KOSEN 한인과학기술자네트워크

닫기

더 많은 혜택을 위해
로그인 하세요.

동향

동향

전체 8345
검색
  • Control of the Cytoskeleton During Neurite Initiation and Axon Guidance
    • - Frank Gertler, Ph.D., Massachusetts Institute of Technology (2010/11/18)
    • - Category : Neuroscience
    Dr. Gertler has made fundamental contributions to our understanding of the relationship of signal transduction to cell motility, particularly in axon growth and guidance. He identified the founding member of the ENA/VASP family of proteins, encoded by the Drosophila gene enabled, as well as its mouse ortholog, MENA, and he has been a pioneer in uncovering the central role these proteins play in control of actin organization and dynamics. This work has been instrumental in shaping our view of how cell morphology and motility arises from the complex dynamics of the actin cytoskeleton.

    NIH Neuroscience Seminar Series

    Control of the Cytoskeleton During Neurite Initiation and Axon Guidance

    세미나 비디오 동영상 보기
  • Genomics of Tolerance (NIH-Only)
    • - Christophe Benoist, M.D., Ph.D., Harvard Medical School (2010/11/18)
    • - Category : NCI CCR Grand Rounds (NIH Only)
    Dr. Benoist received his M.D. from the University of Paris, France, and his Ph.D. in Molecular Biology from the University of Strasbourg, France. He was a postdoctoral fellow with Professor L. Herzenberg in the Department of Genetics at Stanford University Medical School in California. He was later a postdoctoral fellow with Professor H. McDevitt in the Department of Medical Microbiology at Stanford University Medical School. Dr. Benoist then returned to Strasbourg, where he was a research officer at Centre National de la Sant챕 et la Recherche M챕dicale (CNRS), Laboratoire de G챕n챕tique Mol챕culaire des Eucaryotes (LGME). He then served for 10 years as the research director of CNRS, LGME and the Institut de G챕n챕tique et de Biologie Mol챕culaire et Cellulaire (IGBMC). After that he served as the section head of Joslin Diabetes Center？？？s Section on Immunology and Immunogenetics and as professor of medicine at Harvard Medical School in Boston. He is currently a professor of pathology in Harvard Medical School？？？s Department of Pathology. Dr. Benoist is a member of numerous professional societies, advisory boards, and editorial boards. He was elected to the Acad챕mie des Sciences, France, and the National Academy of Sciences in the United States. He has published more than 200 peer-reviewed articles. His lab explores how T cells differentiate into their different lineages and final effector states, particularly from the standpoint of self-tolerance and autoimmunity. The lab also explores bioinformatic approaches to the regulation and connectivity of gene expression at the ？？？systems immunology？？？ level. Most of his work involves mouse models, but he also translates some of the leads to human diseases.

    NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link: http://bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx.

    Genomics of Tolerance (NIH-Only)

    세미나 비디오 동영상 보기
  • Travel HPOC Meeting for GovTrip (NIH-Only)
    • - Jennifer Martin (2010/11/18)
    • - Category : Travel (NIH Only)
    We will be discussing common GovTrip issues and resolutions, reviewing functionality and answering questions regarding the system.

    Travel HPOC Meeting for GovTrip (NIH-Only)

    세미나 비디오 동영상 보기
  • Pharmacogenomics
    • - Howard McLeod, Pharm.D. (2010/11/18)
    • - Category : Current Topics in Genome Analysis
    Current Topics in Genome Analysis

    http://genome.gov/COURSE2010

    Pharmacogenomics

    세미나 비디오 동영상 보기
  • Postsynaptic Mechanisms Guiding Synapse Development
    • - Matthew B. Dalva, PhD (2010/11/18)
    • - Category : Special
    Candidate for NIMH-DIRP Neurodevelopment Principal Investigator

    Postsynaptic Mechanisms Guiding Synapse Development

    세미나 비디오 동영상 보기
  • The Seattle Obesity Study: Measuring Access to Healthy, Affordable Foods
    • - Dr. Adam Drewnowski, PhD (2010/11/18)
    • - Category : Brain & Obesity
    Seattle Obesity Study Results Presentation by Dr. Adam Drewnowski, PhD Director, UW Center for Obesity Research Uiversity of Washington, Seattle, WA

    The Seattle Obesity Study: Measuring Access to Healthy, Affordable Foods

    세미나 비디오 동영상 보기
  • Inflammatory Bowel Disease: Crohns Disease and Ulcerative Colitis
    • - Warren Strober (NIDDK), Michael Yao (NIDDK) (2010/11/18)
    • - Category : Demystifying Medicine
    The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.

    For more information, visit
    http://www1.od.nih.gov/oir/DemystifyingMed

    Inflammatory Bowel Disease: Crohns Disease and Ulcerative Colitis

    세미나 비디오 동영상 보기
  • CC Grand Rounds - Update in Endocrinology 2010
    • - Monica C. Skarulis, MD and Lynnette Nieman, MD (2010/11/18)
    • - Category : Clinical Center Grand Rounds
    Monica C. Skarulis, MD,
    Chief, Clinical Endocrinology Section, Clinical Endocrinology Branch, NIDDK

    Lynnette Nieman, MD,
    Senior Investigator, Intramural Research Program on Reproductive and Adult Endocrinology, NICHD

    CC Grand Rounds - Update in Endocrinology 2010

    세미나 비디오 동영상 보기
  • Directors Consumer Liaison Group Spring 2010 Face-to-Face Meeting (Day 1)
    • - Office of Advocacy Relations, NCI, NIH (2010/11/18)
    • - Category : Directors Consumer Liaison Group
    Advisory Group Meeting

    Directors Consumer Liaison Group Spring 2010 Face-to-Face Meeting (Day 1)

    세미나 비디오 동영상 보기
  • Role of Regulatory T Cells in Tolerance: Implication in Human Diseases
    • - Dr. Maria Grazia Roncarolo (2010/11/18)
    • - Category : Wednesday Afternoon Lectures
    Cells with regulatory function exist within all major T and NK cell subsets. Most attention has been focused on regulatory T (Tr) cells with a CD4+ phenotype: the naturally occurring Tr (nTreg) cells and the adaptive type 1 Tr (Tr1) cells. These two subsets of Tr cells, which are developmentally and functionally distinct, cooperate in suppressing activation of the immune system and thereby in maintaining immunological homeostasis and inducing tolerance to self and foreign antigens.

    nTreg cells arise from the thymus and their suppressor function is strictly dependent on high expression of the transcription factor FOXP3, whereas Tr1 cells are induced in the periphery upon chronic stimulation with antigen in the presence of IL-10, secrete high levels of IL-10 in the absence of IL-4, and suppress antigen presenting cells and effector T cells through a cytokine-dependent mechanism. In humans, the presence of Tr1 cells is associated with tolerance, whereas defects in nTreg or Tr1 cells lead to autoimmune mediated diseases or to chronic inflammation, respectively.

    We and others have dedicated much effort to establish methods to isolate and expand nTreg cells or to induce antigen-specific Tr1 cells ex vivo to be used as cell therapy to promote or rebuilt tolerance. We established a protocol to selectively expand CD4+CD25+FOXP3+ T cells with suppressive activity using rapamycin. Alternatively, we showed that exogenous IL-10 or IL-10-derived from tolerogenic dendritic cells promote the in vitro induction of Tr1 cells. Moreover, we are exploring a novel approach to generate a homogeneous population of antigen-specific Tr cells using lentiviral vector mediated gene transfer.

    Alternatively, to the use of ex vivo expanded/differentiated Tr cells, these cells can be induced directly in vivo. We demonstrated that a combination therapy with depleting agents (i.e. anti CD45 mAb) and rapamycin/IL-10 treatment efficiently promoted tolerance via the induction of both nTreg and Tr1 cells. In addition, we recently showed that a small molecular weight compound that specifically activates the aryl hydrocarbon receptor is able to induce tolerance through a direct or DC mediated effects on Tr cells.

    These approaches represent the first step towards the definition of new therapeutic protocols aimed to suppress pathology and restore peripheral tolerance in immune-mediated diseases.

    Lecture Objectives:
      1. Specify the major characteristics of human nTreg and Tr1 cells.
      2. Define the role for FOXP3 in different subset of human Tr cells.
      3. Outline approaches used to expand/generate human Tr cells in vitro and in vivo.

    The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    Role of Regulatory T Cells in Tolerance: Implication in Human Diseases

    세미나 비디오 동영상 보기
  • Science in the Public Health - Alcohol Use to Alcoholism: Molecules to Management (HHS Only)
    • - NIH (2010/11/18)
    • - Category : STEP (HHS Only)
    STEP: Staff Training in Extramural Programs

    NIH is thinking about drinking. You may be thinking about drinking too. But when does a good time become a big problem? Most Americans know someone who abuses alcohol; for example, 30 percent of 12th-graders have engaged in binge drinking. What are the recent advances in the molecular biology and genetics of alcoholism, and potential drug therapies? Come learn about the latest approaches in dealing with the behavioral aspects of alcoholism and managing the disease via rehabilitation programs.

    Committee Members:
    • Chair: Arnold Revzin
    Members:
    • Bill Elwood
    • Nicole Fleisher
    • John Glowa
    • Vishnu Purohit
    • Mike Small
    For more information, visit
    http://odoerdb2-1.od.nih.gov/oer/training/step/step_training_20100325.htm

    Science in the Public Health - Alcohol Use to Alcoholism: Molecules to Management (HHS Only)

    세미나 비디오 동영상 보기
  • Directors Consumer Liaison Group Spring 2010 Face-to-Face Meeting (Day 2)
    • - Office of Advocacy Relations, NCI, NIH (2010/11/18)
    • - Category : Directors Consumer Liaison Group
    Advisory Group Meeting

    Directors Consumer Liaison Group Spring 2010 Face-to-Face Meeting (Day 2)

    세미나 비디오 동영상 보기
  • The Anita B. Roberts Lecture: Brain Development in Healthy, Hyperactive and Psychotic Children
    • - Judith Rapoport, M.D. (2010/11/18)
    • - Category : Anita B. Roberts
    The Anita B. Roberts Lecture Series, ？？？Distinguished Women Scientists at NIH,？？？ highlights outstanding research achievements of women scientists at the NIH. The seminar is dedicated to Dr. Anita Roberts and honors her role as an exceptional mentor and scientist.

    The Anita B. Roberts Lecture: Brain Development in Healthy, Hyperactive and Psychotic Children

    세미나 비디오 동영상 보기
  • The Health Consequences of Low Adherence among Practitioners and Patients:
    • - R. Brian Haynes (2010/11/18)
    • - Category : BSSR Lecture Series
    Efficacious innovations in health care, including many that can save lives and improve quality of life, are substantially blocked from application by a myriad of ？？？knowledge translation？？？ factors, including limitations in research design and scope, inadequate local policy formulation and implementation, suboptimal changes in practice performance by clinicians, and low adherence by patients. These barriers are ？？？multiplicative？？？ such that whatever efficacy (？？？can work in ideal circumstances？？？) may be in an intervention, little or no effectiveness (？？？does work in usual circumstances？？？) remains in usual care settings. This presentation will review the steps and problems of knowledge translation from advanced clinical research into health care practice and then focus on research addressing both quality of clinical care and patient adherence. A case will be made for combining practitioner and patient research involving behavioral change in ambulatory care settings as an opportunity to advance health care.

    The Health Consequences of Low Adherence among Practitioners and Patients:

    세미나 비디오 동영상 보기
  • SAMHSA and the Ad Council Announce the Prevention of Underage Drinking Campaign
    • - SAMHSA (2010/11/18)
    • - Category : Special
    Special guests are briefed of SAMHSA？？？s new national Underage Drinking Prevention Campaign.

    The campaign, developed in partnership with the Ad Council encourages parents to speak with their children about underage drinking in order to delay the onset of and ultimately reduce underage drinking. New television, radio, print, outdoor, and Web PSA？？？s will launch this month to reach parents in the general market, as well as Hispanic American, Asian American and American Indian communities.

    Viewers are encouraged to visit www.stopalcoholabuse.gov for resources.

    SAMHSA and the Ad Council Announce the Prevention of Underage Drinking Campaign

    세미나 비디오 동영상 보기
  • Directors Consumer Liaison Group Spring 2010 Face-to-Face Meeting (Day 3)
    • - Office of Advocacy Relations, NCI, NIH (2010/11/18)
    • - Category : Directors Consumer Liaison Group
    Advisory Group Meeting

    Directors Consumer Liaison Group Spring 2010 Face-to-Face Meeting (Day 3)

    세미나 비디오 동영상 보기
  • The Payment Management System - Some Things Have Changed - Some Remain the Same (NIH-Only)
    • - Lori Burge and Eileen Hyde (2010/11/18)
    • - Category : GMAC (HHS Only)
    This training session will provide an overview of the Division of Payment Management and the services it provides. This session will cover the consolidation of the Federal Financial Report (FFR or Standard Form 425) which replaces the SF 269 (Financial Status Report) and PSC 272 (Federal Cash Transaction Report) into a single form. In addition, this training will provide a basic understanding of the roles and responsibilities of the Awarding Agency and those of the Division of Payment Management as it pertains to the Grant Cycle and Reporting Requirements. This will also include information pertaining to American Recovery and Reinvestment Act (ARRA) awards in the Payment Management System.

    http://odoerdb2.od.nih.gov/gmac/gmac/trs_flyer_20100211.html

    The Payment Management System - Some Things Have Changed - Some Remain the Same (NIH-Only)

    세미나 비디오 동영상 보기
  • Womens Health Update on Nutrition, Fitness, and Weight Management
    • - Richard Kreider, Ph.D. and Kathryn McMurray, M.S. as Senior Moderator (2010/11/18)
    • - Category : Womens Health
    Sponsored by the Intramural Program on Research on Womens Health - Womens Health Special Interest Group

    Womens Health Update on Nutrition, Fitness, and Weight Management

    세미나 비디오 동영상 보기
  • Imaging Protein Interactions During Single Endocytic and Exocytic Events
    • - Wolfhard Almers, Ph.D., Vollum Institute (2010/11/18)
    • - Category : Neuroscience
    Dr. Almers has made fundamental contributions to our understanding of vesicle exocytosis and endocytosis in secretory cells, including nerve terminals. He pioneered in the study of fusion pore opening and was the first to give estimate of the fusion pore size based on the measurement of the fusion pore conductance. In the last decade, he has pioneered in imaging protein interactions during single vesicle docking, exocytosis and endocytosis using Total Internal Reflection Fluorescence Microscopy. His findings have wide impact in the field of cell biology and neuroscience. Dr. Almers received KS. Cole Award and Barnard Katz？？？s Award from the Biophysical Society. He is a member of the National Academy of Sciences in USA.

    NIH Neuroscience Seminar Series

    Imaging Protein Interactions During Single Endocytic and Exocytic Events

    세미나 비디오 동영상 보기
  • TGFbeta: A Master Regulator of the Tumor Microenvironment (NIH-Only)
    • - Harold L. Moses, M.D. (2010/11/18)
    • - Category : NCI CCR Grand Rounds (NIH Only)
    Dr. Moses obtained an M.D. in 1962 from the Vanderbilt University School of Medicine in Nashville, TN. He completed his residency training in pathology at Vanderbilt and postdoctoral research training at the National Institutes of Health before spending 5 years as a faculty member in pathology at Vanderbilt. He then worked for 12 years at the Mayo Clinic in Rochester, MN, serving as chair of the Department of Cell Biology for his last 6 years there. After that he returned to Vanderbilt as professor and chair of the Department of Cell Biology in the School of Medicine. Fifteen years ago he became the founding director of the E. Bronson Ingram Cancer Center, now known as the Vanderbilt-Ingram Cancer Center, with a concurrent appointment as the B.F. Byrd, Jr., Professor of Clinical Oncology. He resigned as chair of the Department of Cell Biology in 1998 to devote more time to the Cancer Center. At the end of 2004, he became director emeritus of the Cancer Center and the Hortense B. Ingram Professor of Medical Oncology. Dr. Moses is well known for his work on the transforming growth factor-？？ family of growth regulatory peptides and has received several awards for his research.

    NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link: http://bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx.

    TGFbeta: A Master Regulator of the Tumor Microenvironment (NIH-Only)

    세미나 비디오 동영상 보기