전체 8345
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- OHR Brown Bag - March 2010 (NIH Only)
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- - OHR - CIVIL (2010/11/18)
- - Category : Human Resources (NIH Only)
- OHR Brown Bag
OHR Brown Bag - March 2010 (NIH Only)
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- CC Grand Rounds: (1) Ankylosing Spondylitis: HLA-B27 and Beyond (2)Treatment of Autoantibody-Receptor Disease: The Story of Type B Insulin Resistance
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- - Robert A. Colbert, MD, PhD and Rana Malek, MD (2010/11/18)
- - Category : Clinical Center Grand Rounds
- Clinical Center Grand Rounds
Robert A. Colbert, MD, PhD,
Chief, Pediatric Translational Research Branch, NIAMS
Rana Malek, MD,
Staff Clinician, Diabetes Branch, NIDDK
For more information, visit
http://www.cc.nih.gov/about/news/grcurrent.html
CC Grand Rounds: (1) Ankylosing Spondylitis: HLA-B27 and Beyond (2)Treatment of Autoantibody-Receptor Disease: The Story of Type B Insulin Resistance
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- OHR - The Next Generation Leadership Program (NIH Only)
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- - OHR - CIVIL (2010/11/18)
- - Category : Human Resources (NIH Only)
- OHR The Next Generation Leadership Program
OHR - The Next Generation Leadership Program (NIH Only)
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- Genomic Variation and the Inherited Basis of Common Disease
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- - Dr. David Altshuler (2010/11/18)
- - Category : Wednesday Afternoon Lectures
- Despite great progress in medical science, we have limited knowledge of the molecular causes of disease in human populations; this ignorance is one of the gating factors in efforts to design rationale approaches to prevent and treat disease. Family history is a strong and largely unexplained contributor to essentially all human diseases, and genetic mapping offers an approach to study disease that is unbiased by prior hypotheses about disease mechanisms.
We have worked to make possible genetic mapping of common diseases by developing maps of human sequence variation (the SNP Consortium HapMap, and 1000 Genomes Projects), and by developing technologies and analytical methods to enable genome-wide association studies. In the past three years these methods have led to the identification of over 250 novel and reproducible SNP associations for a wide variety of common diseases, including our own work on type 2 diabetes, hyperlipidemia, prostate cancer, age related macular degeneration, rheumatoid arthritis, and systemic lupus erythematosis.
We are now focusing on discovering the genes and mutations responsible at each locus, extending the mapping approach to query all genetic variation (not only common variants), and using this information to gain new insights into disease mechanisms, with the ultimate goal of developing new targets for therapeutic intervention and disease prevention.
Lecture Objectives:- 1. To review recent progress in human genetics.
- 2. To consider the uses of genetic information in drug discovery.
- 3. To consider the uses of genetic information in medicine.
Genomic Variation and the Inherited Basis of Common Disease
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- An MHC-independent macromolecular ligand for a human tumor-reactive a/b T-cell receptor
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- - Ken-ichi Hanada (2010/11/18)
- - Category : Immunology
- Dr. Ken-ichi Hanada received his MD from the Tokyo Medical and Dental University and completed a residency in Internal Medicine at that University Hospital. He then completed his PhD and post graduate work in the Department of Biochemistry at the University of Tokyo. He was involved in the identification of the murine hematopoetic stem cell during post-graduate work and as a research member of the Japanese Foundation for Cancer Research. In 1997 he arrived as an Exchange Scientist in the Surgery Branch, NCI. As a Research Fellow and then a Staff Scientist, he has been involved in studying the cellular immune response to human renal cancer. In 2004, he published the first description of vertebrate post-translational protein splicing in Nature, when he identified the spliced epitope from a renal cancer antigen recognized by a T-cell. Now pursuing new T-cell reactivities which can recognize renal cancer, he has elucidated the molecular basis for an unprecedented ligand which can trigger a human alpha-beta T-cell receptor.
The Immunology Interest Group
An MHC-independent macromolecular ligand for a human tumor-reactive a/b T-cell receptor
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- Core Curriculum Part Five - NIH Extramural R&D Contracting Policy and Procedure (HHS Only)
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- - NIH (2010/11/18)
- - Category : Core Curriculum (HHS Only)
- 2010 Orientation to NIH Extramural Activities Core Curriculum
ESA Program
For more information, visit
http://odoerdb2-1.od.nih.gov/oer/training/esa/esa_cores_2010.htm
Core Curriculum Part Five - NIH Extramural R&D Contracting Policy and Procedure (HHS Only)
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- Proteomics of Tumor Extracellular Matrix - The "Matrisome Project"
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- - Karl Clauser and Alexandra Naba (2010/11/18)
- - Category : Proteomics
Proteomics of Tumor Extracellular Matrix - The "Matrisome Project"
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- Representation of Object Information in Human and Monkey Visual Cortex
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- - Sabine Kastner, M.D., Ph.D. (2010/11/18)
- - Category : Neuroscience
- Dr. Kastner studies the neural basis of visual perception, attention, and awareness using a translational approach that combines neuroimaging in humans and monkeys, monkey physiology and studies in patients with brain lesions. A major long-term goal is to provide a neural basis for human visual attention in the framework of biased competition theory. Other recent work has focused on the topographic organization of human higher-order and visual cortex, parietal cortex functions, object representations in human and monkey visual cortex, and the neural basis of conscious perception. Dr. Kastner earned an M.D. degree from the Heinrich-Heine University of Duesseldorf (Germany) and received a PHD degree in neurophysiology from the Georg-August University, Goettingen (Germany).
After a postdoc at the Max-Planck-Institute for Biophysical Chemistry, Goettingen and an internship in psychiatry, Dr. Kastner joined Leslie Ungerleiders and Robert Desimones lab at the NIMH for several years before taking on a faculty position at Princeton in 2000, where she currently holds the rank of full professor. Dr. Kastners contributions to the field of cognitive neuroscience were recognized with the Young Investigator Award from the Cognitive Neuroscience Society in 2005. Dr. Kastner serves on several editorial boards and is a Senior Editor for the Journal of Neuroscience and a Section Editor for Neuropsychologia.
NIH Neuroscience Seminar Series
Representation of Object Information in Human and Monkey Visual Cortex
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- NIMH Schizophrenia Lecture Series: Cognitive Impairment in Schizophrenia
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- - Dwight Dickinson, PhD, JD (2010/11/18)
- - Category : Special
- A broad range of cognitive problems is common in schizophrenia, affecting memory, attention, mental speed and problem-solving, among other capacities. These cognitive problems are associated with problems in everyday life, more so even than more obvious symptoms like delusions and hallucinations. Yet, currently available treatments are not especially effective in addressing this facet of the disorder. An Ask the Doctor session will follow the lecture.
Participants will learn:- The methods that have been used to assess cognitive problems in schizophrenia
- The profile of cognitive problems that is typical in this disorder
- The relationship of cognitive problems to illness course and other illness characteristics
- The development of treatments for cognitive problems
- Current research at NIMH
- How to volunteer for research at NIMH and how to refer patients for research
NIMH Schizophrenia Lecture Series: Cognitive Impairment in Schizophrenia
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- Core Curriculum Part Two - Program Policies and Procedures (HHS-Only)
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- - Chuck Selden (2010/11/18)
- - Category : Core Curriculum (HHS Only)
- 2010 Orientation to NIH Extramural Activities Core Curriculum
The session will have a panel of program experts commenting on the questions posed in the outline？？？things you do when performing the program job. Variations in methodological preference must be recognized among the different Institutes and Centers. Approaches to the program job learned in this core may be at variance to accustomed ways, and should be first discussed with staff colleagues and supervisors before implementing. New ways to get things done may well be appreciated, but surprises are not often well received.
I. Philosophical Issues of Program Role at NIH
II. Electronic Research Administration
III. Identifying the Best Future Science
IV. Identifying the Best PIs to do the science
V. How To Get Them The Money And Resources
VI. Government Oversight
VII. Handling problems
VIII. Additional Resources:
IX. Case Studies to Read and Think About
For more information, visit
http://odoerdb2.od.nih.gov/oer/training/esa/cores_curriculum_2010/core_2/esa_core_2.htm
Core Curriculum Part Two - Program Policies and Procedures (HHS-Only)
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- Large-Scale Expression Analysis
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- - Paul Meltzer, NCI, NIH (2010/11/18)
- - Category : Current Topics in Genome Analysis
- Current Topics in Genome Analysis
http://genome.gov/COURSE2010
Large-Scale Expression Analysis
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- Making the Transition to Industry
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- - Patricia Phelps, Ph.D. (2010/11/18)
- - Category : Career Development/OITE
- Objective: Youre been offered the job, now what? Can you negotiate the offer? What should you expect once you arrive at your new job? Topics: What to look for in a job offer. Understand the new team environment.
http://www.training.nih.gov
Making the Transition to Industry
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- Diarrheal Diseases: Global Killers at All Ages
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- - Roger Glass (FC), John Robbins (NICHD) (2010/11/18)
- - Category : Demystifying Medicine
- The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.
For more information, visit
http://www1.od.nih.gov/oir/DemystifyingMed
Diarrheal Diseases: Global Killers at All Ages
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- CC Grand Rounds: (1) Pitfalls and Promise for Individualized Pain Medicine (2) Symptom Distress Mechanisms in Digestive Disorders
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- - Hyungsuk Kim and Wendy A. Henderson (2010/11/18)
- - Category : Clinical Center Grand Rounds
- Hyungsuk Kim, DDS, PhD,
Staff Scientist, Pain Research Unit, Symptoms Management Branch, Intramural Research Division, NINR
Wendy A. Henderson, CRNP, MSN, PhD,
Assistant Clinical Investigator, Biobehavioral Unit, Symptoms Management Branch, Intramural Research Division, NINR
For more information, visit
http://www.cc.nih.gov/about/news/grcurrent.html
CC Grand Rounds: (1) Pitfalls and Promise for Individualized Pain Medicine (2) Symptom Distress Mechanisms in Digestive Disorders
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- Lunch and Learn Parenting Seminar: Introduction to Developmental Milestones and Delays in Young Children
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- - Audrey Thurm, Ph.D., NIH/NIMH (2010/11/18)
- - Category : Parenting
- This seminar will focus on a discussion of the variation seen in typical development in areas such as cognition, language and social behavior. The discussion will focus on children in the preschool years, as children are learning to talk and tackle other developmental milestones. Emphasis will be given to resources that can be used to help parents keep track of their children？？？s development, and what steps can be taken when there is a concern.
Acrobat Slides
Lunch and Learn Parenting Seminar: Introduction to Developmental Milestones and Delays in Young Children
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- Genetics after Genome-wide Association Studies: Inflammatory Bowel Disease
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- - Judy Cho, M.D., Yale University (2010/11/18)
- - Category : Wednesday Afternoon Lectures
- The first wave of genome-wide association studies across the major chronic inflammatory disorders has been completed and has identified over 100 genome-wide significant loci. There has been a striking degree of overlap for major loci across autoimmune diseases, implicating multiple cytokines and cytokine pathways, notably the interleukin 12/23, IL-10, and TNFa pathways. While the multitude of association signals are, to a large extent, of modest, additive effects, the mosaic of association signals across chronic inflammatory diseases provides important comparative insight.
The precise functional consequences of association signals has not been defined for most loci; however, it is likely that many of these signals modulate RNA expression in a tissue and context specific manner which may best be studied in a comprehensive manner through sequence-based transcriptome analyses. The comparative cytokine pathways implicated across chronic inflammatory disorders may have important implications for therapy; modulation of multiple cytokine pathways may more effectively treat some disorders, such as inflammatory bowel disease.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Genetics after Genome-wide Association Studies: Inflammatory Bowel Disease
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- Chemokine Control of Effector T Cell Trafficking
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- - Andy Luster, M.D., Ph.D. (2010/11/18)
- - Category : Immunology
- Andy Luster has made truly pioneering contributions to immunology, starting with his discovery of one of the first chemokines, IP-10/CXCL10, when he was a graduate student at Rockefeller University. Since then he has continued to be a leader in chemokine discovery, and in defining chemokine mechanisms of action, regulation, and biological roles in both innate and adaptive immunity. In addition, in the past decade he has expanded his research program to include the lipid chemoattractants, particularly leukotrienes and lysophosphatidic acid, and has made seminal contributions in this area as well. Although he may be best known for his detailed work on the molecular and cellular requirements for effector T cell trafficking and in immune responses in mouse models of asthma, he has also made major contributions to the molecular understanding of pathogenesis in cancer, atherosclerosis, malaria, IBD, transplantation and HIV. Andy does important work with broad significance in immunology and is an engaging speaker. His IIG seminar is one you will NOT want to miss.
The Immunology Interest Group
Chemokine Control of Effector T Cell Trafficking
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- Influenza and the Immune System 2010
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- - The NIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI) (2010/11/18)
- - Category : Special
- The H1N1 Pandemic has generated intense interest in the interaction of influenza viruses and the human immune system. This one day meeting will cover such topics as pathogenesis and disease, host factors required for virus replication, immune responses and evasion, and vaccines. Confirmed speakers include Nobel Prize recipient Peter Doherty, Brian Murphy (NIAID), Megan Shaw (Mount Sinai)and Philip Dormitzer (Novartis). A full agenda will be sent shortly. Please reserve the date.
http://web.ncifcrf.gov/events/CHI/default.asp
Influenza and the Immune System 2010
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- From calcium channels to autism
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- - Ricardo Dolmetsch, PhD (2010/11/18)
- - Category : Special
- Candidate for NIMH-DIRP Neurodevelopment Principal Investigator position
From calcium channels to autism
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- New roles for Notch and NF-kappaB signaling during brain development and function
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- - Nicholas Gaiano, PhD (2010/11/18)
- - Category : Special
- Candidate for NIMH-DIRP Neurodevelopment Principal Investigator position
New roles for Notch and NF-kappaB signaling during brain development and function