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- DNA Replication: Start Right, Proceed with Caution
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- - Aladjem, Mirit.
National Institutes of Health (U.S.) (2010/11/18) - - Category : NIH Directors Seminars
- - Aladjem, Mirit.
- 2008-2009 Directors Seminar Series
For more information, visit
http://www.nih.gov/about/director/dirsem.htm
DNA Replication: Start Right, Proceed with Caution
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- An ubiquitous reserve of multipotent stem cells in the walls of blood vessels
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- - P챕ault, Bruno.
National Institutes of Health (U.S.). Stem Cell Interest Group. (2010/11/18) - - Category : Stem Cell
- - P챕ault, Bruno.
- The Stem Cell Interest Group was established to enhance communication and to foster collaboration among scientists from varying disciplines interested in stem cells. Topics of interest include fundamental stem cell biology, ontogeny, gerontology, and the therapeutic potential of stem cells. The SCIG serves as an open forum for discussion and dissemination of knowledge about all aspects of stem cell biology
For more information, visit
http://tango01.cit.nih.gov/sig/home.taf?_function=main&SIGInfo_SIGID=115
An ubiquitous reserve of multipotent stem cells in the walls of blood vessels
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- Nanotechnology at NIH: Basic Concepts, Current Research, and Medical Applications
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- - Trans-NIH Nanotechnology Task Force. (2010/11/18)
- - Category : Conferences
- The all-day Nanotechnology Symposium offers an introduction to nanotechnology ？？？ what it is, what it isn？？？t, and how it impacts medicine with examples of major programs supported by NIH. Please visit the website to view the Symposium agenda: http://www.capconcorp.com/nanoweek2009/tuesday.asp
Nanotechnology at NIH: Basic Concepts, Current Research, and Medical Applications
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- K99/R00 Grants
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- - Sponsored by the NIH Office of Intramural Training & Education (2010/11/18)
- - Category : Career Development/OITE
- Objective: The primary, long-term goal of the Pathway to Independence (PI or K99/R00) Award program is to develop and maintain a strong cohort of new and talented NIH-supported independent investigators.
Presented by Joan Schwartz, PhD, Assistant Director, OIR; Nancy Lohrey, MS MT (ASCP), Program Director, NCI
K99/R00 Grants
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- Demystifying Medicine - Drug resistance and cancer
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- - Gottesman, Michael M.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Demystifying Medicine
- - Gottesman, Michael M.
- The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.
For more information, visit
http://www1.od.nih.gov/oir/DemystifyingMed
Demystifying Medicine - Drug resistance and cancer
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- Dietary fat-Gene Interaction in Prostate Cancer
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- - Chen, Yong.
National Center for Complementary and Alternative Medicine (U.S.) (2010/11/18) - - Category : OCCAM Monthly Lecture Series
- - Chen, Yong.
- The NCIs Office of Cancer Complementary and Alternative Medicine (OCCAM) invites you to view its monthly lecture series.
With the goal of informing the National Cancer Institute (NCI) community about the variety of ongoing research in cancer and complementary and alternative medicine (CAM), NCIs Office of Cancer Complementary and Alternative Medicine (OCCAM) has created a monthly lecture series on cancer CAM. These hour long lectures, occurring from 10 a.m. - 11 a.m. on the second Wednesday of each month, will feature a fifty minute presentation on a cancer CAM topic and allow ten minutes for questions.
For more information, visit
http://www.cancer.gov/cam/news/monthly-lecture-series.html
Dietary fat-Gene Interaction in Prostate Cancer
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- Pathogenesis of Preeclampsia
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- - Karumanchi, S Ananth.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Wednesday Afternoon Lectures
- - Karumanchi, S Ananth.
- Imbalance of angiogenic growth factors in the maternal circulation contributes to the pathogenesis of preeclampsia. Soluble fms-like tyrosine kinase 1 (sFlt1), an endogenous anti-angiogenic protein that antagonizes vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) appears to be a central player in this paradigm. Exogenous gene transfer of sFlt1 into pregnant rats using an adenoviral vector produced hypertension, proteinuria and glomerular endotheliosis, the classical pathological renal lesion of preeclampsia.
High serum sFlt1 and low serum free PlGF and free VEGF have been observed in preeclampsia. Abnormalities in these circulating angiogenic proteins are not only present during clinical preeclampsia, but also antedate clinical symptoms by several weeks. Another potential soluble factor secreted by the placenta that appears to be elevated in women with preeclampsia is soluble endoglin (sEng).
Endoglin (Eng) is an angiogenic receptor expressed mainly on the surface of endothelial cells, but also placental syncytiotrophoblasts. Eng acts as a co-receptor for transforming growth factor-? (TGF-?, a potent pro-angiogenic molecule) signaling in endothelial cells. Eng mRNA is up-regulated in the preeclamptic placenta. In addition, the extra-cellular region of endoglin is proteolytically cleaved and that sEng is released in excess quantities into the circulation of preeclamptic patients.
Furthermore, sEng appeared to exacerbate the vascular damage mediated by sFlt1 in pregnant rats resulting in severe preeclampsia-like illness including the development of HELLP syndrome and fetal growth restriction. What remains unknown is the etiology of the increased sFlt1 and sEng in preeclamptic patients and whether these markers can be used for the diagnosis and prediction of preeclampsia.
Methods aimed at interfering sFlt1 and sEng may be a novel therapeutic strategy in patients with severe premature preeclampsia.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Pathogenesis of Preeclampsia
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- Great Teachers - Hereditary Cancer Predisposition: New Challenges
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- - Garber, Judy.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Clinical Center Grand Rounds
- - Garber, Judy.
- Contemporary Clinical Medicine: Great Teachers
Judy E. Garber, MD, MPH
Director, Cancer Risk and Prevention Program
Dana-Farber Cancer Institute
Associate Professor of Medicine, Harvard Medical School
For more information, visit
http://www.cc.nih.gov/about/news/grcurrent.html
Great Teachers - Hereditary Cancer Predisposition: New Challenges
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- Lunch and Learn: Childhood Anxiety Disorders
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- - Dr. Erin Martin, Clinical Psychologist, NIH/NIMH (2010/11/18)
- - Category : Parenting
- This seminar will review the common signs and symptoms of anxiety in youth as well as provide parents with practical strategies for how to deal with anxiety in children and adolescents.
Handout available for download at http://videocast.nih.gov/pdf/parenting040809.pdf.
Lunch and Learn: Childhood Anxiety Disorders
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- End Stage Renal Disease (ESRD) in Indian Country
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- - Marx, Kitty.
Centers for Medicare & Medicaid Services (U.S.) (2010/11/18) - - Category : CMS - Centers for Medicare & Medicaid Services
- - Marx, Kitty.
- CMS Medicine Dish Series
NIH and CMS presenters will cover:- Impact of ESRD on American Indians and Alaska Natives,
- Considerations in contracting for an onsite dialysis facility,
- Eligibility and enrollment in Medicare for people with ESRD,
- Medicare coverage and beneficiary costs,
- Provider reimbursement,
- Role of ESRD Network Organizations, and
- Information resources for providers and beneficiaries.
- Kitty Marx, Host, Tribal Affairs Director, OEA CMS
- Andrew Narva, MD, National Kidney Disease Education Program, NIH and Chief Clinical Consultant for Nephrology, IHS
- Brenda Hudson, Center for Medicare Management, CMS
E-mail Comments to: medicinedish@cms.hhs.gov
End Stage Renal Disease (ESRD) in Indian Country
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- Powered by NCBC - Finding and Meeting the Challenges in RNA Folding: A Progress Report
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- - Herschlag, Daniel.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Special
- - Herschlag, Daniel.
- The NIH Roadmap National Centers for Biomedical Computing (NCBC) Lecture Series Presents:
Dr. Daniel Herschlag, Department of Biochemistry, Stanford University, will present ？？？Finding and Meeting the Challenges in RNA Folding: A Progress Report？？？ as part of the Powered by NCBC Lecture Series. This lecture series highlight outcomes from the NCBC Driving Biological Projects whose intent is to drive the interaction between computational and biomedical computational science.
It is more and more apparent that RNA molecules play roles in biological function and regulation that go well beyond its role as a passive conveyer of information. Integral to these processes is the formation of RNA structures and complexes and the dynamic rearrangement of these species. Thus, we maintain that a deep understanding of the wide-ranging biological processes that involve RNA will require fundamental understanding of the RNA molecules themselves. RNA folding is both an integral process in the formation of functional RNAs and RNA/protein complexes and an opportunity to deeply interrogate the underlying forces that determine RNA？？？s behavior.
In this talk, I will describe how dissection of simpler and simpler RNAs and model systems can provide rigorous tests of the properties of underlying forces. Further, these simple systems are required for rigorous comparisons of experiment and computation and, in many instances, for meaningful synergy between experiment and computation. The Physics-Based Simulation of Biological Structures (Simbios) at Sanford, one of the NCBC, has stimulated substantial efforts at this interface, although this work represents an initiation rather than a completion of a deep investigation of the physics underlying RNA molecular behavior.
Dr. Daniel Herschlag is a professor in the department of biochemistry, and a professor in the departments of chemistry and chemical engineering (by courtesy) at Stanford University. He is a leader of a Driving Biological Project (DBP)for Physics-based Simulation of Biological Structures (Simbios) at Stanford, one of the seven NCBC Centers funded under the NIH Roadmap for Bioinformatics and Computational Biology . His DBP project represents a macromolecule-scale study of the process of folding. It is ultimately relevant to RNA, DNA and protein, but focuses on RNA as an intriguing experimental system. Dr. Herschlag received his Ph.D. in biochemistry from University of Minnesota in 1988. He has received several awards, including NIH Merit Award, Cope Scholar Award, and Established Investigator of the American Heart Association. His research interests are to understand the molecular and atomic underpinnings of biological systems, and his lab focuses on studies of catalysis by RNA and protein enzymes, RNA folding, and global aspects of RNA processing using a wide array of interdisciplinary tools.
For more information, visit http://www.ncbcs.org/
Powered by NCBC - Finding and Meeting the Challenges in RNA Folding: A Progress Report
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- Face Encoding by Neural Networks in Inferotemporal Cortex
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- - Kendrick, Keith M.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Neuroscience
- - Kendrick, Keith M.
- Prof. Keith Kendrick studies how different brain systems are organised to control a variety of social and emotional behaviours. His research is focused on using a variety of animal models to investigate how the brain processes olfactory and visual cues to effect individual recognition. It also addresses how identity information is linked to that used for communicating and interpreting different emotional states. In one branch of his research, Prof. Kendrick has systematically investigated visual communication in sheep. In the 1980？？？s he discovered that neurons in the temporal cortex of sheep exhibit face-selective responses that closely resemble those in the primate brain. These electrophysiological observations fit well with behavioural data from his laboratory showing that sheep readily perceive the identity and emotional expression of conspecifics faces from photographs. These and other findings from his lab demonstrate that sheep use faces extensively for their social communication, raising questions about the evolution of mammalian face perception, including that of humans.
NIH Neuroscience Seminar Series
Face Encoding by Neural Networks in Inferotemporal Cortex
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- Communicating About Evolution
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- - Nisbet, Matthew.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Evolution and Medicine
- - Nisbet, Matthew.
- How can scientists and lovers of science communicate effectively with students and the public? Long gone is the assumption that mountains of evidence are sufficient to change opinions. Instead, Matthew Nisbet argues that scientists need to understand audiences？？？ worldviews and values. He outlines methods for engaging diverse audiences around the meaning and implications of evolutionary sciences.
Dr. Matthew Nisbet is Assistant Professor in the School of Communication at American University. He has conducted research and written extensively about communication dynamics in policy debates.
Lecture series presented by National Institute of General Medical Sciences, the Office of Science Education, and the National Human Genome Research Institute. For more information, visit
http://www.nigms.nih.gov/News/Meetings/EvolutionSeries2009
Communicating About Evolution
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- NIH Extramural Staff Question and Answer Session on the American Recovery & Reinvestment Act of 2009 (HHS-Only)
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- - National Institutes of Health (U.S.) (2010/11/18)
- - Category : HHS Only
The American Recovery and Reinvestment Act of 2009 (ARRA) gives a total of $10.4 billion to the National Institutes of Health that we will need to expend by September 2010. There have been many policy guidance documents posted in recent weeks. We know NIH staff members have many questions, and we are ready to answer them! Please e-mail your questions to: OER-ARRA@mail.nih.gov before and during the Q&A session and we will address as many as possible.
Viewers will earn Extramural Scientist Administrator (ESA) training credits
Q&A Panelists:
Amero, Sally (NIH/OD); Megan Columbus, (NIH/OD); Noni Byrnes, (NIH/CSR); David Curren, (NIH/OD); Joe Ellis, (NIH/OD); Suzanne Fisher, (NIH/CSR); JoAnne Goodnight, (NIH/OD); Marcia Hahn, (NIH/OD); Della Hann, (NIH/NIMH); Deborah Kassilke, (NIH/OD); Rebecca Kelley, (NIH/OD); Sherry Mills, (NIH/OD); Oliver B. Morton, (NIH/OD); Sally Rockey, (NIH/OD); Walter Schaffer, (NIH/OD); Sara Silver, (NIH/OD).Reference Materials for this program.
- NIH and the ARRA http://www.nih.gov/recovery/
- Implementing the Recovery Act http://www.hhs.gov/recovery/programs/index.html
- Public web page carrying Funding Opportunity Announcements for ARRA http://grants.nih.gov/recovery/
- NIH Intranet for Policy and Guidance Documents http://odoerdb2.od.nih.gov/oer/policies/recovery/index.htm
Frequently Asked Questions:
FAQs (04/07/2009)
Administrative Notices:
- NOT-OD-09-080 (04/03/2009) - NIH Award Terms and Additional Information for Recipients Receiving Recovery Act Grant Funding
- NOT-OD-09-079 (04/03/2009) - ARRA Administrative Supplements and Competitive Revisions: Clarifications on Programmatic Limitations and use of Modular Budgets
- NOT-OD-09-078 (04/03/2009) - NIH ARRA Funding Considerations for Applications with Meritorious Scores that Fall Beyond the Pay-line
- NOT-OD-09-076 (03/27/2009) - Notice Regarding RFA-OD-09-005, "Recovery Act Limited Competition: Biomedical Research Core Centers to Enhance Research Resources (P30)"
- NOT-OD-09-061 (03/06/2009) - Clarification to RFA-OD-09-003-Recovery Act Limited Competition: NIH Challenge Grants in Health and Science Research (RC1)
- NOT-RR-09-008 (03/05/2009) - Addition of Recovery Funds to the Shared Instrumentation Grant Program
- NOT-OD-09-054 (03/04/2009) - Recovery Act of 2009: NIH Review Criteria, Scoring System, and Suspension of Appeals Process
NIH Extramural Staff Question and Answer Session on the American Recovery & Reinvestment Act of 2009 (HHS-Only)
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- Annual Meeting of the Clinical Center Medical Staff (NIH-Only)
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- - National Institutes of Health (U.S.). Medical Executive Committee. (2010/11/18)
- - Category : NIH Only
- Updates and information of interest to the medical staff regarding patient care and clinical research. Topics to be discussed include:
- the Clinical Center Director？？？s report,
- the Barriers to Clinical Research Project,
- the Deputy Director for Intramural Research？？？s report,
- the Intramural Clinical Research Steering Committee,
- clinicaltrials.gov reporting requirements, and
- clinical quality/patient safety issues
Annual Meeting of the Clinical Center Medical Staff (NIH-Only)
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- Challenges and Opportunities in Psychiatric Drug Discovery
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- - Muglia, Pierandrea.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Special
- - Muglia, Pierandrea.
- Candidate presentation for ETP
Challenges and Opportunities in Psychiatric Drug Discovery
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- Inherited Susceptibility for Breast Cancer Metastasis (NIH-Only)
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- - Hunter, Kent W.
National Cancer Institute (U.S.) (2010/11/18) - - Category : NCI CCR Grand Rounds (NIH Only)
- - Hunter, Kent W.
- Dr. Hunter received his Ph.D. at the Massachusetts Institute of Technology. He completed his postdoctoral training in genomics at MIT before accepting a position at the Fox Chase Cancer Center in Philadelphia, where he was an associate member. Dr. Hunter joined the Laboratory of Population Genetics at NCI as an Investigator in 1999. Subsequently, Dr. Hunter joined the Laboratory of Cancer Biology and Genetics and is now a senior investigator where he serves as the head of the Metastasis Susceptibility Section. The primary goal of Dr. Hunter？？？s research is to investigate the role of inherited polymorphism in the dissemination and progression of breast cancer. His laboratory uses an approach termed ？？？systems genetics？？？, a multi-disciplinary approach including genetically engineered mouse models, genome-wide analytical approaches, mouse and human association studies and in vitro and in vivo modeling. His laboratory was the first to demonstrate that breast cancer metastasis has a significant inherited component. Dr. Hunter has authored or co-authored more than 70 articles and book chapters in the fields of mouse genomics and genetics as well as inherited metastasis susceptibility.
SELECTED REFERENCES:
1. Crawford NPS, Qian X, Ziogas Ar, Boersma B, Walker RC, Papageorge AG, Lukes L, Rowe W, Zhang J, Ambs S, Lowy DR, Anton-Culver H, Hunter KW. Rrp1b, a new susceptibility gene for breast cancer progression and metastasis. PLOS Genetics 2007;3(11):2296？？？2311.
2. Hunter KW. Host genetics influences tumor metastasis. Nature Reviews Cancer 2006;6:141？？？146.
3. Park Y-G, Zhao X, Lesueur F, Lowy DR, Lancaster M, Pharoah P, Qian X, Hunter K. Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1. Nature Genetics 2005;37:1055？？？1062.
NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link:
http://www.bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx
Inherited Susceptibility for Breast Cancer Metastasis (NIH-Only)
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- Demystifying Medicine - Aging, progeria, and heart disease
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- - Introne, Wendy.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Demystifying Medicine
- - Introne, Wendy.
- The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.
For more information, visit
http://www1.od.nih.gov/oir/DemystifyingMed
Demystifying Medicine - Aging, progeria, and heart disease
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- Lunch and Learn: Cyber Safety
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- - George Simms, Assistant State？？？s Attorney for Montgomery County, MD (2010/11/18)
- - Category : Parenting
- The internet can be a useful tool to increase knowledge, and inspire creativity and exploration in young children but it also has its dangers. This seminar will help parents teach their children the critical thinking and decision making skills they need to detect dangerous and/or unlawful online behavior.
Handout available for download at http://videocast.nih.gov/pdf/parenting041509.pdf.
Lunch and Learn: Cyber Safety
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- Il-23-From Structural Genomics To The Clinic And What We Learned Along The Way
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- - Kastelein, Robert Adriaan.
National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18) - - Category : Immunology
- - Kastelein, Robert Adriaan.
- Dr. Rob Kastelein has developed, aided by bioinformatics and biochemical tools, a research program aimed at the discovery of novel cytokines, growth factors and receptors in various signal transduction pathways. The targeted signaling systems include the hematopoietic pathways and the IL-1/TLR pathways with the intended goal of studying complete systems rather than individual molecules. Based on early studies to elucidate principles of protein-protein recognition using the interaction of cytokines and their receptors as model systems, sensitive structure-based computational tools were developed to identify novel members in these pathways. Highlights of these investigations include the identification of the family of TLRs (TLR1-10), novel IL-1-related ligands and receptors, novel cytokines related to the IL-17 family and a number of novel hematopoietic cytokines and their receptors, including IL-27 and IL-23. For many of these, interesting biological roles have been uncovered by matching ligand to receptor. Elucidating the function of these novel molecules in human disease is currently the major focus on his research. Dont miss the chance to hear an exciting talk on one the hottest cytokines in the field of immunology.
For more information, visit
The Immunology Interest Group
Il-23-From Structural Genomics To The Clinic And What We Learned Along The Way