전체 8345
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- Role of viral RNA recognition pathways in autoimmune disease susceptibility
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- - Dr. Silvia Bolland, NIAID (2010/11/18)
- - Category : NIH Directors Seminars
- Dr. Bollands group is interested in immune inhibitory pathways and their role in preventing autoimmunity. They have generated a new model for systemic autoimmune disease in mice deficient in FcãRIIB, an IgG-binding receptor that inhibits antibody production and inflammatory responses. These mice develop a spontaneous disease that resembles lupus in humans, but only in certain genetic backgrounds. They are studying genetic modifiers that augment susceptibility and severity of disease so that they can understand cellular mechanisms that induce these pathologies and identify new genes that can be used as therapeutic targets.
Addition of the Y chromosome-linked Yaa modifier in the FcãRII-ko lupus model results in aggravated glomerulonephritis and a switch from anti-chromatin to anti-nucleolar autoantibodies. We have shown that the nucleolar specificity of Yaa-derived antibodies is a B-cell-intrinsic feature resulting from a large genomic duplication that includes the TLR7 gene (Fig.3). Their future experiments will explore expression levels of Toll-like receptors and other genetic factors that regulate the development of autoimmunity.
For more information, visit
http://www.nih.gov/about/director/dirsem.htm
Role of viral RNA recognition pathways in autoimmune disease susceptibility
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- ART-RIM Workshop
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- - NCI, NIH (2010/11/18)
- - Category : Conferences
- National Cancer Institute Workshop
ART-RIM Workshop
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- The Health Information National Trends Survey (HINTS) Pre-Proposal Videocast: Preparing Your HINTS 2010 Proposal
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- - Health Communication and Informatics Research Branch, NCI (2010/11/18)
- - Category : Special
- The purpose of the pre-proposal videocast is to provide information concerning the Governments requirement which may be helpful in the preparation of proposals and for answering any questions which prospective offerors have regarding this solicitation. Prospective offerors are expected to review the solicitation in detail and be prepared with questions in advance of the conference to allow the most efficient use of this time.
The videocast will begin with a panel presentation where speakers will discuss the history of HINTS and the vision behind this solicitation. The presentations will be followed by a question and answer segment where panel presenters respond live to questions submitted via an online form (accessible below) during the presentation. All questions will be received internally and remain anonymous. Representatives from the NCI contract office will be in attendance to answer questions as well.
Participation in the pre-proposal conference is recommended; however, participation is not a prerequisite for proposal submission and will not be considered a factor in proposal evaluation. The video will be archived on this site after the live viewing so that prospective offerors may access it at anytime.
Speakers in alphabetical order by last name:
- Bradford W. Hesse, PhD Chief, Health Communication and Informatics Research Branch, Behavioral Research Program (BRP), Division of Cancer Control and Population Sciences (DCCPS), National Cancer Institute (NCI)
- William Klein, PhD, Associate Director, BRP, DCCPS, NCI
- Richard Moser, PhD, BRP, DCCPS, NCI
- Lila Finney Rutten, PhD, Behavioral Scientist, SAIC-Frederick
The Health Information National Trends Survey (HINTS) Pre-Proposal Videocast: Preparing Your HINTS 2010 Proposal
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- Signaling networks that regulate synapse development and cognitive function
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- - Michael Greenberg, Ph.D. (2010/11/18)
- - Category : Neuroscience
- Research in Dr. Greenbergs laboratory has focused on the identification of a genetic program that is activated by neuronal activity, the mechanisms of signal transduction that carry the neuronal activity-dependent signal from the membrane to the nucleus, and the identification of regulators of this experience-dependent process that affect synapse development and plasticity. They are particularly interested in those activity-dependent processes whose dysfunction can lead to the development of diseases of cognitive function.
NIH Neuroscience Seminar Series
Signaling networks that regulate synapse development and cognitive function
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- National Advisory Research Resources Council (NARRC) - January 2010
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- - NCRR, NIH (2010/11/18)
- - Category : National Advisory Research Resources Council
- The January 26, 2010, meeting of the National Advisory Research Resources Council will feature presentations and discussion on topics including the American Recovery and Reinvestment Act of 2009, Core Facilities Management and Utilization, transforming aspects and challenges within the Clinical and Translational Science Awards, research and collaborations among NCRR？？？s programs, and updates on the National Synchrotron Light Source (NSLS-II) and the National Primate Research Center guidelines.
In addition, Council members who have completed their terms and new NCRR staff members will be recognized.
For more information, visit: http://www.ncrr.nih.gov/about_us/advisory_council/
National Advisory Research Resources Council (NARRC) - January 2010
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- Functional Analysis of Breast Cancer Susceptibility Genes (NIH-Only)
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- - Shayam K. Sharan, Ph.D. (2010/11/18)
- - Category : NCI CCR Grand Rounds (NIH Only)
- Dr. Shyam Sharan obtained his M.Sc. degree in genetics from Delhi University, India, and his Ph.D. degree in genetics from Case Western Reserve University, Cleveland, Ohio, under the supervision of Dr. Terry Magnuson. He then joined Dr. Allan Bradley？？？s laboratory as a Howard Hughes Medical Institute Associate at Baylor College of Medicine in Houston, Texas, where he worked on the functional analysis of BRCA1 and BRCA2 in the mouse. He was the first to show that BRCA2 functions as a tumor suppressor because of its role in maintaining the genomic integrity. His work demonstrated that BRCA2 interacts with a key DNA repair protein RAD51 and participates in the repair of damaged DNA by homologous recombination. In 1998, Dr. Sharan established the Genetics of Cancer Susceptibility Section as a group leader in the ABL-Basic Research Program and later joined the Center for Cancer Research, National Cancer Institute, in 1999. The main focus of his research is to understand the mechanism of genomic instability and how it results in tissue-specific cancer.
His laboratory is generating an array of specific mutations along the length of proteins encoded by BRCA1 and BRCA2 in humanized mouse models. This approach combines the use of existing BRCA1 and BRCA2 knockout mice and bacterial artificial chromosomes (BAC) containing the human BRCA1 or BRCA2 gene. More recently he has utilized mouse embryonic stem cells to develop a functional assay to evaluate the functional significance of variants identified in BRCA1 and BRCA2 genes. In 2008, Dr. Sharan received the NCI Director？？？s Intramural Innovation Award, and in 2009 he received the NIH merit award for his work on functional analysis of BRCA1 and BRCA2.
NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link: http://bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx
Functional Analysis of Breast Cancer Susceptibility Genes (NIH-Only)
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- Biological Sequence Analysis II
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- - Andreas Baxevanis, Ph.D. (2010/11/18)
- - Category : Current Topics in Genome Analysis
- Current Topics in Genome Analysis
Biological Sequence Analysis II
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- HIV: Getting Better and Worse
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- - John Coffin (NCI), Henry Masur (CC) (2010/11/18)
- - Category : Demystifying Medicine
- The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.
For more information, visit
http://www1.od.nih.gov/oir/DemystifyingMed
HIV: Getting Better and Worse
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- NIAID HIV/AIDS Strategic Working Group - Day 1 (NIH-Only)
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- - NIAID (2010/11/18)
- - Category : NIAID Council (NIH Only)
- The first 2010 face-to-face meeting between NIAID funded HIV/AIDS investigators, external experts, invited guests and NIAID leadership to provide provide recommendations on the DAIDS scientific priorities for high resource, high impact studies and important cross-cutting scientific issues.
NIAID HIV/AIDS Strategic Working Group - Day 1 (NIH-Only)
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- CC Grand Rounds: Ciliary Diseases: Converging Observations and Diverging Models
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- - National Institutes of Health (U.S.). Clinical Center. (2010/11/18)
- - Category : Clinical Center Grand Rounds
- Meral Gunay-Aygun, MD,
Staff Clinician, Medical Genetics Branch, NHGRI
Gregory G. Germino, MD,
Deputy Director, NIDDK
For more information, visit
http://www.cc.nih.gov/about/news/grcurrent.html
CC Grand Rounds: Ciliary Diseases: Converging Observations and Diverging Models
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- A New Strategy to Enhance NIMHs Public Health Impact: Connecting Scientists, Policy-Makers, and Other Stakeholders in Innovative Intervention and Services Research
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- - Robert K. Heinssen, Ph.D. ABPP, Acting Director, Division of Services and Intervention Research, National Institute of Mental Health (2010/11/18)
- - Category : Special
- NIMH DSIR Director Candidate Lecture
A New Strategy to Enhance NIMHs Public Health Impact: Connecting Scientists, Policy-Makers, and Other Stakeholders in Innovative Intervention and Services Research
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- Molecular Chaperones in Protein Folding and Neurodegeneration
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- - Arthur Horwich, M.D., Yale School of Medicine (2010/11/18)
- - Category : Wednesday Afternoon Lectures
- Lecture Objectives:
1. Explain the biological function of molecular chaperones, in particular the chaperonin ring class of chaperones.
2. Explain the mechanism of action of chaperonins, including the nature of their use of ATP.
3. Discuss studies of protein misfolding and neurodegenerative disease, relating the action of chaperones in one such condition.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Molecular Chaperones in Protein Folding and Neurodegeneration
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- NOD1 is NOD Your Everyday NOD-Like Receptor (NLR)
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- - Strober, Warren.
National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18) - - Category : Immunology
- - Strober, Warren.
- Warren Strober is a physician/scientist who has had an exceptionally distinguished career devoted to understanding the immunology and immunopathology of the gastrointestinal system. He has made fundamental contributions to problems ranging from the regulation of IgA production to the molecular genetics of effector and regulatory T cell differentiation. He and his co-workers have developed mouse models of inflammatory bowel disease, and have successfully applied their observations in these models to the clinical evaluation of novel therapeutics. Recently, Warren？？？s laboratory has been investigating the roles of the NOD-like receptors such as NOD2, whose loss of function is important for some cases of Crohn？？？s disease, in experimental models of colitis. Warren is widely recognized as a leader in the field of mucosal immunology, and his contributions have been recognized recently by major awards from organizations such as the American Gastroenterological Association. We can be sure that Warren？？？s talk will feature work that is new, creative, and important, presented in an engaging fashion with the breadth and depth of a master.
The Immunology Interest Group
NOD1 is NOD Your Everyday NOD-Like Receptor (NLR)
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- National Advisory Child Health and Human Development Council - January 2010
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- - Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (2010/11/18)
- - Category : National Advisory Child Health and Human Development Council
- The NICHD Advisory Council has two specific functions: (1) to advise the NICHD on policy and procedures affecting the extramural research programs and (2) to provide the second level of review for grant applications requesting Institute funding support. The Council meets for one day three times a year in January, June, and September.
The morning session is Open to the Public and is devoted to bringing Council members up-to-date with a Report of the Director, NICHD, a report by the Council Subcommittee on Planning and Policy, a review of one of the extramural program areas, discussion and review of proposed concepts for NICHD initiatives, the annual review of the Board of Scientific Counselors reports on intramural research programs, and new business items identified by the Council membership and Institute staff. The afternoon session is closed to the Public for the confidential Review of Applications.
National Advisory Child Health and Human Development Council - January 2010
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- Core Curriculum Part One - Funding Mechanisms (HHS Only)
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- - NIH (2010/11/18)
- - Category : Core Curriculum (HHS Only)
- 2010 Orientation to NIH Extramural Activities Core Curriculum
ESA Program
For more information, visit
http://odoerdb2-1.od.nih.gov/oer/training/esa/esa_cores_2010.htm
Core Curriculum Part One - Funding Mechanisms (HHS Only)
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- NIAID HIV/AIDS Strategic Working Group - Day 2 (NIH-Only)
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- - NIAID, NIH (2010/11/18)
- - Category : NIAID Council (NIH Only)
- The first 2010 face-to-face meeting between NIAID funded HIV/AIDS investigators, external experts, invited guests and NIAID leadership to provide provide recommendations on the DAIDS scientific priorities for high resource, high impact studies and important cross-cutting scientific issues.
NIAID HIV/AIDS Strategic Working Group - Day 2 (NIH-Only)
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- NBS GovTrip HPOC Meeting (NIH-Only)
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- - Jennifer Martin (2010/11/18)
- - Category : Travel (NIH Only)
- We will be discussing common GovTrip issues and resolutions, reviewing functionality through demonstrations and answering questions regarding the system.
NBS GovTrip HPOC Meeting (NIH-Only)
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- U.S. Department of Health and Human Services and the U.S. Department of Justices National Summit on Health Care Fraud - Preliminary Session
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- - HHS (2010/11/18)
- - Category : Conferences
- U.S. Department of Health and Human Services Secretary Kathleen Sebelius and U.S. Department of Justice Attorney General Eric Holder will host a National Summit on Thursday, January 28, to discuss new initiatives to address and combat health care fraud. This unprecedented all-day session will bring together leaders from the public and private sectors to discuss and find innovative ways to eliminate fraud in the U.S. health care system.
U.S. Department of Health and Human Services and the U.S. Department of Justices National Summit on Health Care Fraud - Preliminary Session
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- U.S. Department of Health and Human Services and the U.S. Department of Justices National Summit on Health Care Fraud - Afternoon Session
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- - HHS (2010/11/18)
- - Category : Conferences
- U.S. Department of Health and Human Services Secretary Kathleen Sebelius and U.S. Department of Justice Attorney General Eric Holder will host a National Summit on Thursday, January 28, to discuss new initiatives to address and combat health care fraud. This unprecedented all-day session will bring together leaders from the public and private sectors to discuss and find innovative ways to eliminate fraud in the U.S. health care system.
U.S. Department of Health and Human Services and the U.S. Department of Justices National Summit on Health Care Fraud - Afternoon Session
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- 7T Seminar Series: Opportunities and Challenges of High Field and MRS
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- - Dr. John Gore (2010/11/18)
- - Category : 7 T Seminars
- John Gore is Director of the Vanderbilt University Institute of Imaging Science and an authority on what 7T can do with regard to human studies. His group has generated some of the more impressive data seen to date.
7T Seminar Series: Opportunities and Challenges of High Field and MRS