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- The Science of Small Clinical Trials Lecture Series: Methods of Particular Interest for Small Clinical Trials (Part 2 of 2)
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- - Office of Rare Diseases Research (NIH) & Office of Orphan Products Development (FDA) (2010/11/18)
- - Category : Science of Small Clinical Trials
- Over two lectures, Drs. Coffey & Wittes will describe some clinical trial design and analysis methods that are of particular interest in instances of small study populations, including: cross-over, n-of-1, factorial, sequential, adaptive, play-the-winner, risk-based allocation, and case-control, illustrated by case studies of Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrigs Disease) and Mucopolysaccaridosis type VI (Maroteaux-Lamy Syndrome).
The Science of Small Clinical Trials Lecture Series: Methods of Particular Interest for Small Clinical Trials (Part 2 of 2)
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- Environmental Exposures and Womens Health
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- - Office of Research on Womens Health (2010/11/18)
- - Category : Womens Health
- This is part of the Office of Research on Womens Health Sex and Gender Seminar Series
Environmental Exposures and Womens Health
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- Drug Addiction: Marihuana and Stronger Stuff
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- - Nora Volkow (NIDA), George Kunos (NIAAA) (2010/11/18)
- - Category : Demystifying Medicine
- The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.
For more information, visit
http://www1.od.nih.gov/oir/DemystifyingMed
Drug Addiction: Marihuana and Stronger Stuff
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- The Science of Small Clinical Trials Lecture Series: Bayesian and Related Methods
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- - Dr. Donald A. Berry, University of Texas (2010/11/18)
- - Category : Science of Small Clinical Trials
- Office of Rare Diseases Research (NIH) & Office of Orphan Products Development (FDA)
Dr. Donald Berry will describe and basic principles underlying Bayesian clinical trial design and analysis, illustrating his remarks with concrete case studies drawn from his extensive experience.
The Science of Small Clinical Trials Lecture Series: Bayesian and Related Methods
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- CC Grand Rounds: (1) How to Publish Without Perishing: Navigating the Biomedical Publication Process; (2) Pathogen Inactivation of Blood Components
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- - Cynthia E. Dunbar, MD and Harvey G. Klein, MD (2010/11/18)
- - Category : Clinical Center Grand Rounds
- Cynthia E. Dunbar, MD,
Head, Molecular Hematopoiesis Section,
Hematology Branch,NHLBI
Harvey G. Klein, MD,
Chief, Department of Transfusion Medicine, CC
For more information, visit
http://www.cc.nih.gov/about/news/grcurrent.html
CC Grand Rounds: (1) How to Publish Without Perishing: Navigating the Biomedical Publication Process; (2) Pathogen Inactivation of Blood Components
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- Dynamics of PKA Signaling
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- - Dr. Susan Taylor (2010/11/18)
- - Category : Wednesday Afternoon Lectures
- Dr. Taylors research led to solving the crystal structure of the first protein kinase in 1991, providing a template for this entire family of essential regulatory enzymes. Understanding the molecular basis for function, visualizing this one protein kinase and its structure, function and dynamics and translating that information to other related protein kinases continues to provide an ideal interdisciplinary system for coupling technological advances in computation and biophysics with exciting biological questions. She is a member of the National Academy of Sciences, American Academy of Arts and Sciences, Institute of Medicine, Howard Hughes Medical Institute, a fellow of the American Academy of Arts & Sciences, and a Fellow of the American Association for the Advancement of Sciences.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Dynamics of PKA Signaling
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- Thymic selection of MHC-restricted versus MHC-independent abTCR
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- - Francois Van Laethem (2010/11/18)
- - Category : Immunology
- Francois Van Laethem is a Research Fellow in the NCI who has been studying why alpha-beta T cell
recognition is MHC-restricted. Francois did his previous doctoral work in the laboratory of Jacques Urbain at the Free University of Brussels (Universite Libre de Bruxelles) in his native Belgium under the supervision of former NIHer Oberdan Leo. His interest in immune signaling and development began during this PhD, after which he joined Al Singers laboratory in the Experimental Immunology Branch, NCI. Francois is an exceptional scientist who has been addressing a fundamental cornerstone of modern immunology, namely the basis for MHC-restriction. Francois 2007 Immunity publication (Immunity 27:755, 2007) documented for the first time that alpha-beta T cell recognition need not be MHC-restricted as MHC-restriction is imposed on developing thymocytes by coreceptor-mediated Lck sequestration. In this seminar, Francois will describe his latest unpublished findings that reveal the basis for thymic selection of MHC-restricted versus MHC-independent T cells.
The Immunology Interest Group
Thymic selection of MHC-restricted versus MHC-independent abTCR
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- Core Curriculum Part Three - Review Policies and Procedures (HHS Only)
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- - NIH (2010/11/18)
- - Category : Core Curriculum (HHS Only)
- 2010 Orientation to NIH Extramural Activities Core Curriculum
ESA Program
For more information, visit
http://odoerdb2-1.od.nih.gov/oer/training/esa/esa_cores_2010.htm
Core Curriculum Part Three - Review Policies and Procedures (HHS Only)
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- ASA All Hands Meeting - March 2010 (HHS-Only)
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- - HHS (2010/11/18)
- - Category : HHS Only
- Assistant Secretary for Administraton all hands meeting
ASA All Hands Meeting - March 2010 (HHS-Only)
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- Hunger and Health: Focus on Childhood Hunger
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- - Event Sponsored by the Division of Nutrition Research Coordination (2010/11/18)
- - Category : Special
- Nearly 17 million children in America face hunger. Good nutrition is essential to health; therefore, hunger predisposes these children to adverse health risk and poor health outcomes. The purpose of this symposium is to examine the relationship between hunger and health and to illuminate opportunities for future research.
http://www.dnrc.nih.gov
Hunger and Health: Focus on Childhood Hunger
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- The molecular basis for cortical interneuron diversity: implications for neuropsychiatric disease
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- - Stewart Anderson, MD (2010/11/18)
- - Category : Special
- Candidate Presentation for NIMH-DIRP Neurodevelopment Principal Investigator Search
The molecular basis for cortical interneuron diversity: implications for neuropsychiatric disease
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- 7T Seminar Series: The newly-born relationship between 7Tesla and Multiple Sclerosis
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- - Dr. Francesca Bagnato (2010/11/18)
- - Category : 7 T Seminars
- This talk will cover the progresses made in understanding and identifying disease induced by multiple sclerosis in both focal white matter and grey matter lesions as well as outside visible lesions of patients？？？ brain, by using 7T Tesla imaging in vivo and post mortem.
7T Seminar Series: The newly-born relationship between 7Tesla and Multiple Sclerosis
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- CTSA Pre-Submission Meeting ？？？ March 2010
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- - NCRR (2010/11/18)
- - Category : Special
- NCRR and other NIH staff will explain the goals and objectives of the CTSA program and answer questions. The current CTSA RFA (RM-10-001) has several changes compared with the previous RFA, RFA-RM-09-004, which was released January 29, 2010. All prospective applicants are invited to submit questions in advance, and to view the meeting through VideoCast. Questions may be submitted by using the live event feedback form.
The Clinical and Translational Science Award (CTSA) initiative assists institutions to create an integrated academic home for Clinical and Translational Science that has the resources to train and advance multi- and inter-disciplinary investigators and research teams with access to innovative research tools and information technologies that apply new knowledge and techniques to patient care. Clinical and Translational Science Awards (CTSAs) will attract basic, translational, and clinical investigators, community clinicians, clinical practices, networks, professional societies, and industry to develop new professional interactions, programs, and research projects. Through innovative advanced degree programs, CTSAs will foster a new discipline of Clinical and Translational Science that will be much broader and deeper than their separate components.
CTSA Pre-Submission Meeting ？？？ March 2010
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- Systems Biology: from Genome Annotation to in silico Models (NIH-Only)
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- - Bernhard Palsson, Ph.D. (2010/11/18)
- - Category : NIH Only
- NHLBI DIR Presentation
Bernhard Palsson, Ph.D.
Galetti Professor of Bioengineering
University of California, San Diego
Systems Biology: from Genome Annotation to in silico Models (NIH-Only)
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- Toward absolute abundance data for the human proteome: tools for enabling targeted proteomics
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- - Eric Deutsch, Institute for Systems Biology (2010/11/18)
- - Category : Proteomics
- There is a growing effort to define the human proteome in a manner that will provide reference information to accelerate experiments in all aspects of human biomedical research. Mass spectrometry is one of the most popular and flexible tools to assay proteins in complex samples, and therefore a key part of a human proteome project will be to catalog the proteins that have, and can be, observed as well their mass spectrometric signatures to guide further targeted proteomics experimentation via selected reaction monitoring (SRM). PeptideAtlas is an expanding compendium of peptide and protein identifications assembled from hundreds of tandem mass spectrometry (MS/MS) experiments gathered from the community for several species. All experiments are uniformly reprocessed from the raw data using the latest analysis techniques available in the Trans-Proteomic Pipeline (TPP) in order to achieve a consistent picture of the observable proteome with a well understood and controlled false discovery rate. MRMAtlas is a new resource that combines published mass spectrometric signatures, observations in PeptideAtlas, and supplemental theoretical predictions to derive a complete and optimal set of recommended targets for all proteins for several organisms. To obtain observational data on proteins and peptides not yet in PeptideAtlas, we are generating mass spectrometric signatures from synthetic peptides and proteins. These peptides are selected based on proteotypic scores derived from empirical evidence in PeptideAtlas supplemented with theoretically predicted proteotypic peptides. These techniques have been applied to Leptospira interrogans for which an absolute abundance scale for most proteins in cells of different states is now available. The complete MS proteome for yeast, including peptide signatures for 95% of proteins and abundances for most proteins, is now complete. And now we have embarked on the same goal for the human proteome. An abundance scale for over 2000 human plasma proteins is complete. Within a year we expect to have validated SRM transitions for nearly all of the 20,333 primary human isoforms in Swiss-Prot. These full proteome maps, combined with our tools to use them, will enable and accelerate many other research projects.
http://proteome.nih.gov/
Toward absolute abundance data for the human proteome: tools for enabling targeted proteomics
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- NCI Board of Scientific Advisors Meeting
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- - NCI, Division of Extramural Activities (2010/11/18)
- - Category : NCI Board of Scientific Advisors
- The 45th meeting of the Board of Scientific Advisors. Provides scientific advice on a wide variety of matters concerning scientific program policy, progress, and future direction of the NCIs extramural research programs, and concept review of extramural program initiatives.
For more information, visit
http://deainfo.nci.nih.gov/advisory/boards.htm
NCI Board of Scientific Advisors Meeting
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- NIH Consensus Development Conference on Vaginal Birth After Cesarean: New Insights - Day 1
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- - Sponsored by the Eunice Kennedy Shriver National Institute of Child Health and Human Development Office of Medical Applications of Research of the National Institutes of Health (2010/11/18)
- - Category : Conferences
- For most of the 20th century, clinicians believed that once a woman had undergone a cesarean, all of her future pregnancies required delivery by that procedure as well. In the 1980s, vaginal birth after cesarean (VBAC) also began to be considered a viable option for these women. Since 1996, however, VBAC rates in the United States have consistently declined, while cesarean delivery rates have been steadily rising. What accounts for these changing practice patterns? Frequently cited concerns about VBAC include the possibility of uterine rupture during labor, infection, and other complications. However, repeat cesarean delivery carries risks for both mother and baby, and may impact future pregnancies. Be part of a pivotal discussion that will explore these issues.
http://consensus.nih.gov/2010/vbac.htm
NIH Consensus Development Conference on Vaginal Birth After Cesarean: New Insights - Day 1
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- SEER-Medicare Data Training Workshop - March 2010 (Day 1)
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- - Dr. Joan Warren, National Cancer Institute (2010/11/18)
- - Category : Conferences
- The purpose of the training is to assist investigators who are new to the SEER-Medicare data in understanding some of the methodological issues associated with using these data for epidemiologic and health services research.
http://conference.novaresearch.com/SEER/
SEER-Medicare Data Training Workshop - March 2010 (Day 1)
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- Naturopathic Medicine: What is it and what is the state of the evidence
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- - Wendy Weber, N.d,Ph.d,M.P.H. (2010/11/18)
- - Category : Special
- Dr. Weber？？？s portfolio includes research on traditional medical systems, pediatrics, and clinical studies in mental health, cardiovascular disease, and gastrointestinal diseases. Prior to joining NCCAM, she was a Research Associate Professor at Bastyr University. Her practice focused on the treatment of children and adolescents with mental health conditions, abdominal pain, headaches, and allergies. Dr. Weber？？？s research included the study of herbal treatments for pediatric conditions. She has published on echinacea？？？s effect on colds in children, naturopathic treatment of children, and CAM treatments for attention deficit hyperactivity disorder. Her articles have appeared in the Journal of the American Medical Association, the Journal of Alternative and Complementary Medicine, and Pediatrics.
The Complementary and Integrative Medicine Consult Service lecture series sponsosred by NCCAM provides NIH clinical center staff with the opportunity to learn more about how the integration of vaious complementary and alternative medicine treatments can affect approches in the research and practice for medicine.
Naturopathic Medicine: What is it and what is the state of the evidence
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- The Science of Small Clinical Trials Lecture Series: Regulatory Views from Europe; Summing Up: Building an Intellectual Framework for Small Clinical Trials
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- - Office of Rare Diseases Research (NIH) & Office of Orphan Products Development (FDA) (2010/11/18)
- - Category : Science of Small Clinical Trials
- Dr. Brendan Buckley will describe the current state of drugs for rare diseases in the EU; Drs. Day & Rodgers will lead a collective panel discussion attempting to draw patterns and lessons from the course materials.
The Science of Small Clinical Trials Lecture Series: Regulatory Views from Europe; Summing Up: Building an Intellectual Framework for Small Clinical Trials