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  • Navigating the Application Process: Industry CAT Track
    • - Lori M. Conlan, PhD, OD/OITE (2010/11/18)
    • - Category : Career Development/OITE
    Objective: Learn strategies and techniques that will help you apply successfully for non-academic positions. Topics: How to apply for positions, cover letter tips and networking

    Navigating the Application Process: Industry CAT Track

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  • NCCAMs 10th Anniversary Research Symposium: Exploring the Science of Complementary and Alternative Medicine
    • - NCCAMs 10th Anniversary Research Symposium (2010/11/18)
    • - Category : Conferences
    The National Center for Complementary and Alternative Medicine (NCCAM) will celebrate a decade of rigorous research with NCCAMs 10th Anniversary Research Symposium: Exploring the Science of Complementary and Alternative Medicine. Speakers will discuss topics including natural products, mind-body medicine, and the intersection of behavioral science and integrative medicine. People have used some CAM therapies since ancient times and often with little scientific evidence.

    http://nccam.nih.gov/news/events/anniversary_symposium.htm

    NCCAMs 10th Anniversary Research Symposium: Exploring the Science of Complementary and Alternative Medicine

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  • NCI Translational Working Group Pathways: Application in Symptom Management (NIH Only)
    • - Deborah Watkins Bruner, R.N., Ph.D., F.A.A.N. (2010/11/18)
    • - Category : NCI CCR Grand Rounds (NIH Only)
    Dr. Bruner is the Independence Professor of Nursing Education and Founding Director of the Human Subjects Recruitment, Retention and Outreach Core (RROC) facility at the Abramson Cancer Center of the University of Pennsylvania. Dr. Bruner received her bachelor？？？s degree in nursing from West Chester University, as well as a masters degree in oncology nursing and a masters degree in nursing administration from Widener University. She completed her doctoral degree in nursing research, with a focus on outcomes research, at the University of Pennsylvania. Prior to moving to the University of Pennsylvania, Dr. Bruner had been at Fox Chase Cancer Center, Philadelphia, Penn., for 16 years where she was the director of the Symptoms and Outcomes Research Program, was the founding director of the Prostate Cancer Risk Assessment Program, and also directed a Clinical Trials Recruitment Core Facility. Dr. Bruners research has focused on quality of life, patient-reported outcomes (PROs), and symptom management across cancer sites with a focus on pelvic tumors, as well as decision-making, preferences, and utilities for cancer therapies. Dr. Bruner is also internationally recognized for her research in sexuality after cancer therapy. In the area of recruitment and health disparities, Dr. Bruner has applied a novel scientific methodology in health care, has applied social marketing to cancer research, and is leading a unique program to study the behavioral aspects of human subjects recruitment to research trials.

    NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link: http://bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx.

    NCI Translational Working Group Pathways: Application in Symptom Management (NIH Only)

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  • TRACO: Cervical Cancer Vaccine and Inflammation
    • - Schiller, John T.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : TRACO
    For more information, visit
    http://ccr.cancer.gov/careers/traco.asp

    TRACO: Cervical Cancer Vaccine and Inflammation

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  • Therapeutic Effects of Boswellia Extracts and Pure Components in Prostate Cancer and Leukemia
    • - Jing, Yongkui.
      National Cancer Institute (U.S.). Office of Cancer Complementary and Alternative Medicine. (2010/11/18)
    • - Category : OCCAM Monthly Lecture Series
    The NCIs Office of Cancer Complementary and Alternative Medicine (OCCAM) invites you to view its monthly lecture series.

    With the goal of informing the National Cancer Institute (NCI) community about the variety of ongoing research in cancer and complementary and alternative medicine (CAM), NCIs Office of Cancer Complementary and Alternative Medicine (OCCAM) has created a monthly lecture series on cancer CAM. These hour long lectures, occurring from 10 a.m. - 11 a.m. on the second Wednesday of each month, will feature a fifty minute presentation on a cancer CAM topic and allow ten minutes for questions.

    For more information, visit
    http://www.cancer.gov/cam/news_lectures.html

    Therapeutic Effects of Boswellia Extracts and Pure Components in Prostate Cancer and Leukemia

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  • Lunch and Learn Parenting Seminar: Presence for the Holidays
    • - Jennifer Alfonso, MBA, MSW, LCSW-C, LifeWork Strategies (2010/11/18)
    • - Category : Parenting
    NIH Child Care Programs and Services

    This seminar will focus on the value of spending time with your children and the impact of overindulgence. The presenter will define the "freedom of limits" and how parents and grandparents can create meaning for children and their families during the holiday season outside the frenzy of gift-giving. Also, strategies for recognizing and reducing family stress.

    The Parenting Seminar is sponsored by the NIH Child Care Board and the Office of Research Services, Division of Amenities and Transportation Services (DATS). For questions, please contact DATS at 301-402-8180.

    For more information, visit http://does.ors.od.nih.gov/childcare/index.htm

    Acrobat Slides

    Lunch and Learn Parenting Seminar: Presence for the Holidays

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  • Reassessing Influenza Virus Antigenic Drift: A Central Role for Anibody Driven Evolution of Viral Receptor Binding Avidity
    • - Hensley, Scott.
      National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18)
    • - Category : Immunology
    Scott Hensley received his PhD from Penn in 2006. Working with Gundi Ertl, he explored interactions between innate and adaptive immune responses to adenovirus vaccine vectors. In the past three years as a post-doctoral fellow in the Laboratory of Viral Diseases, NIAID, Scott has made a number of valuable contributions to viral immunology, demonstrating that mouse norovirus (endemic in most experimental mouse colonies) has minimal effects on mouse T cell and antibody responses to influenza or vaccinia virus, and that immunoproteasomes play an important role in B cell activation. His focus has been to better understand how influenza A virus escapes host immunity. Antigenic drift is the principal factor for the failure to develop vaccines that provide long lasting effective immunity to influenza, and hence is responsible for the considerable morbidity and mortality caused by influenza, year in and year out. Revisiting a mouse model system developed in the 1950s (!), Scott discovered a key factor in antigenic drift: in response to a partially neutralizing antibody response, influenza escapes immune pressure by single amino acid substitutions in the hemagglutinin that increase viral avidity for host cell receptors. At the same time, these mutations decrease viral fitness in the absence of neutralizing antibodies, providing a dynamic force driving hemagglutinin evolution independently of antigenic alterations. The surprising location of these substitutions provides an explanation for a long standing puzzle in hemagglutinin evolution, and adds an important layer of complexity to understanding HA variation. These findings provide the first significant modification to the paradigm of antigenic drift in 30 years, and are broadly applicable to other viruses. Scott is a dynamic, engaging and entertaining speaker: his seminar provides an opportunity to contemplate and discuss long standing questions about antibody neutralization of viruses that have gained new importance with the drive to develop vaccines for viruses that have eluded standard empirical approaches.

    The Immunology Interest Group

    Reassessing Influenza Virus Antigenic Drift: A Central Role for Anibody Driven Evolution of Viral Receptor Binding Avidity

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  • Great Teachers: Treatment of Parkinsons Disease
    • - Jankovic, Joseph.
      National Institutes of Health (U.S.). Clinical Center. (2010/11/18)
    • - Category : Clinical Center Grand Rounds
    Contemporary Clinical Medicine: Great Teachers

    Joseph Jankovic, MD,
    Professor of Neurology and Distinguished Chair in Movement Disorders,
    Director, Parkinsons Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine

    For more information, visit
    http://www.cc.nih.gov/about/news/grcurrent.html

    Great Teachers: Treatment of Parkinsons Disease

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  • The Novel Physiology of Bone
    • - Karsenty, Gerard.
      National Institutes of Health (U.S.) (2010/11/18)
    • - Category : Wednesday Afternoon Lectures
    The lab aims at using mouse genetics to identify novel functional connections between organs and new physiologies that are relevant to human. The overarching assumption explaining all the projects currently ongoing in the laboratory is that there are many new physiological pathways to be discovered in mammals. Our aim is not so much to identify novel regulatory molecules involved in known functions but rather to identify, study and elucidate molecularly totally novel functions or made of regulation for various organs. To test this hypothesis we use skeleton as an organ and the mouse as a model organism. In particular we have hypothesized based on an evolutionary and clinically-based view of bone modeling and remodeling, the physiological functions whereby bone tissue is constantly renewed that there must be a common endocrine control of bone mass and energy metabolism. We have then embarked in a systematic effort to identify the molecules implicated in this co-regulation, to define the pathways in which they are ordered and to explore whether the skeleton affects in an endocrine manner other organs and functions than bone remodeling and bone mineralization.

    The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    The Novel Physiology of Bone

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  • The Second Annual Trauma Spectrum Disorders Conference: A Scientific Conference on the Impact of Military Service on Families and Caregivers
    • - Trauma Spectrum Disorders Conference (2010/11/18)
    • - Category : Conferences
    This is the second annual collaborative scientific conference examining recent research on trauma spectrum disorders (TSD). This year？？？s conference will focus on the impact of TSD on military and veteran families and caregivers across deployment, homecoming, and reintegration. The conference will examine the needs of families and caregivers in support of military and veterans with TSD, factors related to family functioning and reintegration, and effective approaches that facilitate treatment of trauma disorders and services to families and caregivers, paying particular attention to gender and health disparities. Next steps will be developed for addressing research concerns identified at the conference.

    Click here to Register

    Click here for more information on DCoE Events

    The Second Annual Trauma Spectrum Disorders Conference: A Scientific Conference on the Impact of Military Service on Families and Caregivers

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  • Putting Numbers on the Network: Vvariability in Ligand-Induced Cell Death
    • - Gaudet, Suzanne.
      National Institutes of Health (U.S.). Proteomics Interest Group. (2010/11/18)
    • - Category : Proteomics
    http://proteome.nih.gov/

    Putting Numbers on the Network: Vvariability in Ligand-Induced Cell Death

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  • Constituency Meeting to Welcome the New SAMHSA Administrator
    • - Pamela S. Hyde, J.D. (2010/11/18)
    • - Category : Special
    U.S. Secretary Kathleen Sebelius and Constituents Welcome New SAMHSA Administrator Pamela S. Hyde, J.D.

    Constituency Meeting to Welcome the New SAMHSA Administrator

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  • HHS Science Seminar for Media: Advances in Influenza Vaccine Technologies
    • - United States. Dept. of Health and Human Services. (2010/11/18)
    • - Category : Special
    The U.S. Department of Health and Human Services (HHS) will host a three-hour educational program for the media to learn more about ongoing government research efforts to develop and apply new technologies in the making of seasonal and pandemic influenza vaccines. The flu vaccines we use today are extraordinarily safe and have helped protect millions against influenza, but current egg-based technologies are outdated. There are increasing opportunities for new technologies to help better meet both seasonal influenza vaccine and pandemic preparedness and response needs. In these sessions, attendees will hear from and be able to question a number of HHS？？？ top experts on current research efforts, advanced development support, and the regulatory science being applied to help transform vaccine technologies to support rapid, flexible and reliable approaches to influenza and other emerging threats.

    HHS Science Seminar for Media: Advances in Influenza Vaccine Technologies

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  • Frizzled signaling in development and disease
    • - Jeremy Nathans, M.D., Ph.D. (2010/11/18)
    • - Category : Neuroscience
    The principal research interests of the Nathans lab center on two areas: (1) the structure and function of the vertebrate visual system and (2) the origins of pattern formation in development. The Nathans laboratory is approaching questions related to the visual system by studying the retina. The questions we are asking are: (1) How are the patterns of cell identity in the retina determined at a molecular level? (2) How is the final performance of the system affected by individual molecules and molecular events? (3) How is the remarkable structure of photoreceptor cells generated? (4) What are the pathologic mechanisms responsible for blinding diseases and how can this knowledge be applied to therapeutic intervention? Research in the Nathans laboratory on pattern formation focuses on the mechanism of action and biological role of a large family of transmembrane receptors referred to as Frizzled proteins, a name that reflects the odd appearance of those Drosophila in which one of the Frizzled genes is mutated. The Frizzled proteins act as receptors for a family of secreted signaling proteins referred to as Wnts, but at least one non-Wnt ligand activates one of the Frizzleds. Using knock-out mice, they have shown that a remarkably diverse group of developmental processes relies on Frizzled action, including blood vessel development in the retina, development of the cerebellum, axonal growth and path finding in the spinal cord and forebrain, and hair patterning on the body surface. They are currently investigating the mechanisms underlying Frizzled action in these various contexts, and searching for additional roles of Frizzled proteins. In both areas of research, the Nathans laboratory uses genetically engineered mice, cell culture approaches, in vitro biochemical experiments with purified proteins, and the analysis of genes and proteins responsible for inherited human diseases.

    NIH Neuroscience Seminar Series

    Frizzled signaling in development and disease

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  • FY10 Public Access Training for Extramural Staff (HHS-Only)
    • - Neil M. Thakur, Ph.D. (2010/11/18)
    • - Category : ESA (HHS Only)
    This training will provide Extramural Staff with the information necessary to accurately and efficiently monitor compliance with the Public Access Policy. The training will incorporate findings from the recent evaluation of the Public Access Checklist and offer advice on how extramural staff can complete Public Access compliance checks quickly and accurately. It will include examples of common compliant and non-compliant citations, as well as time for discussion.

    http://odoerdb2-1.od.nih.gov/oer/training/esa/esa_training_20091214.htm

    FY10 Public Access Training for Extramural Staff (HHS-Only)

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  • TRACO: Cancer Stem Cells and Nanotechnology
    • - J. Vogel and S. McNeil (2010/11/18)
    • - Category : TRACO
    For more information, visit
    http://ccr.cancer.gov/careers/traco.asp

    TRACO: Cancer Stem Cells and Nanotechnology

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  • IMAG Futures Meeting- Day 1
    • - Interagency Modeling and Analysis Group (IMAG) (2010/11/18)
    • - Category : Conferences
    This roundtable discussion is an opportunity to assess to what extent computational modeling has succeeded or failed to make a difference in the broader research endeavor, and to discuss these issues in the context of current challenges and opportunities for biomedical, biological and behavioral modeling.

    Meeting discussions will be grouped by five biological scales:
    1) Population;
    2) Whole-Body;
    3) Cell-Tissue-Organ;
    4) Pathways and Networks; and
    5) Atomic and Molecular.

    http://www.imagwiki.org/mediawiki/index.php?title=IFM_Announcement

    IMAG Futures Meeting- Day 1

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  • Balancing Somatic Hypermutation and DNA Repair in Immunoglobulin Genes
    • - Gearhart, P J.
      National Institutes of Health (U.S.). DNA Repair Interest Group. (2010/11/18)
    • - Category : DNA Repair
    The DNA Repair Interest Group is concerned with all forms of DNA damage and repair. As a major defense against environmental damage to cells DNA repair is present in all organisms examined including bacteria, yeast, drosophila, fish, amphibians, rodents and humans. The members of the DNA Repair Interest Group perform research in areas including DNA repair enzymology and fine structure, mutagenesis, gene and cell cycle regulation, protein structure, and human disease.

    Acrobat Slides

    For more information, visit the
    DNA Repair Interest Group

    Balancing Somatic Hypermutation and DNA Repair in Immunoglobulin Genes

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  • Oh, My Achy-Breaky Head: The Latest Science and Management of Headaches (HHS Only)
    • - NIH (2010/11/18)
    • - Category : STEP (HHS Only)
    STEP: Staff Training in Extramural Programs

    Have you had a headache lately? If so, you are one of millions of Americans who suffers from this malady. In fact, headaches are a major cause of absenteeism and loss of productivity. There are several types, including migraine and tension headaches. This forum will discuss the latest scientific advances in understanding the underlying mechanisms of headaches, new research approaches, and therapeutic modalities. It will also explore ways to recognize, prevent and manage headaches.

    Committee Members:
    • Chair: Sally Amero
    Members:
    • Oliver Blondel
    • Jody Engel
    • Blaine Moore
    • Linda Porter
    • Arnold Revzin
    • Mike Small
    • Kate White
    For more information, visit
    http://odoerdb2-1.od.nih.gov/oer/training/step/step_training_20091215.htm

    Oh, My Achy-Breaky Head: The Latest Science and Management of Headaches (HHS Only)

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  • Resistance to Immunotherapy at the Level of the Tumor Microenvironment: Implications as a Predictive Biomarker and Opportunities (NIH Only)
    • - Thomas F. Gajewski, M.D., Ph.D., University of Chicago (2010/11/18)
    • - Category : NCI CCR Grand Rounds (NIH Only)
    Dr. Gajewski received both his Ph.D. in Immunology and his M.D. from the University of Chicago (UC). He did postdoctoral research under Dr. Frank Fitch and completed his internship and residency in the Department of Internal Medicine at UC. He then did postdoctoral research under Dr. Thierry Boom at the Ludwig Institute for Cancer Research in Brussels, Belgium, and returned to UC for a fellowship in the Department of Medicine？？？s Section of Hematology Oncology. Dr. Gajewski remains at the University of Chicago where he currently investigates and develops new treatments for patients with melanoma.

    He has a special interest in the development of immunotherapies against this disease. Dr. Gajewski also leads development of immune-based therapies for other cancers, using new laboratory data on how the immune system is regulated to develop novel clinical trials. He serves as an associate editor for the Journal of Immunology and is on the program committees for the American Society for Clinical Oncology (ASCO) and the American Association for Cancer Research (AACR).

    NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link: http://bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx

    Resistance to Immunotherapy at the Level of the Tumor Microenvironment: Implications as a Predictive Biomarker and Opportunities (NIH Only)

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