전체 8345
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- Administrative Strategies - BODY LANGUAGE: LET ME HEAR YOUR BODY TALK! (HHS Only)
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- - Goldin-Meadow, Susan.
National Institutes of Health (U.S.). Staff Training-Extramural Programs Committee. (2010/11/18) - - Category : STEP (HHS Only)
- - Goldin-Meadow, Susan.
- STEP - Staff Training in Extramural Programs
Overview
You may be surprised to learn how loudly you speak without words. Understanding body language in the workplace isn？？？t just a game ？？？？？？ it？？？s a career necessity. When you are speaking with others, can you assess their interest levels, determine if they are responding truthfully, recognize when they are in disagreement, or identify their emotional responses? More to the point, are they reading your body language and adjusting the conversation accordingly? Facial expressions, postures, gestures, touch, and use of personal space are all under-appreciated aspects of how we communicate. Come and explore the world of body talk! Learn how to read others and select your own body language. This training is recommended for ESA credit.
Speakers- Dr. Susan Goldin-Meadow, University of Chicago
- Dr. Curtis LeBaron, Brigham Young University
- Dr. John Stern, Washington University St. Louis
Blaine Moore (Chair), Marina Broitman, Chris Hatch, Kelli Marciel, Lisa Moeller, Eduardo Montalvo, Dick Okita
For more information, visit
http://odoerdb2-1.od.nih.gov/oer/training/step/step_training_20090423.htm
Administrative Strategies - BODY LANGUAGE: LET ME HEAR YOUR BODY TALK! (HHS Only)
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- Workshop on Comparing Institutional Review Board (IRB) Models for Multi-site Pediatric Studies
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- - Sponsored by NICHD and NCRR (2010/11/18)
- - Category : IRB Models for Multi-site Pediatric Studies
- The purpose of this workshop is to learn, in a structured manner, about different models for IRB evaluation of multi-site pediatric clinical research protocols. The workshop will begin with presentations from experts on regulatory and policy expectations and will continue with discussions of examples of different models of facilitated IRB review (such as central IRB, reciprocal IRB agreements, rotating IRB, and commercial IRB review). A panel will also provide general comments.
The Pediatric Research Ethics Workgroup of the Clinical and Translational Science Awards (CTSA) Consortium Child Health Oversight Committee will use information from this conference, plus feedback from an accompanying Request for Information to select a pilot model to determine what should be adopted by the CTSA Consortium to facilitate multi-site pediatric research.
Workshop on Comparing Institutional Review Board (IRB) Models for Multi-site Pediatric Studies
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- A Journey with T Cells and Retroviruses
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- - Robert C. Gallo, University of Maryland School of Medicine (2010/11/18)
- - Category : James C. Hill
- James C. Hill Memorial Lecture
Robert C. Gallo, M.D. will speak about his past and present work, focusing on how earlier studies and discoveries laid the groundwork for subsequent advances in HIV/AIDS. He will highlight the importance of HIV prevention and discuss challenges and prospects related to HIV vaccine development.
Gallo has been the Director of the Institute of Human Virology at the University of Maryland School of Medicine since 1996. Before that, he spent 30 years at the National Cancer Institute, where he was head of the Laboratory of Tumor Cell Biology. Gallo？？？s legendary research career has led to major diagnostic and therapeutic advances in cancer, HIV/AIDS, and other viral disorders.
Gallo is most famous for co-discovering HIV as the cause of AIDS and developing a life-saving HIV blood test in the early 1980s. Prior to the AIDS epidemic, he discovered the first retrovirus in humans, which has been implicated in several diseases. He and his colleagues also discovered interleukin-2, a growth regulating substance that enables scientists to grow human T-cells in the laboratory and that is now used as a therapy for certain cancers.
For more information, visit
http://www3.niaid.nih.gov/news/events/meetings/2009HillLecture.htm
A Journey with T Cells and Retroviruses
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- The Nutrition and Age-realted Macular Degeneration Lecture
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- - Chew, Emily.
National Institutes of Health (U.S.). Womens Health Special Interest Group. (2010/11/18) - - Category : Womens Health
- - Chew, Emily.
- Womens Health Special Interest Group (WHSIG)
Intramural Program on Research on Womens Health
Sponsored by the NIH Office of Intramural Research
and the NIH Office of Research on Womens Health.
Come join your fellow NIH colleagues in a scientific exchange on issues related to the biology and pathology of sex and gender differences and effects on womens health.
For more information, visit
http://orwh.od.nih.gov
The Nutrition and Age-realted Macular Degeneration Lecture
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- Ion Channel Phosphorylation and Dynamic Regulation of Neuronal Excitability
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- - Trimmer, James.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Neuroscience
- - Trimmer, James.
- As neuroscience enters the post-genomic era, a major goal is the translation of genomic sequence information into a molecular understanding of the mechanisms of neuronal information processing and transfer. Dr. Trimmers research focuses on protein function, biochemical pathways and networks of protein-protein interactions regulating mammalian neuronal signaling. In particular, they are interested in the molecular characteristics of signaling complexes containing voltage-sensitive ion channels, proteins which determine the intrinsic electrical properties of neurons and how these cells respond to external stimuli, integrate the encoded information and generate an appropriate response. Their studies are aimed at a molecular understanding of how these important signaling molecules generate and maintain the fidelity of neuronal signaling, and how these processes can be dynamically regulated to generate phenotypic plasticity. Such information is necessary for an understanding of not only the normal function of neurons, but also in understanding disease states where excitability is altered, such as epilepsy and peripheral demyelinating disorders (e.g. multiple sclerosis). Characterization of native ion channels and associated interacting proteins as potential drug targets for these diseases, for neurodegenerative disorders where restoration of function may come from modulation of ion channel function in surviving neurons, and for other disorders of the nervous system remains an important facet of our analyses. Moreover, these studies are representative of approaches that would prove advantageous to future studies on other neuronal signaling complexes.
Selected Publications:
Misonou, H., Mohapatra, D. P., Park, E. W., Leung, V., Zhen, D., Misono, K., Anderson, A. E., and J. S. Trimmer. (2004). Regulation of Ion Channel Localization and Phosphorylation by Neuronal Activity. Nature Neurosci. 7: 711-718.
Trimmer, J. S. (2004) Peering into the Birth Canal during Ion Channel Parturition. Neuron 44:214-216.
Pyott, S. J., Glowatzki, E., Trimmer, J. S., and R. W. Aldrich. (2004) Extrasynaptic Localization of Inactivating Calcium-Activated Potassium Channels in Mouse Inner Hair Cells. J. Neurosci. 24:9469-9474.
Meyer, M. P., Trimmer, J. S., Gilthorpe, J. D., and S. J. Smith. (2005). Characterization of Zebrafish PSD-95 Gene Family Members. J. Neurobiol. 63:91-105.
Misonou, H., Mohapatra, D. P., Menegola, M., and J. S. Trimmer. (2005). Calcium- and Metabolic State-Dependent Modulation of the Voltage-Dependent Kv2.1 Channel Regulates Neuronal Excitability in Response to Ischemia. J. Neurosci. 25:11184-11193.
Mohapatra, D. P., and J. S. Trimmer. (2006). The Kv2.1 C-Terminus Can Autonomously Transfer Kv2.1-Like Phosphorylation-Dependent Localization, Voltage-Dependent Gating and Muscarinic Modulation to Diverse Kv Channels. J. Neurosci. 26:685-695.
For more information see our website - http://neuroseries.info.nih.gov
Ion Channel Phosphorylation and Dynamic Regulation of Neuronal Excitability
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- Scientific Management Review Board Meeting (Day 1)
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- - National Institutes of Health (U.S.). Scientific Management Review Board. (2010/11/18)
- - Category : Scientific Management Review Board
- Inaugural meeting of the NIH Scientific Management Review Board. The NIH Reform Act of 2006 (Public Law 109-482) provides organizational authorities to HHS and NIH officials to:
- (1) establish or abolish national research institutes;
(2) reorganize the offices within the Office of the Director, NIH including adding, removing, or transferring the functions of such offices or establishing or terminating such offices; and
(3) reorganize, divisions, centers, or other administrative units within an NIH national research institute or national center including adding, removing, or transferring the functions of such units, or establishing or terminating such units.
For more information, if available http://smrb.od.nih.gov/
Scientific Management Review Board Meeting (Day 1)
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- A Causal Role for Epigenetics in Human Cancer (NIH-Only)
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- - Andrew P. Feinberg, MD, MPH (2010/11/18)
- - Category : NCI CCR Grand Rounds (NIH Only)
- NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link:
http://www.bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx
A Causal Role for Epigenetics in Human Cancer (NIH-Only)
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- Aging Well: Promoting Cognitive and Functional Health
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- - Lachman, Margie E.
National Institutes of Health (U.S.) (2010/11/18) - - Category : BSSR Lecture Series
- - Lachman, Margie E.
- Widespread evidence exists for average declines in cognitive and physical functioning with aging, yet there are large individual differences in the nature and patterns of change. Using a lifespan developmental approach, Dr. Lachman considers modifiable psychosocial and behavioral factors that could potentially account for such individual differences in cognitive performance and changes in physical health. The presentation will include findings from the Midlife in the United States (MIDUS) Study, a large national longitudinal survey of adults between ages 25 and 85. Results support a prescription for a combination of social and behavioral factors to slow or compensate for changes with aging, and suggest possibilities for promoting healthy aging by targeting lifestyle factors.
This lecture is an installment of the Behavioral and Social Sciences Research Lecture Series sponsored by the NIH Office of Behavioral and Social Sciences Research and organized by the NIH Behavioral and Social Sciences Research Coordinating Committee.
The Behavioral and Social Sciences Research Coordinating Committee (BSSR CC), with support from the Office of Behavioral and Social Sciences Research (OBSSR), convenes a series of guest lectures and symposia on selected topics in the behavioral and social sciences. These presentations by prominent behavioral and social scientists provide the NIH community with overviews of current research on topics of scientific and social interest. The lectures and symposia are approximately 50 minutes in length, with additional time for questions and discussion. All seminars are open to NIH staff and to the general public.
Aging Well: Promoting Cognitive and Functional Health
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- Family Fitness Equals Family Fun
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- - Brenda Salas, LifeWork Strategies (2010/11/18)
- - Category : Work/Life Center
- NIH Work Life Seminar
While you are out walking, are your kids at home exercising their thumbs? While they are at the swim center, are you folding the laundry? There are so many pulls on our time these days parents and kids often forgo spending time together and finding time to exercise -- if they can find time for it at all. You can solve both problems by making physical activity a Family Affair. It does not have to take long, and it will be fun! Family exercise will not just keep you and your kids healthy, but it will also help to strengthen your relationship.
Attend this seminar to discuss how to make family fitness a priority, even if you only have 10 minutes in your day. Get great ideas for activities that will be fun for all family members and any age group. Do not forget the Grandparents!
For more information, visit
http://wlc.od.nih.gov
Family Fitness Equals Family Fun
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- Holocaust Remembrance Program (HHS-Only)
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- - Erika Eckstut (Newman), a Holocaust survivor (2010/11/18)
- - Category : PSC Programs (HHS Only)
- Program Support Center
Holocaust Remembrance Program
Sponsored by: PSC, AHRQ, FDA, HRSA, IHS, OMH, SAMHSA
Holocaust Remembrance Program (HHS-Only)
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- Bipolar Disorders: Towards a Pathophysiology
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- - Soares, Jair C.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Special
- - Soares, Jair C.
- Dr. Soares will discuss most recent findings from ongoing studies that examine fronto-limbic brain pathways as possibly involved in pathophysiology of bipolar disorders. He will review findings from both adult and pediatric studies with neuroimaging tools (MRI, MRS, DTI), as well findings from neurocognitive studies. These findings will be discussed as related to a hypothesis that abnormalities in brain fronto-limbic pathways may be central to pathophysiology of bipolar disorder.
Objectives:- 1) Understand brain neuroanatomy and regions involved in regulation of emotions.
2) Learn about applications of human brain imaging to the study of psychiatric disorders.
3) Understand available findings and limitations from neuroimaging studies of bipolar disorders
Bipolar Disorders: Towards a Pathophysiology
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- Demystifying Medicine - Human papilloma virus and cancer: Prevention by vaccination
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- - Gillison, Maura.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Demystifying Medicine
- - Gillison, Maura.
- The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.
For more information, visit
http://www1.od.nih.gov/oir/DemystifyingMed
Demystifying Medicine - Human papilloma virus and cancer: Prevention by vaccination
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- Scientific Management Review Board Meeting (Day 2)
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- - National Institutes of Health (U.S.). Scientific Management Review Board. (2010/11/18)
- - Category : Scientific Management Review Board
- Inaugural meeting of the NIH Scientific Management Review Board. The NIH Reform Act of 2006 (Public Law 109-482) provides organizational authorities to HHS and NIH officials to:
- (1) establish or abolish national research institutes;
(2) reorganize the offices within the Office of the Director, NIH including adding, removing, or transferring the functions of such offices or establishing or terminating such offices; and
(3) reorganize, divisions, centers, or other administrative units within an NIH national research institute or national center including adding, removing, or transferring the functions of such units, or establishing or terminating such units.
For more information, if available http://smrb.od.nih.gov/
Scientific Management Review Board Meeting (Day 2)
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- The 2009 Jack Mendelson Honorary Lecture: Recent Findings From a 25-Year Longitudinal Study of Genetic and Environmental Contributors to Alcoholism
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- - Schuckit, Marc Alan.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Special
- - Schuckit, Marc Alan.
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) presents the 2009 Jack Mendelson Honorary Lecture. The first honorary lecturer is Marc A. Schuckit, M.D., Distinguished Professor of Psychiatry, University of California San Diego, and Director of the Alcohol Research Center, VA San Diego Healthcare System. His lecture is titled ？？？Recent Findings From a 25-Year Longitudinal Study of Genetic and Environmental Contributors to Alcoholism.？？？ About the lecture series: As a tribute to Dr. Jack Mendelson？？？s remarkable scientific contributions to the field of alcohol research, NIAAA has established this honorary lecture series to highlight clinical/human research in the alcohol field by featuring an outstanding investigator who has made significant and long-term contributions to our understanding of alcoholism susceptibility, alcohol？？？s effects on the brain and other organs, and the prevention and treatment of alcohol use disorders. NIAAA is pleased to present this series of scientific lectures both to acknowledge continuing advances in alcohol-related areas of clinical research and to honor the memory of an individual whose pioneering research in human alcoholics remains relevant today.
For more information, visit www.niaaa.nih.gov.
The 2009 Jack Mendelson Honorary Lecture: Recent Findings From a 25-Year Longitudinal Study of Genetic and Environmental Contributors to Alcoholism
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- HSPD-12 Update for AO Sponsors (NIH-Only)
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- - Richie Taffet, HSPD-12 Program Manager (2010/11/18)
- - Category : NIH Only
- This session will provide an update on HSPD-12 implementation at NIH and provide details on the upcoming rollout of the new HHS ID Badge. The AO Sponsor community will be the first group to receive the new badges. This session will highlight the essential role that NED Super Users play the next phase of the rollout.
HSPD-12 Update for AO Sponsors (NIH-Only)
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- Vascular Zip Codes in Targeted Delivery of Multifunctional Nanodevices
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- - Ruoslahti, Erkki.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Wednesday Afternoon Lectures
- - Ruoslahti, Erkki.
- This laboratory screens phage libraries in live mice to identify peptides that direct phage homing to a specific target in the body. When the libraries are injected into the circulation, tissue-specific or tumor-specific differences in endothelial cells are primarily targeted.
We have identified tumor-homing peptides that recognize angiogenesis-associated or tumor-type specific markers in tumor blood vessels, or distinguish the vessels of pre-malignant lesions from those of the corresponding normal tissues and of fully malignant tumors. Homing peptides have also revealed a zip code system of molecular changes in tumor lymphatics.
We have used synthetic homing peptides identified by phage display to target nanoparticles to tumors. The vasculature is an excellent target because blood supply is important for tumor growth and because tumor vessels are readily available for circulating particles. The homing peptides deliver nanoparticles into tumors in a highly selective manner, and we have developed a nanoparticle that amplifies its own homing to tumors.
Quite recently, we have discovered peptides that specifically home to tumor vessels, extravasate, enter into cells, and spread within tumor tissue. These tumor-penetrating peptides are capable of taking a payload, such as nanoparticles, deep into tumor tissue. We have elucidated the molecular pathway for the cell and tissue penetration by these peptides. We are using these peptides to construct multifunctional, targeted nanoparticles that also serve as tumor imaging probes and drug carriers.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Vascular Zip Codes in Targeted Delivery of Multifunctional Nanodevices
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- T-reg and Th17 cells in tissue inflammations
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- - Kuchroo, Vijay K.
National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18) - - Category : Immunology
- - Kuchroo, Vijay K.
- The interests of Vijay Kuchroo and his lab revolve around the function and regulation of the effector and regulatory T cell responses and how they are involved in autoimmune and inflammatory disease. His laboratory pioneered the study of the Th17 lineage and its regulation, and was one of the first to show that IL6+TGFb are the commitment factors for the lineage, whereas IL23 stabilizes the phenotype. They also were among the first to define the reciprocal relationship between induced T-regulatory cells and Th17 cells, defined the factors that affect plasticity of the lineage decisions and conversion between effector T cell lineages. Their recent work on the diversity of the T cell response culminated in the definition of a novel effector T cell lineage termed Th9 and demonstration that the prototypic Th2-related transcription factor cMaf is also involved in development of follicular T-helper and Th17 cells.
Vijay has received many awards and honors for his outstanding work on mechanisms driving central nervous system autoimmunity, including in 2002 The Javits Neuroscience Investigator Award administered by NINDS which is awarded for 7 years to a scientist who has already has made seminal contributions to neurological research and is expected to continue to do cutting edge research for the next 7 years.
Vijay is an engaging speaker who keeps his audience awake and on their toes. Not to miss!
For more information, visit
The Immunology Interest Group
T-reg and Th17 cells in tissue inflammations
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- NSABB - National Science Advisory Board for Biosecurity, April 2009
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- - National Science Advisory Board for Biosecurity (U.S.). Meeting (2010/11/18)
- - Category : National Science Advisory Board for Biosecurity
- The NSABB has been established to provide advice to federal departments and agencies on ways to minimize the possibility that knowledge and technologies emanating from vitally important biological research will be misused to threaten public health or national security. The NSABB is a critical component of a set of federal initiatives to promote biosecurity in life science research.
Presentations and discussions at the April 29, 2009 meeting will focus on findings and recommendations regarding an optimal program of personnel reliability for individuals with access to Select Agents and Toxins and a brief overview of the Public Consultation meeting on April 3, 2009 on proposed optimal characteristics of individuals with access to Select Agents.
For more information, visit
http://www.biosecurityboard.gov/meetings.asp
NSABB - National Science Advisory Board for Biosecurity, April 2009
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- CC Grand Rounds: (1) Genetic Variation of HIV-1 Populations in vivo, (2) Recent Findings in the Epidemiology of Cancer in HIV-Infected People
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- - Maldarelli, F.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Clinical Center Grand Rounds
- - Maldarelli, F.
- Clinical Center Grand Rounds
Frank Maldarelli, MD, PhD
Staff Clinician, HIV Drug Resistance Program, NCI
Eric A. Engels, MD, MPH
Senior Investigator, Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI
For more information, visit
http://www.cc.nih.gov/about/news/grcurrent.html
CC Grand Rounds: (1) Genetic Variation of HIV-1 Populations in vivo, (2) Recent Findings in the Epidemiology of Cancer in HIV-Infected People
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- GMAC Seminar - Payment Management System (HHS Only)
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- - NIH (2010/11/18)
- - Category : GMAC (HHS Only)
- GMAC Subcommittee on Training
http://odoerdb2.od.nih.gov/gmac/gmac/trs_main.html
GMAC Seminar - Payment Management System (HHS Only)