전체 8345
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- Academic CAT Tracks: Evaluating Positions and Negotiating Offers
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- - Sharon Milgram, PhD, Director of the Office of Intramural Training & Education (2010/11/18)
- - Category : Career Development/OITE
- Objective: So youve got the job offer! Now what do you do? In this workshop, learn what you should consider when beginning negotiations. Also, learn the details you can and cannot negotiate. Topics include: Should you pursue this discussion/negotiation; and Verbal/Written offers.
Academic CAT Tracks: Evaluating Positions and Negotiating Offers
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- Induction of Pluripotency by Defined Factors
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- - Yamanaka, Shinya.
National Institutes of Health (U.S.) (2010/11/18) - - Category : Wednesday Afternoon Lectures
- - Yamanaka, Shinya.
- Human ES cells have been expected as suitable resources for cell transplantation therapies. However, it has sparked ethical controversy and causes immune rejection. Hence, we decided to generate an ideal pluripotent stem cell for innovative medicine.
At first, we constructed a pluripotency assay system that the candidate factors are introduced into neonate fibroblasts via retrovirus vectors. As the result, the set of Oct3/4, Sox2, c-Myc, and Klf-4 gave rise to drug resistant colonies implying potential pluripotency. The survived cells resembled ES cells in terms of morphology and proliferation showed ES cell markers and formed teratoma. It was named as induced pluripotent stem cell (iPS cell). iPS cells were created even from adult mouse fibroblasts. Moreover, iPS cells based on Nanog-expression demonstrated germline transmission. Furthermore, we successfully generated iPS cells from human adult fibroblasts, using a modified protocol.
However, tumor formation was observed in chimera mouse, probably due to c-Myc retrovirus integrated into genome. We re-modified the protocol and successfully established iPS cells without using c-Myc. As further effort to lower a risk of tumorigenesis, we recently succeeded in developing a virus-free method - using a pair of plasmid vectors, instead of retrovirus vectors, to introduce the four genes into mouse fibroblasts.
Further research results are discussed from the points of safety and induction efficiency of iPS cells for future clinical grade.
The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Induction of Pluripotency by Defined Factors
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- Induced Pluripotent Stem Cells and the NIH Intramural Research Program
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- - Drs. Collins, Gottesman, Yamanaka, Blau, Baldwin, McKay, Reijo Pera, Cheng, Studer, Goodell, Scadden, Ellis and Puri (2010/11/18)
- - Category : Conferences
- A workshop to discuss the state-of-the-art field of induced pluripotent stem cells and its impact on associated areas.
Induced Pluripotent Stem Cells and the NIH Intramural Research Program
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- 7T Seminar Series: Methods for Anatomy and Function
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- - Speck, Oliver.
National Institutes of Health (U.S.) (2010/11/18) - - Category : 7 T Seminars
- - Speck, Oliver.
- Dr. Oliver Speck from Otto-von-Guericke-University, Magdeburg, Germany, runs what is arguably the best functioning human 7T in the world today. He is a physicist who works closely with people performing both MRI, processing, and coil development as well as people performing a wide range of fMRI and MRI experiments that have both neuroscience and clinical impact. His seminar is on his experience with his 7T scanner.
7T Seminar Series: Methods for Anatomy and Function
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- AIDS Therapy: Successes, Challenges, and Opportunities (NIH-Only)
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- - Hiroaki Mitsuya, M.D., PH.D. (2010/11/18)
- - Category : NCI CCR Grand Rounds (NIH Only)
- Dr. Hiroaki Mitsuya obtained his M.D. and Ph.D. in Kumamoto University School of Medicine in Japan. After receiving immunology/hematology/oncology training at Kumamoto University Hospital, Dr. Mitsuya joined the National Cancer Institute in 1982 and began studying the outcomes of infection by human T cell leukemia virus type 1, the first known human pathogenic retrovirus. In 1984, Dr. Mitsuya steered his attention to human immunodeficiency virus or HIV with two other NCI researchers, Drs. Samuel Broder and Robert Yarchoan. Dr. Mitsuya soon established the first assay system to evaluate the activity of drugs against HIV. Using this system, in 1985, he found anti-HIV activity in vitro in a number of compounds including 3-azido-2,3-dideoxythymidine (AZT, zidovudine), 2,3-dideoxyinosine (ddI, didanosine), and 2,3-dideoxycytidine (ddC, zalcitabine). Based on his data, it was eventually shown that antiretroviral therapy improves immunologic functions in patients with AIDS and blocks the progression of the disease.
Dr. Mitsuya has since been a leading researcher in the area of development of AIDS therapeutics and study of HIV resistance. Recently he has been playing a major role in the development of the next generation of anti-HIV drugs such as darunavir. The drugs that he found, combined with a protease inhibitor, comprised the first highly active antiretroviral therapy (HAART) for HIV, which resulted in a dramatic prolongation of survival of AIDS patients and a profound reduction in the morbidity and mortality from this worldwide epidemic. Moreover, AZT and other antiretroviral drugs have proven effective at interrupting vertical transmission of HIV and have dramatically reduced the incidence of perinatal AIDS. It has recently been estimated that combination antiretroviral therapy has saved over 3 million person-years of life in the Unites States alone.
Dr. Mitsuya has been Chief, Experimental Retrovirology Section, NCI, USA since 1991; and Chairman and Professor, Departments of Hematology and Rheumatology, and Director, Division of Infectious Diseases, Kumamoto University School of Medicine, Japan since 1997. He has received various awards including NIH Directors Award (1992), First NIH World AIDS Day Award (2006), Medal with Purple Ribbon from Japan (2007), NCI HIV/AIDS Research Excellence Award (2007), Keio Medical Science Prize (2007) and Takamine Sankyo Memorial Award (2007). Dr. Mitsuya currently serves as Program Leader
NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link: http://bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx
AIDS Therapy: Successes, Challenges, and Opportunities (NIH-Only)
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- IACC Full Committee Meeting
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- - Insel, Thomas R.
Interagency Autism Coordinating Committee (U.S.) (2010/11/18) - - Category : Interagency Autism Coordinating Committee
- - Insel, Thomas R.
IACC Full Committee Meeting
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- A New Year, a New Application, a New Progress Report, and a New Stem Cell Policy (HHS-Only)
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- - Carol Wigglesworth; Sponsor: GMAC Subcommittee on Training (2010/11/18)
- - Category : GMAC (HHS Only)
- Enhancing Peer Review, a new Progress Report, a new Human Embryonic Stem Cell Policy, and the continued Transition to Electronic Submission, oh my! The implementation of new policies means a number of changes for NIH staff and grantees in 2010. This seminar will summarize recent changes and address frequent questions we are facing, including what to do with the new All Personnel Report.
http://odoerdb2-1.od.nih.gov/gmac/gmac/trs_main.html
A New Year, a New Application, a New Progress Report, and a New Stem Cell Policy (HHS-Only)
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- Amino Acid Neurotransmitter Systems Contributions to the Pathophysiology and Treatment of Depression
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- - Gerard Sanacora, MD, PhD (2010/11/18)
- - Category : Special
- Candidate for NIMH-DIRP Mood and Anxiety Disorders Program Principal Investigator
Amino Acid Neurotransmitter Systems Contributions to the Pathophysiology and Treatment of Depression
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- Biological Sequence Analysis I
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- - Andreas Baxevanis, Ph.D. (2010/11/18)
- - Category : Current Topics in Genome Analysis
- Current Topics in Genome Analysis
Biological Sequence Analysis I
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- Telomerase and the Consequences of Telomere Dysfunction
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- - Carol Greider, Ph.D., 2009 Nobel Laureate in Physiology or Medicine (2010/11/18)
- - Category : Special
- National Human Genome Research Institute Division of Intramural Research
The Seventh Annual Jeffrey M. Trent Lectureship in Cancer Research
Carol Greider, Ph.D.
Daniel Nathans Professor and Director, Department of Molecular Biology and Medicine The Johns Hopkins Institute for Basic Biomedical Sciences
2009 Nobel Laureate in Physiology or Medicine
Telomerase and the Consequences of Telomere Dysfunction
About the Lecturer
Dr. Greider received her B.A. from the University of California at Santa Barbara in 1983 and her Ph.D. in 1987 from the University of California at Berkeley. In 1984, working together with Dr. Elizabeth Blackburn, she discovered telomerase, an enzyme that maintains telomeres, or chromosome ends.
Dr. Greider first isolated and characterized telomerase from the ciliate Tetrahymena. In 1988, as an independent Cold Spring Harbor Fellow, she cloned and characterized the RNA component of telomerase. In 1990, Dr. Greider was appointed as an Assistant Investigator at Cold Spring Harbor Laboratory and became an Investigator in 1994. She expanded the focus of her telomere research to include the role of telomere length in cell senescence, cell death, and cancer. Together with Dr. Calvin Harley, she showed that human telomeres shorten progressively in primary human cells. This work, along with work of other researchers, led to the idea that telomere maintenance and telomerase may play important roles in cellular senescence and cancer.
In 1997, Dr. Greider moved her laboratory to the Department of Molecular Biology and Genetics at The Johns Hopkins University School of Medicine. In 1999, she was appointed Professor and, in 2004, she was appointed the Daniel Nathans Professor and Director of the Department of Molecular Biology and Genetics. Once at Hopkins, Dr. Greiders group continued to study the biochemistry of telomerase and determined the secondary structure of human telomerase RNA. She also expanded her work on a mouse model of dyskeratosis congenita and stem cell failure in response to short telomeres. Dr. Greider currently studies both the biochemistry of telomeres and telomerase, as well as the cellular organismal consequences of short telomeres.
Dr. Greider has won numerous prestigious awards for her work on telomerase, including the Gairdner Foundation Award in 1998, the Albert Lasker Award for Basic Medical Research in 2006, and the Dickson Prize in Medicine in 2007. This past year, she accepted the Paul Ehrlich and Ludwig Darmstaedter Prize and the Pearl Meister Greengard Prize.
On October 5, 2009, Dr. Grieder was awarded the Nobel Prize in Physiology or Medicine for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase.
About the Jeffrey M. Trent Lectureship in Cancer Research
Dr. Trent was the National Human Genome Research Institutes (NHGRI) founding Scientific Director, serving in this role for more than nine years. His leadership and vision was instrumental in establishing NHGRIs Division of Intramural Research as one of the premier research programs in the world devoted to genetics and genomics. In recognition of his significant contributions to the research environment at NIH, NHGRI established the annual Jeffrey M. Trent Lectureship in Cancer Research in 2003. This lecture is given by a prominent cancer researcher who brings the kind of energy, creativity and enthusiasm to cancer research that Dr. Trent has exemplified throughout his career.
Telomerase and the Consequences of Telomere Dysfunction
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- Hepatitis C: A Global Time Bomb
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- - Harvey Alter (CC), Patrizia Farci (NAID) (2010/11/18)
- - Category : Demystifying Medicine
- The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.
For more information, visit
http://www1.od.nih.gov/oir/DemystifyingMed
Hepatitis C: A Global Time Bomb
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- Brain Navigator Training (NIH Only)
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- - David Marques and Sarah Tyrchniewicz from Elsevier (2010/11/18)
- - Category : NIH Only
- BrainNavigator is a powerful 3D brain interactive software tool for research in the neurosciences. The BrainNavigator Rodent Edition combines a number of atlases with 3D virtual brain software capabilities to provide imaging for research, education and structure analysis. Login is required for every user to have access to BrainNavigator？？？s custom features like personalized workspace annotation, calibration, notes sharing, 3D slice configuration and saving of 3D model configurations.
Find it among other databases offered by the NIH Library at our Database page, or http://bit.ly/5TR7BP.
This event is sponsored by the NIH Library as part of its Resource Training Program on new or existing research tools.
Brain Navigator Training (NIH Only)
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- CC Grand Rounds: (1) Updates in Obesity Research (2) Measuring Energy Expenditure in Humans: Tales from the Metabolic Chamber
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- - NIH Clinical Center (2010/11/18)
- - Category : Clinical Center Grand Rounds
- Giovanni Cizza, MD, PhD, Sc,
Tenure-Track Investigator, Clinical Endocrinology Branch,
Divison of Intramural Research, NIDDK
Kong Chen, PhD, MSCI,
Director, Metabolic Research Core,
Division of Intramural Research, NIDDK
For more information, visit
http://www.cc.nih.gov/about/news/grcurrent.html
CC Grand Rounds: (1) Updates in Obesity Research (2) Measuring Energy Expenditure in Humans: Tales from the Metabolic Chamber
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- Grants.gov Quarterly Stakeholder Webcast - January 2010
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- - Michael Pellegrino (2010/11/18)
- - Category : Grants.gov
- The Grants.gov Quarterly Stakeholder Webcast is a quarterly meeting where applicants and grantors are provided information regarding the Grants.gov program.
Grants.gov Quarterly Stakeholder Webcast - January 2010
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- When pathways intersect: MCSF-R AND ITAMs in myeloid cell functions
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- - Colonna, M.
National Institutes of Health (U.S.). Immunology Interest Group. (2010/11/18) - - Category : Immunology
- - Colonna, M.
- Dr Colonna is a Professor of Pathology and Immunology at Washington University School of Medicine in St. Louis. He received his MD in Parma Italy, and trained with Jack Strominger at Harvard. His work has contributed significantly to our understanding of inhibitory receptor signaling in natural killer cells. Dr Colonna has also done seminal work on plasmacytoid dendritic cells, including identifying Siglec-H, and showing that it is a pDC specific receptor that can inhibit IFN secretion via DAP12. He always has new and interesting data to present.
The Immunology Interest Group
When pathways intersect: MCSF-R AND ITAMs in myeloid cell functions
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- Utilizing Results from the NIH GIST Clinics to Plan for the Future
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- - Kim, Su Young.
Pediatric GIST Clinic Invitational Lecture (2010/11/18) - - Category : Special
- - Kim, Su Young.
- 4th Pediatric and wildtype GIST Clinic Invitational Lecture
For more information, visit http://www.pediatricgist.cancer.gov
Utilizing Results from the NIH GIST Clinics to Plan for the Future
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- NCI Communications Strategy Roundtable Seminar Series: Cancer Communication in Clinical Settings
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- - Sponsored by the NCI Communications Strategy Roundtable, Office of Communications and Education, NCI (2010/11/18)
- - Category : Special
- Researchers from the NCI-funded Cancer Communication Research Center of the Kaiser Foundation Health Plan of Colorado will present findings on patient-provider communication and communication issues of care coordination among providers, in addition to information technology support of patient-centered communication. The primary goal of the seminar is to identify potential practical application of these research findings.
Topics to be discussed:
- Cancer Communication in Clinical Settings: an Overview
Jim Dearing- Testing an Optimal Model of Patient-Centered Cancer Care
Kathryn Horner- Effective Communication for Preventing Oncology Adverse Events
Kathleen Mazor and Thomas Gallagher- Dissemination and Harmonization of Behavioral Science Measures Across Clinical Settings
Russ Glasgow
Each seminar in the series, designed for those interested in using current communication research information to enhance the impact and effectiveness of health-related communications, will include a networking session from 11 to 11:30 a.m. The series is sponsored by the NCI Communications Strategy Roundtable, Office of Communications and Education, NCI. This seminar is produced in collaboration with the Health Communications & Informatics Research Branch in the Division of Cancer Control and Population Sciences, NCI. - Cancer Communication in Clinical Settings: an Overview
NCI Communications Strategy Roundtable Seminar Series: Cancer Communication in Clinical Settings
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- Self- Determination Theory and Motivating Health Behavior
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- - Dr. Geoffrey Williams (2010/11/18)
- - Category : Crosstalk Lectures
- Crosstalk Lecture Series
The goal of the "Crosstalk" Lecture Series is to engage researchers whose work explicitly translates theory and/or methods from one literature or topic area (e.g., obesity) to another (e.g., tobacco cessation). ？？？Crosstalk？？？ is part of a Behavioral Research Program (Division of Cancer Control and Population Sciences, National Cancer Institute) initiative to expand connections between, and among, behavioral science disciplines ？？？ both in our own work and in that of our constituency.
Self- Determination Theory and Motivating Health Behavior
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- Directing Traffic: Tethers, SNAREs and Vesicle Tranport
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- - Fred Hughson, Princeton University (2010/11/18)
- - Category : Structural Biology
- The SBIG is a clearinghouse for discussions and interactions between scientists interested in all aspects of molecular structure, from experimental determination by x-ray crystallography, electron microscopy, mass spectrometry, and NMR, to theoretical and computational biology and biophysics, and to the biological application of structural data.
For more information, visit
Structural Biology Interest Group
Directing Traffic: Tethers, SNAREs and Vesicle Tranport
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- New Models for Large Prospective Studies
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- - National Institutes of Health (U.S.). Division of Program Coordination, Planning, and Strategic Initiatives. (2010/11/18)
- - Category : Conferences
- Large prospective, population-based cohorts are the optimal design for defining disease burden and studying the many genetic, lifestyle, and environmental factors that underlie human disease. Leveraging or expanding existing efforts to establish a large-scale population cohort may serve to create a much needed national research resource with which to examine genetic and environmental contributions to disease and advance personalized medicine. The symposium, organized by the NIH Office of the Director, will feature the UK Biobank and other large-scale national and international efforts and involve a series of plenary sessions and discussion panels to highlight novel approaches, lessons learned, and emerging opportunities in key aspects of study design including recruitment, examination and assessment, biospecimens, health records, IT infrastructure; consent, ethics, and access; and funding.
New Models for Large Prospective Studies