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  • Appreciating the little things in life: Investigating small RNA function in neuronal development and disease
    • - Erik M. Ullian, PhD (2010/11/18)
    • - Category : Special
    NIMH-DIRP Candidate for Neurodevelopment Principal Investigator

    Appreciating the little things in life: Investigating small RNA function in neuronal development and disease

  • Microtubule Motors and Axonal Transport: Function and Dysfunction in Neurodegenerative Disease
    • - Erika Holzbaur, Ph.D. (2010/11/18)
    • - Category : Neuroscience
    Dr. Holzbaur is interested in the mechanisms of microtubule-based motility. This motility is involved in basic cellular processes such as organelle trafficking, and in more specialized functions such as the transport of vesicles along the extended axonal processes of the neuron. Her laboratory focuses on the motor cytoplasmic dynein and its activator complex dynactin. Dynein function is essential in higher eukaryotes, yet its basic mechanisms of action including coupling to cargo and cellular regulation remain to be determined.

    Currently Dr. Holzbaur???s lab is focusing on (1) biophysical assays for motor function using single molecule approaches; (2) elucidating the mechanisms driving bidirectional transport along the axon; (3) determining the mechanisms that regulate bidirectional transport; and (4) exploring the link between defects in axonal transport and the development of neuropathogenesis in degenerative diseases such as ALS.

    NIH Neuroscience Seminar Series

    Microtubule Motors and Axonal Transport: Function and Dysfunction in Neurodegenerative Disease

  • RNAi-mediated Epigenetic Control of the Genome (NIH-Only)
    • - Shiv Grewal, Ph.D. (2010/11/18)
    • - Category : NCI CCR Grand Rounds (NIH Only)
    NCI???s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link: http://bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx.

    RNAi-mediated Epigenetic Control of the Genome (NIH-Only)

  • Genomics of Microbes and Microbiomes
    • - Julie Segre, Ph.D. (2010/11/18)
    • - Category : Current Topics in Genome Analysis
    Current Topics in Genome Analysis

    http://genome.gov/COURSE2010

    Genomics of Microbes and Microbiomes

  • A Multiprotein Complex in DNA Damage Response Network of Fanconi Anemia, Bloom Syndrome and Breast Cancer
    • - Dr. Weidong Wang, Lab of Genetics, NIA, NIH (2010/11/18)
    • - Category : DNA Repair
    The DNA Repair Interest Group is concerned with all forms of DNA damage and repair. As a major defense against environmental damage to cells DNA repair is present in all organisms examined including bacteria, yeast, drosophila, fish, amphibians, rodents and humans. The members of the DNA Repair Interest Group perform research in areas including DNA repair enzymology and fine structure, mutagenesis, gene and cell cycle regulation, protein structure, and human disease.

    Acrobat Slides

    For more information, visit the
    DNA Repair Interest Group

    A Multiprotein Complex in DNA Damage Response Network of Fanconi Anemia, Bloom Syndrome and Breast Cancer

  • Enhancing Peer Review: A Conversation about Application Changes (HHS Only)
    • - Megan Columbus (2010/11/18)
    • - Category : ESA (HHS Only)
    NIH Extramural Staff Training Seminar ??? Videocast Discussion for Review and Program Staff and Others Interested in the Topic

    Do you have any of the questions listed below? Join a conversation to hear the new policies, your colleagues??? thinking, and to share your ideas!

    Please send your questions to EnhancingPeerReview@mail.nih.gov ahead of time so we will be sure to address them during the session.
    • How do I answer applicant questions about the new application format?
    • What advice should be given to reviewers about evaluating the restructured applications?
    • What do reviewers need to know about the guidance given to applicants?
    • Given the shorter page limits, what level of detail is it reasonable for reviewers to expect?
    • How should resubmission applications be handled?
    • What other reminders do reviewers need?
    • Are there tips for providing meaningful comments in the critiques to support the scores?
    • What should reviewers do when the Personal Statement in the Biosketch is missing?
    • How many publications are accepted in the Biosketch?
    • What are the new instructions for Facilities & Other Resources section?
    • How should reviewers consider application sections without page limits when they include information that should have been part of sections with page limits?
    • What are the impacts for program staff?
    • How will shorter applications change the summary statements seen by Council members and IC funding decision makers?
    • What will ensure the most level playing field possible as we transition to the new application structure?
    • What is the policy for enforcing compliance with page limits?
    • What should be the consistent review practices at all ICs?
    • Is there a requirement for consent of AOR/SO for additional materials?
    • What can we be doing to prepare for the end of A2 resubmissions?
    • How should Program Staff advise applicants?
    • What constitutes a new application?
    • What should IC Staff do when they receive a ???virtual??? A2 resubmission?
    • What is the status of current evaluation efforts?
    • Who is getting surveyed?
    • What is the timeline for the surveys, especially those for staff?
    • What will happen with the results of the surveys?

    Enhancing Peer Review: A Conversation about Application Changes (HHS Only)

  • Academic CAT Tracks: Making the Move to Academia
    • - Sharon Milgram, PhD, Director Office of Intramural Training & Education (2010/11/18)
    • - Category : Career Development/OITE
    Objective: Congratulations, youve accepted the job! In this seminar, learn what you need to know about navigating the academic environment in you future department. Youll learn important points to consider when deciding what equipment you need to set up your lab and how to find the best people to work in your lab. Also, learn about other expectations of a junior faculty member.

    Topics:
    • What to expect
    • Setting up your lab
    • Finding/hiring research assistants
    http://www.training.nih.gov

    Academic CAT Tracks: Making the Move to Academia

  • Stars in Nutrition and Cancer: The Human Microbiome-Host Metabolic Axis in Health and Disease
    • - Dr. Jeremy Nicholson (2010/11/18)
    • - Category : Stars in Nutrition
    NCI Stars in Nutrition Lecture Series

    This lecture will explore: gene-environment interactions; molecular epidemiology of disease risk factors and biomarker discovery; measuring and modeling metabolic profiles and microbial mammalian co-metabolism; and personalized healthcare.

    This lecture series features extraordinary contributors or stars in the field of cancer and nutrition research. Speakers highlight the important role that nutrition plays in modifying cancer development. The lectures aim to facilitate interdisciplinary interactions among basic scientists, clinicians, and behavioral and social scientists. Lectures typically occur each fall and spring.

    For more information, visit
    http://prevention.cancer.gov

    Stars in Nutrition and Cancer: The Human Microbiome-Host Metabolic Axis in Health and Disease

  • Natural Products: Keys to Treating Cancer and Infection
    • - Carole Bewley (NIDDK), David Newman (NCI) (2010/11/18)
    • - Category : Demystifying Medicine
    The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.

    For more information, visit
    http://www1.od.nih.gov/oir/DemystifyingMed

    Natural Products: Keys to Treating Cancer and Infection

  • NIH Womens History Month Observance - NIH Only
    • - Dr. Elizabeth Fee (2010/11/18)
    • - Category : NIH Only
    March of 2010 will mark the 30th Anniversary of the NIH Womens History Month Observance

    NIH Womens History Month Observance - NIH Only

  • Panel Discussion: The Institutional Review Board: Safety First (NIH-Only)
    • - NIDDK/NIAMS Institutional Review Board (2010/11/18)
    • - Category : NIH Only
    Members from the NIDDK/NIAMS Institutional Review Board (IRB) will discuss the purpose of the IRB and how the IRB works with our Investigators to ensure clinical studies have minimized risks to study subjects. IRB members will describe their role in the IRB and answer your questions.

    http://www2.niddk.nih.gov/

    Panel Discussion: The Institutional Review Board: Safety First (NIH-Only)

  • CC Grand Rounds: (1)Therapeutic Gene Delivery: Using Hematopoietic Stem Cells in Sickle Cell Disease (2) Multiple Myeloma and Its Precurser (MGUS): Looking into the Future
    • - John F. Tisdale, MD, and Ola Landgren, MD, PhD (2010/11/18)
    • - Category : Clinical Center Grand Rounds
    Clinical Center Grand Rounds

    John F. Tisdale, MD,
    Senior Investigator, Molecular and Clinical Hematology Branch, NHLBI

    Ola Landgren, MD, PhD,
    Investigator, Medical Oncology Branch,
    Center for Cancer Research, NCI

    For more information, visit
    http://www.cc.nih.gov/about/news/grcurrent.html

    CC Grand Rounds: (1)Therapeutic Gene Delivery: Using Hematopoietic Stem Cells in Sickle Cell Disease (2) Multiple Myeloma and Its Precurser (MGUS): Looking into the Future

  • Memory and the Aging Brain
    • - Dr. Carol Barnes (2010/11/18)
    • - Category : Wednesday Afternoon Lectures
    Dr. Barnes is past-president of the 40,000 member Society for Neuroscience, an elected Fellow of the American Association for the Advancement of Science and an Elected Foreign Member fo the Royal Norwegian Society of Sciences and Letters.

    The central goal of Dr. Barnes??? research program is to understand how the brain changes during the aging process and what the functional consequences of these changes are on information processing and memory in the elderly. Her research program involves behavioral, electrophysiological and molecular biological approaches to the study of young and aged rodents and non-human primates. This work provides a basis for understanding the basic mechanisms of normal aging in the brain and sets a background against which it is possible to assess the effects of pathological changes such as Alzheimers disease. Some current work also includes an assessment of therapeutic agents that may be promising in the alleviation or delay of neural and cognitive changes that occur with age. Dr. Barnes has written over 190 articles in the area of memory changes during normal aging and their possible neurobiological correlates.

    The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    Memory and the Aging Brain

  • Core Curriculum Part Four - Staff Interactions; How The Extramural Team Functions (HHS Only)
    • - NIH (2010/11/18)
    • - Category : Core Curriculum (HHS Only)
    2010 Orientation to NIH Extramural Activities Core Curriculum

    ESA Program

    For more information, visit
    http://odoerdb2-1.od.nih.gov/oer/training/esa/esa_cores_2010.htm

    Core Curriculum Part Four - Staff Interactions; How The Extramural Team Functions (HHS Only)

  • Role Of MeCP2 & HDACs In Regulating Synapse Function and Behavior
    • - Lisa M. Monteggia, PhD (2010/11/18)
    • - Category : Special
    NIMH-DIRP Candidate for Neurodevelopment Principal Investigator

    Role Of MeCP2 & HDACs In Regulating Synapse Function and Behavior

  • Heart Failure in Women
    • - National Center on Minority Health and Health Disparities (NCMHD) (2010/11/18)
    • - Category : Health Disparities
    NIH Health Disparities Seminar Series

    March is Women???s History month and the National Center on Minority Health and Health Disparities (NCMHD) is pleased to present the March 2010 NIH Health Disparities Seminar Series in collaboration with the Office of Research on Women???s Health (ORWH). The theme for the March seminar series is Women???s Health Disparities.

    Heart disease is the leading cause of death for U.S. women as well as men. Among all U.S. women who die each year, one in four dies of heart disease. It is the third leading cause of death among women aged 25 - 44 and the second leading cause of death among women aged 45 - 64. African American women and Hispanic women tend to have more risk factors for heart disease, including obesity, lack of physical activity, high blood pressure and diabetes.

    Guest Speaker: Dr. Anne L. Taylor is a cardiologist and Vice Dean for Academic Affairs at the College of Physicians and Surgeons, Columbia University Medical Center. Dr. Taylor, an established researcher who has authored or coauthored more than 62 publications, chaired the steering committee for the African-American Heart Failure Trials which was the first major clinical trial to test the effectiveness of a heart failure medication in African Americans. The focus of Dr. Taylor???s research has been cardiovascular disease in minorities and women as well as the translation of scientific knowledge about cardiovascular disease prevention from academic medicine to communities. She has had leading roles in historic research studies that have significantly enhanced our understanding of disparities in cardiovascular disease in women and minorities. Dr. Taylor???s presentation will focus on her research findings about what we know and don???t know about heart failure in women and minorities.

    http://www.ncmhd.nih.gov/hdss/hdss_Mar10.html

    Heart Failure in Women

  • Closing the Implementation Gap to Stop HIV/AIDS
    • - Dr. Julio Montaner (2010/11/18)
    • - Category : Wednesday Afternoon Lectures
    In 1988, Dr. Montaner became the director of the AIDS Research Program and the Immunodeficiency Clinic at St. Pauls Hospital and UBC and since 1996, has held the Endowed Chair in AIDS Research. He is a professor of Medicine, head of the Division of AIDS, a founding co-director of the CIHR Canadian HIV Trials Network and director of the BC Center for Excellence in HIV/AIDS. He has been a member of the International AIDS Society since 1988, an elected member of the USA and Canada Region since 2002 and president of the IAS since August 2008. Dr. Montaner has authored over 400 scientific publications on HIV/AIDS.

    The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    Closing the Implementation Gap to Stop HIV/AIDS

  • NIH Blue Ribbon Panel - March 2010
    • - NIH (2010/11/18)
    • - Category : NIH Blue Ribbon Panel
    The purpose of this notice is to inform the public about a meeting of the NIH Blue Ribbon Panel to Advise on the Risk Assessment of the National Emerging Infectious Diseases Laboratories at Boston University Medical Center. The meeting will be held on Friday, March 19, 2010, at the National Institutes of Health, Building 31, 31 Center Drive, Floor 6C, Room 6, Bethesda, MD 20892, from approximately 8:30 a.m. to 2:00 p.m. This meeting is the second in a series of public meetings with the National Research Council to review the ongoing supplementary risk assessment study. It was originally scheduled to take place on February 12, 2010, but had to be postponed due to extreme weather conditions on the East Coast.

    http://nihblueribbonpanel-bumc-neidl.od.nih.gov/

    NIH Blue Ribbon Panel - March 2010

  • Administrative Fellows Program Information Session
    • - Cheryl Stevens, Executive Officer, National Institute of Nursing Research; Additional Speakers TBD (2010/11/18)
    • - Category : Special
    The NIH AFP Information Session will provide potential AFP applicants with a chance to learn more about the Program, meet with current professionals in the hiring career tracks, gain valuable information on applying for federal careers, and tour the beautiful NIH campus.

    http://www.jobs.nih.gov/afp/default.htm

    Administrative Fellows Program Information Session

  • 7T Seminar Series: The Rapidly Changing Brain ??? Of Taxi Driving Mice and Maze Running Men
    • - Dr. Jason Lerch (2010/11/18)
    • - Category : 7 T Seminars
    How does the shape of the brain change with learning? Initial studies indicated that spatial expertise - in the form of experienced Taxi drivers - enlarged the hippocampus, one of the key structures involved in spatial navigation. Whether regional growth or shrinkage in the brain can be induced with specific training administered over short time periods is, however, unknown. The talk will present results of training studies in both mice and men, including some initial investigations using histology to ascertain the cellular bases of training induced volume changes.

    Dr. Jason Lerch is a scientist at the Hospital for Sick Children in Toronto. His research program is focused on how the brain changes its shape, with activities including the MRI of learning and memory, the effect of specialized training on the human brain, and methods of analyzing neuroanatomy.

    7T Seminar Series: The Rapidly Changing Brain ??? Of Taxi Driving Mice and Maze Running Men