전체 8345
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- The Th2 environment and autoimmunity: Making sense of IgE in lupus
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- - Nicolas Charles, NIAMS (2010/11/18)
- - Category : Immunology
- The first seminar of the new year features one of our own, Dr. Nicolas Charles of the Laboratory of Molecular Immunogenetics of NIAMS. As a native of France, Nico appropriately began his scientific career working towards the discovery of new molecules to combat cryptogamic diseases of the grapevine. He then started his PhD studies in the laboratory of Boris Vargaftig at the Institut Pasteur but subsequently moved to Xavier Bichat Medical School in Paris with his mentor, Marc Benhamou. During his PhD studies, Nico discovered that phospholipid scramblase and p28 are part of the high affinity IgE receptor signal transduction cascade and showed that phospholipid scramblase is activated by the IgE receptor and is required for normal mast cell degranulation, a previously unrecognized role for this family of proteins. Nico received his PhD in 2005 and subsequently came to the NIH to work in the Laboratory of Molecular Immunogenetics with Juan Rivera. Since his arrival he has explored whether there exists a relationship between allergic and autoimmune diseases. In recently published work (Immunity 30:533-543, 2009), Nico found that basophils control the Th2 differentiation and that basophil-expressed Lyn kinase is necessary to govern the extent of Th2 differentiation and response. In more recent work he has uncovered a connection between the dysregulation of the Th2 environment and lupus nephritis. This provocative finding is supported by preliminary studies in SLE patients. Don？？？t miss this exciting presentation!
The Immunology Interest Group
The Th2 environment and autoimmunity: Making sense of IgE in lupus
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- Tox21 Quarterly General Meeting - January 2010
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- - Christopher Austin, M.D., NIH Chemical Genomics Center (2010/11/18)
- - Category : Conferences
- Quarterly meeting between NIH/NIEHS/EPA/FDA to go over Tox 21 issues
Tox21 Quarterly General Meeting - January 2010
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- NIH Observance of Dr. Martin Luther King Jr. National Holiday 2010
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- - Dr. Michael Eric Dyson, Professor Georgetown University (2010/11/18)
- - Category : Black History Observance
- Theme: ？？？Remember! Celebrate! Act! A Day On Not A Day Off？？？
Program Speaker: Dr. Michael Eric Dyson, Professor at Georgetown University
The program includes music by the Thelonious Monk Institute of Jazz.
NIH Observance of Dr. Martin Luther King Jr. National Holiday 2010
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- Martin Luther King Program (HHS - Only)
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- - PSC, AHRQ, FDA, HRSA, IHS, SAMHSA (2010/11/18)
- - Category : PSC Programs (HHS Only)
- Remember! Celebrate! Act! A Day On - Not A Day Off
Martin Luther King Program (HHS - Only)
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- Alzheimers Disease: From ApoE Alleles to Amyloid to New Drugs
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- - Steven Paul, MD (2010/11/18)
- - Category : Special
- Candidate for NIMH-DIRP Mood and Anxiety Disorders Program Director
Alzheimers Disease: From ApoE Alleles to Amyloid to New Drugs
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- Innovative Mass Spectrometry Technology for the Identification of Cancer Immunotherapeutics and Protein Post-Translational Modifications
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- - Hunt, Donald F.
National Institutes of Health (U.S.). Proteomics Interest Group. (2010/11/18) - - Category : Proteomics
- - Hunt, Donald F.
- (Part I) Development of a new ion source that facilitates simultaneous generation of positive and negative ions by electrospray ionization and chemical ionization, respectively, will be presented. This source makes it possible to record collision activated dissociation (CAD) and electron transfer dissociation (ETD) (1,2) mass spectra on high-resolution instruments such as LTQ-FT. Parent ion and fragment ion mass spectra can be obtained at resolutions in excess of 40,000 and with mass measurement accuracy in the high ppb range.
(Part II) At present, the most effective treatment for metastatic melanoma is adoptive T-cell therapy (ACT) (3,4). In this approach, tumor-infiltrating lymphocytes (TIL) are isolated from resected tumor and expanded ex vivo. After the patients immune system is ablated by a combination of chemotherapy and total body irradiation, the TIL plus cytokine (IL-2) are re-infused. Objective (tumor skrinkage) and complete responses for this therapy in a recent clinical trial of 25 late stage patients with metastatic melanoma were 72% and 28%, respectively. Efforts to improve this technology are in progress and involve transfecting patient CD8+ T-cells (prior to expansion) with high affinity receptors for specific tumor associated class I MHC peptides. With this additional step, it should be possible to use ACT to treat any human tumor. What is lacking are MHC class I peptides that are; (a) differentially displayed on cancer vs normal cells, (b) shared by large cohorts of patients with the same tumor and HLA haplotype, (c) shared my multiple tumor types, (d) derived from proteins whose genes cannot be deleted without compromising the tumor cell, and (e) not available for display on MHC molecules in the thymus and lymph nodes to trigger deletion of reactive T-cells (tolerance). Outlined in this lecture are our efforts to identify class I and class II MHC phosphopeptide antigens that are presented to immune system at the level of 5-50 copies/cell and result from dysregulated signal transduction pathways in cancer cells (5-7). Many of these phosphopeptide antigens satisfy the above criteria and should make it possible to use adoptive T-cell therapy for the treatment of many additional types of human tumors.
(Part III, Time permitting). Also presented will be new technology for the enrichment and characterization of O-GlcNAc sites on proteins. In humans, O-GlcNAcylation, the addition of N-acetylglucosamine to Ser and Thr residues on proteins, is catalyzed by a single enzyme and removed by a single GlcNAcase. Discovered by Gerry Hart at Johns Hopkins University in 1984, O-GlcNAcylation is now thought to rival phosphorylation in its abundance and play an equally important role in cell signaling. The O-GlcNAc modification is labile and easily lost under CAD collisions but stable to ETD. Peptides, with and without, the modification also co-elute under conventional HPLC conditions. Like phosphorylation, O-GlcNAcylation is usually found to be substoichiometric and ionization of the modified peptide is suppressed in the presence of the unmodified peptide. Technology for enriching O-GlcNAcylated peptides from complex mixtures will be discussed and results from a recent study to probe the relationship between phosphorylation and O-GlcNAcylation during mitosis under conditions that promote aneuploidy will be presented (8,9).
http://proteome.nih.gov/
Innovative Mass Spectrometry Technology for the Identification of Cancer Immunotherapeutics and Protein Post-Translational Modifications
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- Technical and Regulatory Challenges to Biomedical Research on Dietary Supplements
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- - Joseph M. Betz, Ph.D, Dietary Supplements Methods and Reference Materials Program, NIH (2010/11/18)
- - Category : NCCAM Lectures
- Joseph M. Betz, Ph.D. joined the ODS as Director of the newly formed Dietary Supplements Methods and Reference Materials Program in December of 2001. In this role, he oversees efforts to enhance and stimulate research and training in fields relevant to dietary supplements at the NIH and to promote development of validated analytical methods and reference materials for use by industry, regulatory agencies, and clinical researchers. Prior to this, he was Vice President for Scientific and Technical Affairs at the American Herbal Products Association (AHPA). Before joining the AHPA, he spent 12 years as a research chemist at Food and Drug Administration？？？s Center for Food Safety and Applied Nutrition.
For more information, visit
http://nccam.nih.gov/research/consultservice/lecture.htm
Technical and Regulatory Challenges to Biomedical Research on Dietary Supplements
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- Genetic Dissection of a Dynamic C. Elegans Synapse
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- - Joshua Kaplan, Ph.D., Massachusetts General Hospital (2010/11/18)
- - Category : Neuroscience
- Work in Dr. Kaplans lab is focused on understanding how signals in the brain lead to particular patterns of behavior. They utilize a combination of behavioral, genetic, biochemical, imaging, and electrophysiological techniques to study signaling in the brain of the worm C. elegans. Signals in the brain occur at specialized intercellular connections, known as synapses. There is a surprising amount of diversity in the structural and functional characteristics of synapses. Some synapses are large, others are small. Some are strong others are weak. Very little is known about the molecular differences that underlie this diversity in synaptic function. Their goal is to define the cell biological mechanisms by which synapses are made different from each other.
Dr. Kaplans lab showed that two G proteins (Go and Gq) antagonistically regulate neurotransmitter release at a particular set of C. elegans synapses, and that these G proteins directly regulate several aspects of synaptic vesicle recycling. Current projects aim to identify downstream targets of these G proteins, and to determine the mechanisms by which they act. The brain is an exceedingly complex circuit that somehow maintains the specificity of connections made between cells and of the signals transmitted at these connections. They have developed methods for visualizing individual synapses in living worms. Using these methods, they identified several genes that regulate synapse formation, targeting of receptors to synapses, and the abundance of receptors at each synapse.
NIH Neuroscience Seminar Series
Genetic Dissection of a Dynamic C. Elegans Synapse
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- Surgeon General Swearing-In and Change of Command Ceremony
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- - HHS/OPHS (2010/11/18)
- - Category : Special
- Swearing-In and Change of Command Ceremony for Dr. Regina Benjamin, 18th Surgeon General of the United States
Surgeon General Swearing-In and Change of Command Ceremony
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- Regulation of Hematopoietic Stem Cells
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- - Margaret Goodell, Ph.D. (2010/11/18)
- - Category : Stem Cell
- The Stem Cell Interest Group was established to enhance communication and to foster collaboration among scientists from varying disciplines interested in stem cells. Topics of interest include fundamental stem cell biology, ontogeny, gerontology, and the therapeutic potential of stem cells. The SCIG serves as an open forum for discussion and dissemination of knowledge about all aspects of stem cell biology
For more information, visit
http://tango01.cit.nih.gov/sig/home.taf?_function=main&SIGInfo_SIGID=115
Regulation of Hematopoietic Stem Cells
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- Seven Long Years Validating BRAF as a Therapeutic Target (NIH-Only)
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- - Keith T. Flaherty, M.D. (2010/11/18)
- - Category : NCI CCR Grand Rounds (NIH Only)
- NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link: http://bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx
Seven Long Years Validating BRAF as a Therapeutic Target (NIH-Only)
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- The Genomic Landscape circa 2010
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- - Eric Green, M.D., Ph.D. (2010/11/18)
- - Category : Current Topics in Genome Analysis
- Current Topics in Genome Analysis 2010
The scientific community celebrated the achievement of the Human Genome Projects major goal in April of 2003: completion of a high-accuracy sequence of the human genome. The significance of this milestone cannot be underestimated, as it firmly marks the entrance of modern biology into the genomic era (and not the post-genomic era, as many have stated). The intelligent use of sequence data from human and other organisms, along with technological innovations fostered by the Human Genome Project, will lead to significant advances in our understanding of diseases that have a genetic basis and, more importantly, in how health care is delivered in the future.
Given the rapid advances in genomics and bioinformatics that have taken place in the past few years, an intensive review of the major areas of ongoing genome research would be of great value to our fellow National Institutes of Health investigators. To that end, the National Human Genome Research Institute is pleased to once again sponsor the Current Topics in Genome Analysis lecture series.
The Genomic Landscape circa 2010
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- Lean Six Sigma Continuous Improvement Meeting - January 2010 (HHS-Only)
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- - Greg Monaco (2010/11/18)
- - Category : HHS Only
- This is the Lean Six Sigma / Continuous Process Improvement (LSS/CPI) Federal Sector Community of Practice Quarterly Meeting. Executive Branch practitioners of LSS/CPI meet in person each quarter along with representative colleagues from the Legislative Branch to share and discuss LSS/CPI practices, techniques, and lessons learned.
In the January 12, 2010 meeting, we are hosting 3 world-class guest speakers:
- ？？？Federal Government Community of Practice？？？
Dennis Viera, Director of LSS Operations, Lockheed Martin
- ？？？Lean Six Sigma at the Cross Roads ？？？ Challenges and Pathways for Boosting Lean Six Sigma Returns and Relevancy in Tough Times？？？
Robert ？？？Bob？？？ Cresenzi, President, The Conference Board
- ？？？Building Excellence on Fundamentals: Outstanding Service through Superior Execution？？？
Max Allway, Executive Advisor, Booz Allen Hamilton - ？？？Federal Government Community of Practice？？？
Lean Six Sigma Continuous Improvement Meeting - January 2010 (HHS-Only)
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- Tuberculosis: The Great White Plague
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- - Steven Holland (NIAID), Clifton Barry (NIAID) (2010/11/18)
- - Category : Demystifying Medicine
- The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.
For more information, visit
http://www1.od.nih.gov/oir/DemystifyingMed
Tuberculosis: The Great White Plague
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- NBBTP Graduation
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- - Deborah E. Wilson, DrPH, CBSP; Murray L. Cohen, PhD, MPH, CIH (2010/11/18)
- - Category : Special
- Graduation ceremony for NBBTP Fellows
NBBTP Graduation
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- Great Teachers: Treating Chronic Hepatitis B and C
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- - NIH Clinical Center (2010/11/18)
- - Category : Clinical Center Grand Rounds
- Jenny Heathcote, MBBS, MD,
Professor of Medicine and Francis Family Chair in Hepatology, University of Toronto;
Division Head, Patient Based Clinical Research, Toronto Western Research Institute
For more information, visit
http://www.cc.nih.gov/about/news/grcurrent.html
Great Teachers: Treating Chronic Hepatitis B and C
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- Developmental Signaling in Stem cells and Cancer
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- - Reya, Tannishtha.
National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18) - - Category : Immunology
- - Reya, Tannishtha.
- Tannishtha Reya is interested in the role of Wnt and the Hedgehog signaling pathways in hematopoietic stem cells and cancer. She has made several important and highly cited contributions in this area. More recently she had become interested in how asymmetric cell division shapes cell fate in the hematopoietic system. Dr. Reya has received many awards including the NIH Pioneer Award in 2009. She is an excellent speaker and we look forward to her seminar at the NIH.
The Immunology Interest Group
Developmental Signaling in Stem cells and Cancer
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- Science in the Public Health - Out of the Lab and Into Our Lunch: Nanotechnology and Food (HHS Only)
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- - Cindy Davis, Sally Amero, Jody Engel, Abby Ershow, Nicole Fleisher, Andy Jones, Laura Moen and Yasaman Shirazi (2010/11/18)
- - Category : STEP (HHS Only)
- STEP: Staff Training in Extramural Programs
Do you know that nanotechnology is being used to modify some foods you eat? This is not science fiction-- hundreds of nanofoods are on the market already. Nanotechnology has the potential to improve our food supply, making it tastier, healthier, and more nutritious. Yet little is known about how nanoparticles behave in the body or the toxic effects they could have. What is the science behind nanofoods? What are their potential benefits and risks? You may be surprised at some of the answers.
Committee Members:- Chair: Cindy Davis
- Sally Amero
- Jody Engel
- Abby Ershow
- Nicole Fleisher
- Andy Jones
- Laura Moen
- Yasaman Shirazi
http://odoerdb2-1.od.nih.gov/oer/training/step/step_training_20100114.htm
Science in the Public Health - Out of the Lab and Into Our Lunch: Nanotechnology and Food (HHS Only)
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- OHR Brown Bag Session - SWA & Customer Service (NIH-Only)
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- - Travis Peterson, NE Regional Manager for Human Resources, Southwest Airlines (2010/11/18)
- - Category : Human Resources (NIH Only)
- A representative from Southwest Airlines will be speaking to the OHR/NIH community about customer service best practices. The speaker will focus on the following topics; Internal Customer Service, Difficult People, "The ？？？Southwest Experience？？？.
OHR Brown Bag Session - SWA & Customer Service (NIH-Only)
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- Lifelong Bilingualism: Linguistic Costs, Cognitive Benefits, and Long-term Consequences
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- - Ellen Bialystok, Ph.D. (2010/11/18)
- - Category : BSSR Lecture Series
- A growing body of research points to the importance of specific experiences in modifying cognitive outcomes and supports the interpretation that there is long term brain plasticity. Thus, cognitive systems are fundamentally shaped by our experiences. One such experience is bilingualism, with dramatic outcomes found across the lifespan, beginning in the first year of life. The two primary consequences of bilingualism are slower and more effortful linguistic processing than comparable monolinguals but faster and more efficient executive control, especially applied to nonverbal tasks. Dr. Bialystok will report research illustrating these two opposing outcomes, taking examples from studies with children, adults, and older adults. These effects have been found into older age and are evidenced as well in patients diagnosed with dementia. She will review this evidence and propose a framework for understanding the mechanism that leads to both these positive and negative consequences of bilingualism.
Lifelong Bilingualism: Linguistic Costs, Cognitive Benefits, and Long-term Consequences