postdoctoral experience. Using several helminth infection models and allergic airway inflammation as a read-out, Mark has elucidated the major role played by IL-10 and the cytokine decoy receptor IL-13R慣2 in suppressing distinct immunopathologic features of asthmatic allergy and helminth-associated fibrosis. In related studies employing intestinal whip-worm infections, he uncovered a potential function for the IL-13 receptor alpha 2 in colitis. In Marks most recent work he has returned to the study of lung inflammation identifying a novel pathway involved in pulmonary fibrosis with correlative observations in idiopathic pulmonary fibrosis (IPF) patients.
During his time at the NIH, Mark has been an enthusiastic member of the NIH immunology community and IIG Steering Committee. Since he is leaving this spring to head his own group at the National Institute for Medical Research (Mill Hill) in London, his upcoming Wednesday IIG seminar will be his swan song as an NIH fellow. Come and wish him well and hear about the exciting research program that he has developed during his 5 years working in the Wynn lab.
The Immunology Interest Group
Regulation of Inflammation and Immunopathology During Helminth Infections, Colitis, and Airway Allergy
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- CTSA Industry Forum: Promoting Efficient and Effective Collaborations among Academia, Government and Industry - Day 2
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- - National Center for Research Resources (NCRR) (2010/11/18)
- - Category : Conferences
- Join stakeholders from CTSAs, government, industry, academia and nonprofit research communities as they explore current ground-breaking practices and successful management models as ways to streamline the development of new drugs, devices and diagnostics. Participate in interactive breakout sessions to discuss ways to accelerate the discovery and development of new drugs; promote efficient and effective collaborations with the CTSAs, industry and nonprofit organizations; and explore public？？？private partnership opportunities. A networking reception and poster session also are planned.
www.palladianpartners.com/CTSAIndustryForum
CTSA Industry Forum: Promoting Efficient and Effective Collaborations among Academia, Government and Industry - Day 2
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- GovTrip HPOC Meeting (NIH-Only)
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- - Jennifer Martin (2010/11/18)
- - Category : Travel (NIH Only)
- Monthly meeting to discuss common GovTrip issues and resolutions, reviewing functionality and answering questions regarding the system.
GovTrip HPOC Meeting (NIH-Only)
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- The National Cancer Advisory Board Meeting - February 2010
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- - Various Speakers (2010/11/18)
- - Category : National Cancer Advisory Board
- The 153rd meeting of the National Cancer Advisory Board
The National Cancer Advisory Board Meeting - February 2010
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- DDM - Diversity and Inclusion 2.0: A 21st Century Approach. (NIH-Only)
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- - Steve Robbins (2010/11/18)
- - Category : DDM Seminar Series (NIH Only)
- 2009-2010 Deputy Director for Management (DDM) Seminar Series
Click here to respond to a Survey about this DDM Seminar. Information will be used to evaluate the program and improve future seminars.
On behalf of Colleen Barros, Deputy Director for Management (DDM), the NIH Training Center is pleased to announce the second seminar of the 2009 - 2010 DDM Seminar Series featuring Steve Robbins. He will address the NIH community in a presentation on organizational success strategies entitled ？？？Diversity and Inclusion 2.0: A 21st Century Approach.？？？ A powerful storyteller with a powerful story to tell, Dr. Steve L. Robbins has an unmatched ability to inspire people even in the midst of disrupting and challenging the way they think about the world. Born in Vietnam, Dr. Robbins immigrated to the United States when he was five years old. He and his mother faced many challenges as Vietnamese immigrants in a new land, during a time when there was much anti-war and anti-Vietnamese sentiment. Working through and rising out of the challenges of poverty, discrimination and the tough streets of Los Angeles, Dr. Robbins now brings insightful perspectives on issues of diversity, inclusion, and the power of caring. Drawing upon a compelling life journey, his talks and workshops are filled with intriguing stories, laugh-out-loud humor and a keen understanding of the human condition.
During his presentation, Steve Robbins will discuss ？？？Unintentional Intolerance？？？ which refers to the manner in which nice, well-meaning people (and organizations) go about potentially excluding others and their ideas, even when they want to include them. Research and experience reveals that we all have unconscious biases. These biases influence our decision-making, behaviors and attributions of others on a daily basis. Could we be making "bad" decisions and engaging in exclusive behavior without knowing? Could we being throwing away creative ideas and the next big innovation? The answer is, "Yes." Dr. Robbins explores the "how？？？s" and "why？？？s" surrounding unintentional intolerance in this interactive, humorous and eye-opening presentation, and also gives the antidote for such behavior.
Topics Include:- Culture: Lenses and Filters for Interpreting the World
- Social Justice and Creativity/Innovation frameworks for diversity & inclusion
- The ？？？Efficiency Principle？？？ and closed-mindedness
- Cognitive Dissonance and how we respond to inconsistencies
- Mindfulness + Knowledge: The antidote for Unintentional Intolerance
- The power of ？？？What if?？？？ to spur open-mindedness and inclusion
DDM - Diversity and Inclusion 2.0: A 21st Century Approach. (NIH-Only)
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- NIH Black History Month Observance
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- - Dr. Russell Adams (2010/11/18)
- - Category : Black History Observance
- The National Theme is "The History of Black Economic Empowerment"
NIH Black History Month Observance
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- National Eye Institute 40th Anniversary Symposia Series Focus on Glaucoma - Day 1
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- - National Eye Institute (2010/11/18)
- - Category : Conferences
- The symposia is part of the 40th anniversary series. And will be focusing on Glaucoma.
http://nationaleyeinstitute.net/annivsary/symposia/glaucoma.asp
National Eye Institute 40th Anniversary Symposia Series Focus on Glaucoma - Day 1
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- caHUB Public Meetings
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- - Carolyn Compton (2010/11/18)
- - Category : Special
- The NCI invites you to attend one of two public meetings to learn more about the caHUB planning process and mission, and review the implementation, structure, timeline and funding process for this national resource. These meetings will bring together academic and government researchers, non-profit foundations, private industries and interested public.
http://216.128.12.99/clients/biospecimen/cahub/meetings/default.asp
caHUB Public Meetings
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- National Eye Institute 40th Anniversary Symposia Series Focus on Glaucoma - Day 2
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- - National Eye Institute (2010/11/18)
- - Category : Conferences
- The symposia is part of the 40th anniversary series. And will be focusing on Glaucoma.
http://nationaleyeinstitute.net/annivsary/symposia/glaucoma.asp
National Eye Institute 40th Anniversary Symposia Series Focus on Glaucoma - Day 2
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- SAMHSA Parity Briefing: Paul Wellstone and Pete Domenici Mental Health Parity and Addiction Equity Act of 2008 (MHPAEA)
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- - Pam S. Hyde, SAMHSA Administrator (2010/11/18)
- - Category : Special
- The Department of Health and Human Services (HHS) Substance Abuse and Mental Health Services Administration (SAMHSA) together with the Office of the Assistant Secretary for Planning and Evaluation, will host an in-person briefing on the recently released Interim Final Rule for the Paul Wellstone and Pete Domenici Mental Health Parity and Addiction Equity Act of 2008 (MHPAEA). In addition to HHS Deputy Assistant Secretary for Planning and Evaluation Dr. Richard Frank and SAMHSA Administrator Pam Hyde, representatives from Department of Labor, Department of the Treasury, and the Centers for Medicaid and Medicare Services will be available to discuss the regulation, the comment period, and implementation
SAMHSA Parity Briefing: Paul Wellstone and Pete Domenici Mental Health Parity and Addiction Equity Act of 2008 (MHPAEA)
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- ARRA CER KM1 Pre-submission
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- - NCI Ming Lei and NCRR Anthony Hayward (2010/11/18)
- - Category : Special
- A pre-submission videoconference will be conducted on February 10, 2010, from 2:00 to 4:00 pm ET at which NCI and other NIH staff will explain the goals and objectives of this Mentored Career Development Program and answer questions.
ARRA CER KM1 Pre-submission
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- 7T Seminar Series: Laminar Analysis of the Human Visual Cortex Using 7T fMRI
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- - Jonathan Polimeni (2010/11/18)
- - Category : 7 T Seminars
- Jonathan Polimeni is a research fellow in the Martinos Center for Biomedical Imaging at MGH. He received his PhD degree (Computational Neuroscience) from Boston University in 2007 where he developed computational models of conformal visuotopic maps within visual cortex based on experimental human fMRI data. Currently he works on developing novel techniques for acquiring isotropic 3D FMRI data with 7T and highly parallel encoding techniques such as echo volume imaging. The overall goal of this work to be able to functionally resolve laminar and columnar structures using FMRI in the human brain.
7T Seminar Series: Laminar Analysis of the Human Visual Cortex Using 7T fMRI
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- Unraveling the basics of rare ectodermal disorders
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- - Dr. Maria Morasso (2010/11/18)
- - Category : NIH Directors Seminars
- Dr. Morassos research has focused in characterizing the regulation and function of Dlx3 homeobox transcription factor, a member of the murine Dlx family, with essential roles in epidermal, osteogenic and placental development. Dlx3 is specifically expressed in developing ectodermal appendages (hair, teeth, nail) as well as in developing bone (craniofacial and appendicular). The importance of Dlx3 in the patterning and development of ectodermal structures derived from epithelial-mesenchymal interactions during embryogenesis (i.e. tooth, hair) is corroborated by the effects of DLX3 mutations in patients with the autosomal dominant Tricho-Dento-Osseous (TDO) syndrome. Anomalies in epithelial/mesenchymal-derived organs are characteristics of a group of about 150 human heritable pathological disorders defined as ectodermal dysplasias (EDs). DLX3 is among the few genes for which mutations have been directly linked with EDs.
Dr. Morassos current work on the epidermal-conditional ablation of Dlx3 has determined the crucial role of this homeodomain transcription factor in epidermal stratification and hair development. Although Dlx3 has been implicated in skeletal development in the human autosomal dominant TDO syndrome, where the mutation is associated with defects in the intramembranous and endochondral bone (increased bone density), a direct role for Dlx3 in bone formation has not been identified. Up to now, our collaborative work has accumulated ex vivo evidence showing that Dlx3 induction coincides with the onset of commitment to osteogenic lineage, and that key markers of bone differentiation are regulated by Dlx3. Future projects will involve the analysis of mouse models (KO, Kin and transgenic) established in the laboratory to further elucidate the role of Dlx3 in bone formation and homeostasis. We are also performing analysis of conditional knockout lines to elucidate the signaling and regulatory pathways requiring normal Dlx3 function during embryogenesis.
For more information, visit
http://www.nih.gov/about/director/dirsem.htm
Unraveling the basics of rare ectodermal disorders
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- NIH Consensus Development Conference: Lactose Intolerance and Health - Day 1
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- - National Institute of Child Health and Human Development (U.S.) (2010/11/18)
- - Category : Conferences
- Be part of pivotal discussions on lactose intolerance--the inability to digest significant amounts of lactose, a sugar found in milk and other dairy products. After weighing the evidence from a systematic literature review, expert presentations, and audience input, an impartial, independent panel will present a statement of its collective assessment of the evidence to address five predetermined conference questions; these are listed at http://www.consensus.nih.gov.
http://consensus.nih.gov/2010/lactose.htm
NIH Consensus Development Conference: Lactose Intolerance and Health - Day 1
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- The Science of Small Clinical Trials Lecture Series: Enrichment Designs
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- - National Institutes of Health (U.S.). Office of Rare Diseases Research. (2010/11/18)
- - Category : Science of Small Clinical Trials
- Dr. Temple will describe the vitally important role which patient characteristics (demographic, pathophysiologic, historical, genetic, and others) play in hindering or aiding the detection of a drug effect; the talk will be punctuated with examples drawn from his extensive experience.
The Science of Small Clinical Trials Lecture Series: Enrichment Designs