전체 8345
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- Dissecting cortical information processing with optogenetics: Synergistic roles of parvalbumin interneurons and gamma oscillation
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- - Sohal, Vikaas.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Special
- - Sohal, Vikaas.
- Candidate for Tenure Track Investigator in the NIMH-DIRP Genes, Cognition and Psychosis Program
Dissecting cortical information processing with optogenetics: Synergistic roles of parvalbumin interneurons and gamma oscillation
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- Fevers, Genes, and Histories: Adventures in the Genomics of Inflammation
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- - Kastner, Dan.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Wednesday Afternoon Lectures
- - Kastner, Dan.
- Fever is a fundamental sign of inflammation, and hereditary disorders that present with recurrent fever provide a unique opportunity to understand the human biology of inflammation. Stimulated by encounters with patients suffering from hereditary recurrent fevers and utilizing the tools of modern genetics and genomics, it has been possible to identify new genes, gene families, and biochemical pathways that control inflammation, and to discover new meaning for genes and proteins already in the inflammatory lexicon. In some cases, these discoveries have not only given molecular explanations and suggested targeted therapies for the patients we see today, but have shed light on the histories of human populations and their possible evolving interactions with microbial pathogens.
Please note: The patient interview included in this presentation was added after the original taping due to technical difficulties the day of the lecture.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Fevers, Genes, and Histories: Adventures in the Genomics of Inflammation
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- The quest for psychiatric disorder biomarkers: from protein expression to isoforms to pathways
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- - Chris Turck, Max Planck Institute (2010/11/18)
- - Category : Proteomics
- Proteomics Interest Group Special Seminar
Biomarkers, which are measures of biological parameters of disease that also can predict which new molecular entities will be effective and safe in treating patients, are experiencing a great deal of attention in today？？？s life sciences. For both types of investigation, drug response and disease susceptibility, biomarkers are needed in order to move the area of psychiatric disorders into the rest of medicine. Ultimately, it is hoped that biomarkers will assist in stratifying patient groups with similar clinical features for a personalized medicine approach and at the same time help in the identification of neural circuitries that are responsible for disease etiology. This will enable the complementation of the presently applied DSM-IV and ICD-10 criteria with specific sets of biomarkers and result in a more precise nosological framework for psychiatric disorders.
Good animal models representing distinct features of a psychiatric disorder phenotype are one way to come up with specific biomarkers. Here a good representation of the relevant psychiatric disease mechanisms in an animal disease model is critical in order to enable subsequent pre-clinical to clinical study translation. The identified biomarker candidates can also provide important information on pathways that are relevant for psychiatric disorder pathophysiology. We have implemented a comprehensive and sensitive platform that is based on metabolic labeling of mouse models with stable isotopes and subsequent mass spectrometry-based quantitation. Proteomic and metabolomic analyses are implicating pathways relevant for disease pathobiology.
The quest for psychiatric disorder biomarkers: from protein expression to isoforms to pathways
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- Methodologies to Set Priorities for Child Health Clinical Research
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- - National Institute of Child Health and Human Development (U.S.) (2010/11/18)
- - Category : Conferences
- The goal of this conference is to explore and discuss approaches to establish priorities for research. Systematic approaches are needed to allocate the available resources and infrastructure that account for factors such as public health need, scientific opportunity, available infrastructure, technical feasibility, resource footprint of projects, potential impact, cultural willingness, investigator interest, availability of appropriate and informative populations, regulatory programs, and funding and economic incentives.
Methodologies to Set Priorities for Child Health Clinical Research
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- American Indian/Alaska Native Health Disparities
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- - Dr. Victoria Warrens-Mears (2010/11/18)
- - Category : Health Disparities
- NIH Health Disparities Seminar Series
In recognition of Native American Heritage Month, the theme for the November seminar series is ？？？American Indian/Alaska Native Health Disparities.？？？ American Indians and Alaska Natives experience a disproportionate number of health disparities. For example, according to data from the Indian Health Service, they have a life expectancy nearly six years less than any other racial or ethnic group in the United States. The age-adjusted mortality rate for American Indian and Alaska Native adults are nearly three times more than that of the national population for death due to accidental injuries and diabetes, four times greater for death due to liver disease, and 50 percent greater for death due to pneumonia, influenza, suicide, and homicide.
The Indian Health Service (IHS) supports the Tribal Epidemiology Centers to improve the health of American Indians/Alaska Natives by identifying and understanding health problems and disease risks, strengthening public health capacity, and developing solutions for disease prevention and control. Dr. Victoria Warren-Mears will discuss some of the research projects being undertaken at the Northwest Tribal Epidemiology Center as a model to demonstrate how the scientific and health community collaborate with American Indian Tribes to provide health-related research, surveillance, and training to improve the quality of life of American Indians and Alaska Natives.
www.ncmhd.nih.gov
American Indian/Alaska Native Health Disparities
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- Obesity, Stress, and Sex Differences: The Role of Steroids and Central Neuroendocrine Networks
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- - Pasquali, Renato.
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) (2010/11/18) - - Category : Brain & Obesity
- - Pasquali, Renato.
- A Brain and Obesity Intramural Lecture Series talk by Dr. Renato Pasquali, M.D.
Obesity, Stress, and Sex Differences: The Role of Steroids and Central Neuroendocrine Networks
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- In Search of Work/Life Balance
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- - The Division of Amenities and Transportation Services (DATS) (2010/11/18)
- - Category : Focus on You Wellness
- Focus on You Wellness Lecture Series. Featuring NIH Executives sharing and discussing their thoughts on striking a balance between work and wellness.
Speakers:
- Maureen Gormley, Chief Operating Officer, CC
- Dr. Eric Green, Scientific Director, NHGRI
- Alfred Johnson, Phd. Director ORS
- Randy Schools, CEO Recreation and Welfare Association
- Chris Major, Director, Office of Human Resources
In Search of Work/Life Balance
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- Symposium on "Neuroscience and Vision" - Day 1
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- - Symposium on Neuroscience and Vision
National Eye Institute. (2010/11/18) - - Category : Conferences
- - Symposium on Neuroscience and Vision
- The symposium will focus on the development of neural circuits, neuronal cell imaging and physiology, detection of sensory stimuli, neural mechanisms underlying visual perception, and neurological disorders. The speakers will discuss recent accomplishments and challenges in the field of neuroscience, with a focus on the visual system.
http://www.nei.nih.gov/anniversary/symposia/neuroscience.asp
Symposium on "Neuroscience and Vision" - Day 1
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- Symposium on "Neuroscience and Vision" - Day 2
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- - Symposium on Neuroscience and Vision
National Eye Institute. (2010/11/18) - - Category : Conferences
- - Symposium on Neuroscience and Vision
- The symposium will focus on the development of neural circuits, neuronal cell imaging and physiology, detection of sensory stimuli, neural mechanisms underlying visual perception, and neurological disorders. The speakers will discuss recent accomplishments and challenges in the field of neuroscience, with a focus on the visual system.
http://www.nei.nih.gov/anniversary/symposia/neuroscience.asp
Symposium on "Neuroscience and Vision" - Day 2
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- The Challenges and Opportunities of Interdisciplinary Research: The Case of Genetics and Demography (NIH-Only)
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- - Boardman, Jason D.
National Institutes of Health (U.S.) (2010/11/18) - - Category : BSSR Lecture Series
- - Boardman, Jason D.
- In the past decade, there have been substantial advances in our
understanding of the genetic etiology of disease including genetic influences on health-related behaviors. Some of the emerging research has emphasized the interplay between genetic and environmental influences as concomitant forces. To date, most of this work has emphasized micro-level measures of the environment such as stressful live events or the experience of trauma. Less work has attempted to situate these influences within a broader social demographic and social historical context. In this presentation, I demonstrate the usefulness of a more broadly defined environmental perspective in the gene-environment interplay framework and I apply this perspective to a relatively complex behavior: smoking. I conclude by sketching out a conceptual model that will facilitate an interdisciplinary approach that, to date, has been absent in this body of work.
This lecture is an installment of the Behavioral and Social Sciences Research Lecture Series sponsored by the NIH Office of Behavioral and Social Sciences Research and organized by the NIH Behavioral and Social Sciences Research Coordinating Committee.
The Behavioral and Social Sciences Research Coordinating Committee (BSSR CC), with support from the Office of Behavioral and Social Sciences Research (OBSSR), convenes a series of guest lectures and symposia on selected topics in the behavioral and social sciences. These presentations by prominent behavioral and social scientists provide the NIH community with overviews of current research on topics of scientific and social interest. The lectures and symposia are approximately 50 minutes in length, with additional time for questions and discussion. All seminars are open to NIH staff and to the general public.
The Challenges and Opportunities of Interdisciplinary Research: The Case of Genetics and Demography (NIH-Only)
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- Maintaining and Enhancing Representativeness of State Health Surveys: Lessons for the California Health Interview Survey
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- - National Cancer Institute (NCI) and UCLA Center for Health Policy Research (2010/11/18)
- - Category : Conferences
- The California Health Interview Survey (CHIS) is the leading statewide local health survey in the United States. CHIS leaders are continuously exploring and developing methodological innovations to improve representativeness and response rates. This workshop will bring together leading survey methodologists to discuss the most pressing issues confronting CHIS and most other telephone surveys. The discussion will focus especially on response rates in population-based surveys with large, ethnically diverse populations, and alternative approaches to random-digit-dial landline surveys given the continued growth of cell-phone only households. Participants will explore alternative future options.
Maintaining and Enhancing Representativeness of State Health Surveys: Lessons for the California Health Interview Survey
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- Evolutionary conserved pathways suppress genomic instability
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- - Myung, Kyungjae.
National Institutes of Health (U.S.) (2010/11/18) - - Category : NIH Directors Seminars
- - Myung, Kyungjae.
- 2008-2009 Directors Seminar Series
For more information, visit
http://www.nih.gov/about/director/dirsem.htm
Evolutionary conserved pathways suppress genomic instability
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- Genetic regulation of Neuregulin-ErbB signaling: A systems biology approach to understanding gene networks implicated in complex brain disorders
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- - Law, Amanda.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Special
- - Law, Amanda.
- Candidate for Tenure Track Investigator in the NIMH-DIRP Genes, Cognition and Psychosis Program
Genetic regulation of Neuregulin-ErbB signaling: A systems biology approach to understanding gene networks implicated in complex brain disorders
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- Selectivity of local circuits in the neocortex
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- - Hestrin, Shaul.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Neuroscience
- - Hestrin, Shaul.
- Dr. Shaul Hestrin？？？s main research interest is to understand how the properties of neocortical neurons and the circuits they form give rise to cortical activity and function. The neocortex represents about 80% of the human brain and is associated with wide range of functions including sensory perception, motor movement, memory and higher aspects of cognition. Most of the synaptic connections that any cortical cell receives are from other cortical neurons, including GABAergic neurons. Thus, the interactions among cortical cells within the microcircuit play a critical role in determining cortical activity. His lab has developed methods to define cell types using genetics and other means, and then use brain slices to record simultaneously from individual neurons that are synaptically connected. These methods allow them to characterize the wiring pattern of microcircuits and the synaptic properties of specific connections. They also use calcium imaging to monitor the activity of large number of neurons. More recently he used optogenetic approaches to determine how external inputs affect the activity of cortical circuits.
NIH Neuroscience Seminar Series
Selectivity of local circuits in the neocortex
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- TRACO: Epigenetics and Lung Cancer
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- - Verma, Mukesh.
National Institutes of Health (U.S.) (2010/11/18) - - Category : TRACO
- - Verma, Mukesh.
- For more information, visit
http://ccr.cancer.gov/careers/traco.asp
TRACO: Epigenetics and Lung Cancer
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- Enhancing Peer Review: Application Changes and Impact on NIH Staff (HHS Only)
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- - NIH (2010/11/18)
- - Category : ESA (HHS Only)
Major changes are coming on January 25, 2010 to the NIH application process. Learn about restructured applications, shorter page limits, new instructions, and the impact of these changes on NIH Staff.
Draft Agenda:- Welcome and Introduction
- Brief Overview of Peer Review Enhancements
- Summary of Upcoming Application Changes
- Impact on NIH Staff
- Communication with Applicants and Grantees
- Enforcement/Compliance Issues
- Page limits for Applicants
- Biosketch
- A2 submissions
- FOA development/updating
- Update/Re-issue FOAs
- Page limit exceptions
- Q&A Session
http://odoerdb2-1.od.nih.gov/oer/training/esa/esa_training_20091123.htm
Enhancing Peer Review: Application Changes and Impact on NIH Staff (HHS Only)
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- Name That Tune: The Science of the Musical Mind (HHS Only)
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- - NIH (2010/11/18)
- - Category : STEP (HHS Only)
- STEP: Staff Training in Extramural Programs
Why does hearing a few notes from a favorite song bring back memories? Why are we moved by different genres of music? Music is the universal language of the human spirit and touches nearly every aspect of our lives. Music is used for therapeutic purposes. Neuroimaging research has shown connections with cognitive and emotional functioning, giving us valuable information about how the brain works. This forum will explore the relationship between music and the human experience. Participants will engage in different forms and expressions of music.
Committee Members:- Chair: Valerie Maholmes
- Abby Ershow
- Valery Gordon
- Martha Hare
- Andy Jones
- Bob Mays
http://odoerdb2-1.od.nih.gov/oer/training/step/step_training_20091124.htm
Name That Tune: The Science of the Musical Mind (HHS Only)
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- Cord Blood Transplantation for Hematologic Malignancies: Where Are We and Where Are We Going? (NIH-Only)
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- - Barker, Juliet.
National Institutes of Health (U.S.) (2010/11/18) - - Category : NCI CCR Grand Rounds (NIH Only)
- - Barker, Juliet.
- Dr. Barker received her MBBS from Adelaide University Medical School, Australia, and her FRACP in Internal Medicine/Hematology from University of Adelaide (Royal Adelaide Hospital) and University of Sydney (Westmead Hospital), Australia. She also did a fellowship in Hematology, Oncology and Blood and Marrow Transplantation at the University of Minnesota and remained there as an instructor and later assistant professor of Medicine.
She then joined Memorial Sloan-Kettering Cancer Center and Weill Medical College of Cornell University in New York. Her expertise is in donor-derived hematopoietic (blood-forming) stem-cell transplantation, with a particular emphasis on the use of umbilical cord blood from healthy newborns as a source of stem cells. She also conducts clinical research investigating new ways to use umbilical cord blood to treat diseases of the blood and bone marrow. She has a number of peer-reviewed journal articles and has spoken across the country on the topic of blood and marrow transplantation.
NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link:
Cord Blood Transplantation for Hematologic Malignancies: Where Are We and Where Are We Going? (NIH-Only)
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- National American Indian & Alaska Native Heritage Month Opening Ceremony
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- - Centers for Medicare & Medicaid Services (2010/11/18)
- - Category : CMS - Centers for Medicare & Medicaid Services
- Video coverage of the November 6, 2009 Opening Ceremony "Revitalizing Health - Energizing Our Mission in an Era of Change"
Presenters:- Ruben Little Head
- Kevin Gover, Smithsonian National Museum of the American Indian
- Laura Petrou, Department of Health and Human Services
- Yvette Roubideaux, M.D., M.P.H., Indian Health Service
- Lori Arviso Alvord, M.D.
- Gyasi Ross
National American Indian & Alaska Native Heritage Month Opening Ceremony
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- Delta Awakens: Use of Low Frequency Oscillations in Attentive Processing
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- - Schroeder, Charlie.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Neuroscience
- - Schroeder, Charlie.
- Charles Schroeder, Director of the Laboratory for Cognitive Neuroscience and Neuroimaging at The Nathan S. Kline Institute for Psychiatric Research and Professor of Psychiatry at Columbia University, is a neuroscientist interested in investigating the neural mechanisms of sensory and cognitive processes using methods that allow one to relate the functioning of single neurons and groups of neurons to that of the brain as a whole. Dr. Schroeder？？？s primary research method is to use brain electrical field potentials and their derivatives, in combination with action potentials, to study brain processing in awake non-human primates. Actual signals are collected from within the brain using multi-electrode arrays, and processed with 96 channel amplifier systems. Dr. Schroeder？？？s research staff is continually developing and refining this approach to increase our resolution of the way the brain interprets basic properties of sensory stimuli, and higher order properties such as an objects biological significance. Of particular interest at this point is the interaction of the stimulus-evoked response with ongoing oscillatory activity at each point in the system.
NIH Neuroscience Seminar Series
Delta Awakens: Use of Low Frequency Oscillations in Attentive Processing