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  • Town Hall Meeting and Information Session: BTRIS, the NIH Biomedical Translational Research Information System
    • - Umberto Tachinardi, MD, PhD (2010/11/18)
    • - Category : Special
    The Biomedical Translational Research Information System (BTRIS) team invites you to a series of lectures focused on informatics in biomedical and translational research. This series brings leading 詮？gures in the study and use of translational information systems from academic centers across the U.S. and will promote discussion about the future of informatics at the Clinical Center.

    Learn more about how BTRIS will be developed, opportunities for investigators to participate in its design, and project goals.

    For more information, visit http://btris.nih.gov

    Town Hall Meeting and Information Session: BTRIS, the NIH Biomedical Translational Research Information System

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  • Demystifying Medicine - Viral hepatitis: A global problem and the role of interferon
    • - Marc Ghany, M.D. (CC) and Katherine Zoon, PhD (NIAID) (2010/11/18)
    • - Category : Demystifying Medicine
    The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.

    For more information, visit
    http://www1.od.nih.gov/oir/DemystifyingMed

    Demystifying Medicine - Viral hepatitis: A global problem and the role of interferon

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  • Pathways of Memory CD8 T Cell Development During Infection
    • - Kaech, Susan.
      National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18)
    • - Category : Immunology
    Susan Kaech will be visiting NIH on May 20th as our speaker for the IIG seminar series. As most of you probably know, Sue has been at the forefront of characterizing the CD8+ T cell response to viral infections both as a post-doc in Rafi Ahmeds lab and since starting her own group at Yale in 2004. She has recently focused on finding ways of discriminating short-lived effector T cells from the precursors of long-lasting memory T cells in response to model pathogens. Sue is an engaging speaker and this should be a great seminar.

    Recent publications from her lab include these:
    Expression of IL-7R alpha is necessary but not sufficient for the formation of memory CD8 T cells during viral infection http://www.pnas.org/content/104/28/11730.full
    Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor http://www.cell.com/immunity/retrieve/pii/S1074761307003718

    For more information, visit
    The Immunology Interest Group

    Pathways of Memory CD8 T Cell Development During Infection

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  • Mechanisms of Protein Translocation Across Membranes
    • - Rapoport, Tom A.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : Wednesday Afternoon Lectures
    Many proteins in bacteria are transported during their biosynthesis across or are integrated into the plasma membrane, a process that is similar to protein translocation across endoplasmic reticulum (ER) membrane in eukaryotes. Transport occurs through a protein-conducting channel that is formed from a conserved heterotrimeric membrane protein complex (SecY or Sec61 complex). The channel associates with different partners in different translocation pathways. In bacteria, the SecY channel can associate with the translating ribosome (co-translational translocation) or with the cytoplasmic ATPase SecA (post-translational translocation).

    The crystal structure of an archaeal SecY complex shows the architecture of the closed channel. The structure suggests that a single SecY copy forms the translocation pore. This prediction was confirmed for SecA-mediated translocation by disulfide bridge crosslinking experiments, which show that both the signal sequence and the mature region of a translocating polypeptide chain are contained in the same SecY copy. However, translocation appears to be mediated by oligomers of the SecY complex; nucleotide-binding fold 1 (NBF1) of SecA interacts with a non-translocating SecY copy, while other domains of SecA ？？？push？？？ the polypeptide chain through a neighboring SecY copy.

    We have recently determined the crystal structure of SecA bound to the SecY complex at 4.5？？ resolution. The structure shows one copy of SecA in its transitions state of ATP hydrolysis bound to one copy of SecY complex. The latter corresponds to the translocating SecY copy. Both SecA and SecY undergo major conformational changes upon interaction. The structure suggests mechanisms for how SecA moves polypeptides through the SecY channel. In addition, the data reveal that SecA binding opens the lateral gate of SecY for signal sequence intercalation, and induces plug movement. These results indicate that the channel is opened for translocation in two distinct steps, indu

    The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    Mechanisms of Protein Translocation Across Membranes

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  • Personal Electronic Health Records: From Biomedical Research to Peoples Health (Day 1)
    • - Organized by the National Library of Medicine (NLM) and the Friends of the NLM (2010/11/18)
    • - Category : Conferences
    This is the first national conference on reducing costs and improving health care through implementation of personal electronic health records (PEHR) since the Obama Administration announced its intent to make this technology a cornerstone of its health reform efforts. (A personal electronic health record refers to an individual patient？？？s medical record in digital format. Electronic health record systems coordinate the storage and retrieval of individual records with the aid of computers.)

    Expert developers and implementers (from such companies as Google, Microsoft and IBM) will review alternative systems and their settings. In addition, presentations from top government healthcare officials, healthcare industry leaders and bioinformatics experts will cover system, clinical, patient, research, legal/ethical and national policy issues.

    See the home page of conference co-sponsor, the Friends of the NLM ？？？www.fnlm.org

    See the agenda at: http://www.fnlm.org/pdfs/FNLM_Conference_Program_draft.pdf

    Personal Electronic Health Records: From Biomedical Research to Peoples Health (Day 1)

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  • CC Grand Rounds: (1) Suicide Screening in Medically Ill Children, (2) Suicidality Emerging During Antidepressant Treatment
    • - Pao, Maryland.
      McMahon, Francis J.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : Clinical Center Grand Rounds
    Contemporary Clinical Medicine

    Maryland Pao, MD
    Clinical Director, NIMH

    Francis J. McMahon, MD
    Chief, Genetic Basis of Mood and Anxiety Disorders Unit, Mood and Anxiety Program, NIMH

    For more information, visit
    http://www.cc.nih.gov/about/news/grcurrent.html

    CC Grand Rounds: (1) Suicide Screening in Medically Ill Children, (2) Suicidality Emerging During Antidepressant Treatment

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  • The Strain in Pain Lies Mainly in the Brain: What Have We Learned from the Neuroimaging of Pain?
    • - Mackey, Sean.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : Special
    NIDCR 2009 Seminar Series: From Basic Research to Therapy -- The Latest Frontier

    Dr. Sean Mackey of Stanford University School of Medicine will discuss his work on elucidating the mechanisms of pain perception and control using neuroimaging techniques such as Virtual Reality and fMRI. One study uses real-time fMRI images to show patients how their brain functions when in pain, and trains them to gain more control of their pain experience through relaxation and other cognitive techniques. Another project uses neuroimaging to investigate how chronic pain causes changes within the brain that amplify and maintain pain.

    Dr. Sean Mackey is an Associate Professor in the Departments of Anesthesia and Neurosciences at Stanford University School of Medicine. He is also a co-director of the Stanford Pain Research and Clinical Center, which brings together clinicians, researchers, engineers, and patients to work toward solving the problem of chronic pain.

    For more information, visit http://www.nidcr.nih.gov/NewsAndFeatures/Announcements/NewSeminarSeries.htm

    The Strain in Pain Lies Mainly in the Brain: What Have We Learned from the Neuroimaging of Pain?

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  • Personal Electronic Health Records: From Biomedical Research to Peoples Health (Day 2)
    • - Organized by the National Library of Medicine (NLM) and the Friends of the NLM (2010/11/18)
    • - Category : Conferences
    This is the first national conference on reducing costs and improving health care through implementation of personal electronic health records (PEHR) since the Obama Administration announced its intent to make this technology a cornerstone of its health reform efforts. (A personal electronic health record refers to an individual patient？？？s medical record in digital format. Electronic health record systems coordinate the storage and retrieval of individual records with the aid of computers.)

    Expert developers and implementers (from such companies as Google, Microsoft and IBM) will review alternative systems and their settings. In addition, presentations from top government healthcare officials, healthcare industry leaders and bioinformatics experts will cover system, clinical, patient, research, legal/ethical and national policy issues.

    See the home page of conference co-sponsor, the Friends of the NLM ？？？www.fnlm.org

    See the agenda at: http://www.fnlm.org/pdfs/FNLM_Conference_Program_draft.pdf

    Personal Electronic Health Records: From Biomedical Research to Peoples Health (Day 2)

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  • Feeling Stressed? Debt on a Diet, Deskercise, and Stress Management Techniques for Busy Busy People
    • - Grants Management Professional Development Committee (2010/11/18)
    • - Category : Special
    If you are feeling stressed by the many activities taking place in the Grants Management community lately, you are not alone! Please join the Grants Management Professional Development Committee for a seminar discussing different stressors that may be negatively affecting you and solutions for coping! Speakers will be discussing ways to deal with financial stress, how to de-stress at your desk as well as stress management for the multi-tasker.

    Speakers:
    • Rosemary Hill, Money Management International
    • Laura Lavrin, NIH R&W Fitness Center Director
    • Terry Bowers, NIH R&W Fitness Center Staff
    • Rachel Permuth-Levine, Ph.D., MSPH Deputy Director
    For more information, visit http://odoerdb2.od.nih.gov/gmac/gmac/profdev_main.html

    Feeling Stressed? Debt on a Diet, Deskercise, and Stress Management Techniques for Busy Busy People

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  • Advances in Pain Research 2009
    • - NIH Pain Consortium. Symposium (2010/11/18)
    • - Category : Conferences
    The NIH Pain Consortium 4th Annual Symposium on Advances in Pain Research

    The theme of this year？？？s symposium will be genetics and pain. Topics will include human genetic risk factors for chronic pain, genes relevant to treatment response and abuse potential, and genetic tools and models for pain research. A poster session will include a broad selection of current pain research findings presented by young investigators. Members of the extramural scientific community, the NIH scientific community, health care providers, and the public are invited to attend. The event will be hosted by the co-chairs of the NIH Pain Consortium.

    For more information, visit
    http://guest.cvent.com/EVENTS/Info/Summary.aspx?e=634ee984-9a4f-4385-8df1-2948932d4780

    Advances in Pain Research 2009

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  • High-Quality Human Biospecimens: The Key to Molecular Medicine
    • - Dr. Carolyn Compton, Director of the Office of Biorepositories and Biospecimen Research (2010/11/18)
    • - Category : Biospecimens
    Biospecimens Interest Group

    The NIH interest group Biospecimens is sponsored by: The Office of Rare Diseases Research (ORDR,OD/NIH), Yaffa Rubinstein, and the Office of Biorepositories and Biospecimens Research (OBBR,OD/NCI), John Gillespie.

    One of the major goals of the Biospecimens Interest Group is to promote and facilitate interaction between intramural and extramural scientists who are interested and involved in a variety of clinically-oriented research projects using biospecimens. We intend to use this interest group as a forum where investigators can get together to exchange scientific data, ideas and information, using biospecimens for research and validation of assays and technologies development.

    In addition, this forum will be used to discuss ways to access high-quality biospecimens and better harmonize and standardize procedures and SOPs for collecting, handling, and storing samples to ensure maximum reproducibility of outcome, while protecting the privacy of the patients (donors) and adhering to the ethical and legal requirements associated with the use of biospecimens.

    http://sigs.nih.gov/biospecimens/Pages/default.aspx

    High-Quality Human Biospecimens: The Key to Molecular Medicine

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  • Building a Bridge: Transitional Programs from the Criminal Justice to the Community Setting for HIV+ Drug Users
    • - Frederick L. Altice, M.D., Yale University (2010/11/18)
    • - Category : BSSR Lecture Series
    American？？？s thirst for incarceration has resulted in the highest per capita rate of incarceration in the world. Our failed legal policies on drug abuse contribute greatly to 13 million people interfacing with the criminal justice system each year and 1 in 100 Americans being behind bars. The failure to adequately treat substance abuse, a chronic and relapsing condition within our criminal justice system, has resulted in a concentration of individuals with HIV/AIDS, viral hepatitis, mental illness and tuberculosis behind bars. Though in recent years, prisons and jails have become increasingly successful in treating chronic conditions such as HIV/AIDS, but less successful in ensuring continuity of care after release. As such, 26% of all people living with HIV are released to the community, yet their HIV treatment outcomes less than optimal. In this presentation, we will review the epidemiology of HIV/AIDS within the criminal justice system and explore evidence-based solutions and alternative mechanisms to improve HIV detection, treatment and continuity of care for those with HIV/AIDS who interface with the criminal justice system.

    Dr. Altice？？？s research interests are focused on the interface between infectious diseases and substance abuse. As a clinical epidemiologist, health services and intervention researcher, he has created novel programs for the treatment of HIV, HCV, and tuberculosis in vulnerable populations, including injection drug users and prison inmates. Specifically, he has been an international leader in research related to adherence to antiretroviral therapy, particularly among HIV+ drug users, has made considerable inroads into novel approaches HIV+ using directly administered antiretroviral therapy and other structural interventions to facilitate adherence both nationally and internationally.

    More biographical information:
    http://www.med.yale.edu/intmed/faculty/altice.html

    HANDOUTS are posted at http://sigs.nih.gov/bssrig/Documents/Forms/AllItems.aspx

    This lecture is an installment of the Behavioral and Social Sciences Research Lecture Series sponsored by the NIH Office of Behavioral and Social Sciences Research and organized by the NIH Behavioral and Social Sciences Research Coordinating Committee.

    The Behavioral and Social Sciences Research Coordinating Committee (BSSR CC), with support from the Office of Behavioral and Social Sciences Research (OBSSR), convenes a series of guest lectures and symposia on selected topics in the behavioral and social sciences. These presentations by prominent behavioral and social scientists provide the NIH community with overviews of current research on topics of scientific and social interest. The lectures and symposia are approximately 50 minutes in length, with additional time for questions and discussion. All seminars are open to NIH staff and to the general public.

    Building a Bridge: Transitional Programs from the Criminal Justice to the Community Setting for HIV+ Drug Users

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  • Quick & Healthy Recipes for Busy People
    • - Susan Mudd, CNS - Life/Work Strategies (2010/11/18)
    • - Category : Work/Life Center
    NIH Work Life Seminar

    Do you think it takes time and effort to plan a genuinely healthy meal?
    Sometimes it seems as if we dont have enough time to prepare a nutritious and wholesome meal given our busy, fast-paced reality. But it might not take as much effort as you think. Attend this seminar to discuss the general guidelines for healthy, whole food meal planning and review the steps required to plan a meal both nutritious and delicious. Find out some quick and easy ways to increase the healthy foods in your diet, while decreasing unhealthy choices. Sample recipes are provided for quick healthful meals with suggested options for breakfast, lunch, and dinner ？？？ even DESSERT can be healthy! Come and check it out!

    For more information, visit
    http://wlc.od.nih.gov

    Quick & Healthy Recipes for Busy People

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  • Genomic Strategies for Personalized Cancer Therapy (NIH-Only)
    • - Nevins, Joseph R.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : NCI CCR Grand Rounds (NIH Only)
    NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link:
    http://www.bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx

    Genomic Strategies for Personalized Cancer Therapy (NIH-Only)

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  • New Grantee Workshop: Working Together to Advance Cancer Control Research (Day 1)
    • - National Cancer Institute, Division of Cancer Control and Population Sciences (2010/11/18)
    • - Category : Conferences
    The Division of Cancer Control and Population Sciences (DCCPS) New Grantee Workshop (NGW) will bring together investigators that were awarded their first R01 in 2007 and 2008. At the workshop, grantees will interact with each other and program staff to discuss their research; learn about the grants process; and develop strategies for future success. The major focus of the meeting is to provide junior investigators with the tools, techniques, and information they need to successfully manage their current grant and secure subsequent funding.

    New Grantee Workshop: Working Together to Advance Cancer Control Research (Day 1)

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  • NIH Workshop on Nonpharmacologic Management of Back Pain
    • - NIH Workshop on Nonpharmacologic Management of Back Pain (2010/11/18)
    • - Category : Conferences
    This 1-day workshop will identify clinical research questions related to nonpharmacologic interventions to treat back pain. This information will help inform future research directions.

    This workshop is organized in three sessions that will feature presentations and discussions focusing on:
      1) The current understanding and complexity of chronic back pain
      2) Promising questions associated with testable hypotheses
      3) Relevant outcome measures
    Speaker Names (in alphabetical order):

    A. Vania Apkarian, Ph.D.
    Northwestern University
    Department of Physiology
    Chicago, Illinois

    Josephine P. Briggs, M.D.
    Director
    National Center for Complementary and Alternative Medicine, NIH
    Bethesda, Maryland

    Gert Bronfort, D.C., Ph.D.
    Vice President of Research
    Research Professor
    Northwestern Health Sciences University
    Bloomington, Minnesota

    Daniel C. Cherkin, Ph.D.
    Senior Investigator
    Group Health Center for Health Studies
    Seattle Washington

    Roger Chou, M.D.
    Associate Professor, School of Medicine
    Oregon Health and Science University
    Portland, Oregon

    Richard Deyo, M.D., M.P.H.
    Kaiser Permanente Professor of Evidence-Based Family Medicine
    Oregon Health and Science University
    Portland, Oregon

    Andrea Furlan, M.D., Ph.D.
    Associate Scientist
    Institute for Work and Health
    Toronto, Ontario, Canada

    Partap S. Khalsa, D.C., Ph.D.
    Program Officer
    National Center for Complementary and Alternative Medicine, NIH
    Bethesda, Maryland

    Judy Turner, Ph.D.
    Department of Psychiatry and Behavioral Sciences
    University of Washington
    Seattle, Washington

    For more information, visit http://nccam.nih.gov/news/events/backworkshop/

    NIH Workshop on Nonpharmacologic Management of Back Pain

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  • Systems Biology Approaches to DNA Damage Signaling
    • - Michael Yaffe, Ph.D., Department of Biology, Massachusetts Institute of Technology (2010/11/18)
    • - Category : Proteomics
    Play Video (Real Player - no slides) without audio problems

    Many protein kinases along with phosphoserine/threonine-binding domains such as 14-3-3 proteins, WW domains, FHA domains, Polo-box domains, and BRCT domains function together within signaling networks to control growth factor responses, cell cycle progression, the response to DNA damage, and the onset of apoptosis. How signals emerging from these pathways are integrated and processed as a network is unclear. To address this, we have been developing systems models of signaling where kinase activities, protein phosphorylation, binding of substrates to phosphoserine/threonine binding domains, and cellular responses such as cell cycle arrest and apoptosis are quantitatively measured at densely sampled points in time, and related mathematically using partial least squares regression and principal components analysis. We used this approach to construct a systems model of cytokine-induced apoptosis in HT-29 cells, where 7980 intracellular signaling events were linked to 1440 response outputs associated with apoptosis. The model accurately predicted multiple time-dependent apoptotic responses induced by a combination of the death-inducing cytokine tumor necrosis factor (TNF) with the pro-survival factors epidermal growth factor (EGF) and insulin. The model revealed new molecular mechanisms connecting signaling to apoptosis including the role of unsuspected autocrine circuits activated by TGF-慣 and IL-1慣, All of the molecular signals could be divided along two primary signaling axes that constitute fundamental dimensions (molecular ？？？basis axes？？？) within the apoptotic signaling network. Projections of different stimuli along these axes captures the entire observed apoptotic response, suggesting that cell survival is determined by signaling through this canonical basis set. We have developed a new technique termed ？？？network breakpoint analysis？？？ to probe essential features of information transfer in signaling pathways. Applying this approach to TNF慣-induced cell death revealed that the p38MAPK-MAPKAP Kinase-2 pathway is optimally ？？？tuned？？？ to maximize apoptosis in response to pro-death stimuli while minimzing death in their absence. We have now applied this methodology to study signal transduction events that control cell cycle arrest and apoptosis in response to DNA damage. Our data indicates that, in addition to the well-established ATM-Chk2 and ATR-Chk1 pathways, p53-defective tumor cells have re-wired the checkpoint signaling network to incorporate the p38MAPK-MAPKAP Kinase-2 pathway as an essential component of the DNA damage response.

    http://proteome.nih.gov

    Systems Biology Approaches to DNA Damage Signaling

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  • A Fresh Look at Host-Pathogen Interactions: New Tools
    • - Ploegh, Hidde L.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : Wednesday Afternoon Lectures
    Interactions between pathogens and their hosts are an intricate web of measures and countermeasures, the study of which has uncovered basic mechanisms of how cells operate. My laboratory has been interested in how herpesviruses disable pathways of antigen presentation, an effort that has shed light on mechanisms of glycoprotein quality control and turnover.

    Our studies rely on protein modification to visualize cells and proteins within them, and to control their functional properties. This can be done genetically through fusions with fluorescent reporter proteins. Alternatively, installation of tags that can be detected with antibodies or upon chemoenzymatic conversion with colored or fluorescent reporters allows visualization of the proteins of interest. I shall describe sortagging, a new method that exploits a sortase-catalyzed transacylation reaction as a straightforward method to produce proteins labeled in solution or on the surface of cells in site-specific fashion at the C- or the N-terminus. This method of protein labeling succeeds where GFP fails, as in the case of many type II membrane proteins, and further allows the installation of functional groups that cannot be encoded genetically. A related strategy is used to produce circular proteins in high yields, with improvement of stability of the proteins in question as a possible application.

    Finally, I shall report results from recent experiments, conducted in collaboration with the laboratory of Rudolf Jaenisch, that exploit somatic cell nuclear transfer to generate new mouse models for infectious disease. By reprogramming the nucleus of an antigen specific T cell, isolated from a mouse actively resolving a virus or parasite infection, embryonic stem cells can be obtained that are capable of transmitting through the germline the rearranged T cell receptor genes harbored by the donor T cell. These mice carry in all of their somatic cells, including T cells, the rearrangements in question, generated

    The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    A Fresh Look at Host-Pathogen Interactions: New Tools

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  • CC Grand Rounds: (1) Use of Genomic and Proteomic Tools for the Diagnosis of Infectious Diseases, (2) Genomic Analysis of the Human Skin Microbiome
    • - Patrick R. Murray, PhD and Heidi H. Kong, MD (2010/11/18)
    • - Category : Clinical Center Grand Rounds
    Contemporary Clinical Medicine

    Patrick R. Murray, PhD
    Chief, Microbiology Service, Department of Laboratory Medicine, CC

    Heidi H. Kong, MD
    Assistant Clinical Investigator, Dermatology Branch, Center for Cancer Research, NCI

    For more information, visit
    http://www.cc.nih.gov/about/news/grcurrent.html

    CC Grand Rounds: (1) Use of Genomic and Proteomic Tools for the Diagnosis of Infectious Diseases, (2) Genomic Analysis of the Human Skin Microbiome

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  • Powered by NCBC Lecture Series: Dissecting Human Lymphoid Malignancies Using a Systems Biology Approach
    • - Califano, Andrea.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : Special
    The NIH Roadmap National Centers for Biomedical Computing (NCBC) Lecture Series Presents: ？？？Dissecting Human Lymphoid Malignancies Using a Systems Biology Approach？？？

    About the lecture:

    Comprehensive repertoires of molecular interactions (interactomes) are increasingly useful in the dissection of biological processes. However, their role in the elucidation of novel, validated mechanisms of regulation of physiologic and pathologic human phenotypes is still largely untested. Additionally, while multi-cellular regulation is exquisitely cell-context dependent, most interactomes lack context specificity because their interactions are supported by ex vivo assays or context-free literature data. Finally, available mammalian interactomes only represent individual interaction layers, such as transcriptional regulation or signal transduction, rather than a more realistic, integrated view of regulatory processes across multiple layers.

    A multi-layer Human B-cell interactome (HBCI), representing approximately 66,000 B-cell-specific transcriptional, signaling, and protein-complex interactions, has been assembled using an evidence integration approach. The HBCI constitutes a unique resource for a humancell context and integrates evidence supporting specific molecular interactions from multiple computational and experimental sources. This talk will address the application of the HBCI to the elucidation of master regulators of both physiologic and tumor-related phenotypes in mature human B cells.

    About the program and speakers:

    Drs. Dalla-Favera and Califano will be presenting as part of the Powered by NCBC Lecture Series. This series highlights outcomes from the NIH Roadmap National Centers for Biomedical Computing (NCBC) Driving Biological Projects (DBP), which are intended to drive interactions between computational and biomedical scientists.

    Dr. Califano is Principal Investigator of the National Center for the Multiscale Analysis of Genomic and Cellular Networks (MAGNet) and Professor of Biomedical Informatics at Columbia, with appointments in the Department of Biomedical Informatics and in the Institute for Cancer Genetics. He received his Ph.D. in physics from the University of Florence. His scientific interests are broadly defined within the field of systems biology, with specific application to human malignancies.

    Dr. Dalla-Favera, leader of one of MAGNet？？？s several DBPs, is Professor of Pathology and Genetics and Development at the College of Physicians and Surgeons of Columbia University, Director of the Institute for Cancer Genetics, and Director of the Herbert Irving Comprehensive Cancer Center at Columbia University. Dr. Dalla-Favera has been recognized with several national awards, including the Stohlman Award from the Leukemia Society of America, two NIH MERIT Awards, the Outstanding Achievement Award from the American-Italian Cancer Foundation, and the William Dameshek Prize for Outstanding Contribution to Hematology from the American Society of Hematology. He has made major contributions to the understanding of the pathogenesis of cancer, particularly lymphoma.

    For more information, visit http://www.ncbcs.org/

    Powered by NCBC Lecture Series: Dissecting Human Lymphoid Malignancies Using a Systems Biology Approach

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