전체 8345
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- Enhancements to Peer Review: The Nuts and Bolts of How To Implement (HHS Only)
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- - NIH (2010/11/18)
- - Category : ESA (HHS Only)
- The presentations will provide Program, Grants Management, Review Staff, and the DEAS Training Staff, ？？？how-to-do-it？？？ presentations with step-by-step guidance for implementing the enhancements to peer review.
Chuck Selden (chair); Sally Amero; Kerry Brink; Megan Columbus; Suzanne Fisher; Robert Freund; Donald Luckett; Sherry Mills; Lubna Sher; Jean D. Sipe, Alan Willard
For more information, visit
http://odoerdb2-1.od.nih.gov/oer/training/esa/esa_training_20090325.htm
Enhancements to Peer Review: The Nuts and Bolts of How To Implement (HHS Only)
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- CC Grand Rounds: (1) Trapped in TRAPS, (2) Two Diseases that Teach Us About the Role of IL-1 in Human Inflammation
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- - Siegel, Richard M.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Clinical Center Grand Rounds
- - Siegel, Richard M.
- Clinical Center Grand Rounds
Richard Siegel, MD, PhD
Chief, Immunoregulation Section, Autoimmunity Branch, NIAMS
Raphaela Goldbach-Mansky, MD, MHS
Acting Chief, Translational Autoinflammatory Disease Section, NIAMS
For more information, visit
http://www.cc.nih.gov/about/news/grcurrent.html
CC Grand Rounds: (1) Trapped in TRAPS, (2) Two Diseases that Teach Us About the Role of IL-1 in Human Inflammation
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- Working at the NIH: Then and Now (NIH Only)
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- - Dr. Yvonne Maddox, Deputy Director, NICHD (2010/11/18)
- - Category : Human Resources (NIH Only)
- OHR Brown Bag Luncheon
Working at the NIH: Then and Now (NIH Only)
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- The Universe of GTP-binding proteins: un tema con variationi
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- - Alfred Wittenhofer (2010/11/18)
- - Category : Wednesday Afternoon Lectures
- GTP binding (G) proteins of the Ras superfamily cycle between a GDP-bound inactive and a GTP-bound active state. The switch-ON reaction involves the exchange of tightly bound GDP against GTP, while the switch-OFF mechanism involves the enzymatic cleavage of GTP to GDP. The switch function is tightly regulated since those reactions are intrinsically very slow and are stimulated through factors acting in trans. The first reaction is catalysed by guanine nucleotide exchange factors, GEFs, while the second is activated by GTPase-activating proteins called GAPs. The inability of certain of these proteins to be down-regulated or their unregulated activation leads to various forms of diseases including cancer.
A lot is known about the structural requirements for the switch function of Ras proteins, the GEF and the GAP reaction, their membrane recruitment and the interaction with effectors.
The basic features and mechanistic principles using Ras and G proteins, the structural basis of the molecular switch, how it is activated and how it interacts with downstream effectors, will be presented. Particular attention will be given to the GTPase reaction and its importance for disease formation such as cancer, Retinitis pigmentosa or Parkinson.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
The Universe of GTP-binding proteins: un tema con variationi
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- Tips for Going Green at Home
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- - Cindy Oleson (2010/11/18)
- - Category : Work/Life Center
- NIH Work Life Seminar
Join us for this informative seminar to learn ways for making your home environmentally friendly. With global warming occurring at an alarming rate, the decrease of fish populations in local streams, and major ecological habitats such as the Chesapeake Bay area experiencing increasing environmental damage, it is more important than ever to understand the consequences of our daily use of resources. Did you know that your home might cause the emission of more than twice as much carbon dioxide as the average car? Even small changes can have a big impact on reducing energy usage, and 2009 is a great time to start. Attend this seminar to learn tips for greening your light bulbs to your landscaping. Greening your home can also add more ？？？green？？？ to your wallet!
For more information, visit
http://wlc.od.nih.gov
Tips for Going Green at Home
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- Overtreated: The Role of Medical Evidence in Reducing Practice Variation and Controlling Costs
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- - Brownlee, Shannon.
NIH Consensus Development Program. (2010/11/18) - - Category : Special
- - Brownlee, Shannon.
- Medicine: Mind the Gap
Bridging the Gap Between Evidence and Practice
An NIH Seminar Series
Comparative effectiveness research has been touted as one of the most important paths to bending the health care cost curve downward. In the long run, medical evidence will undoubtedly rationalize the delivery of health care and help control costs, but what about the short term? The Dartmouth Atlas Project has documented a 2.5-fold variation in per capita Medicare spending in different parts of the country, most of which cannot be explained by variation in prevalence of illness or patient preference. These studies suggest that as much as a third of health care dollars are wasted on unnecessary care, the delivery of which is driven in part by a lack of evidence. We can？？？t wait until the evidence is in. What are some other possible solutions to addressing the problem of unwarranted variation?
About Shannon Brownlee
Shannon Brownlee is a writer and essayist who is currently serving as a Visiting Scholar at the NIH Clinical Center, Dept. of Bioethics; a Woodrow Wilson Visiting Scholar; and a Senior Fellow at the New America Foundation, in Washington, DC. Her articles and essays have appeared in such publications as the Atlantic Monthly, BMJ, New York Times Magazine, New Republic, Slate, and Time. She is a recipient of the Association of Health Care Journalists Award for Excellence, the Victor Cohn Prize for Excellence in Medical Science Reporting, the National Association of Science Writers Science-in-Society Award, and the Sigma Delta Chi Award from the Society of Professional Journalists, among many other awards. Her most recent work focuses on the lack of evidence in medicine and the problem of unnecessary health care, which accounts for as much as a third of the nation？？？s health care bills. Brownlee？？？s book, Overtreated: Why Too Much Medicine is Making Us Sicker and Poorer, was named the best economics book of 2007 by New York Times economics correspondent David Leonhardt. She holds a Master of Science in marine science from the University of California, Santa Cruz.
Bridging the gap between evidence and practice
The Medicine: Mind the Gap series will explore a wide range of issues at the intersection of research, evidence, and clinical practice？？？especially areas in which conventional wisdom may lead us astray. From the role of advocacy organizations in medical research and policy, to off-label drug use, to the effectiveness of continuing medical education, the seminar series will aim to engage the NIH community in thought-provoking discussions to challenge what we think we know and to think critically about our role in today？？？s research environment.
Presented by the NIH Consensus Development Program
Overtreated: The Role of Medical Evidence in Reducing Practice Variation and Controlling Costs
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- Primate Cortico-Basal Ganglia Network and Decision Making
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- - Lee, Daeyeol.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Neuroscience
- - Lee, Daeyeol.
- Decision making is ubiquitous, and the ability to develop the knowledge about the animals environment from experience and use this knowledge to produce a series of actions that will maximize the overall reward is essential for survival. Dr. Lees laboratory focuses on the role of the prefrontal cortex and the basal ganglia in evaluating the outcomes of the animals previous choices and incorporating this information to improve the animals decision-making strategies. His research is highly inter-disciplinary and capitalizes on the insights from formal theories of economics and reinforcement learning as well as computational neuroscience of neural coding and behavioral studies of decision making. His laboratory also develops novel behavioral paradigms that can probe the core processes of decision making. Combined with the use of a large-scale multi-electrode recording system, this research seeks to unravel the biological basis of willful actions.
Selected Publications:
Behavioral and neural changes after gains and losses of conditioned reinforcers.
Seo H, Lee D., J Neurosci. 2009 Mar 18;29(11):3627-41.
Neural dissociation of delay and uncertainty in intertemporal choice.
Luhmann CC, Chun MM, Yi DJ, Lee D, Wang XJ., J Neurosci. 2008 Dec 31;28(53):14459-66.
Prefrontal coding of temporally discounted values during intertemporal choice.
Kim S, Hwang J, Lee D., Neuron. 2008 Jul 10;59(1):161-72. Erratum in: Neuron. 2008 Aug 14;59(3):522.
Game theory and neural basis of social decision making.
Lee D., Nat Neurosci. 2008 Apr;11(4):404-9. Epub 2008 Mar 26. Review.
Order-dependent modulation of directional signals in the supplementary and presupplementary motor areas.
Sohn JW, Lee D., J Neurosci. 2007 Dec 12;27(50):13655-66.
To touch or not to touch: posterior parietal cortex and voluntary behavior.
Lee D., Neuron. 2007 Nov 8;56(3):419-21.
For more information see our website - NIH Neuroscience Seminar Series
Primate Cortico-Basal Ganglia Network and Decision Making
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- A New Strategy to Enhance Public Health Impact at NIMH: Intramural Research on Economics and Health Services
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- - Schoenbaum, Michael.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Special
- - Schoenbaum, Michael.
- Candidate Presentation for Director of the Scientific Core for Mental Health Services, Economics, and Public Health.
A New Strategy to Enhance Public Health Impact at NIMH: Intramural Research on Economics and Health Services
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- HHS-OWH National Lupus Awareness Campaign Launch
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- - United States. Dept. of Health and Human Services. Office on Womens Health. (2010/11/18)
- - Category : Special
- HHS-OWH and the Advertising Council are pleased to launch the first ever National Lupus Awareness campaign. This campaign is dedicated to increasing awareness of lupus to improve early diagnosis and treatment among those who are at increased risk for the disease. The campaign is targeted toward young minority women, who are most impacted by lupus and will provide them and their family members with information to help them to take action if they have symptoms. The campaign includes TV and radio PSAs, a website, bulletin boards and other media tools. The campaign will also generate long overdue public attention for lupus and raise recognition of the disease as a significant national public health problem.
HHS-OWH National Lupus Awareness Campaign Launch
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- Hematopoietic Stem Cell Transplantation: Transformation of a Field (NIH-Only)
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- - Bishop, Michael R.
National Institutes of Health (U.S.) (2010/11/18) - - Category : NCI CCR Grand Rounds (NIH Only)
- - Bishop, Michael R.
- Dr. Bishop received his M.D. from the University of Illinois College of Medicine in Chicago. He completed clinical training in internal medicine at Northwestern University and a fellowship in hematology and oncology at Loyola University Medical Center. He was an assistant professor of medicine at the University of Kentucky Medical Center before accepting a position at the University of Nebraska Medical Center to serve as director of the Leukemia and Allogeneic Stem Cell Transplantation Programs. Dr. Bishop joined the National Cancer Institute in March 1999 to serve as the clinical head of the Stem Cell Transplantation Program. Dr. Bishop currently serves as head of the Transplant Clinical Research Section in the NCI Experimental Transplantation and Immunology Branch. The primary goal of the Clinical Transplantation Therapy Program is to develop and conduct novel clinical trials in hematopoietic stem cell transplantation. Particular areas of interest within the program include the therapeutic use of T cells to enhance engraftment T-cell reconstitution as well as accentuate graft-versus-tumor effects. In addition, the program focuses on methods to prevent and treat recurrent disease following allogeneic stem cell transplantation, with a primary focus on B-cell malignancies. Dr. Bishop has authored or co-authored more than 120 peer-reviewed articles and over 20 book chapters relative to the fields of hematologic malignancies and hematopoietic stem cell transplantation. In 2003, he received the National Institutes of Health Distinguished Clinical Teacher Award. He received tenure as senior investigator at NIH in 2007.
SELECTED REFERENCES:
1. Bishop MR, Whit-Shan Hou J, Wilson WH, Steinberg SM, Odom J, Castro K, Kasten-Sportes C, Gea-Banacloche J, Marchigiani D, Gress R, Fowler DH. Establishment of early donor engraftment after reduced-intensity allogeneic hematopoietic stem cell transplantation to potentiate the graft-versus-lymphoma effect against refractory lymphomas. Biol Blood Marrow Transplant 2003;9:162？？？9.
2. Fowler DH, Odom J, Steinberg SM, Chow CK, Foley J, Kogan Y, Hou J, Gea-Banacloche J, Sportes C, Pavletic S, Leitman S, Read EJ, Carter C, Mair R, Beatty GL, Vonderheide RH, Levine BL, June CH, Gress RE, Bishop MR. Phase I clinical trial of hematopoietic stem cell allograft augmentation with co-stimulated, IL-4 polarized donor CD4+ T cells. Biol Blood Marrow Transplant 2006;12:1150？？？60.
3. Dean RM, Fry T, Mackall C, Steinberg SM, Hakim F, Fowler D, Odom J, Foley J, Gress R, Bishop MR. Association of serum interleukin-7 levels with the development of acute graft-versus-host disease. J Clin Oncol 2008;26:5735？？？41.
NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link:
http://www.bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx
Hematopoietic Stem Cell Transplantation: Transformation of a Field (NIH-Only)
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- Demystifying Medicine - Fragile X: Most common inheritable retardation defect
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- - Kaufmann, Walter E.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Demystifying Medicine
- - Kaufmann, Walter E.
- The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.
For more information, visit
http://www1.od.nih.gov/oir/DemystifyingMed
Demystifying Medicine - Fragile X: Most common inheritable retardation defect
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- Lunch and Learn: Ten Concepts Every Working Parent Needs to Know
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- - Chris Essex, M.A., LifeWork Strategies (2010/11/18)
- - Category : Parenting
- Parenting is one of the most challenging roles we have. We may have received training to become the professional we are today, but we rarely receive training for being a parent. This workshop is designed to give working parents practical information to deal with the challenges of being a working parent.
Handout available for download at http://videocast.nih.gov/pdf/parenting040109.pdf.
Lunch and Learn: Ten Concepts Every Working Parent Needs to Know
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- Dynamic Regulation of Immune Cell Function During Inflammatory Responses
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- - Egen, Jackson.
National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18) - - Category : Immunology
- - Egen, Jackson.
- For more information, visit
The Immunology Interest Group
Dynamic Regulation of Immune Cell Function During Inflammatory Responses
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- Ethics Rounds - Looking for Clinical Findings in Research Subjects: When is it a Good Idea?
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- - Wolf, Susan M.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Clinical Center Grand Rounds
- - Wolf, Susan M.
- Clinical Center Grand Rounds
Susan M. Wolf, JD
McKnight Presidential Professor of Law, Medicine and Public Policy Faegre and Benson Professor of Law, University of Minnesota Law School
Professor of Medicine, University of Minnesota Medical School
For more information, visit
http://www.cc.nih.gov/about/news/grcurrent.html
Ethics Rounds - Looking for Clinical Findings in Research Subjects: When is it a Good Idea?
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- Making an Effort to Listen: Mechanical Amplification by Myosin Molecules and Ion Channels in Hair Cells of the Inner Ear
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- - A. James Hudsdpeth (2010/11/18)
- - Category : Wednesday Afternoon Lectures
- Our hearing is remarkable for its physical capabilities. We can discern sounds at frequencies up to 20 kHz, a bandwidth one thousandfold that of our vision. At the auditory threshold, our ears detect vibrations of only 짹0.3 nm, an atomic dimension.
Finally, our hearing responds over twelve order of magnitude in intensity, a range unmatched by other sensory systems or indeed by manmade detectors. Uniquely among vertebrate sensory receptors, the ears mechanoreceptive hair cells amplify their inputs by means of an active process that increases responsiveness to sound, sharpens frequency selectivity, and compresses the dynamic range of hearing.
An overly exuberant active process can even cause the spontaneous emission of sound from an ear! Each hair cell uses its hair bundle, an elaborate array of tiny biological strain gauges, both to transduce mechanical stimuli and to implement the active process. Mechanical amplification is accomplished through the interaction of negative hair-bundle stiffness with the activity of the motor protein myosin-1c.
The operation of the active process near a dynamical instability, the Hopf bifurcation, explains many of the characteristics of our hearing.
About Dr. Hudspeth:- Served on the faculties of the California Institute of Technology, the University of California, San Francisco, and the University of Texas Southwestern Medical Center.
- Honors include the Spencer Award from Columbia University, the Lamport Award from the New York Academy of Sciences, the Cole Award from the Biophysical Society, the Dana Award from the Charles A. Dana Foundation, among others.
- Serves as member of the National Academy of Sciences and the American Academy of Arts and Sciences.
Making an Effort to Listen: Mechanical Amplification by Myosin Molecules and Ion Channels in Hair Cells of the Inner Ear
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- Science in the Public Health - Your Body or Your Life: Healthy and Unhealthy Body Image (HHS Only)
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- - Kelli Marciel (2010/11/18)
- - Category : STEP (HHS Only)
- Science in the Public Health
Overview:
Have you ever asked, ？？？Does this make me look fat?？？？ We constantly evaluate our physical selves, and how we think others see us, though perhaps with different ideals in mind. Body image？？？positive or negative？？？affects us all, regardless of gender, age, or ethnicity. Unhealthy body image can lead to behaviors that have serious consequences. This STEP forum will explore individual, societal, cultural, and especially gender differences that influence body image. Come and learn what current research tells us about developing a healthy body image.
Speakers:- Harrison G. Pope, MD, MPH, McLean Hospital, Harvard Medical School
- Katharine Phillips, MD, Butler Hospital, Brown University
- James J. Gray, Ph.D., American University
- Jane L. Debnam, Studio of Ballet Arts, Sandy Spring, MD
Kelli Marciel (Chair), Sally Amero, Prabha Atreya, Cindy Davis, Lisa Moeller, Laura Moen, Blaine Moore, Larry Stanford
For more information, visit
http://odoerdb2-1.od.nih.gov/oer/training/step/step_training_20090402.htm
Science in the Public Health - Your Body or Your Life: Healthy and Unhealthy Body Image (HHS Only)
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- The Expanding Proteomics Tool Kit: Choosing the Proper Tool for the Job
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- - Loo, Joseph A.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Proteomics
- - Loo, Joseph A.
- Characterization of the proteome and of protein structure has been greatly enhanced by the plethora of new analytical tools available. Mass spectrometry (MS) has been at the forefront of this advancement, as new modes of analyte ionization and introduction, detection and measurement, and fragmentation processes have allowed proteins (and their products) to be measured more sensitively, providing a deeper understanding of their structure and function. However, the expansion of the tool box presents a dilemma for the experimentalist: which tool should be selected for a given task? Is there a single tool (or experimental platform) that can accommodate all possible jobs?
Various experimental methods to address different questions will be discussed, including both top-down and bottom-up mass spectrometry and proteomic strategies. High-throughput proteomic measurements using MS has been facilitated largely by the ability of the LC-MS/MS to acquire data in the data dependent mode. To further increase the level of proteome coverage for proteome analysis, we are exploring an approach to mass spectrometry-based protein identification that facilitates the simultaneous acquisition of qualitative and quantitative information in a data independent fashion without the use of stable isotope labeling. Using this strategy, we have quantified (relative and absolute) over 200 proteins from human whole saliva. Saliva is the fluid that irrigates the mouth and oral cavity. It has a rich proteome that is derived from the salivary glands, the linings of the oral cavity, and blood. The use of saliva for diagnostic purposes presents an attractive potential option.
In addition, mass spectrometry is quickly becoming a technology of choice for analyzing biochemical binding partners and large protein assemblies. Examples of how many of these new MS-based tools are applied to generate structural information for intact proteins will be discussed.
http://proteome.nih.gov
The Expanding Proteomics Tool Kit: Choosing the Proper Tool for the Job
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- The National Eye Institutes 40th Anniversary Event
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- - NEI (2010/11/18)
- - Category : Special
- Featured Erik Weihenmayer, blind athlete and adventurer and his experiences going blind and working with NEI-supported scientists in testing BrainPort.
Agenda:
Welcome and Remarks
Paul A. Sieving, M.D., Ph.D.
Director, National Eye Institute
Low Vision Research Program Highlights
Michael D. Oberdorfer, Ph.D.
Program Director, Strabismus, Amblyopia and Visual Processing
NEI Extramural Research
BrainPort Presentation
Robert A. Beckman
President and CEO, Wicab, Inc.
Keynote Address
Erik Weihenmayer
Blind Athlete and Adventurer
The National Eye Institutes 40th Anniversary Event
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- Public Consultation Meeting of the National Science Advisory Board for Biosecurity (NSABB) Personnel Reliability Working Group
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- - Sponsored by the NIH Office of Biotechnology Activities (2010/11/18)
- - Category : National Science Advisory Board for Biosecurity
- The NSABB was established to provide advice, guidance and leadership regarding federal oversight of dual use research, defined as biological research with legitimate scientific purposes that could be misused to pose a biological threat to public health and/or other aspects of national security.
Given the heightened concerns about insider threats at organizations that work with highly pathogenic agents, the Federal government has charged the NSABB with recommending a personnel reliability program for individuals who work with Select Agents. A portion of their recommendations will address the measures that institutions should undertake to assess whether individuals are trustworthy and reliable to work with these agents.
The meeting will be conducted as a series of panels where participants will be asked to discuss particular topics relevant to NSABB deliberations.
For more information, please visit the NSABB website: www.biosecurityboard.gov
Public Consultation Meeting of the National Science Advisory Board for Biosecurity (NSABB) Personnel Reliability Working Group
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- NHLBI Extramural Implementation of ARRA (NIH-Only)
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- - Nabel, Elizabeth G.
National Heart, Lung, and Blood Institute. (2010/11/18) - - Category : NIH Only
- - Nabel, Elizabeth G.
- NHBI Director, Dr. Elizabeth G. Nabel, will provide NHLBI staff with an update on activities associated with the American Recovery and Reinvestment Act (ARRA)
NHLBI Extramural Implementation of ARRA (NIH-Only)