전체 8345
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- TRACO: Lung Cancer Vaccine and Colon Cancer Prevention
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- - J.Morris and N. Colburn (2010/11/18)
- - Category : TRACO
- For more information, visit
http://ccr.cancer.gov/careers/traco.asp
TRACO: Lung Cancer Vaccine and Colon Cancer Prevention
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- The National Cancer Advisory Board Meeting - December 2009 (Day 1)
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- - United States. National Cancer Advisory Board. Meeting (2010/11/18)
- - Category : National Cancer Advisory Board
- The 152nd meeting of the National Cancer Advisory Board
The National Cancer Advisory Board Meeting - December 2009 (Day 1)
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- "Healthy" Individuals with Early Signs of Follicular Lymphomagenesis (NIH-Only)
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- - Bertrand Nadel, Ph.D. (2010/11/18)
- - Category : NCI CCR Grand Rounds (NIH Only)
- Dr. Nadel？？？s group has been working for many years on the molecular mechanisms underlying genomic instability in human Hemopathies, and has developed over the years a particular focus on the early steps of lymphomagenesis in individuals devoid of manifest clinical lymphoma/leukemia. Follicular Lymphoma has ever been center to his studies and stands now in his lab as a paradigm of the complex multi-step process of lymphoid neoplasia. The recent characterization in his lab of Follicular lymphoma-like B-cells in healthy individuals strongly impacts on the current understanding of disease progression, on the key role played by the microenvironment as support for early maintenance and growth of follicular lymphoma precursors, and on the proper handling of their frequency in blood as potential early biomarker for lymphoma. Dr. Nadel received his Masters degree in Biochemistry in 1988 and his PhD in Genetics in 1992, both from the Pierre & Marie Curie University in Paris, France. He was a post-doctoral Research Fellow in Immunology in Ann J. Feeney？？？s laboratory at The Scripps Research Institute in La Jolla, CA from 1992 to 1998. He moved to Austria in 1998 to take the position of Group Leader in the Department of Internal Medicine, Division of Hematology at the University of Vienna. From 2002 to the present, Dr. Nadel has been at the Center of Immunology of Marseille-Luminy in Marseille, France, advancing from Group Leader to Deputy Director in 2008. He has held a tenured position with the National Institute of Health and Medical Research (INSERM), France since 2002.
NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link:
"Healthy" Individuals with Early Signs of Follicular Lymphomagenesis (NIH-Only)
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- Recombinant DNA Advisory Committee (RAC) December 2009 - Day 1
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- - National Institutes of Health (U.S.). Recombinant DNA Advisory Committee. (2010/11/18)
- - Category : Recombinant DNA Advisory Committee
- The RAC is a technical committee whose goal is to consider the current state of knowledge and technology regarding recombinant DNA. This includes review of human gene transfer trials, and an assessment of the ability of DNA recombinants to survive in nature and the potential for transfer of genetic material to other organisms. It also considers hypothetical hazards and methods for monitoring and minimizing risks. Approximately one-third of the 15 members do not have scientific expertise but represent public interests and attitudes. This balance is intended to provide a forum for open public debate of social and scientific issues attendant to recombinant DNA research. The RAC has been overwhelmingly successful in achieving this goal.
For more information, visit the
Recombinant DNA Advisory Committee (RAC) Conference Web Site
Recombinant DNA Advisory Committee (RAC) December 2009 - Day 1
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- Moving On Up: Tools for Effective Resume Writing (NIH-Only)
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- - Dr. Martha Chase (2010/11/18)
- - Category : NIH Only
- Career Seminar Series sponsored by OEODM and the NIH Federal Womens Network Committee
Moving On Up: Tools for Effective Resume Writing (NIH-Only)
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- Role of Type 1 Interferons in Autoimmune Diseases
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- - Coyle, Anthony.
National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18) - - Category : Immunology
- - Coyle, Anthony.
- Tony is one of the leading figures in allergy and asthma research. He is currently Vice President of R&D at MedImmune and Global Head of Inflammation Biologics at AstraZeneca. Since 2004, Tony has been the head of MedImmune？？？s Respiratory Inflammation and Autoimmune Research (RIA) which sponsors the annual Respiratory, Immunology and Autoimmunity Research Abstract Competition to highlight the work of students and postdoctoral fellows from across the country in this field.
Tony developed a keen interest in the mechanisms of allergy and asthma since his early years as a Ph.D. student at the University of London, Kings College, and then as a postdoctoral fellow with Charles Irvin at the National Jewish Center for Immunology and Respiratory Medicine. With Charles Irvin and later Gary Anderson at CIBA in Switzerland, Tony made the seminal discovery of the roles of eosinophil activation and cationic protein release during airway hyperresponsiveness. After a brief stint at the Glaxo Institute for Molecular Biology, he moved to Millennium Pharmaceuticals in 1997 and then to MedImmune in 2004. Throughout his years in industry, he has made major contributions to our understanding of the roles of IgE, Th2 cytokines and chemokines in pulmonary immune response and inflammation. More recently, his group reported that the interaction of HMGB1 and its receptor RAGE is essential for the recognition of DNA-containing immune complexes by TLR9 and may contribute to systemic autoimmune diseases such as lupus (Nature Immunol 8(5):487-96, 2007); macrophage deficiency underlies airway occlusion in primary RSV bronchiolitis (J Infect Dis 198(12):1783-93, 2008); acute influenza infection results in proinflammatory responses that enhances Th2 polarized allergic reaction to house dust mite (J Immunol 182(5):3095-104, 2009); suppression of interferon-inducible genes in systemic lupus erythematosus patients by an anti-interferon-alpha monoclonal antibody in a phase I clinical trial (Arthritis Rheum 60(6):1785-96, 2009). His talk will focus on these exciting new findings and promise to be a stimulating seminar for the general IIG community. Don？？？t miss it!
The Immunology Interest Group
Role of Type 1 Interferons in Autoimmune Diseases
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- Using Patients Circumstances to Answer Research Questions: When is it Ethical?
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- - Sulmasy, Daniel P.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Clinical Center Grand Rounds
- - Sulmasy, Daniel P.
- Ethics Rounds
Daniel P.Sulmasy, OFM, MD, PhD,
Kilbride-Clinton Professor of Medicine and Ethics,
Department of Medicine and the Divinity School,
Associate Director, MacLean Center for Clinical Medical Ethics,
University of Chicago
For more information, visit
http://www.cc.nih.gov/about/news/grcurrent.html
Using Patients Circumstances to Answer Research Questions: When is it Ethical?
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- The National Cancer Advisory Board Meeting - December 2009 (Day 2)
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- - United States. National Cancer Advisory Board. Meeting (2010/11/18)
- - Category : National Cancer Advisory Board
- The 152nd meeting of the National Cancer Advisory Board
The National Cancer Advisory Board Meeting - December 2009 (Day 2)
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- PSC 4th Quarter All Hands Meeting (HHS-Only)
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- - PSC Director Paul Bartley (2010/11/18)
- - Category : PSC Programs (HHS Only)
- PSC 4th Quarter All Hands Meeting and Operation: High GEAR awards ceremony. The meeting will highlight eight initiatives that have been completed and recognize PSC employees who have volunteered their time and expertise to help us achieve PSC？？？s strategic goals.
PSC 4th Quarter All Hands Meeting (HHS-Only)
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- Recombinant DNA Advisory Committee (RAC) December 2009 - Day 2
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- - National Institutes of Health (U.S.). Recombinant DNA Advisory Committee. (2010/11/18)
- - Category : Recombinant DNA Advisory Committee
- The RAC is a technical committee whose goal is to consider the current state of knowledge and technology regarding recombinant DNA. This includes review of human gene transfer trials, and an assessment of the ability of DNA recombinants to survive in nature and the potential for transfer of genetic material to other organisms. It also considers hypothetical hazards and methods for monitoring and minimizing risks. Approximately one-third of the 15 members do not have scientific expertise but represent public interests and attitudes. This balance is intended to provide a forum for open public debate of social and scientific issues attendant to recombinant DNA research. The RAC has been overwhelmingly successful in achieving this goal.
For more information, visit the
Recombinant DNA Advisory Committee (RAC) Conference Web Site
Recombinant DNA Advisory Committee (RAC) December 2009 - Day 2
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- Shotgun siRNA Perturbation to Dissect Growth Factor Triggered Proliferation and Migration Signaling Systems
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- - Meyer, Tobias.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Wednesday Afternoon Lectures
- - Meyer, Tobias.
- Cells make use of an elaborate control system that integrates inputs from multiple receptors, computes this information and makes decisions about key cellular outputs such as cell migration and proliferation. Our laboratory is focusing on discovering the rules that govern these decision processes by perturbing signaling steps, by monitoring signaling events and cell functions, and by employing mathematical modeling. We have developed a number of novel biosensors and microscopy techniques to monitor cell signaling and functional processes over time, developed novel chemically induced enzyme activities for rapid signaling pathway perturbations and created a set of 3000 RNAis to perturb signaling pathways by selectively reducing the expression of most human signaling proteins (shotgun perturbation strategy.
We are particularly intrigued by the roles of calcium, lipid second messenger and small GTPases in the spatial and temporal coordination of cellular responses and a current focus of the laboratory is on the questions how cells polarize and collectively migrate and how they proliferate in response to growth factor stimuli. This talk will give a general introduction into how to investigate complex signaling systems and in a second part focus on growth factor-triggered collective migration of endothelial cells. Using live cell imaging and systematic siRNA perturbations, we identified a modular control structure for this collective migration process. A third part of the talk will focus on an interlinked positive feedback system that we discovered using this same systematic perturbation strategy. This control system allows quiescent cells stimulated by growth factors to decide in an all-or-none fashion whether they will remove a barrier protein and enter the cell cycle.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Shotgun siRNA Perturbation to Dissect Growth Factor Triggered Proliferation and Migration Signaling Systems
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- Understanding Factors that Influence Health Through the Tools of The Social Sciences: Education
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- - Shaw, Susan J.
National Institutes of Health (U.S.) (2010/11/18) - - Category : BSSR Lecture Series
- - Shaw, Susan J.
- BACKGROUND: Though mortality from breast cancer on the whole has declined over the past 15 years, the risk of African-American women dying from the disease is 37 percent higher than that of white women. Previous explanations have
considered the role of environmental (social and ecological) and genetic
factors separately. However, because 70-80 percent of breast cancers are due
to sporadic rather than hereditary mutations, it is important to understand the
social and ecological factors that influence sporadic mutations. The current
research conducted at the Center for Interdisciplinary Health Disparities
Research (CIHDR) explores the connection between genes and environment by
utilizing a downward causal model developed by the transdisciplinary research
team in which social environmental factors ultimately impact genetic expression
of breast cancer through psychosocial factors such as social isolation,
depression, and acquired vigilance, and biological processes.
METHOD: The team uses animal models and interviews with newly-diagnosed African-American women of a variety of socioeconomic backgrounds in a mutually-informative, multi-modal approach to understanding the influences of the social environment on biology, In-home interviews were conducted with the women newly diagnosed with breast cancer. As a means to explore the impact of the social environment in disrupting stress responses, saliva samples were collected four times per day for three days following the interview. Breast tumor tissue was collected at the time of surgery. In addition, researchers map the social ecology of the four-block area around each participant？？？s home, noting features known to inhibit or encourage social interaction, including vacant buildings and lots (and their use), the amount of foot traffic, and location of key services in relation to the participant？？？s home. Geo-coded data from the public domain will allow us to measure crime, population density, housing quality, and other features of the participants？？？ neighborhoods. Relationships among the geo-coded public data, observer collected neighborhood variables, psychosocial data collected from interviews, and biological specimens were analyzed.
RESULTS: Women in the study exhibited high rates of felt loneliness and higher rates of sexual assault than previously reported for African-American women. Women also exhibited high rates of depression compared to those in prior studies of women with invasive breast cancer. We found that felt loneliness, depression, and sexual assault were strongly correlated with one another and seem to form a ？？？psychosocial suite？？？ of social and traumatic variables that connects the neighborhood- level variables to stress hormone response. Cluster analysis of the diurnal salivary cortisol data revealed two clusters, one with a flat pattern and a more typical pattern. We were able to predict into which group the women fall, using logistic regression analysis, with number of crimes that occurred that year in a quarter-mile buffer zone constructed around each woman？？？s home and psychological response as predictors. Additional analyses reveal that nighttime rise in salivary cortisol can be predicted by crimes and depression. In preliminary analyses of constructing and analyzing our final, inclusive multi-level models, we are able to predict hormone receptor status from social and psychological variables. Implications: Preliminary findings from our studies suggest biological processes are impacted by social environmental factors in which felt loneliness and depression may be pathways through which the social environment ？？？gets under the skin.？？？ Identifying the causal chain from the social environment to disease will shed light on the social structural conditions that must be targeted to reduce overall mortality from the disease, as well as the disparate outcomes between African-American and white women.
This lecture is an installment of the Behavioral and Social Sciences Research Lecture Series sponsored by the NIH Office of Behavioral and Social Sciences Research and organized by the NIH Behavioral and Social Sciences Research Coordinating Committee.
The Behavioral and Social Sciences Research Coordinating Committee (BSSR CC), with support from the Office of Behavioral and Social Sciences Research (OBSSR), convenes a series of guest lectures and symposia on selected topics in the behavioral and social sciences. These presentations by prominent behavioral and social scientists provide the NIH community with overviews of current research on topics of scientific and social interest. The lectures and symposia are approximately 50 minutes in length, with additional time for questions and discussion. All seminars are open to NIH staff and to the general public.
Understanding Factors that Influence Health Through the Tools of The Social Sciences: Education
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- Sorting It All Out: Signal-mediated Protein Trafficking in the Endosomal-Lysosomal System
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- - Bonifacino, Juan S.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Wednesday Afternoon Lectures
- - Bonifacino, Juan S.
- The interior of eukaryotic cells is organized into an array of membrane-bound compartments. Each of these compartments has a characteristic protein composition that is responsible for its specific function. My laboratory has been interested in the molecular mechanisms that determine protein localization to different intracellular compartments, with a particular focus on organelles that make up the endosomal-lysosomal system. This system comprises various types of endosome (e.g., early, late, recycling), lysosomes and a family of ？？？lysosome-related organelles？？？ (LROs) (e.g., melanosomes, platelet dense bodies, cytotoxic granules, etc.), as well as the trans-Golgi network (TGN) and domains of the plasma membrane, which feed into this system. We have found that delivery of transmembrane proteins to these compartments is mediated by an elaborate system of sorting signals and adaptor proteins. Endosomal-lysosomal sorting signals generally occur within the cytosolic domains of transmembrane proteins and consist of linear arrays of amino acids that fit one of several consensus motifs. These include different types of ？？？tyrosine-based？？？ and ？？？dileucine-based？？？ sorting signals, so named on the basis of the most conserved and critical amino acids in the signal. These signals function as ？？？bar codes？？？ that are decoded by adaptors such as the AP-1, AP-2, AP-3 and AP-4 heterotetrameric complexes, the monomeric GGA1, GGA2, and GGA3 proteins, and several others, all of which are components of protein coats associated with the cytosolic face of membranes (e.g., clathrin coats). Signal-adaptor interactions result in incorporation of transmembrane cargoes into coated transport carriers destined to different organelles of the endosomal-lysosomal system. Understanding the mechanisms of protein sorting in this system is key to the elucidation of the pathogenesis of various genetic disorders caused by mutations in the signals (e.g., some forms of familial hypercholesterolemia) or the adaptors (e.g., Hermansky-Pudlak syndrome type 2), or by their exploitation by intracellular pathogens such as viruses and bacteria. Over the years we have discovered and characterized various sorting signals and adaptors, and examined their involvement in several pathologies. We have recently found that the heterotetrameric AP-4 complex plays a role in the intracellular trafficking and processing of the Alzheimer？？？s Disease (AD) amyloid precursor protein (APP). An interaction screen showed that a previously unknown signal in the cytosolic tail of APP binds to the mu4 subunit of AP-4. The biochemical and structural details of this interaction are distinct from others that have been characterized to date. Mutation of the signal or depletion of cellular mu4 shift the steady-state localization of APP from endosomes to the TGN, and enhance amyloidogenic processing of APP to the pathogenic amyloid-beta (Abeta) peptide. These findings indicate that AP-4 sorts APP from the TGN to endosomes, and that amyloidogenic processing of APP is favored by localization to the TGN or the late secretory pathway. Thus, AP-4 exerts a protective effect that guards against excessive Abeta production. Defective expression of AP-4 should therefore be considered a potential risk factor for AD.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Sorting It All Out: Signal-mediated Protein Trafficking in the Endosomal-Lysosomal System
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- The Future of Personalized Medicine
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- - Niederhuber, John E. (2010/11/18)
- - Category : Special
- The NCI Director, Dr. John Niederhuber, will be presenting to the NCI Community Cancer Centers Program participants. Immeditately following his presentation there will be a moderated Q and A session.
The Future of Personalized Medicine
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- NSABB - National Science Advisory Board for Biosecurity, December 2009
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- - NIH Office of Biotechnology Activities (2010/11/18)
- - Category : National Science Advisory Board for Biosecurity
- The NSABB was established to advise on oversight of dual use life sciences research, defined as biological research that generates information and technologies that could be misused to pose a biological threat to public health and other aspects of national security. The December 3 meeting will focus on the introduction of new NSABB voting members, federal responses to NSABB reports, activities of the Working Groups on Outreach and Education and on International Engagement, and synthetic biology and the NSABB draft report on biosecurity issues raised by synthetic biology.
For more information, visit
http://www.biosecurityboard.gov/meetings.asp
NSABB - National Science Advisory Board for Biosecurity, December 2009
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- DDM - An Attitude of Excellence: How to Succeed at Work and at Home (NIH Only)
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- - Willie Jolley (2010/11/18)
- - Category : DDM Seminar Series (NIH Only)
- 2009-2010 Deputy Director for Management (DDM) Seminar Series
Click here to respond to a Survey about this DDM Seminar. Information will be used to evaluate the program and improve future seminars.
Willie Jolley is the author of ？？？It Only Takes a Minute to Change Your Life？？？ and ？？？A Setback is a Setup for a Comeback.？？？ During his presentation on organizational success strategies entitled ？？？An Attitude of Excellence (How to Succeed at Work and at Home),？？？ he will share insights in areas such as:
？？？ Leadership Development
？？？ Change Management
？？？ Team Building
？？？ Customer Service
？？？ Attitude Enhancement
The DDM Seminar Series offers the NIH community engaging presentations that provide meaningful insights into leadership and management concepts, challenges, and solutions. The seminars provide NIH employees the opportunity to advance their knowledge of best practices in a variety of workplace topics. The DDM Seminar Series is open to all NIH employees. No pre-registration is necessary.
http://www.ddmseries.od.nih.gov
DDM - An Attitude of Excellence: How to Succeed at Work and at Home (NIH Only)
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- Rhythms of the Night and Day: Update on Insomnia and Sleep Disruptions
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- - William Riley, Ph.D., NHLBI and Michael Twery, Ph.D., NHLBI (2010/11/18)
- - Category : Womens Health
- Womens Health Special Interest Group (WHSIG)
Intramural Program on Research on Womens Health
Sponsored by the NIH Office of Intramural Research
and the NIH Office of Research on Womens Health.
William Riley, Ph.D.
Health Scientist Administrator
Clinical Applications and Prevention Branch
Division of Prevention and Population Sciences
National Heart, Lung, and Blood Institute
Michael Twery, Ph.D.
Senior Moderator
Director and Branch Chief
National Center on Sleep Disorders Research
National Heart, Lung, and Blood Institute
Come join your fellow NIH colleagues in a scientific exchange on issues related to the biology and pathology of sex and gender differences and effects on womens health.
For more information, visit
http://orwh.od.nih.gov
Rhythms of the Night and Day: Update on Insomnia and Sleep Disruptions
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- Advisory Committee to the Director of the NIH - December 2009
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- - Advisory Committee to the Director, National Institutes of Health. Meeting (2010/11/18)
- - Category : Advisory Committee to the Director of the NIH
- Bi-annual meeting of the Advisory Committee to the Director. The Committee will provide advice on matters pertinent to National Institutes of Health (NIH) mission responsibilities in the conduct and support of biomedical research, medical science, and biomedical communications.
http://acd.od.nih.gov
Advisory Committee to the Director of the NIH - December 2009
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- CTSA Pharmaceutical Assets Portal: Matching Academia and Industry for Drug Repositioning
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- - National Center for Research Resources (U.S.) (2010/11/18)
- - Category : Special
- This meeting will introduce the NIH community to the topic of drug repositioning and learn about the CTSA Pharma Portal. NIH Intramural researchers will be able to learn to match their scientific interests with the repositioning needs of the industry, resulting in an increased number of approved drugs for new indications.
Drug repositioning, or finding new uses for drugs originally designed for another purpose, has become more important recently as many pharmaceutical companies are seeing their drug pipelines dry up. With the high cost of drug research and development, drug repositioning offers a way to explore these previously shelved assets. The Clinical and Translational Science Award (CTSA) Pharmaceutical Assets Portal is a tool that aims to match researchers？？？ scientific knowledge of targets and diseases with the repositioning needs of the pharmaceutical industry to potentially increase the number of approved drugs for alternative uses.
Speakers include representatives from Pharma and NIH investigators involved in drug repositioning efforts.
http://www.palladianpartners.com/pharm-assets
CTSA Pharmaceutical Assets Portal: Matching Academia and Industry for Drug Repositioning
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- Motivational control of memory expression in Drosophila
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- - Waddell, Scott.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Neuroscience
- - Waddell, Scott.
- It is well established that memory exists in time-dependent phases and is converted from a labile to a stable state after training by a process termed consolidation. Further, the memory process can be strongly affected by motivational state. Using olfactory memory in the fruit fly Drosophila as a model, and applying state-of-the-art genetic manipulations, Dr. Waddell？？？s laboratory studies the mechanisms by which memory is encoded and stabilized at the molecular, cellular and neural network level, and by which motivational states can regulate access to memory.
Scott Waddell received his B. Sc. from the Department of Biochemistry at the University of Dundee and his Ph.D. from the University of London, U.K. He has received numerous awards and honors including a Wellcome International Prize Traveling Fellowship and a Merck / M.I.T. Fellowship to do postdoctoral work at the Massachusetts Institute of Technology. He joined the Department of Neurobiology at the University of Massachusetts Medical School as a faculty member in October 2001 where he is presently an associate professor.
NIH Neuroscience Seminar Series
Motivational control of memory expression in Drosophila